KEGG   ENZYME: 2.4.1.46
Entry
EC 2.4.1.46                 Enzyme                                 
Name
monogalactosyldiacylglycerol synthase;
uridine diphosphogalactose-1,2-diacylglycerol galactosyltransferase;
UDP-galactose:diacylglycerol galactosyltransferase;
MGDG synthase;
UDP galactose-1,2-diacylglycerol galactosyltransferase;
UDP-galactose-diacylglyceride galactosyltransferase;
UDP-galactose:1,2-diacylglycerol 3-beta-D-galactosyltransferase;
1beta-MGDG;
1,2-diacylglycerol 3-beta-galactosyltransferase;
UDP-galactose:1,2-diacyl-sn-glycerol 3-beta-D-galactosyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
Sysname
UDP-alpha-D-galactose:1,2-diacyl-sn-glycerol 3-beta-D-galactosyltransferase
Reaction(IUBMB)
UDP-alpha-D-galactose + a 1,2-diacyl-sn-glycerol = UDP + a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol [RN:R02691]
Reaction(KEGG)
R02691
Substrate
UDP-alpha-D-galactose [CPD:C00052];
1,2-diacyl-sn-glycerol [CPD:C00641]
Product
UDP [CPD:C00015];
1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol
Comment
This enzyme adds only one galactosyl group to the diacylglycerol; EC 2.4.1.241, digalactosyldiacylglycerol synthase, adds a galactosyl group to the product of the above reaction. There are three isoforms in Arabidopsis that can be divided into two types, A-type (MGD1) and B-type (MGD2 and MGD3). MGD1 is the isoform responsible for the bulk of monogalactosyldiacylglycerol (MGDG) synthesis in Arabidopsis [4].
History
EC 2.4.1.46 created 1972, modified 2003, modified 2005
Pathway
ec00561  Glycerolipid metabolism
ec01100  Metabolic pathways
Orthology
K03715  1,2-diacylglycerol 3-beta-galactosyltransferase
Genes
ATHAT2G11810(MGDC) AT4G31780(MGD1) AT5G20410(MGD2)
ALY9305384 9308006 9319839
CRB17878480 17882958 17892650
CSAT104700063 104706388 104717012 104721659 104730134 104736117 104748635 104767934 104770420
EUSEUTSA_v10013431mg EUTSA_v10022676mg EUTSA_v10024883mg
BRP103837651 103851349 103851545 103862083
BNA106354743 106366315 106368692 106372755 106375399 106392218 106420497 106423395 106425766 111204520
BOE106301258 106316128 106316193 106325403
RSZ108824363 108842169 108843682 108853953
THJ104808956 104811011 104819949
CPAP110808254 110826136
CIT102614331 102616808 102624996
CICCICLE_v10007936mg CICLE_v10008213mg CICLE_v10010220mg
PVY116108379 116108383 116138108
MINC123194445 123195049 123199903
TCC18587678 18588847
GRA105770833 105773757 105776111 105781160
GHI107901653 107953724 107961718 121212595 121217451 121225007 121229214 121232004
GAB108450048 108477428 108486783
DZI111284770 111286736 111299430 111303304
EGR104436070 104438405 104438611 104438888
GMX100794727 100804814 100806325 547469(MGD1)
GSJ114374435 114385082 114392744 114394029
PVUPHAVU_001G042600g PHAVU_003G171300g
VRA106762909 106766883
VAR108323869 108338531
VUN114175823 114194729
CCAJ109808150 109817751
APRC113846505 113874985
MTR11428752 11439263 25500699
CAM101510704 101515157
PSAT127073476 127092901
LJALj0g3v0327859.1(Lj0g3v0327859.1) Lj4g3v1935530.1(Lj4g3v1935530.1)
ADU107461393 107470593 107495613
AIP107605453 107623603 107640550
AHF112697606 112701499 112716006 112723333 112755834 112783732
LANG109326041 109328766 109339323 109343788 109345964 109354684
FVE101295108 101304410
RCN112173289 112188707
PPER18770365 18793552
PMUM103320709 103341171
PAVI110752682 110762666
PDUL117633726 117635731
MDM103401643 103417972 103440567 103442345
PXB103949172 103949703 103949750 103953356 103953874
ZJU107407197 107419930
MNT21396532 21407637
CSV101209030 101215352
CMO103488358 103496946
BHJ120075858 120079310
MCHA111004707 111013024
CMAX111465534 111493715 111496183
CMOS111444335 111450318 111454498
CPEP111798450 111799315 111806023
RCU8263869 8274155
JCU105637529 105641265
HBR110636479 110657369 110671192 110671419
MESC110600030 110604125 110611819
POP18099909 18111074 7465432 7468702
PEU105121074 105122665 105130558 105134120
PALZ118032612 118050172 118051142 118052055
JRE108995671 109000998 109005204 109008297
QSU111986418 111998614 112024357
QLO115974813 115977130
TWL119993637 119997838
VVI100247378 100248939
VRI117912821 117924660
SLY101246362 101259856 101263085
SPEN107007576 107026350 107028612
SOT102578822 102588275 102600797 102600922
SSTN125842124 125855119 125875926
CANN107840795 107848737 107877723
NTA107758934 107778411 107787940(NtMGD1) 107796922 107814929 107815856
NSY104220710 104239147 104244772
NTO104091472 104102546 104108525
NAU109207107 109208351 109234432
INI109147300 109168378 109169926 109178727
ITR116001911 116007458 116012054 116023241
SIND105162237 105164881 105166432
OEU111374436 111388678 111398224 111399376 111407920
EGT105960665 105975327
SSPL121748721 121751961 121752090 121783436 121801630 121805604 121808305
APAN127239996 127251388 127255782 127266408
HAN110877347 110899401 110928684 110930343
ECAD122599393 122600251
LSV111877804 111908547
CCAV112501081 112507778 112529284
DCR108201943 108206444 108211851 108215641
CSIN114256679 114266251 114284431
BVG104887802 104901921
SOE110791699 110805894
CQI110708023 110712165 110723048 110725562
NNU104586160 104589849 104592530 104605433
MING122066766 122073030 122082450
TSS122646141 122652759 122655935 122666759
PSOM113282742 113301280 113306106 113355890
OSA4331045 4345212 4347099
DOSAOs02t0802700-01(Os02g0802700) Os08t0299400-01(Os08g0299400) Os09t0423600-01(Os09g0423600)
OBR102704776 102712378 102717644
BDI100822971 100838296 100844719
ATS109741872 109755152 109769532
TDC119286449 119293432 119301677 119309621 119318371 119323792
TAES123082162 123094585 123099670 123112071 123121603 123128831 123139279 123145979 542965
TUA125509420 125515215 125553653
LPER127301516 127305230 127331070
SBI8055186 8055993 8084656
ZMA100274282 100281388 100383973
SITA101760868 101764122 101764643
SVS117841430 117844563 117860076
PVIR120645267 120657513 120660703 120679264 120695685 120711695
PHAI112873981 112882799 112896381
PDA103706476 103707463 103710116 103715894
EGU105033793 105039544 105049423 105050115
MUS103981301 103985478 103992285 103997383 103999153
ZOF121970519 121970748 121970955 121975592 121975845 121992261 121996202 122002492 122006748 122029369 122042030 122043366 122046547 122047891 122050454
DCT110103531 110103945 110104020
PEQ110023378 110026955
AOF109820101 109841163 109844529
NCOL116250941 116253683 116261104
ATR18435298 18442588
SMOSELMODRAFT_271007(MGD)
PPP112295608 112296119
CRECHLRE_13g585301v5
VCNVOLCADRAFT_58564
MNGMNEG_3776
CSLCOCSUDRAFT_35261
OLUOSTLU_119506(mgdA)
OTAOT_ostta02g01930
BPGBathy14g01530(MGDG)
MISMICPUN_107335(MGDA)
MPPMICPUCDRAFT_45255
CMECYME_CMI271C
GSLGasu_39500
CCPCHC_T00008381001 CHC_T00008619001 CHC_T00009002001
SMINv1.2.024400.t1(symbB.v1.2.024400.t1)
PTIPHATRDRAFT_14125 PHATRDRAFT_9619 PHATR_43938
FCYFRACYDRAFT_198887 FRACYDRAFT_275442
TPSTHAPSDRAFT_264013 THAPSDRAFT_264314 THAPS_263200
NGDNGA_0081800(MGD)
AAFAURANDRAFT_1716 AURANDRAFT_24670
EHXEMIHUDRAFT_414703 EMIHUDRAFT_467938 EMIHUDRAFT_470522 EMIHUDRAFT_73870
GTTGUITHDRAFT_118033 GUITHDRAFT_146693 GUITHDRAFT_156659
 » show all
Reference
1  [PMID:4838219]
  Authors
Veerkamp JH.
  Title
Biochemical changes in Bifidobacterium bifidum var. pennsylvanicus after cell-wall inhibition. VI. Biosynthesis of the galactosyldiglycerides.
  Journal
Biochim Biophys Acta 348:23-34 (1974)
DOI:10.1016/0005-2760(74)90089-7
Reference
2  [PMID:5681471]
  Authors
Wenger DA, Petitpas JW, Pieringer RA.
  Title
The metabolism of glyceride glycolipids. II. Biosynthesis of monogalactosyl diglyceride from uridine diphosphate galactose and diglyceride in brain.
  Journal
Biochemistry 7:3700-7 (1968)
DOI:10.1021/bi00850a049
Reference
3  [PMID:10518794]
  Authors
Miege C, Marechal E, Shimojima M, Awai K, Block MA, Ohta H, Takamiya K, Douce R, Joyard J
  Title
Biochemical and topological properties of type A MGDG synthase, a spinach chloroplast envelope enzyme catalyzing the synthesis of both prokaryotic and eukaryotic MGDG.
  Journal
Eur J Biochem 265:990-1001 (1999)
DOI:10.1046/j.1432-1327.1999.00801.x
  Sequence
Reference
4  [PMID:15590685]
  Authors
Benning C, Ohta H.
  Title
Three enzyme systems for galactoglycerolipid biosynthesis are coordinately regulated in plants.
  Journal
J Biol Chem 280:2397-400 (2005)
DOI:10.1074/jbc.R400032200
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.46
IUBMB Enzyme Nomenclature: 2.4.1.46
ExPASy - ENZYME nomenclature database: 2.4.1.46
BRENDA, the Enzyme Database: 2.4.1.46
CAS: 37277-55-7

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