KEGG ENZYME: 2.4.1.374

ENZYME: 2.4.1.374

Entry

EC 2.4.1.374                Enzyme

Name

beta-1,2-mannooligosaccharide synthase;
MTP1 (gene name);
MTP2 (gene name)

Class

Transferases;
Glycosyltransferases;
Hexosyltransferases

Sysname

GDP-alpha-D-mannose:(1->2)-beta-D-mannan mannosyltransferase (configuration-inverting)

Reaction(IUBMB)

GDP-alpha-D-mannose + [(1->2)-beta-D-mannosyl]n = GDP + [(1->2)-beta-D-mannosyl]n+1 [RN:R12529]

Reaction(KEGG)

R12529

Substrate

GDP-alpha-D-mannose [CPD:C00096];
[(1->2)-beta-D-mannosyl]n [CPD:C21335]

Product

GDP [CPD:C00035];
[(1->2)-beta-D-mannosyl]n+1

Comment

The enzyme, characterized from Leishmania parasites, is involved in synthesis of mannogen, a beta-(1->2)-mannan oligosaccharide used by the organisms as a carbohydrate reserve.

History

EC 2.4.1.374 created 2019

Orthology

K23982

beta-1,2-mannooligosaccharide synthase

Genes

LMA:	LMJF_10_1230 LMJF_10_1240

LIF:	LINJ_10_1370 LINJ_10_1380

LDO:	LDBPK_101370 LDBPK_101380

LMI:	LMXM_10_1230 LMXM_10_1240

LMAT:

92517030(LSCM1_07130) 92517031(LSCM1_07131)

LBZ:	LBRM_10_1380 LBRM_10_1390

LPAN:

LPMP_101180 LPMP_101190

Reference

1 [PMID:31513773]

Authors

Sernee MF, Ralton JE, Nero TL, Sobala LF, Kloehn J, Vieira-Lara MA, Cobbold SA, Stanton L, Pires DEV, Hanssen E, Males A, Ward T, Bastidas LM, van der Peet PL, Parker MW, Ascher DB, Williams SJ, Davies GJ, McConville MJ

Title

A Family of Dual-Activity Glycosyltransferase-Phosphorylases Mediates Mannogen Turnover and Virulence in Leishmania Parasites.

Journal

Cell Host Microbe 26:385-399.e9 (2019)
DOI:10.1016/j.chom.2019.08.009

Sequence

[lmi:LMXM_10_1230 LMXM_10_1240]

Other DBs

ExplorEnz - The Enzyme Database:

2.4.1.374

IUBMB Enzyme Nomenclature:

2.4.1.374

ExPASy - ENZYME nomenclature database:

2.4.1.374

BRENDA, the Enzyme Database:

2.4.1.374

All links

Chemical substance (3)   
   KEGG COMPOUND (3)   
Chemical reaction (1)   
   KEGG REACTION (1)   
Gene (15)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (14)   
All databases (19)   

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