KEGG   ENZYME: 2.4.1.66
Entry
EC 2.4.1.66                 Enzyme                                 
Name
procollagen glucosyltransferase;
galactosylhydroxylysine glucosyltransferase;
collagen glucosyltransferase;
collagen hydroxylysyl glucosyltransferase;
galactosylhydroxylysyl glucosyltransferase;
UDP-glucose-collagenglucosyltransferase;
uridine diphosphoglucose-collagen glucosyltransferase;
UDP-glucose:5-(D-galactosyloxy)-L-lysine-procollagen D-glucosyltransferase;
UDP-glucose:(2S,5R)-5-O-(beta-D-galactosyl)-5-hydroxy-L-lysine-[procollagen] D-glucosyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
Sysname
UDP-alpha-D-glucose:[procollagen]-(5R)-5-O-(beta-D-galactosyl)-5-hydroxy-L-lysine 2-alpha-D-glucosyltransferase (configuration-retaining)
Reaction(IUBMB)
UDP-alpha-D-glucose + [procollagen]-(5R)-5-O-(beta-D-galactosyl)-5-hydroxy-L-lysine = UDP + [procollagen]-(5R)-5-O-[alpha-D-glucosyl-(1->2)-beta-D-galactosyl]-5-hydroxy-L-lysine [RN:R04491]
Reaction(KEGG)
R04491
Substrate
UDP-alpha-D-glucose [CPD:C00029];
[procollagen]-(5R)-5-O-(beta-D-galactosyl)-5-hydroxy-L-lysine
Product
UDP [CPD:C00015];
[procollagen]-(5R)-5-O-[alpha-D-glucosyl-(1->2)-beta-D-galactosyl]-5-hydroxy-L-lysine
Comment
Involved in the synthesis of carbohydrate units in the complement system (cf. EC 2.4.1.50 procollagen galactosyltransferase).
History
EC 2.4.1.66 created 1972
Pathway
ec00514  Other types of O-glycan biosynthesis
Orthology
K13646  lysyl hydroxylase/galactosyltransferase/glucosyltransferase
Genes
HSA8985(PLOD3)
PTR463618(PLOD3)
PPS100968399(PLOD3)
GGO101151570(PLOD3)
PON100189797(PLOD3)
NLE100597272(PLOD3)
MCC714283(PLOD3)
MCF101867014(PLOD3)
CSAB103246688(PLOD3)
CATY105593407(PLOD3)
PANU101020298(PLOD3)
TGE112620036(PLOD3)
RRO104681188(PLOD3)
RBB108518931(PLOD3)
TFN117072346(PLOD3)
PTEH111527915(PLOD3)
CJC100390092(PLOD3)
SBQ101043341(PLOD3)
MMUR105868206 105874704
LCAT123632023(PLOD3)
OGA100962184(PLOD3)
MMU26433(Plod3)
MCAL110294972(Plod3)
MPAH110339077(Plod3)
RNO288583(Plod3)
MCOC116068572(Plod3)
MUN110566258(Plod3)
MAUA106021964(Plod3)
PLEU114710313(Plod3)
MORG121446082(Plod3)
MFOT126491910
AAMP119824992(Plod3)
NGI103733492(Plod3)
HGL101701075(Plod3)
CPOC100733225(Plod3)
CCAN109692822(Plod3)
DORD105997327(Plod3)
DSP122113534(Plod3)
NCAR124970077
OPI101533570(PLOD3)
TUP102476916(PLOD3)
CFA479730(PLOD3)
CLUD112646206(PLOD3)
VVP112935697(PLOD3)
VLG121487921(PLOD3)
AML100484476(PLOD3)
UMR103670197(PLOD3)
UAH113267834(PLOD3)
UAR123777278(PLOD3)
ELK111146121
LLV125090429
MPUF101679995(PLOD3)
ORO101383290(PLOD3)
EJU114214465(PLOD3)
ZCA113933351(PLOD3)
MLX117999442(PLOD3)
NSU110589725(PLOD3)
FCA101089668(PLOD3)
PYU121017669(PLOD3)
PBG122471319(PLOD3)
LRUF124519191
PTG102950927(PLOD3)
PPAD109250535(PLOD3)
AJU106988106(PLOD3)
HHV120239329(PLOD3)
BTA514996(PLOD3)
BOM102276636(PLOD3)
BIU109578633(PLOD3)
BBUB102415837(PLOD3)
CHX100861039(PLOD3)
OAS101121738(PLOD3)
ODA120878960(PLOD3)
CCAD122433016(PLOD3)
SSC100624420(PLOD3)
CFR102505707(PLOD3)
CBAI105067244(PLOD3)
CDK105092397(PLOD3)
VPC102527284(PLOD3)
BACU103018042(PLOD3)
LVE103090807(PLOD3)
OOR101272678(PLOD3)
DLE111181992(PLOD3)
PCAD102994038(PLOD3)
PSIU116739866(PLOD3)
ECB100059479(PLOD3)
EPZ103566973(PLOD3)
EAI106839342(PLOD3)
MYB102249872(PLOD3)
MYD102755224(PLOD3)
MMYO118656360(PLOD3)
MLF102417167(PLOD3)
MNA107526507(PLOD3)
PKL118703384(PLOD3)
HAI109385048(PLOD3)
DRO112314858(PLOD3)
SHON118992841(PLOD3)
AJM119044717(PLOD3)
PDIC114500553(PLOD3)
PHAS123806488(PLOD3)
MMF118641652(PLOD3)
RFQ117024816(PLOD3)
PALE102879015(PLOD3)
PGIG120591731(PLOD3)
PVP105299719(PLOD3)
RAY107511774(PLOD3)
MJV108395755(PLOD3)
TOD119241561(PLOD3)
SARA101558289(PLOD3)
LAV100675876(PLOD3)
TMU101349481
DNM101416474(PLOD3)
MDO100017782(PLOD3)
GAS123244749(PLOD3)
SHR100921874(PLOD3)
PCW110194378(PLOD3)
OAA100086224(PLOD3)
ASN102379166
AMJ102561107(PLOD3)
PSS102444474(PLOD3)
CPIC101943910(PLOD3)
MRV120381391(PLOD3)
ACS100558042(plod3)
PVT110087641(PLOD3)
SUND121933382(PLOD3)
PBI103051832(PLOD3)
PMUR107291310(PLOD3)
CTIG120301057(PLOD3)
PGUT117679687(PLOD3)
VKO123018930(PLOD3)
PMUA114581701(PLOD3)
ZVI118094932(PLOD3)
GJA107118151(PLOD3)
STOW125444847(PLOD3)
XLA380138(plod3.L) 495489
XTR734090(plod3)
NPR108800474(PLOD3)
RTEM120933651(PLOD3)
BBUF120990542
DRE556077(plod3)
SRX107709211 107737962
SANH107673154 107676175
SGH107567109 107575731
CAUA113041328(plod3)
PPRM120463468(plod3)
MAMB125260123(plod3)
IPU108275691(plod3)
PHYP113525458
SMEO124398795(plod3)
TFD113646092(plod3)
AMEX103037645
EEE113568782
TRU100101242(plod3)
TNGGSTEN00003803G001
ELY117245834(plod3)
EFO125883736(plod3)
PLEP121965451(plod3)
SLUC116065859(plod3)
PFLV114574041(plod3)
GAT120822297(plod3)
PPUG119221736(plod3)
MSAM119912035 119912612(plod3)
CUD121504490(plod3)
ALAT119026698(plod3)
MZE101473400
ONL100697420
OAU116334646(plod3)
OLA101154842(plod3)
OML112141494(plod3)
XMA102223949
XHE116732017(plod3)
PFOR103129610
PLAI106958328(plod3)
PMEI106904637(plod3)
GAF122820891(plod3)
CVG107102307(plod3)
CTUL119774676(plod3)
GMU124880767(plod3)
KMR108229421(plod3)
ALIM106511660
NWH119410195(plod3)
AOCE111567088(plod3)
MCEP125008878(plod3)
CSEM103389255
POV109643399(plod3)
SSEN122767094(plod3)
HHIP117751848(plod3)
HSP118102891(plod3)
LCF108892696 108892807
SDU111239991
SLAL111647817
XGL120797240(plod3)
HCQ109518414(plod3)
BPEC110174873
MALB109952454(plod3)
BSPL114851242(plod3)
SASA100196315(plod3)
STRU115183238(plod3)
OTW112235044 121847355
OMY110532881(plod3)
OGO124008310
CCLU121557767(plod3)
ELS105008588
SFM108920367 108923182
PKI111835052 111860867
AANG118223708(plod3)
LOC102685790
PSPA121305608 121306609
ARUT117404435 117967929
LCM102347396(PLOD3)
RTP109923769
BBEL109469521
CIN100178986
SCLV120344031
FEX115245513
TPRE106655232
FAS105272692
DAM107042269
AGIF122848610
LHT122507079
CCIN107263621
AGB108915013
LDC111517758
APLN108733015
OTU111417207
DCI103506550
FOC113206291
TPAL117640830
PJA122246560 122260753 122262496
PCHN125036057 125041711 125042482
HAME121857217 121863340 121868820
PCLA123759111 123759160 123760181 123768393
PTRU123512406 123519830
HAZT108679845
PPOI119096284 119096383
DSV119446574
RSAN119389743
RMP119177002
VDE111244671
VJA111260478
DFR124490505
SDM118192558 118196474
TSPTsp_03029
HROHELRODRAFT_185714
BGT106067603
GAE121390029
HRF124110780
HRJ124279706
CRG105335547
PMAX117344468
MMER123527641
OSN115209243
NVE5513198
EPA110241798
ATEN116302656
ADF107346845
AMIL114959945
PDAM113682513
SPIS111329220
DGT114518278
XEN124443869
SREPTSG_00122
 » show all
Reference
1  [PMID:5637038]
  Authors
Bosmann HB, Eylar EH.
  Title
Attachment of carbohydrate to collagen. Isolation, purification and properties of the glucosyl transferase.
  Journal
Biochem Biophys Res Commun 30:89-94 (1968)
DOI:10.1016/0006-291X(68)90717-1
Reference
2  [PMID:4968368]
  Authors
Bosmann HB, Eylar EH.
  Title
Collagen-glucosyl transferase in fibriblasts transformed by oncogenic viruses.
  Journal
Nature 218:582-3 (1968)
DOI:10.1038/218582a0
Reference
3  [PMID:4288358]
  Authors
Butler WT, Cunningham LW.
  Title
Evidence for the linkage of a disaccharide to hydroxylysine in tropocollagen.
  Journal
J Biol Chem 241:3882-8 (1966)
Reference
4
  Authors
Kivirikko, K.I. and Myllyla, R.
  Title
In: Hall, D.A. and Jackson, D.S. (Eds.), International Review of Connective Tissue Research, vol. 8, Academic Press, New York, 1979, p. 23.
Reference
5  [PMID:21220425]
  Authors
Sricholpech M, Perdivara I, Nagaoka H, Yokoyama M, Tomer KB, Yamauchi M
  Title
Lysyl hydroxylase 3 glucosylates galactosylhydroxylysine residues in type I collagen in osteoblast culture.
  Journal
J Biol Chem 286:8846-56 (2011)
DOI:10.1074/jbc.M110.178509
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.66
IUBMB Enzyme Nomenclature: 2.4.1.66
ExPASy - ENZYME nomenclature database: 2.4.1.66
BRENDA, the Enzyme Database: 2.4.1.66
CAS: 9028-08-4

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