KEGG   ENZYME: 2.4.1.68Help
Entry
EC 2.4.1.68                 Enzyme                                 

Name
glycoprotein 6-alpha-L-fucosyltransferase;
GDP-fucose---glycoprotein fucosyltransferase;
GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1->6fucosyltransferase;
GDP-L-fucose-glycoprotein fucosyltransferase;
glycoprotein fucosyltransferase;
guanosine diphosphofucose-glycoprotein fucosyltransferase;
GDP-L-fucose:glycoprotein (L-fucose to asparagine-linked N-acetylglucosamine of 4-N-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl}asparagine) 6-alpha-L-fucosyltransferase;
FucT;
GDP-L-fucose:glycoprotein (L-fucose to asparagine-linked N-acetylglucosamine of N4-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl}asparagine) 6-alpha-L-fucosyltransferase;
GDP-beta-L-fucose:glycoprotein (L-fucose to asparagine-linked N-acetylglucosamine of N4-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl}asparagine) 6-alpha-L-fucosyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
GDP-beta-L-fucose:N4-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] 6-alpha-L-fucosyltransferase (configuration-inverting)
Reaction(IUBMB)
GDP-beta-L-fucose + N4-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] = GDP + N4-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc-(1->6)]-beta-D-GlcNAc}-L-asparaginyl-[protein] [RN:R05988]
Reaction(KEGG)
R05988(G) > R09319(G)
Show
Substrate
GDP-beta-L-fucose [CPD:C00325];
N4-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein]
Product
GDP [CPD:C00035];
N4-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc-(1->6)]-beta-D-GlcNAc}-L-asparaginyl-[protein]
Comment
This enzyme catalyses a reaction similar to that of EC 2.4.1.214, glycoprotein 3-alpha-L-fucosyltransferase, but transfers the L-fucosyl group from GDP-beta-L-fucose to form an alpha1,6-linkage rather than an alpha1,3-linkage.
History
EC 2.4.1.68 created 1972, modified 2002
Pathway
ec00510  N-Glycan biosynthesis
ec00513  Various types of N-glycan biosynthesis
ec00533  Glycosaminoglycan biosynthesis - keratan sulfate
ec01100  Metabolic pathways
Orthology
K00717  glycoprotein 6-alpha-L-fucosyltransferase
Genes
HSA: 2530(FUT8)
PTR: 449506(FUT8)
PPS: 100995214(FUT8)
GGO: 101124316(FUT8)
PON: 100437943(FUT8)
NLE: 100605115(FUT8)
MCC: 708839(FUT8)
MCF: 101865484(FUT8)
CSAB: 103229185(FUT8)
RRO: 104660090(FUT8)
RBB: 108542431(FUT8)
CJC: 100393693(FUT8)
SBQ: 101029110(FUT8)
MMU: 53618(Fut8)
RNO: 432392(Fut8)
CGE: 100751648(Fut8)
NGI: 103749280(Fut8)
HGL: 101697170(Fut8)
CCAN: 109682255(Fut8)
OCU: 100341974(FUT8)
TUP: 102482164(FUT8)
CFA: 448804(FUT8)
AML: 100470244(FUT8)
UMR: 103672147(FUT8)
ORO: 101385771(FUT8)
FCA: 101089525(FUT8)
PTG: 102964874(FUT8)
AJU: 106971545(FUT8)
BTA: 281177(FUT8)
BOM: 102272152(FUT8)
BIU: 109565258(FUT8)
PHD: 102328772(FUT8)
CHX: 102190043(FUT8)
OAS: 101111372(FUT8)
SSC: 396933(FUT8)
CFR: 102517686(FUT8)
CDK: 105086181(FUT8)
BACU: 103000193(FUT8)
LVE: 103072802(FUT8)
OOR: 101279082(FUT8)
ECB: 100052546(FUT8)
EPZ: 103550210(FUT8)
EAI: 106844896(FUT8)
MYB: 102254224(FUT8)
MYD: 102774852(FUT8)
HAI: 109382084(FUT8)
RSS: 109448340(FUT8)
PALE: 102882725(FUT8)
LAV: 100657054(FUT8)
TMU: 101354646
MDO: 100022835(FUT8)
SHR: 100919552(FUT8)
OAA: 100089222
GGA: 423178(FUT8)
MGP: 100546497(FUT8)
CJO: 107314793(FUT8)
APLA: 101800631(FUT8)
ACYG: 106043901(FUT8)
TGU: 100229671(FUT8)
GFR: 102038721(FUT8)
FAB: 101808667(FUT8)
PHI: 102109111(FUT8)
PMAJ: 107205549(FUT8)
CCAE: 111930038 111930152(FUT8)
CCW: 104696182(FUT8)
FPG: 101910308(FUT8)
FCH: 102052916(FUT8)
CLV: 102093557(FUT8)
EGZ: 104134058(FUT8)
AAM: 106498302(FUT8)
ASN: 102375447(FUT8)
AMJ: 102562325(FUT8)
PSS: 102448855(FUT8)
CMY: 102936338(FUT8)
CPIC: 101932923(FUT8) 101933702
ACS: 100553032(fut8)
PVT: 110082285(FUT8)
PBI: 103068068(FUT8)
GJA: 107112585(FUT8)
XLA: 394383(fut8.L) 779338(fut8.S)
XTR: 407913(fut8)
NPR: 108801723 108801942(FUT8)
DRE: 797512(fut8a)
AMEX: 103043605 103044460(fut8)
TRU: 101067080 445893(fut8)
LCO: 104924926(fut8)
NCC: 104950064(fut8)
MZE: 101465074(fut8)
OLA: 101174316(fut8)
XMA: 102216924(fut8)
PRET: 103457388(fut8)
NFU: 107377715(fut8)
KMR: 108233337(fut8)
CSEM: 103381164(fut8)
LCF: 108873492(fut8)
SDU: 111240065(fut8)
HCQ: 109514667(fut8)
BPEC: 110164297(fut8)
MALB: 109962326(fut8)
OTW: 112237275(fut8)
LCM: 102348117(FUT8)
CMK: 103175217(fut8)
SPU: 592434
APLC: 110988060
DME: Dmel_CG2448(FucT6)
DPO: Dpse_GA15369(Dpse_FucT6)
DER: 6551324
DPE: 6600409
DSI: Dsimw501_GD15979(Dsim_GD15979)
DWI: 6641223
DYA: Dyak_GE17606(Dyak_FucT6)
MDE: 101891448
AAG: 5570202
AME: 552522
BIM: 100742618
BTER: 100648217
SOC: 105199368
AEC: 105153391
ACEP: 105619499
PBAR: 105425245
HST: 105180734(Fut8)
DQU: 106742315
CFO: 105250044
LHU: 105678578
PGC: 109858584
PCF: 106784117
NVI: 100114017(FucT6)
MDL: 103579219
TCA: 657565
DPA: 109540828
NVL: 108562120
BMOR: 101745965
PMAC: 106711967
PRAP: 110991721
HAW: 110372143
PXY: 105386852
CLEC: 106669161
ZNE: 110841379
TUT: 107367100
CEL: CELE_C10F3.6(fut-8)
CBR: CBG09273(Cbr-fut-8)
BMY: Bm1_22280
TSP: Tsp_04291
CRG: 105346775
MYI: 110441900
OBI: 106882187
EPA: 110241153
ADF: 107333388
DFA: DFA_12228(fut8)
 » show all
Taxonomy
Reference
1  [PMID:7083256]
  Authors
Longmore GD, Schachter H.
  Title
Product-identification and substrate-specificity studies of the GDP-L-fucose:2-acetamido-2-deoxy-beta-D-glucoside (FUC goes to Asn-linked GlcNAc) 6-alpha-L-fucosyltransferase in a Golgi-rich fraction from porcine liver.
  Journal
Carbohydr Res 100:365-92 (1982)
DOI:10.1016/S0008-6215(00)81049-6
Reference
2  [PMID:3364733]
  Authors
Voynow JA, Scanlin TF, Glick MC.
  Title
A quantitative method for GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha 1----6fucosyltransferase activity with lectin affinity chromatography.
  Journal
Anal Biochem 168:367-73 (1988)
DOI:10.1016/0003-2697(88)90331-4
Reference
3  [PMID:8910378]
  Authors
Uozumi N, Yanagidani S, Miyoshi E, Ihara Y, Sakuma T, Gao CX, Teshima T, Fujii S, Shiba T, Taniguchi N.
  Title
Purification and cDNA cloning of porcine brain GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1-->6fucosyltransferase.
  Journal
J Biol Chem 271:27810-7 (1996)
DOI:10.1074/jbc.271.44.27810
  Sequence
[ssc:396933]
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.68
IUBMB Enzyme Nomenclature: 2.4.1.68
ExPASy - ENZYME nomenclature database: 2.4.1.68
BRENDA, the Enzyme Database: 2.4.1.68
CAS: 9033-08-3

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