KEGG   ENZYME: 2.4.1.380
Entry
EC 2.4.1.380                Enzyme                                 
Name
GDP-Man:alpha-D-Man-(1->3)-alpha-D-Gal diphosphoundecaprenol alpha-1,2-mannosyltransferase;
wbaW (gene name);
rfbW (gene name)
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
Sysname
GDP-alpha-D-mannose:alpha-D-mannopyranosyl-(1->3)-alpha-D-galactopyranosyl-diphospho-ditrans,octacis-undecaprenol 2II-alpha-mannosyltransferase (configuration-retaining)
Reaction(IUBMB)
GDP-alpha-D-mannose + alpha-D-Man-(1->3)-alpha-D-Gal-PP-Und = GDP + alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Gal-PP-Und [RN:R12742]
Reaction(KEGG)
R12742(G)
Substrate
GDP-alpha-D-mannose [CPD:C00096];
alpha-D-Man-(1->3)-alpha-D-Gal-PP-Und
Product
GDP [CPD:C00035];
alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Gal-PP-Und
Comment
The enzyme, present in Salmonella strains that belong to group C2, participates in the biosynthesis of the repeat unit of O antigens produced by these strains.
History
EC 2.4.1.380 created 2021
Orthology
K25197  O-antigen biosynthesis alpha-1,2-mannosyltransferase
Genes
SEESNSL254_A2265
SENNSN31241_31890
SENBBN855_21720
SALZEOS98_08560
PDVFFU37_01080
Reference
1  [PMID:1722557]
  Authors
Brown PK, Romana LK, Reeves PR.
  Title
Cloning of the rfb gene cluster of a group C2 Salmonella strain: comparison with the rfb regions of groups B and D.
  Journal
Mol Microbiol 5:1873-81 (1991)
DOI:10.1111/j.1365-2958.1991.tb00811.x
Reference
2  [PMID:1379320]
  Authors
Brown PK, Romana LK, Reeves PR.
  Title
Molecular analysis of the rfb gene cluster of Salmonella serovar muenchen (strain M67): the genetic basis of the polymorphism between groups C2 and B.
  Journal
Mol Microbiol 6:1385-94 (1992)
DOI:10.1111/j.1365-2958.1992.tb00859.x
  Sequence
Reference
3  [PMID:7684736]
  Authors
Liu D, Haase AM, Lindqvist L, Lindberg AA, Reeves PR.
  Title
Glycosyl transferases of O-antigen biosynthesis in Salmonella enterica: identification and characterization of transferase genes of groups B, C2, and E1.
  Journal
J Bacteriol 175:3408-13 (1993)
DOI:10.1128/JB.175.11.3408-3413.1993
  Sequence
Reference
4  [PMID:28929089]
  Authors
Zhao X, Dai Q, Jia R, Zhu D, Liu M, Wang M, Chen S, Sun K, Yang Q, Wu Y, Cheng A.
  Title
Two Novel Salmonella Bivalent Vaccines Confer Dual Protection against Two Salmonella Serovars in Mice.
  Journal
Front Cell Infect Microbiol 7:391 (2017)
DOI:10.3389/fcimb.2017.00391
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.380
IUBMB Enzyme Nomenclature: 2.4.1.380
ExPASy - ENZYME nomenclature database: 2.4.1.380
BRENDA, the Enzyme Database: 2.4.1.380

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