KEGG   ENZYME: 2.4.1.69
Entry
EC 2.4.1.69                 Enzyme                                 
Name
type 1 galactoside alpha-(1,2)-fucosyltransferase;
galactoside 2-alpha-L-fucosyltransferase (ambiguous);
blood group H alpha-2-fucosyltransferase (ambiguous);
guanosine diphosphofucose-galactoside 2-L-fucosyltransferase;
alpha-(1->2)-L-fucosyltransferase (ambiguous);
alpha-2-fucosyltransferase (ambiguous);
alpha-2-L-fucosyltransferase (ambiguous);
blood-group substance H-dependent fucosyltransferase (ambiguous);
guanosine diphosphofucose-glycoprotein 2-alpha-fucosyltransferase (ambiguous);
guanosine diphosphofucose-beta-D-galactosyl-alpha-2-L-fucosyltransferase (ambiguous);
guanosine diphosphofucose-galactosylacetylglucosaminylgalactosylglucosylceramide alpha-L-fucosyltransferase (ambiguous);
guanosine diphosphofucose-glycoprotein 2-alpha-L-fucosyltransferase (ambiguous);
secretor-type beta-galactoside alpha1->2fucosyltransferase;
beta-galactoside alpha1->2fucosyltransferase (ambiguous);
GDP-beta-L-fucose:beta-D-galactosyl-R 2-alpha-L-fucosyltransferase (ambiguous);
FUT2 (gene name);
GDP-beta-L-fucose:beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide 2-alpha-L-fucosyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
Sysname
GDP-beta-L-fucose:beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-R alpha-(1,2)-L-fucosyltransferase (configuration-inverting)
Reaction(IUBMB)
GDP-beta-L-fucose + beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-R = GDP + alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-R [RN:R04081]
Reaction(KEGG)
R04081 > R05968(G) R06024(G) R06031(G) R06035(G) R06041(G) R06085(G) R06086(G) R06089(G) R06090(G) R06156(G);
(other) R06170(G)
Substrate
GDP-beta-L-fucose [CPD:C00325];
beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-R [CPD:C04656]
Product
GDP [CPD:C00035];
alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-R
Comment
The enzyme acts on a glycoconjugates where R (see reaction) is a glycoprotein or glycosphingolipid. The recognized moiety of the substrate is known as a type 1 histo-blood group antigen precursor disaccharide, and the action of the enzyme produces an H type 1 antigen. In humans the main enzyme performing this reaction is encoded by the FUT2 gene (also known as the Secretor gene), which is also able to act on type 2 substrates (see EC 2.4.1.344). The enzyme from the bacterium Helicobacter pylori cannot act on type 2 substrates.
History
EC 2.4.1.69 created 1972 (EC 2.4.1.89 created 1976, incorporated 1984), modified 2002, modified 2017
Pathway
ec00601  Glycosphingolipid biosynthesis - lacto and neolacto series
ec00603  Glycosphingolipid biosynthesis - globo and isoglobo series
ec01100  Metabolic pathways
Orthology
K00718  galactoside 2-L-fucosyltransferase 1/2
K12245  bifunctional glycosyltransferase PgtA
Genes
HSA2523(FUT1) 2524(FUT2)
PTR104001169 468944(FUT2) 468947(FUT1)
PPS100990363(FUT1) 100991035 103785330
GGO101131113(FUT1) 101146871
PON100445051(FUT2)
NLE100589182 100589750(FUT2) 100592672(FUT1)
HMH116478236(FUT1) 116478240(FUT2) 116478242
MCC718252(FUT1) 718794 722582
MCF102121228 102121606 102125198(FUT1)
MTHB126943584 126943586 126943611
MNI105478651 105478653 105478657(FUT1)
CSAB103234986 103234988 103234996(FUT1)
CATY105595250 105595251 105595255(FUT1)
PANU101013578 101015696(FUT2)
TGE112612788 112613043(FUT1) 112613472
MLEU105539174(FUT1) 105539183
RRO104666550(FUT1) 104666555 104666558
RBB108523627 108523645(FUT2) 108523649(FUT1)
TFN117091518 117091519 117091525(FUT1)
PTEH111520070 111520123(FUT2) 111520144(FUT1)
CANG105514796(FUT1) 105514799(FUT2) 105514801
CJC100389529(FUT1) 100896666(FUT2)
SBQ101047116 101047433 101048065(FUT1)
CIMI108283885(FUT2) 108283894(FUT1)
CSYR103250047(FUT2) 103250056 103250472(FUT1)
MMUR105865666 105865678(FUT1) 105865687(FUT2) 105870481
LCAT123623855(FUT1) 123623859(FUT2) 123623862
PCOQ105809311(FUT1) 105809326 105809425(FUT2)
OGA100948058(FUT1) 100948992 100959714(FUT2)
MMU14343(Fut1) 14344(Fut2) 56546(Sec1)
MCAL110298382 110298509(Fut2) 110299147(Fut1)
MPAH110334098(Fut1) 110334752(Fut2) 110335813
RNO308586(Sec1) 58924(Fut2) 81919(Fut1)
MCOC116100499(Fut1) 116102215(Fut2) 116102218
ANU117694287 117714079(Fut1) 117724308(Fut2)
MUN110550459 110550494 110550500(Fut1)
CGE100751185(Fut2) 100757047(Fut1) 113836307
MAUA101823506 101841663(Fut1) 121136185(Fut2)
PROB127213939(Fut1) 127213941 127213946
PLEU114684672 114684692(Fut1) 114684704(Fut2)
MORG121449596(Fut1) 121450863 121452406
MFOT126488097 126488122 126488214
AAMP119802606(Fut2) 119802944 119803072(Fut1)
NGI103743624 103743625 103743628(Fut1)
HGL101709834(Fut1) 101710190(Fut2)
CPOC100728677(Fut1) 100729517 100732186(Fut2)
CCAN109682667(Fut2) 109682669(Fut1) 109682676
DORD105994138 105994139 105994140 105994357 105994359 105994380(Fut1)
DSP122125587 122125760(Fut1) 122125806 122125807 122125827 122125850
PLOP125338861(Fut1) 125338862 125368094 125368096
NCAR124966644 124967481
MMMA107151277(Fut1) 107151717 107151718
OCU100009290(RFT-II) 100009291(FUT1) 100349124
OPI101528747(FUT2) 101533603(FUT1) 101534586
TUP102471780 102474609(FUT1)
GVR103587747 103587749(FUT1) 103587776
CFA102151792 484396(FUT1) 484398(FUT2)
CLUD112645188(FUT1) 112645194(FUT2) 112645195
VVP112931221(FUT1) 112931228(FUT2)
VLG121484100 121485417(FUT1) 121485419(FUT2)
NPO129499635(FUT2) 129499872(FUT1) 129500309
AML100472596 100478397(FUT1) 100478902(FUT2)
UMR103657100(FUT1) 103657240 103657242
UAH113243333(FUT1) 113243338(FUT2) 113243340
UAR123776277(FUT1) 123776296(FUT2) 123776330
ELK111160712 111160713 111160721
LLV125088646 125088954 125088957
MPUF101671692(FUT2) 101671981 101692582(FUT1)
MNP132004756 132005251(FUT1) 132005746(FUT2)
MLK131818708 131818949(FUT1) 131818951(FUT2)
NVS122911857(FUT1) 122911858(FUT2) 122911865
ORO101374079(FUT1) 101374953(FUT2) 101375248
EJU114199504(FUT2) 114199506 114199624(FUT1)
ZCA113935287(FUT2) 113936331 113936763(FUT1)
MLX117998045(FUT2) 117998229 117998234(FUT1)
NSU110572840 110572845(FUT1) 123323182(FUT2)
LWW102727872(FUT1) 102728175 102747703
FCA101080847(FUT1) 101085847(FUT2)
PYU121018729(FUT2) 121018738(FUT1) 121026260
PCOO112851000(FUT1)
PBG122494860(FUT1) 122494868(FUT2) 122494869
PVIV125153069(FUT1) 125153413(FUT2) 125153414
LRUF124510939 124510940 124511820
PTG102962287(FUT2) 102969895(FUT1)
PPAD109253109(FUT1) 109253122(FUT2)
PUC125915148 125915780 125915781
AJU106988654 106988710 113593452
HHV120240643(FUT2) 120240672 120243441(FUT1)
BTA281174(FUT1) 281175(FUT2) 281483(SEC1)
BOM102282547(FUT1) 102283305(FUT2) 102283588
BIU109572956 109573030(FUT2) 109573041(FUT1)
BBUB102393140(FUT2) 102395162(FUT1) 102410181
BBIS104995617 104995618 104995621(FUT1)
CHX102178850 102185028 102185596(FUT1)
OAS101107465 101108248(FUT1) 105608435(FUT2)
BTAX128063786 128063792(FUT1) 128063999
ODA120872177(FUT1) 120872179(FUT2) 120872184
CCAD122420846 122420957(FUT1) 122421650(FUT2)
MBEZ129546587 129546588 129546591(FUT2)
SSC100524201(FUT2A) 397138(FUT1) 397139(FUT2)
CFR102521344(FUT1) 102522076(FUT2) 102522586 116661616
CBAI105062593 105062594 105062601(FUT1)
CDK105090616 105102900(FUT1) 105102904 105102922
VPC102530733 102531228 107033936(FUT1)
BACU103015344(FUT1)
BMUS118885425 118885442(FUT2) 118885708(FUT1)
LVE103080875(FUT2) 103081703(FUT1)
OOR101289561(FUT2)
DLE111180647(FUT1) 111180654(FUT2) 111180655
PCAD102973479(FUT1) 102996473(FUT2) 102996580
PSIU116744079 116744335(FUT1) 116744531(FUT2)
NASI112415333(FUT1) 112415664(FUT2) 112415665
ECB100054216 100054259 100054308 100054499(FUT1)
EPZ103544534 103553324(FUT1) 103553326(FUT2)
EAI106838254(FUT2) 106838255 106838257(FUT1)
MYB102257351(FUT1) 102259445(FUT2)
MYD102760565(FUT2) 102767518 102768655(FUT1)
MMYO118655350 118655402(FUT2) 118655429(FUT1)
MLF102425138 102430088(FUT1) 102433448 102433757
PKL118712167(FUT2) 118712169(FUT1) 118712177
EFUS103297654(FUT1) 103297656 103297782(FUT2)
MNA107531808(FUT2) 107531852(FUT1)
DRO112310077(FUT2) 112310079(FUT1)
AJM119043799(FUT1) 119044277(FUT2) 119059557
PDIC114511479 114511480 114511482(FUT1)
PHAS123830209(FUT1) 123830244 123830310(FUT2)
MMF118638875(FUT1) 118639085(FUT2) 118639300
PPAM129082692(FUT1) 129082792 129082793
HAI109391063(FUT2) 109391098(FUT1)
RFQ117034335(FUT1) 117035221(FUT2)
PALE102885708(FUT1) 102886704(FUT2)
PGIG120606939(FUT1) 120606992(FUT2)
PVP105301801(FUT1) 105301804(FUT2)
RAY107498802(FUT2) 107498851(FUT1)
MJV108393134 108393209(FUT2) 108400331(FUT1)
TOD119249527 119249528 119249532(FUT1)
SARA101558921(FUT1)
SETR126028611(FUT1)
LAV100662459 100674697(FUT1) 100675832(FUT2)
TMU101356480 101358508 101359037
ETF101648281 101648592(FUT2) 101649208(FUT1)
DNM101422926 101443440(FUT1) 101444337(FUT2)
MDO100009874 100009916 100010332 100010378 100010422 100015624(FUT1) 100018242
GAS123232152 123232153 123239882 123243077 123243086 123243105 123256126
SHR100930940 100931578(FUT1)
AFZ127548168 127556565
PCW110196105 110196106 110219782(FUT1)
OAA100080706 100085980 100681084
ASN102379237 102387217
AMJ102565316 102575664(FUT2) 102577364
CPOO109320810
PSS102452892 102460361 102460609 106732458
CMY102930615 102930836 102941010
CCAY125627898 125627915 125628449
DCC119847267 119847277 119847460 119847462
CPIC101931375 101931943 101933588 101933861 101936896 101949841 101950478 101950859 101953396
TST117888428 117888432 117888709 117888950 117888951
CABI116823121 116828793 116840050 116840062 116840063 116840072 116840074 116840075 116840076 116840077 116840142
MRV120388297 120388304 120388307 120388308 120388309 120388310 120388311 120388316 120388318 120388321 120388322 120388326
ACS100561462(fut2)
ASAO132779376(FUT2)
PVT110078544(FUT2)
SUND121934331(FUT2)
PBI103053688(FUT2)
PMUR107282448(FUT2)
CTIG120304493(FUT2)
TSR106538382(FUT2)
PGUT117669071(FUT2)
APRI131198518(FUT2)
PTEX113443732(FUT2)
NSS113418488(FUT2)
VKO123032081(FUT2)
PMUA114583227 114583228 114583229 114583232 114583233 114583234
PRAF128398891 128398892 128398893 128398895 128398896 128398897
ZVI118078806 118095493 118095494 118095495 118095498 118095499
HCG128329642 128331733 128331734 128332105(FUT2)
GJA107122202(FUT2)
STOW125444294 125444295
EMC129338430 129338638 129339526
XLA108696739(fut2.L) 108696766(fut1.L) 108697042 108697990(fut2.S) 398668(fut1.S)
XTR100487812 100493351(fut2) 100497569 447958(fut1)
NPR108792625 108792632 108795149 108796048 108796049 108801078 108801079 108801081 108801082
RTEM120915317 120915828 120916049 120916521 120916523 120916524 120916525 120916526 120936079 120936080 120936081 120936083 120936086
BBUF120986925 120998931 120999020 121002347 121002358
BGAR122926147 122926616 122926697 122926698 122926699
MUO115464602 115465011 115465017 115465019 115466539 115466542 115466543 115466544
GSH117365462 117368079 117368667 117368675 117368676 117368677 117368679 117368716 117368717
ARUT117411838 117414304 117414310 117414311 117414321 117962737 117971578
LCM102356194 102357968(FUT1)
CMK103173436 103183767 103183768 103183770
RTP109912480
CPLA122539633 122561471
HOC132826575 132830762 132830763 132830764
LERI129707910 129710321
AME726095
ACER107996340
ALAB122712867
ADR102677933
AFLR100866896
BIM100743109
BBIF117205737
BVK117230790
BVAN117166399
BTER100642421
BAFF126924378
BPYO122575423
BPAS132911906
FVI122529980
CCAL108630635
OBB114874445
OLG117604109
MGEN117229000
NMEA116431575
CGIG122405371
SOC105199316
MPHA105835366
AEC105148166
ACEP105624787
PBAR105431936
VEM105564089
HST105188950
DQU106741823
CFO105255117
FEX115240039
LHU105672546
PGC109852313
OBO105284978
PCF106790045
PFUC122518204
VPS122627880
VCRB124422476
VVE124947470
NVI100116336
LHT122511689
LBD127288464
MDL103570941
CGLO123263839
FAS105263616
DAM107042564
AGIF122849782
VCAN122407733
CCIN107270440
DSM124412855
NPT124221446
NFB124184711
NLO107220001
NVG124307120
AROA105690947
TCA655912
DPA109540163 109540165 109542888 109542896
SOY115885653
AGRG126734434 126734435 126734494
ATD109609698
CSET123319092
AGB108917833
LDC111505639
DVV114326684
NVL108559505
APLN108734594 108734597 108744520
PPYR116173637 116173643 116174628
OTU111421329
DCI103507867 103522072
PHUPhum_PHUM354220
FOC113208685
ZNE110826935 110834024
CSEC111866362 111869870
BROR134530846
IEL124153245 124154927 124155046 124167590
DPXDAPPUDRAFT_307215
DMK116929405
DPZ124328541 124340530
PVM113801332 113803224 113816156 113816158 113820062
PJA122244225 122244256 122245168 122249172 122250806 122259041 122259042 122264522 122264523 122265313
PCHN125040729 125041424 125041464 125041465 125042669 125047484
PMOO119588325 119589676 119591936
HAME121857928 121859712 121865565 121873191 121876429 121878319
PCLA123745380 123745839 123745855 123747543 123749803 123756248 123760817 123761082 123761209 123761439 123764310 123764311 123768844 123769133 123772508
CQD128685556 128685558 128689706 128700882 128703075
PTRU123503225 123503453 123503506 123503571 123503641 123503707 123503854 123506921 123507897 123520469
ESN126988039
MNZ135205632 135205767 135210404 135211191 135214440 135219154 135219163 135219168 135222828 135222829 135223332
HAZT108666313 108673714 108674749 108674892 108675421 108676677 108677708 108678420 108680766 108682691
EAF111697555 111698433 111698456 111700124 111700941 111701088 111703567 111703690 111708462 111709293 111713736
LSM121114872 121115871 121117554 121124525
TCF131877363 131877909 131879050 131880150 131881971 131882006 131883310 131883353 131884204 131884529 131885589 131885628 131885632 131887742 131887743 131888594 131888597 131888932 131889071 131889121 131891177 131891513
PPOI119090213 119090214 119090217 119092029 119096627 119096629 119097540 119097541 119101623 119103070 119104293 119104529 119104540 119104706
CSCU111616725 111635294 111635298 111635299 111635300 111639905 111639907
PTEP107436408 107453824 107453825
ABRU129976331 129976523
UDV129224795
SDM118190819
LPOL106457771 106457772 106476526
PMEO129587364 129587582 129598752
HROHELRODRAFT_110149 HELRODRAFT_113553 HELRODRAFT_158795 HELRODRAFT_164388 HELRODRAFT_164391 HELRODRAFT_164398 HELRODRAFT_173606 HELRODRAFT_173990 HELRODRAFT_174656
LGILOTGIDRAFT_107563 LOTGIDRAFT_107907 LOTGIDRAFT_129925 LOTGIDRAFT_150955 LOTGIDRAFT_161584 LOTGIDRAFT_164689 LOTGIDRAFT_167590 LOTGIDRAFT_169777 LOTGIDRAFT_175102 LOTGIDRAFT_229229
PVUL126811086 126811216 126811992 126814935 126815621 126817392 126819265 126819266 126820434 126820900 126822531 126822688 126823435 126824875 126825149 126828496 130012509
PCAN112553292 112553375 112554855 112556519 112556940 112558077 112558225 112560251 112561425 112561426 112561558 112561583 112561593 112561915 112561979 112562553 112562695 112562762 112563041 112563042 112563043 112563185 112563308 112565210 112565435 112577325
BGT106050602 106050836 106059289 106064765 106065819 106066495 106067809 106077555 106078361 106080165
GAE121367132 121367171 121367798 121373000 121373417 121373567 121376740 121377211 121377523 121377693 121377714 121378014 121378114 121378115 121379170 121379733 121382570 121383128 121383519 121383834 121383835 121383836 121387311 121388888 121389756 121389757 121390104 121390458
HRF124112513 124117190 124117210 124121954 124121955 124121957 124124420 124127806 124131613 124132907 124133896 124133906 124140790 124140806 124140821 124143464 124145593 124145594 124145595 124145598 124145599 124149229 124152669 124152705 124152706 125375868
HRJ124254082 124256146 124257211 124257612 124257618 124257620 124258423 124258424 124258425 124260176 124261672 124264378 124264381 124264592 124267335 124268944 124268946 124268947 124270264 124273041 124273428 124273664 124273700 124282283 124284979 124285128 124292343
CRG105324924 105324936 105324937 105325455 105325959 105326082 105326310 105327892 105327909 105330520 105332175 105332210 105332678 105336015 109617642 109618315 109618713 117682678 117682679 117689798
CVN111106526 111106863 111106977 111108056 111108149 111108539 111109325 111114790 111115005 111120678 111128195 111134347 111134834 111137720
CANU128158691 128159975 128159985 128160153 128160154 128165615 128165616 128165618 128165619 128172347 128178534 128179940 128180361 128180692 128181375 128187277
OED125646769 125648322 125651988 125651996 125652130 125652640 125654377 125656101 125656102 125657489 125660723 125660724 125669484 125672815 125672822
MYI110441722 110443797 110446355 110446386 110447282 110447822 110450057 110450361 110452484 110452526 110452548 110452860 110453471 110455288 110460015 110464228 110464242 110464244 110466462 110466463 110466972
PMAX117315627 117315809 117315904 117315942 117316374 117316898 117320004 117320183 117320835 117322155 117324807 117336315 117336348 117337741 117338129 117339346 117339436 117341595
MMER123523565 123523771 123527929 123527930 123539602 123542382 123542599 123549943 123551987 123557094 123566230
RPHI132714121 132718384 132719141 132731407 132737299 132737569 132739401 132744264 132749977 132754589 132755520 132757785 132758061 132758307
DPOL127834834 127838058 127841322 127845359 127848546 127858400 127862968 127866168 127877154 127878513
OBI106868790 106869239 106871940 106875849 106877689
OSN115211963 115222189 115223466 115223552 115232568
LJP135463167 135463939 135463942 135464054 135464099 135464100 135464175 135464859 135465962 135467343 135472485 135473314 135473626 135473852 135473874 135475093 135475230 135475558 135475763 135475777 135481417
LAK106150412 106153096 106158149 106158150 106158152 106158416 106158428 106158482 106159547 106164616 106167399 106174770 106179121 106179122 106179123 106179124 106179300 106179472
LLON135483938 135495322 135503343
HSY130642079 130642080
DDIDDB_G0283761(pgtA)
DPPDICPUDRAFT_159362
DFADFA_01805(pgtA)
 » show all
Reference
1  [PMID:7372640]
  Authors
Beyer TA, Hill RL.
  Title
Enzymatic properties of the beta-galactoside alpha 1 leads to 2 fucosyltransferase from porcine submaxillary gland.
  Journal
J Biol Chem 255:5373-9 (1980)
Reference
2  [PMID:6246105]
  Authors
Beyer TA, Sadler JE, Hill RL.
  Title
Purification to homogeneity of H blood group beta-galactoside alpha 1 leads to 2 fucosyltransferase from porcine submaxillary gland.
  Journal
J Biol Chem 255:5364-72 (1980)
Reference
3  [PMID:6588382]
  Authors
Kumazaki T, Yoshida A
  Title
Biochemical evidence that secretor gene, Se, is a structural gene encoding a specific fucosyltransferase.
  Journal
Proc Natl Acad Sci U S A 81:4193-7 (1984)
DOI:10.1073/pnas.81.13.4193
Reference
4  [PMID:9219535]
  Authors
Koda Y, Soejima M, Wang B, Kimura H
  Title
Structure and expression of the gene encoding secretor-type galactoside 2-alpha-L-fucosyltransferase (FUT2).
  Journal
Eur J Biochem 246:750-5 (1997)
DOI:10.1111/j.1432-1033.1997.t01-1-00750.x
Reference
5  [PMID:10589734]
  Authors
Wang G, Boulton PG, Chan NW, Palcic MM, Taylor DE
  Title
Novel Helicobacter pylori alpha1,2-fucosyltransferase, a key enzyme in the synthesis of Lewis antigens.
  Journal
Microbiology 145 ( Pt 11):3245-53 (1999)
DOI:10.1099/00221287-145-11-3245
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.69
IUBMB Enzyme Nomenclature: 2.4.1.69
ExPASy - ENZYME nomenclature database: 2.4.1.69
BRENDA, the Enzyme Database: 2.4.1.69
CAS: 56093-23-3

DBGET integrated database retrieval system