Entry |
|
Name |
poly(ribitol-phosphate) alpha-N-acetylglucosaminyltransferase;
TarM;
UDP acetylglucosamine-poly(ribitol phosphate) acetylglucosaminyltransferase (ambiguous);
uridine diphosphoacetylglucosamine-poly(ribitol phosphate) acetylglucosaminyltransferase (ambiguous);
UDP-N-acetyl-D-glucosamine:poly(ribitol-phosphate) N-acetyl-D-glucosaminyltransferase (ambiguous);
UDP-N-acetyl-alpha-D-glucosamine:poly(ribitol-phosphate) N-acetyl-alpha-D-glucosaminyltransferase (ambiguous);
poly(ribitol-phosphate) N-acetylglucosaminyltransferase (ambiguous)
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Class |
Transferases;
Glycosyltransferases;
Hexosyltransferases
 |
Sysname |
UDP-N-acetyl-alpha-D-glucosamine:4-O-(D-ribitylphospho)n-di[(2R)-1-glycerophospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol alpha-N-acetyl-D-glucosaminyltransferase (configuration-retaining)
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Reaction(IUBMB) |
n UDP-N-acetyl-alpha-D-glucosamine + 4-O-(D-ribitylphospho)n-di[(2R)-1-glycerophospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol = n UDP + 4-O-(2-N-acetyl-alpha-D-glucosaminyl-D-ribitylphospho)n-di[(2R)-1-glycerophospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol [RN: R12037]
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Reaction(KEGG) |
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Substrate |
UDP-N-acetyl-alpha-D-glucosamine [CPD: C00043];
4-O-(D-ribitylphospho)n-di[(2R)-1-glycerophospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol [CPD: C21508]
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Product |
UDP [CPD: C00015];
4-O-(2-N-acetyl-alpha-D-glucosaminyl-D-ribitylphospho)n-di[(2R)-1-glycerophospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol [CPD: C21870]
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Comment |
Involved in the biosynthesis of poly(ribitol phosphate) teichoic acids in the cell wall of the bacterium Staphylococcus aureus. This enzyme adds an N-acetyl-alpha-D-glucosamine to the hydroxyl group at the 2 position of the ribitol phosphate units. cf. EC 2.4.1.355 [poly(ribitol-phosphate) beta-N-acetylglucosaminyltransferase].
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History |
EC 2.4.1.70 created 1972, modified 2018
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Orthology |
K22710 | poly(ribitol-phosphate) alpha-N-acetylglucosaminyltransferase |
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Genes |
» show all
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Reference |
1 |
Authors |
Nathenson, S.G., Ishimoto, N. and Strominger, J.L. |
Title |
UDP-N-acetylglucosamine:polyribitol phosphate N-acetylglucosaminyltransferases from Staphylococcus aureus. |
Journal |
Methods Enzymol 8:426-429 (1966) |
Reference |
|
Authors |
Xia G, Maier L, Sanchez-Carballo P, Li M, Otto M, Holst O, Peschel A |
Title |
Glycosylation of wall teichoic acid in Staphylococcus aureus by TarM. |
Journal |
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Sequence |
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Reference |
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Authors |
Sobhanifar S, Worrall LJ, Gruninger RJ, Wasney GA, Blaukopf M, Baumann L, Lameignere E, Solomonson M, Brown ED, Withers SG, Strynadka NC |
Title |
Structure and mechanism of Staphylococcus aureus TarM, the wall teichoic acid alpha-glycosyltransferase. |
Journal |
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Sequence |
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Reference |
|
Authors |
Koc C, Gerlach D, Beck S, Peschel A, Xia G, Stehle T |
Title |
Structural and enzymatic analysis of TarM glycosyltransferase from Staphylococcus aureus reveals an oligomeric protein specific for the glycosylation of wall teichoic acid. |
Journal |
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Sequence |
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Other DBs |
ExplorEnz - The Enzyme Database: | 2.4.1.70 |
ExPASy - ENZYME nomenclature database: | 2.4.1.70 |
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