KEGG   ENZYME: 2.4.1.374
Entry
EC 2.4.1.374                Enzyme                                 

Name
beta-1,2-mannooligosaccharide synthase;
MTP1 (gene name);
MTP2 (gene name)
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
Sysname
GDP-alpha-D-mannose:(1->2)-beta-D-mannan mannosyltransferase (configuration-inverting)
Reaction(IUBMB)
GDP-alpha-D-mannose + [(1->2)-beta-D-mannosyl]n = GDP + [(1->2)-beta-D-mannosyl]n+1 [RN:R12529]
Reaction(KEGG)
R12529
Substrate
GDP-alpha-D-mannose [CPD:C00096];
[(1->2)-beta-D-mannosyl]n [CPD:C21335]
Product
GDP [CPD:C00035];
[(1->2)-beta-D-mannosyl]n+1
Comment
The enzyme, characterized from Leishmania parasites, is involved in synthesis of mannogen, a beta-(1->2)-mannan oligosaccharide used by the organisms as a carbohydrate reserve.
History
EC 2.4.1.374 created 2019
Orthology
K23982  beta-1,2-mannooligosaccharide synthase
Genes
LMA: LMJF_10_1230 LMJF_10_1240
LIF: LINJ_10_1370 LINJ_10_1380
LDO: LDBPK_101370 LDBPK_101380
LMI: LMXM_10_1230 LMXM_10_1240
LBZ: LBRM_10_1380 LBRM_10_1390
LPAN: LPMP_101180 LPMP_101190
Reference
1  [PMID:31513773]
  Authors
Sernee MF, Ralton JE, Nero TL, Sobala LF, Kloehn J, Vieira-Lara MA, Cobbold SA, Stanton L, Pires DEV, Hanssen E, Males A, Ward T, Bastidas LM, van der Peet PL, Parker MW, Ascher DB, Williams SJ, Davies GJ, McConville MJ
  Title
A Family of Dual-Activity Glycosyltransferase-Phosphorylases Mediates Mannogen Turnover and Virulence in Leishmania Parasites.
  Journal
Cell Host Microbe 26:385-399.e9 (2019)
DOI:10.1016/j.chom.2019.08.009
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.374
IUBMB Enzyme Nomenclature: 2.4.1.374
ExPASy - ENZYME nomenclature database: 2.4.1.374
BRENDA, the Enzyme Database: 2.4.1.374

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