KEGG   ENZYME: 2.4.1.50Help
Entry
EC 2.4.1.50                 Enzyme                                 

Name
procollagen galactosyltransferase;
hydroxylysine galactosyltransferase;
collagen galactosyltransferase;
collagen hydroxylysyl galactosyltransferase;
UDP galactose-collagen galactosyltransferase;
uridine diphosphogalactose-collagen galactosyltransferase;
UDPgalactose:5-hydroxylysine-collagen galactosyltransferase;
UDP-galactose:procollagen-5-hydroxy-L-lysine D-galactosyltransferase;
UDP-alpha-D-galactose:procollagen-5-hydroxy-L-lysine D-galactosyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
UDP-alpha-D-galactose:[procollagen]-(5R)-5-hydroxy-L-lysine 5-beta-D-galactosyltransferase (configuration-inverting)
Reaction(IUBMB)
UDP-alpha-D-galactose + [procollagen]-(5R)-5-hydroxy-L-lysine = UDP + [procollagen]-(5R)-5-O-(beta-D-galactosyl)-5-hydroxy-L-lysine [RN:R03380]
Reaction(KEGG)
Substrate
UDP-alpha-D-galactose [CPD:C00052];
[procollagen]-(5R)-5-hydroxy-L-lysine
Product
UDP [CPD:C00015];
[procollagen]-(5R)-5-O-(beta-D-galactosyl)-5-hydroxy-L-lysine
Comment
Involved in the synthesis of carbohydrate units in the complement system (cf. EC 2.4.1.66 procollagen glucosyltransferase).
History
EC 2.4.1.50 created 1972, modified 1983
Pathway
ec00310  Lysine degradation
ec00514  Other types of O-glycan biosynthesis
Orthology
K11703  collagen beta-1,O-galactosyltransferase
K13646  lysyl hydroxylase/galactosyltransferase/glucosyltransferase
Genes
HSA: 23127(COLGALT2) 79709(COLGALT1) 8985(PLOD3)
PTR: 455843(COLGALT1) 463618(PLOD3) 469611(COLGALT2)
PPS: 100968399(PLOD3) 100982312(COLGALT1) 100992518(COLGALT2)
GGO: 101137283(COLGALT2) 101150827(COLGALT1) 101151570(PLOD3)
PON: 100189797(PLOD3) 100459610(COLGALT1)
NLE: 100583272(COLGALT2) 100595902(COLGALT1) 100597272(PLOD3)
MCC: 714283(PLOD3) 717508(COLGALT2) 719980(GLT25D1)
MCF: 101865063(COLGALT2) 101867014(PLOD3) 102132871(COLGALT1)
CSAB: 103230445(COLGALT2) 103234147(COLGALT1) 103246688(PLOD3)
RRO: 104660965(COLGALT1) 104666808(COLGALT2) 104681188(PLOD3)
RBB: 108512743(COLGALT2) 108518931(PLOD3) 108534234(COLGALT1)
CJC: 100389508(COLGALT2) 100390092(PLOD3) 100411398(COLGALT1)
SBQ: 101031144(COLGALT1) 101041943(COLGALT2) 101043341(PLOD3)
MMU: 234407(Colgalt1) 26433(Plod3) 269132(Colgalt2)
RNO: 288583(Plod3) 289081(Colgalt2) 290637(Colgalt1)
CGE: 100764465(Colgalt2) 100774081(Colgalt1)
NGI: 103726669(Colgalt2) 103726894(Colgalt1) 103733492(Plod3)
HGL: 101701075(Plod3) 101711193(Colgalt1) 101713780(Colgalt2)
CCAN: 109690213(Colgalt2) 109692822(Plod3) 109698599(Colgalt1)
OCU: 103345704 103346432(COLGALT2)
TUP: 102473246(COLGALT1) 102476916(PLOD3) 102489015(COLGALT2)
CFA: 479730(PLOD3) 484834(COLGALT1) 608413(COLGALT2)
AML: 100467880(COLGALT2) 100472987(COLGALT1) 100484476(PLOD3)
UMR: 103670197(PLOD3) 103672506(COLGALT2) 103675173(COLGALT1)
ORO: 101362716(COLGALT2) 101367464(COLGALT1) 101383290(PLOD3)
FCA: 101087701(COLGALT2) 101089668(PLOD3) 101091350(COLGALT1)
PTG: 102950927(PLOD3) 102964832(COLGALT1) 102970872(COLGALT2)
AJU: 106969160(COLGALT1) 106975927(COLGALT2) 106988106(PLOD3)
BTA: 513167(COLGALT1) 514996(PLOD3) 789150(COLGALT2)
BOM: 102271514(COLGALT2) 102276636(PLOD3) 102285165(COLGALT1)
BIU: 109561429(COLGALT1) 109570504(COLGALT2) 109578633(PLOD3)
PHD: 102321876(PLOD3) 102330626(COLGALT1) 102334725(COLGALT2)
CHX: 100861039(PLOD3) 102172883(COLGALT1) 102173322(COLGALT2)
OAS: 101107209(COLGALT2) 101114107 101121738(PLOD3)
SSC: 100517457(COLGALT1) 100624420(PLOD3) 100624924(COLGALT2)
CFR: 102505707(PLOD3) 102510366(COLGALT2) 102511754(COLGALT1)
CDK: 105092397(PLOD3) 105096219(COLGALT2) 105101852(COLGALT1)
BACU: 103009205(COLGALT2) 103014456(COLGALT1) 103018042(PLOD3)
LVE: 103070607(COLGALT2) 103079321(COLGALT1) 103090807(PLOD3)
OOR: 101272678(PLOD3) 101285205(COLGALT1) 101285957(COLGALT2)
ECB: 100055683(COLGALT2) 100059479(PLOD3) 100070236(COLGALT1)
EPZ: 103542128(COLGALT1) 103552127(COLGALT2) 103566973(PLOD3)
EAI: 106828761 106830869(COLGALT1) 106836999(COLGALT2) 106839342(PLOD3)
MYB: 102245948(COLGALT2) 102249872(PLOD3) 102255507(COLGALT1)
MYD: 102755224(PLOD3) 102764013(COLGALT2) 102768849(COLGALT1)
HAI: 109379173(COLGALT2) 109382476(COLGALT1) 109385048(PLOD3)
RSS: 109450043(COLGALT1) 109451098(COLGALT2) 109458817(PLOD3)
PALE: 102879015(PLOD3) 102890053(COLGALT2) 102897385(COLGALT1)
LAV: 100660775(COLGALT2) 100674443(COLGALT1) 100675876(PLOD3)
MDO: 100014550(COLGALT1) 100017782(PLOD3) 100024267(COLGALT2)
SHR: 100916266(COLGALT1) 100919157(COLGALT2) 100921874(PLOD3)
OAA: 100085874(COLGALT2) 100086224(PLOD3) 103171451(COLGALT1)
GGA: 424447(COLGALT2) 425607
MGP: 100540024(COLGALT2) 100546534
CJO: 107307504 107307505 107317303(COLGALT2)
APLA: 101799213(COLGALT2)
ACYG: 106031407 106034046(COLGALT2)
TGU: 100232475(COLGALT2)
GFR: 102039137(COLGALT2)
FAB: 101810055(COLGALT2)
PHI: 102106145(COLGALT2) 102111969(COLGALT1)
PMAJ: 107207923(COLGALT2)
CCAE: 111932545(COLGALT2) 111945326(COLGALT1)
CCW: 104693618(COLGALT2)
FPG: 101911382(COLGALT1) 101921319(COLGALT2)
FCH: 102046872(COLGALT1) 102051949(COLGALT2)
CLV: 102091883 102093133(COLGALT2)
EGZ: 104124555(COLGALT2)
AAM: 106495757(COLGALT2) 106500199(COLGALT1)
ASN: 102378832(COLGALT2) 102379166 102384904(COLGALT1)
AMJ: 102557914(COLGALT1) 102561107(PLOD3) 106736985(COLGALT2)
PSS: 102444350 102444474(PLOD3) 102449386(COLGALT2) 102452170(COLGALT1)
CMY: 102940302(COLGALT2) 102942537(COLGALT1)
CPIC: 101931851(COLGALT2) 101943910(PLOD3) 101949377(COLGALT1)
ACS: 100556788(colgalt2) 100558042(plod3) 100566962(colgalt1) 103282019
PVT: 110071761(COLGALT1) 110079763(COLGALT2) 110087641(PLOD3)
PBI: 103051832(PLOD3) 103058805(COLGALT1) 103059171(COLGALT2) 103067401
GJA: 107114906(COLGALT1) 107117514(COLGALT2) 107118151(PLOD3)
XLA: 100125229(colgalt1.L) 108704485 108714512 108715018 380138(plod3.L) 495489 495521(colgalt1.S)
XTR: 100488616(colgalt1) 100495682(colgalt2) 734090(plod3)
NPR: 108784216(COLGALT2) 108797752(COLGALT1) 108800474(PLOD3)
DRE: 100003546(colgalt2) 556077(plod3) 558068(si:ch211-13f8.2) 565862(colgalt1) 567859(si:ch211-114l13.7)
IPU: 108257422(colgalt1) 108258749(colgalt1) 108265394 108268058 108275691(plod3)
TRU: 100101242(plod3) 101066165(cercam) 101072217(colgalt2) 101072864 101078978(colgalt1)
OLA: 101154842(plod3) 101156942(cercam) 101160659 101161789 101162193(colgalt1)
LCM: 102347396(PLOD3) 102352198(CERCAM) 102356750(COLGALT2) 102363063(COLGALT1)
CMK: 103172022 103172253(colgalt1) 103172951 103180076(colgalt2) 103183070(cercam)
SPU: 577713
APLC: 110981575
DME: Dmel_CG31915(CG31915)
DER: 26526048
DPE: 113565576
DSI: Dsimw501_GD27319(Dsim_GD27319)
DWI: 26529805
MDE: 101895701
AGA: AgaP_AGAP012208(GLT25_ANOGA)
AAG: 5578193
AME: 413713
BIM: 100741640
BTER: 100647026
SOC: 105201825
ACEP: 105624184
PBAR: 105428657
HST: 105188515
DQU: 106750910
CFO: 105258051
LHU: 105671171
PGC: 109855948
PCF: 106789098
NVI: 100124230
MDL: 106693048
TCA: 658855
DPA: 109539394
NVL: 108562399
BMOR: 100141463(Cap-d3)
PMAC: 106717239
PRAP: 110998157
HAW: 110374524
CLEC: 106661464
ZNE: 110840025
FCD: 110862634
TUT: 107363264
CEL: CELE_D2045.9(D2045.9)
CBR: CBG18383
CRG: 105333944
MYI: 110451334
OBI: 106878759
SHX: MS3_07870
EGL: EGR_01083
HMG: 100212895
SMIN: v1.2.030016.t1(symbB.v1.2.030016.t1)
 » show all
Taxonomy
Reference
1  [PMID:5722225]
  Authors
Bosmann HB, Eylar EH.
  Title
Glycoprotein biosynthesis: the biosynthesis of the hydroxylysine-galactose linkage in collagen.
  Journal
Biochem Biophys Res Commun 33:340-6 (1968)
DOI:10.1016/0006-291X(68)90790-0
Reference
2
  Authors
Kivirikko, K.I. and Myllyla, R.
  Title
In: Hall, D.A. and Jackson, D.S. (Eds.), International Review of Connective Tissue Research, vol. 8, Academic Press, New York, 1979, p. 23.
Reference
3  [PMID:19075007]
  Authors
Schegg B, Hulsmeier AJ, Rutschmann C, Maag C, Hennet T
  Title
Core glycosylation of collagen is initiated by two beta(1-O)galactosyltransferases.
  Journal
Mol Cell Biol 29:943-52 (2009)
DOI:10.1128/MCB.02085-07
  Sequence
[hsa:79709 23127]
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.50
IUBMB Enzyme Nomenclature: 2.4.1.50
ExPASy - ENZYME nomenclature database: 2.4.1.50
BRENDA, the Enzyme Database: 2.4.1.50
CAS: 9028-07-3

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