KEGG   ENZYME: 2.4.1.52
Entry
EC 2.4.1.52                 Enzyme                                 

Name
poly(glycerol-phosphate) alpha-glucosyltransferase;
UDP glucose-poly(glycerol-phosphate) alpha-glucosyltransferase;
uridine diphosphoglucose-poly(glycerol-phosphate) alpha-glucosyltransferase;
tagE (gene name);
UDP-glucose:poly(glycerol-phosphate) alpha-D-glucosyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
Sysname
UDP-alpha-D-glucose:4-O-{poly[(2R)-glycerophospho]-(2R)-glycerophospho}-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol alpha-D-glucosyltransferase (configuration-retaining)
Reaction(IUBMB)
n UDP-alpha-D-glucose + 4-O-{poly[(2R)-glycerophospho]-(2R)-glycerophospho}-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol = n UDP + 4-O-{poly[(2R)-2-alpha-D-glucosyl-1-glycerophospho]-(2R)-glycerophospho}-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol
Substrate
UDP-alpha-D-glucose [CPD:C00029];
4-O-{poly[(2R)-glycerophospho]-(2R)-glycerophospho}-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol
Product
UDP [CPD:C00015];
4-O-{poly[(2R)-2-alpha-D-glucosyl-1-glycerophospho]-(2R)-glycerophospho}-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol
Comment
Involved in the biosynthesis of poly glycerol phosphate teichoic acids in bacterial cell walls. This enzyme, isolated from Bacillus subtilis 168, adds an alpha-D-glucose to the free OH groups of the glycerol units. The enzyme has a strong preference for UDP-alpha-glucose as the sugar donor. It has no activity with poly(ribitol phosphate).
History
EC 2.4.1.52 created 1972, modified 2017
Orthology
K00712  poly(glycerol-phosphate) alpha-glucosyltransferase
Genes
ETE: ETEE_3362
EDW: QY76_13070
EDL: AAZ33_07150
PSKY: A6B44_08675
AIO: EXH44_04335
PGB: H744_2c2867
ABM: ABSDF2312
ACC: BDGL_000003(tagE)
ALC: OTEC02_15270
ACV: AMD27_04695
BSU: BSU35730(tagE)
BSR: I33_3702
BSH: BSU6051_35730(tagE)
BSUT: BSUB_03806(tagE)
BSUL: BSUA_03806(tagE)
BSQ: B657_35730(tagE)
BAMP: B938_16875
BAMT: AJ82_18555
BAO: BAMF_3412(tagE)
BAZ: BAMTA208_18080(tagE)
BQL: LL3_03707(tagE)
BXH: BAXH7_03696(tagE)
BPU: BPUM_3229
BPUS: UP12_16725
BACW: QR42_16230
BACL: BS34A_38860(tagE)
BALM: BsLM_3589
SER: SERP0208
SEPP: SEB_00254
SHA: SH2251
SCA: SCA_2110(tagE)
SDT: SPSE_0282
SCAP: AYP1020_2024(gtf1_2) AYP1020_2194(tagE_2) AYP1020_2313(tagE_3)
SSCZ: RN70_02040
SARL: SAP2_17890
SPIC: SAMEA4384060_0442(tagE_4)
SSH: NCTC13712_00516(tagE_1) NCTC13712_00517(tagE_2)
EAN: Eab7_2556
LLA: L76469(yohH) L78550(yohJ)
LLK: LLKF_1561(yohH) LLKF_1562(yohJ)
LLT: CVCAS_1364(yohH)
LLS: lilo_1372(yohH) lilo_1373(yohJ)
LLJ: LG36_0924(yohJ) LG36_0925(yohH)
LLW: kw2_0793(gtfA)
SPN: SP_1758
SPW: SPCG_1734
SJJ: SPJ_1655
SPV: SPH_1869
SAG: SAG1448
SAN: gbs1517
SAK: SAK_1481
SGC: A964_1362
SAGS: SaSA20_1189(gtf1)
SAGM: BSA_15290
SAGI: MSA_15720
SAGR: SAIL_15090
SAGE: EN72_08010
SAGG: EN73_06800
SAGN: W903_1463(gtfA)
STC: str0413
STL: stu0413
STE: STER_0452
STN: STND_0410
STW: Y1U_C0398
STHE: T303_03190
SGO: SGO_0975(gtaA)
SMB: smi_1648
SOR: SOR_1575
SCF: Spaf_1925(gtf1)
SANS: DK43_06790
SIK: K710_0476
SLU: KE3_0869
SSOB: DK181_06840(gtfA)
SKI: D7D50_03995(gtfA)
SRAT: FY406_07895(gtfA)
SPLR: C0J00_05990(gtfA)
SVB: NCTC12167_00457(tagE_1) NCTC12167_01334(tagE_2)
SPSU: NCTC13786_00804(gtaA)
SCHJ: DDV21_007170(gtfA)
SPOC: NCTC10925_00426(gtaA)
LCB: LCABL_10040(tagE2) LCABL_10050(tagE3)
LRH: LGG_00348(yohJ) LGG_00349(yohH) LGG_01586(yohH) LGG_01587(yohJ) LGG_02284 LGG_02285(yohH)
LPL: lp_1299(tagE1) lp_1311(tagE2) lp_1312(tagE3) lp_2498(tagE4) lp_2843(tagE5) lp_2844(tagE6)
LPJ: JDM1_1099(tagE1) JDM1_1106(tagE2) JDM1_1107(tagE3) JDM1_2011(tagE4) JDM1_2280(tagE5) JDM1_2282(tagE6)
LPT: zj316_1318(tagE1) zj316_1327(tagE2) zj316_1328(tagE3) zj316_2429(tagE4) zj316_2714(tagE5) zj316_2715(tagE6)
LPS: LPST_C1052(tagE1) LPST_C1058(tagE2) LPST_C1059(tagE3) LPST_C2058(tagE4) LPST_C2332(tagE5) LPST_C2333(tagE6)
LBH: Lbuc_2160
LSJ: LSJ_0068
LCI: LCK_01447(yohH) LCK_01613
AUR: HMPREF9243_0770(gtfA)
CBI: CLJ_B2934
PXV: FXF36_10330(gtfA)
ERT: EUR_26310
ERA: ERE_07800
EBM: SG0102_22120(gtf1)
LXL: KDY119_02600(tagE)
MLV: CVS47_00551(tagE)
MOY: CVS54_01046(tagE)
ARM: ART_1251
AAGI: NCTC2676_1_01717(tagE_1) NCTC2676_1_01725(tagE_3)
XCE: Xcel_2591
IDO: I598_3339(tagE_1) I598_3340(tagE_2)
SERJ: SGUI_1312
RBA: RB2471
 » show all
Reference
1  [PMID:14245359]
  Authors
GLASER L, BURGER MM.
  Title
THE SYNTHESIS OF TEICHOIC ACIDS. 3. GLUCOSYLATION OF POLYGLYCEROPHOSPHATE.
  Journal
J Biol Chem 239:3187-91 (1964)
Reference
2  [PMID:21558268]
  Authors
Allison SE, D'Elia MA, Arar S, Monteiro MA, Brown ED
  Title
Studies of the genetics, function, and kinetic mechanism of TagE, the wall teichoic acid glycosyltransferase in Bacillus subtilis 168.
  Journal
J Biol Chem 286:23708-16 (2011)
DOI:10.1074/jbc.M111.241265
  Sequence
[bsu:BSU35730]
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.52
IUBMB Enzyme Nomenclature: 2.4.1.52
ExPASy - ENZYME nomenclature database: 2.4.1.52
BRENDA, the Enzyme Database: 2.4.1.52
CAS: 37277-60-4

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