KEGG ENZYME: 2.4.1.53

ENZYME: 2.4.1.53

Entry

EC 2.4.1.53                 Enzyme

Name

poly(ribitol-phosphate) beta-glucosyltransferase;
TarQ;
UDP glucose-poly(ribitol-phosphate) beta-glucosyltransferase;
uridine diphosphoglucose-poly(ribitol-phosphate) beta-glucosyltransferase;
UDP-D-glucose polyribitol phosphate glucosyl transferase;
UDP-D-glucose:polyribitol phosphate glucosyl transferase;
UDP-glucose:poly(ribitol-phosphate) beta-D-glucosyltransferase

Class

Transferases;
Glycosyltransferases;
Hexosyltransferases

Sysname

UDP-alpha-D-glucose:4-O-[(1-D-ribitylphospho)n-(1-D-ribitylphospho)-(2R)-1-glycerophospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol beta-D-glucosyltransferase (configuration-inverting)

Reaction(IUBMB)

n UDP-alpha-D-glucose + 4-O-[(1-D-ribitylphospho)n-(1-D-ribitylphospho)-(2R)-1-glycerophospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol = n UDP + 4-O-[(2-beta-D-glucosyl-1-D-ribitylphospho)n-(1-D-ribitylphospho)-(2R)-1-glycerophospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol [RN:R12036 R12866]

Reaction(KEGG)

R12036 R12866(G);
(other) R02716 R06181(G)

Substrate

UDP-alpha-D-glucose [CPD:C00029];
4-O-[(1-D-ribitylphospho)n-(1-D-ribitylphospho)-(2R)-1-glycerophospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol [CPD:C21504]

Product

UDP [CPD:C00015];
4-O-[(2-beta-D-glucosyl-1-D-ribitylphospho)n-(1-D-ribitylphospho)-(2R)-1-glycerophospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol [CPD:C21869]

Comment

Involved in the biosynthesis of poly ribitol phosphate teichoic acids in the cell wall of the bacterium Bacillus subtilis W23. This enzyme adds a beta-D-glucose to the hydroxyl group at the 2 position of the ribitol phosphate units.

History

EC 2.4.1.53 created 1972, modified 2018

Pathway

ec00552

Teichoic acid biosynthesis

Orthology

K22709

poly(ribitol-phosphate) beta-glucosyltransferase

Genes

BSY:	I653_17345

BSUS:

Q433_19495

BSX:	C663_3447(tarQ)

BSS:	BSUW23_17465(tarQ)

BST:

GYO_3914

BIT:	BIS30_07435

BHT:	DIC78_13285

BMOJ:

HC660_34470

BIQ:	AN935_17915

BRY:	M0696_18030(tarQ)

BJS:

MY9_3611

BACY:

QF06_16200

BGI:	BGM20_11945

SBAT:

G4Z16_17965

» show all

Reference

1 [PMID:4960203]

Authors

Chin T, Burger MM, Glaser L

Title

Synthesis of teichoic acids. VI. The formation of multiple wall polymers in Bacillus subtilis W-23.

Journal

Arch Biochem Biophys 116:358-67 (1966)
DOI:10.1016/0003-9861(66)90042-7

Reference

2 [PMID:23027967]

Authors

Brown S, Xia G, Luhachack LG, Campbell J, Meredith TC, Chen C, Winstel V, Gekeler C, Irazoqui JE, Peschel A, Walker S

Title

Methicillin resistance in Staphylococcus aureus requires glycosylated wall teichoic acids.

Journal

Proc Natl Acad Sci U S A 109:18909-14 (2012)
DOI:10.1073/pnas.1209126109

Sequence

[bss:BSUW23_17465]

Other DBs

ExplorEnz - The Enzyme Database:

2.4.1.53

IUBMB Enzyme Nomenclature:

2.4.1.53

ExPASy - ENZYME nomenclature database:

2.4.1.53

BRENDA, the Enzyme Database:

2.4.1.53

CAS:	37277-61-5

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