KEGG   ENZYME: 2.4.1.381
Entry
EC 2.4.1.381                Enzyme                                 
Name
dTDP-Rha:alpha-D-Man-(1->3)-alpha-D-Gal diphosphoundecaprenol alpha-1,2-rhamnosyltransferase;
wbaQ (gene name);
rfbQ (gene name)
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
Sysname
dTDP-beta-L-rhamnose:alpha-D-mannopyranosyl-(1->2)-alpha-D-mannopyranosyl-(1->3)-alpha-D-galactopyranosyl-diphospho-ditrans,octacis-undecaprenol 2III-alpha-rhamnosyltransferase (configuration-inverting)
Reaction(IUBMB)
dTDP-beta-L-rhamnose + alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Gal-PP-Und = dTDP + alpha-L-Rha-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Gal-PP-Und [RN:R12743]
Reaction(KEGG)
R12743(G)
Substrate
dTDP-beta-L-rhamnose [CPD:C03319];
alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Gal-PP-Und
Product
dTDP [CPD:C00363];
alpha-L-Rha-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Gal-PP-Und
Comment
The enzyme, present in Salmonella strains that belong to group C2, participates in the biosynthesis of the repeat unit of O antigens produced by these strains.
History
EC 2.4.1.381 created 2021
Orthology
K25198  O-antigen biosynthesis alpha-1,2-rahmnosyltransferase
Genes
SEESNSL254_A2267
SENNSN31241_31910
SENBBN855_21740
SAVIJYB87_13115
DPHEHF33_04375
Reference
1  [PMID:1722557]
  Authors
Brown PK, Romana LK, Reeves PR.
  Title
Cloning of the rfb gene cluster of a group C2 Salmonella strain: comparison with the rfb regions of groups B and D.
  Journal
Mol Microbiol 5:1873-81 (1991)
DOI:10.1111/j.1365-2958.1991.tb00811.x
Reference
2  [PMID:1379320]
  Authors
Brown PK, Romana LK, Reeves PR.
  Title
Molecular analysis of the rfb gene cluster of Salmonella serovar muenchen (strain M67): the genetic basis of the polymorphism between groups C2 and B.
  Journal
Mol Microbiol 6:1385-94 (1992)
DOI:10.1111/j.1365-2958.1992.tb00859.x
  Sequence
Reference
3  [PMID:7684736]
  Authors
Liu D, Haase AM, Lindqvist L, Lindberg AA, Reeves PR.
  Title
Glycosyl transferases of O-antigen biosynthesis in Salmonella enterica: identification and characterization of transferase genes of groups B, C2, and E1.
  Journal
J Bacteriol 175:3408-13 (1993)
DOI:10.1128/JB.175.11.3408-3413.1993
  Sequence
Reference
4  [PMID:28929089]
  Authors
Zhao X, Dai Q, Jia R, Zhu D, Liu M, Wang M, Chen S, Sun K, Yang Q, Wu Y, Cheng A.
  Title
Two Novel Salmonella Bivalent Vaccines Confer Dual Protection against Two Salmonella Serovars in Mice.
  Journal
Front Cell Infect Microbiol 7:391 (2017)
DOI:10.3389/fcimb.2017.00391
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.381
IUBMB Enzyme Nomenclature: 2.4.1.381
ExPASy - ENZYME nomenclature database: 2.4.1.381
BRENDA, the Enzyme Database: 2.4.1.381

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