KEGG   ENZYME: 2.4.1.379
Entry
EC 2.4.1.379                Enzyme                                 
Name
GDP-Man:alpha-D-Gal-diphosphoundecaprenol alpha-1,3-mannosyltransferase;
wbaZ (gene name);
rfbZ (gene name)
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
Sysname
GDP-alpha-D-mannose:alpha-D-mannopyranosyl-(1->3)-alpha-D-galactopyranosyl-diphospho-ditrans,octacis-undecaprenol 3-alpha-mannosyltransferase (configuration-retaining)
Reaction(IUBMB)
GDP-alpha-D-mannose + alpha-D-galactosyl-diphospho-ditrans-octacis-undecaprenol = GDP + alpha-D-Man-(1->3)-alpha-D-Gal-PP-Und [RN:R12741]
Reaction(KEGG)
R12741(G)
Substrate
GDP-alpha-D-mannose [CPD:C00096];
alpha-D-galactosyl-diphospho-ditrans-octacis-undecaprenol
Product
GDP [CPD:C00035];
alpha-D-Man-(1->3)-alpha-D-Gal-PP-Und
Comment
The enzyme, present in Salmonella strains that belong to group C2, participates in the biosynthesis of the repeat unit of O antigens produced by these strains.
History
EC 2.4.1.379 created 2021
Orthology
K25196  O-antigen biosynthesis alpha-1,3-mannosyltransferase
Genes
SEESNSL254_A2264
SENNSN31241_31880
SENBBN855_21710
SALZEOS98_08565
SENPKHA73_08135
Reference
1  [PMID:1722557]
  Authors
Brown PK, Romana LK, Reeves PR.
  Title
Cloning of the rfb gene cluster of a group C2 Salmonella strain: comparison with the rfb regions of groups B and D.
  Journal
Mol Microbiol 5:1873-81 (1991)
DOI:10.1111/j.1365-2958.1991.tb00811.x
Reference
2  [PMID:1379320]
  Authors
Brown PK, Romana LK, Reeves PR.
  Title
Molecular analysis of the rfb gene cluster of Salmonella serovar muenchen (strain M67): the genetic basis of the polymorphism between groups C2 and B.
  Journal
Mol Microbiol 6:1385-94 (1992)
DOI:10.1111/j.1365-2958.1992.tb00859.x
  Sequence
Reference
3  [PMID:7684736]
  Authors
Liu D, Haase AM, Lindqvist L, Lindberg AA, Reeves PR.
  Title
Glycosyl transferases of O-antigen biosynthesis in Salmonella enterica: identification and characterization of transferase genes of groups B, C2, and E1.
  Journal
J Bacteriol 175:3408-13 (1993)
DOI:10.1128/JB.175.11.3408-3413.1993
  Sequence
Reference
4  [PMID:28929089]
  Authors
Zhao X, Dai Q, Jia R, Zhu D, Liu M, Wang M, Chen S, Sun K, Yang Q, Wu Y, Cheng A.
  Title
Two Novel Salmonella Bivalent Vaccines Confer Dual Protection against Two Salmonella Serovars in Mice.
  Journal
Front Cell Infect Microbiol 7:391 (2017)
DOI:10.3389/fcimb.2017.00391
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.379
IUBMB Enzyme Nomenclature: 2.4.1.379
ExPASy - ENZYME nomenclature database: 2.4.1.379
BRENDA, the Enzyme Database: 2.4.1.379

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