KEGG   ENZYME: 2.4.1.52
Entry
EC 2.4.1.52                 Enzyme                                 
Name
poly(glycerol-phosphate) alpha-glucosyltransferase;
UDP glucose-poly(glycerol-phosphate) alpha-glucosyltransferase;
uridine diphosphoglucose-poly(glycerol-phosphate) alpha-glucosyltransferase;
tagE (gene name);
UDP-glucose:poly(glycerol-phosphate) alpha-D-glucosyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
Sysname
UDP-alpha-D-glucose:4-O-{poly[(2R)-glycerophospho]-(2R)-glycerophospho}-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol alpha-D-glucosyltransferase (configuration-retaining)
Reaction(IUBMB)
n UDP-alpha-D-glucose + 4-O-{poly[(2R)-glycerophospho]-(2R)-glycerophospho}-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol = n UDP + 4-O-{poly[(2R)-2-alpha-D-glucosyl-1-glycerophospho]-(2R)-glycerophospho}-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol [RN:R12807 R12862]
Reaction(KEGG)
R12807 R12862(G)
Substrate
UDP-alpha-D-glucose [CPD:C00029];
4-O-{poly[(2R)-glycerophospho]-(2R)-glycerophospho}-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol [CPD:C22411]
Product
UDP [CPD:C00015];
4-O-{poly[(2R)-2-alpha-D-glucosyl-1-glycerophospho]-(2R)-glycerophospho}-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol [CPD:C22412]
Comment
Involved in the biosynthesis of poly glycerol phosphate teichoic acids in bacterial cell walls. This enzyme, isolated from Bacillus subtilis 168, adds an alpha-D-glucose to the free OH groups of the glycerol units. The enzyme has a strong preference for UDP-alpha-glucose as the sugar donor. It has no activity with poly(ribitol phosphate).
History
EC 2.4.1.52 created 1972, modified 2017
Pathway
ec00552  Teichoic acid biosynthesis
Orthology
K00712  poly(glycerol-phosphate) alpha-glucosyltransferase
Genes
ETEETEE_3362
EDWQY76_13070
EDLAAZ33_07150
PSKYA6B44_08675
AIOEXH44_04335
PGBH744_2c2867
ABMABSDF2312
ACCBDGL_000003(tagE)
ALCOTEC02_15270
ACVAMD27_04695
AWGGFH30_10175
ABOUACBO_11520(tagE)
IGNMMG00_00790
NSTNstercoris_01989
CHACHAB381_1475
SDOSD1155_04980 SD1155_05610
PCONB0A89_07635
PAMNJCM7685_1531
SARIH5J25_04885
BSUBSU35730(tagE)
BSRI33_3702
BSHBSU6051_35730(tagE)
BSUTBSUB_03806(tagE)
BSULBSUA_03806(tagE)
BSNBSn5_08780
BSQB657_35730(tagE)
BSPU712_17935
BAMPB938_16875
BAMTAJ82_18555
BAOBAMF_3412(tagE)
BAZBAMTA208_18080(tagE)
BQLLL3_03707(tagE)
BXHBAXH7_03696(tagE)
BPUBPUM_3229
BPUSUP12_16725
BXIBK049_10725
BALTCFN77_17145
BSAFBSL056_17860
BCABEFK13_18390
BACWQR42_16230
BACLBS34A_38860(tagE)
BALMBsLM_3589
VIGBKP57_07905
SAUSA0522 SA0523
SAVSAV0564 SAV0565
SAWSAHV_0562 SAHV_0563
SAHSaurJH1_0601 SaurJH1_0602
SAJSaurJH9_0587 SaurJH9_0588
SAMMW0519 MW0520
SASSAS0522 SAS0523
SARSAR0568 SAR0569
SACSACOL0052 SACOL0611 SACOL0612
SAXUSA300HOU_0558 USA300HOU_0559
SAASAUSA300_0549 SAUSA300_0550
SAOSAOUHSC_00547 SAOUHSC_00548
SAENWMN_0526 NWMN_0527
SADSAAV_0527 SAAV_0528
SUUM013TW_0551 M013TW_0552
SUVSAVC_02410 SAVC_02415
SUESAOV_0599 SAOV_0600c
SUJSAA6159_00518 SAA6159_00519
SUKSAA6008_00572 SAA6008_00573
SUCECTR2_518 ECTR2_519
SUTSAT0131_00625 SAT0131_00626
SUQHMPREF0772_12624 HMPREF0772_12625
SUZMS7_0554 MS7_0555
SUDST398NM01_0638 ST398NM01_0640
SUXSAEMRSA15_04910 SAEMRSA15_04920
SUWSATW20_06340 SATW20_06350
SUGSAPIG0638 SAPIG0640
SUFSARLGA251_05000 SARLGA251_05010
SAUASAAG_00985 SAAG_00986
SAUERSAU_000518 RSAU_000519
SAUNSAKOR_00552 SAKOR_00553
SAUSSA40_0504 SA40_0505
SAUUSA957_0519 SA957_0520
SAUGSA268_0517 SA268_0518
SAUZSAZ172_0566 SAZ172_0567
SAUTSAI1T1_2000400 SAI1T1_2004340 SAI1T1_2004350
SAUJSAI2T2_1000400 SAI2T2_1004360 SAI2T2_1004370
SAUKSAI3T3_1000400 SAI3T3_1004350 SAI3T3_1004360
SAUQSAI4T8_1000400 SAI4T8_1004340 SAI4T8_1004350
SAUVSAI7S6_1000400 SAI7S6_1004350 SAI7S6_1004360
SAUWSAI5S5_1000400 SAI5S5_1004310 SAI5S5_1004320
SAUXSAI6T6_1000400 SAI6T6_1004320 SAI6T6_1004330
SAUYSAI8T7_1000400 SAI8T7_1004350 SAI8T7_1004360
SAUFX998_0054 X998_0606 X998_0607
SABSAB0514 SAB0515c
SUYSA2981_0541 SA2981_0542
SAUBC248_0639 C248_0640
SAUMBN843_5580 BN843_5590
SAUCCA347_580 CA347_581
SAURSABB_00615 SABB_00616
SAUIAZ30_02855 AZ30_02860
SAUDCH52_02930 CH52_02935
SAMSNI36_02805 NI36_02810
SUHSAMSHR1132_05080 SAMSHR1132_05090
SERSERP0208
SEPSE_0332 SE_2393
SEPPSEB_00254
SEPSDP17_1426 DP17_1641
SHASH2251
SCASCA_2110(tagE)
SLGSLGD_00512 SLGD_02180
SLNSLUG_05110 SLUG_21540
SDTSPSE_0282
SWAA284_11030
SPASSTP1_1545 STP1_1652
SXYBE24_04185
SXLSXYLSMQ121_1423
SXOSXYL_01509
SCAPAYP1020_2024(gtf1_2) AYP1020_2194(tagE_2) AYP1020_2313(tagE_3)
SSCZRN70_02040
SEQOSE1039_26270
SSIFAL483_11575
SCVA4G25_09675
SPETCEP67_06460 CEP67_06465
SCOHBZ166_05120
SNLBJD96_00780 BJD96_00785
SFQC7J90_04485
SCARDWB96_11705
SARLSAP2_17890
SPICSAMEA4384060_0442(tagE_4)
SSHNCTC13712_00516(tagE_1) NCTC13712_00517(tagE_2)
SSIMSAMEA4384339_0211(tagE_2) SAMEA4384339_0513(tagE_3) SAMEA4384339_0514(tagE_4)
SDBCNQ82_03010
SLLOISP08_08060
SSACI6I31_05590
SSCUCEP64_10590 CEP64_10685 CEP64_13970
SFFFOB90_11085
MVTI6J10_00150
MARYLAU42_10770
EANEab7_2556
EXMU719_14295
EXUESP131_09260 ESP131_09305
EACEKKI46_07095
LLAL76469(yohH) L78550(yohJ)
LLKLLKF_1561(yohH) LLKF_1562(yohJ)
LLTCVCAS_1364(yohH)
LLSlilo_1372(yohH) lilo_1373(yohJ)
LLDP620_07955 P620_07960
LLXNCDO2118_1463(gtf1) NCDO2118_1464
LLJLG36_0924(yohJ) LG36_0925(yohH)
LLWkw2_0793(gtfA)
LACTD7I46_05135 D7I46_05140 D7I46_05465 D7I46_05470 D7I46_07320
LACKFLP15_10075 FLP15_12470
SPNSP_1758
SPWSPCG_1734
SJJSPJ_1655
SNVSPNINV200_15810
SNESPN23F17670
SPVSPH_1869
SNMSP70585_1798
SNIINV104_15020
SAGSAG1448
SANgbs1517
SAKSAK_1481
SGCA964_1362
SAGSSaSA20_1189(gtf1)
SAGMBSA_15290
SAGIMSA_15720
SAGRSAIL_15090
SAGTGBSCOH1_1240
SAGEEN72_08010
SAGGEN73_06800
SAGNW903_1463(gtfA)
STCstr0413
STLstu0413
STESTER_0452
STNSTND_0410
STUSTH8232_0516
STWY1U_C0398
STHET303_03190
STHSAVT04_02815
SGOSGO_0975(gtaA)
SMBsmi_1648
SORSOR_1575
SCPHMPREF0833_11288(gtfA) HMPREF0833_11303
SCFSpaf_1925(gtf1)
SSRSALIVB_0409 SALIVB_0624
STFSsal_00683 Ssal_01782(tagE)
STJSALIVA_0390 SALIVA_1463 SALIVA_1698
STRSSSAL8618_02220 SSAL8618_07190 SSAL8618_08365
SSAHHSISS4_00330 HSISS4_01314 HSISS4_01542
SANSDK43_06790
SOII872_07235
SIKK710_0476
SIQDQ08_02285
SIODW64_02270
SIZSI82_02520
SLUKE3_0869
SIGN596_06355
SIPN597_08235
STVV470_07710
SPATA0O21_01935
SSOBDK181_06840(gtfA)
SEQIA6J79_00935 A6J79_04935(gtfA)
SKID7D50_03995(gtfA)
SRATFY406_07895(gtfA)
SPLRC0J00_05990(gtfA)
SVBNCTC12167_00457(tagE_1) NCTC12167_01334(tagE_2)
SPSUNCTC13786_00804(gtaA)
SCHJDDV21_007170(gtfA)
SPOCNCTC10925_00426(gtaA)
SLATJ4854_08425 J4854_09455(gtfA)
SAUPNCTC3168_00949(tagE)
SURNNCTC13766_00260(tagE)
SACOSAME_01502(tagE)
SVFNCTC3166_01799(tagE)
SOSINT76_01865(gtfA)
FPENKIW23_05475
LDELDBND_1203
LKEWANG_p1126
LAWLACWKB8_0712
LAMYB1745_02560
LKLDKL58_03520
LAPIDKL56_02860 DKL56_02865 DKL56_02870
LHSDLD54_03385
LUUH4B44_06520
LPAIGYM71_03940
LCALSEI_0891 LSEI_0892
LCZLCAZH_0834 LCAZH_0835
LCSLCBD_0986 LCBD_0987
LCELC2W_0990 LC2W_0991
LCWBN194_09760 BN194_09770
LCLLOCK919_1036 LOCK919_1037
LPQAF91_09450 AF91_09455
LPILBPG_00061 LBPG_00062
LPAPLBPC_0831 LBPC_0832
LCBLCABL_10040(tagE2) LCABL_10050(tagE3)
LCXLCA12A_2180 LCA12A_2181
LRHLGG_00348(yohJ) LGG_00349(yohH) LGG_01586(yohH) LGG_01587(yohJ) LGG_02284 LGG_02285(yohH)
LRGLRHM_0335 LRHM_0336 LRHM_1523 LRHM_1524 LRHM_2195 LRHM_2196
LRLLC705_00333(yohJ) LC705_00334(yohH) LC705_01567(yohH) LC705_01568(yohJ) LC705_02275 LC705_02276(yohH)
LRALRHK_1556 LRHK_1557 LRHK_2282 LRHK_2284 LRHK_343 LRHK_344
LROLOCK900_0327 LOCK900_0328 LOCK900_1529 LOCK900_1530 LOCK900_2247 LOCK900_2248
LRCLOCK908_0339 LOCK908_0340 LOCK908_1622 LOCK908_1623 LOCK908_2339 LOCK908_2340
LCHIKG086_10015 KG086_10020
LZEKG087_05270 KG087_05290 KG087_05295 KG087_05340 KG087_10675 KG087_10680 KG087_11680 KG087_11745 KG087_11750
LPLlp_1299(tagE1) lp_1311(tagE2) lp_1312(tagE3) lp_2498(tagE4) lp_2843(tagE5) lp_2844(tagE6)
LPJJDM1_1099(tagE1) JDM1_1106(tagE2) JDM1_1107(tagE3) JDM1_2011(tagE4) JDM1_2280(tagE5) JDM1_2282(tagE6)
LPTzj316_1318(tagE1) zj316_1327(tagE2) zj316_1328(tagE3) zj316_2429(tagE4) zj316_2714(tagE5) zj316_2715(tagE6)
LPSLPST_C1052(tagE1) LPST_C1058(tagE2) LPST_C1059(tagE3) LPST_C2058(tagE4) LPST_C2332(tagE5) LPST_C2333(tagE6)
LPRLBP_cg0993 LBP_cg1001 LBP_cg1002 LBP_cg2051 LBP_cg2327 LBP_cg2328
LPZLp16_1003 Lp16_1009 Lp16_1010 Lp16_1984 Lp16_2241 Lp16_2242
LPBSH83_05445 SH83_05480 SH83_05485 SH83_10640 SH83_11975 SH83_11980
LPXASU28_02740 ASU28_02745 ASU28_05175 ASU28_05205 ASU28_05210 ASU28_10670
LPGBB562_03595 BB562_03600 BB562_05205 BB562_10875 BB562_10880 BB562_10910
LARGLPA65_05215 LPA65_05245 LPA65_05250 LPA65_10895 LPA65_12295 LPA65_12300
LRELreu_0080 Lreu_0081 Lreu_1256
LRFLAR_0075 LAR_0076 LAR_1190
LRUHMPREF0538_21222 HMPREF0538_21223
LRTLRI_0088 LRI_0089 LRI_0710
LRRN134_00425 N134_00430 N134_07030
LFELAF_0051 LAF_0052
LFRLC40_0037 LC40_0038
LFFLBFF_0052 LBFF_0053
LMULBLM1_10605 LBLM1_10610
LORAYI71_09165 AYI71_09170
LVALV515_00355 LV515_00360 LV515_01785
LFNLF145_00305 LF145_00310 LF145_08220
LPONLP475_00320 LP475_00325
LGASLG045_00255 LG045_00265
LPASKZE55_01555 KZE55_01560 KZE55_06240 KZE55_06245(asp1) KZE55_09805
LNGBSQ50_10735
LHWBSQ49_04425
LLEAYR59_02420
LFVLF543_06835
FIXM8332_06290
LBHLbuc_2160
LBNLBUCD034_2263
LPARFAM21731_00669 FAM21731_01238
LCUPL11_002040
LBRLVIS_1464 LVIS_1465
LBKLVISKB_1412 LVISKB_1413
LKOABN16_11195 ABN16_11200 ABN16_11210
LZYLZ3411_0940 LZ3411_0941 LZ3411_2326
LSUAH3M12_02280 H3M12_07965 H3M12_07970
LJIELX58_01065 ELX58_01070
LSJLSJ_0068
LAGLBEN83_09500 BEN83_09555
LBTAYR52_00995 AYR52_01000 AYR52_09140 AYR52_09145 AYR52_10965
LCYLC20004_10685 LC20004_10690
LHOLOOC260_122100 LOOC260_122110
LOLLACOL_1656 LACOL_1657 LACOL_1677(gtfA)
LNNF0161_10380 F0161_10385 F0161_10770
LKUAPS55_01670 APS55_01675
ABOMD7I45_00625 D7I45_00630 D7I45_05780 D7I45_05785
LMAEFGL90_04210 FGL90_04215
PPEPEPE_0067 PEPE_0224 PEPE_0225
PPENT256_01240 T256_01245
PCEPECL_1756 PECL_1757 PECL_622 PECL_651 PECL_652
PDMADU72_0665 ADU72_0666
PACIA4V11_03755 A4V11_07725 A4V11_07730
PIOPI20285_01215 PI20285_01220
LROSLROSL1_0030 LROSL1_0031 LROSL1_0321
LBMDS830_05475
LHBD1010_12080 D1010_12735
OOEOEOE_1300 OEOE_1301
OENDSM07_09355 DSM07_09360
OSIDLJ48_00785 DLJ48_00790
LMELEUM_0010 LEUM_0011 LEUM_1923
LMMMI1_00050 MI1_00055 MI1_08390
LMKLMES_0010 LMES_0011 LMES_1677
LCILCK_01447(yohH) LCK_01613
LKILKI_06420 LKI_07900
LECLGMK_04255 LGMK_05715
LCNC270_00675
LGSLEGAS_0544(gtfA) LEGAS_1748
LGEC269_02680 C269_08380
LLFBCR17_04555
LGCA9176_03090
LSUA6B45_00050 A6B45_00055 A6B45_09275
LPSEFGL85_02950 FGL85_03340 FGL85_06625 FGL85_06630
WKOWKK_04380 WKK_04385 WKK_06600
WCBAO080_01170 AO080_01175 AO080_04930 AO080_05885 AO080_11400 AO080_11415
WJOFOL01_0197 FOL01_0198 FOL01_0723
WPACO680_07410 CO680_07415
WCFC6P13_02595 C6P13_07190 C6P13_09770 C6P13_09775
WSOWSWS_01431(tagE) WSWS_01432
WHEEFA59_00875 EFA59_00880 EFA59_03545
WDIH9L19_04375 H9L19_04380
WVRIE337_01355
WCOG7084_03370(gtfA) G7084_07825 G7084_07830
LBEMOO44_05035 MOO44_05040
EGAAL523_00415
ERAFJ9537_16610
EIEENLAB_08960(tagE)
VCPH9L18_03440
VHYG7082_02510
AURHMPREF9243_0770(gtfA)
AUNAWM73_05830
ABAECL176_06675
CBICLJ_B2934
CSBCLSA_c28570
PXVFXF36_10330(gtfA)
EREEUBREC_2507 EUBREC_2518
ERTEUR_26310
ERAERE_07800
EBMSG0102_22120(gtf1)
LXLKDY119_02600(tagE)
MTSMTES_0795 MTES_0867
MIPAXH82_10855
MCWA8L33_06710
MPALBO218_07765
MIHBJP65_05695 BJP65_06060
MLVCVS47_00551(tagE)
MWAE4K62_03535
MPRTET475_02610
MSEDE3O41_11015
MOYCVS54_01046(tagE)
MCAWF6J84_12080
MLZF6J85_03400
MCHNHCR76_08745
MICSC1N74_03190
MBINLXM64_12710
AGYATC03_02345
AGMDCE93_01760
ASOIMTP13_01990
MALKMalAC0309_0118
MYLC3E77_03680 C3E77_03690
GRYD7I44_17720
PLAPEAO79_11330
ARMART_1251
ACRYAC20117_19715
AAGINCTC2676_1_01717(tagE_1) NCTC2676_1_01725(tagE_3)
AJGKKR91_11360
ASUFMNQ99_09150
AAIAARI_14900 AARI_14980
PAEYKUF55_10290 KUF55_10370
XCEXcel_2591
IDOI598_3339(tagE_1) I598_3340(tagE_2)
SERJSGUI_1312
BLYA2T55_13875
BLINBLSMQ_2862 BLSMQ_3087
BLUTEW640_07370
BCAUI6G59_00195
MIKFOE78_08215 FOE78_12170
NPSKRR39_17420
MUZH4N58_17610
SHIShel_14750
SYNPSyn7502_02485
LSKJ5X98_21805
NONNOS3756_45220
RBARB2471
 » show all
Reference
1  [PMID:14245359]
  Authors
GLASER L, BURGER MM.
  Title
THE SYNTHESIS OF TEICHOIC ACIDS. 3. GLUCOSYLATION OF POLYGLYCEROPHOSPHATE.
  Journal
J Biol Chem 239:3187-91 (1964)
Reference
2  [PMID:21558268]
  Authors
Allison SE, D'Elia MA, Arar S, Monteiro MA, Brown ED
  Title
Studies of the genetics, function, and kinetic mechanism of TagE, the wall teichoic acid glycosyltransferase in Bacillus subtilis 168.
  Journal
J Biol Chem 286:23708-16 (2011)
DOI:10.1074/jbc.M111.241265
  Sequence
[bsu:BSU35730]
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.52
IUBMB Enzyme Nomenclature: 2.4.1.52
ExPASy - ENZYME nomenclature database: 2.4.1.52
BRENDA, the Enzyme Database: 2.4.1.52
CAS: 37277-60-4

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