KEGG   ENZYME: 2.4.1.88
Entry
EC 2.4.1.88                 Enzyme                                 
Name
globoside alpha-N-acetylgalactosaminyltransferase;
uridine diphosphoacetylgalactosamine-globoside alpha-acetylgalactosaminyltransferase;
Forssman synthase;
globoside acetylgalactosaminyltransferase;
UDP-N-acetyl-D-galactosamine:N-acetyl-D-galactosaminyl-1,3-D-galactosyl-1,4-D-galactosyl-1,4-D-glucosylceramide alpha-N-acetyl-D-galactosaminyltransferase;
UDP-N-acetyl-D-galactosamine:N-acetyl-D-galactosaminyl-(1->3)-D-galactosyl-(1->4)-D-galactosyl-(1->4)-D-glucosyl-(1<->1)-ceramide alpha-N-acetyl-D-galactosaminyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
Sysname
UDP-N-acetyl-alpha-D-galactosamine:N-acetyl-beta-D-galactosaminyl-(1->3)-alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide alpha-N-acetyl-D-galactosaminyltransferase
Reaction(IUBMB)
UDP-N-acetyl-alpha-D-galactosamine + N-acetyl-beta-D-galactosaminyl-(1->3)-alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide = UDP + N-acetyl-alpha-D-galactosaminyl-(1->3)-N-acetyl-beta-D-galactosaminyl-(1->3)-alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide [RN:R04182 R05965]
Reaction(KEGG)
R04182 R05965(G);
(other) R11322(G)
Substrate
UDP-N-acetyl-alpha-D-galactosamine [CPD:C00203];
N-acetyl-beta-D-galactosaminyl-(1->3)-alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide
Product
UDP [CPD:C00015];
N-acetyl-alpha-D-galactosaminyl-(1->3)-N-acetyl-beta-D-galactosaminyl-(1->3)-alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide
History
EC 2.4.1.88 created 1976
Pathway
ec00603  Glycosphingolipid biosynthesis - globo and isoglobo series
ec01100  Metabolic pathways
Orthology
K00722  globoside alpha-N-acetylgalactosaminyltransferase
Genes
HSA26301(GBGT1)
PTR464823(GBGT1)
PPS100978291(GBGT1)
GGO101145846(GBGT1)
PON100453106(GBGT1)
NLE100590023(GBGT1)
MCC106993582(GBGT1)
MCF102119767(GBGT1)
CSAB103239703(GBGT1)
PANU103881072(GBGT1)
TGE112607917(GBGT1)
RRO104669732(GBGT1)
RBB108513510(GBGT1)
TFN117073852(GBGT1)
PTEH111524005(GBGT1)
CJC103795439(GBGT1)
SBQ104652637(GBGT1)
CSYR103250924(GBGT1)
MMUR105859872(GBGT1)
LCAT123646556(GBGT1)
OGA105887449(GBGT1)
MMU227671(Gbgt1)
MCAL110290105(Gbgt1)
MPAH110319298(Gbgt1)
RNO499764(Gbgt1)
MCOC116089896(Gbgt1)
MUN110549880(Gbgt1)
CGE100771256(Gbgt1)
MAUA101832682(Gbgt1)
PLEU114702787(Gbgt1)
MORG121462826(Gbgt1)
AAMP119819957(Gbgt1)
HGL101726516(Gbgt1)
CPOC100736120(Gbgt1)
CCAN109690998(Gbgt1)
DORD105989368(Gbgt1)
DSP122109016(Gbgt1)
NCAR124964855
TUP102477690(GBGT1)
CFA403833(GBGT1)
VVP112928011(GBGT1)
VLG121473804(GBGT1)
AML100479644 117800745
UMR103670247(GBGT1)
UAH113266556(GBGT1)
UAR123775725(GBGT1)
ELK111146249
LLV125083159
MPUF101672439(GBGT1)
ORO101386326(GBGT1)
EJU114198874(GBGT1)
ZCA113935141(GBGT1)
MLX118017554(GBGT1)
FCA101090810(GBGT1)
PYU121024025 121026244
PBG122475454(GBGT1)
PTG102954717(GBGT1)
PPAD109249974(GBGT1)
AJU106985321(GBGT1)
HHV120230207(GBGT1)
BTA618517(GBGT1)
BOM102282202(GBGT1)
BIU109566575(GBGT1) 109566576
BBUB102405974(GBGT1)
CHX102180325(GBGT1)
OAS101112039(GBGT1)
ODA120852132(GBGT1)
CCAD122442307(GBGT1)
SSC110256486(GBGT1)
CFR102511010(GBGT1)
CBAI105069725(GBGT1)
CDK105085187(GBGT1)
VPC102544102(GBGT1)
BACU103008412
LVE103086807(GBGT1)
OOR105747968(GBGT1)
DLE111177084(GBGT1)
PCAD102993265(GBGT1)
PSIU116755506(GBGT1)
ECB100069388(GBGT1)
EPZ103553672(GBGT1)
EAI106845361(GBGT1)
MYB102239613(GBGT1)
MYD102767739(GBGT1)
MMYO118666918(GBGT1)
MNA107524628(GBGT1)
PKL118708886(GBGT1)
HAI109381005(GBGT1)
DRO112306338(GBGT1)
SHON118980198(GBGT1)
AJM119036120(GBGT1)
PDIC114503822(GBGT1)
PHAS123823587(GBGT1)
MMF118629656(GBGT1)
RFQ117032435(GBGT1)
PALE102880609(GBGT1)
PGIG120602748(GBGT1)
PVP105298649(GBGT1) 105310501
RAY107504585(GBGT1)
MJV108388221(GBGT1)
TOD119231237(GBGT1)
LAV100665584(GBGT1)
TMU101349194
DNM101413632(GBGT1)
MDO100017839(GBGT1)
GAS123235206(GBGT1)
SHR100918940(GBGT1)
PCW110205392(GBGT1)
OAA100090987(GBGT1)
GGA417163(GBGT1)
PCOC116234290(GBGT1)
MGP100540036(CCDC180) 116216187(GBGT1)
CJO107321913(GBGT1)
NMEL110406850
APLA101799653(GBGT1)
ACYG106044126(GBGT1)
AFUL116496885(GBGT1)
TGU100225394(GBGT1)
LSR110477722(GBGT1)
SCAN103818975(GBGT1)
PMOA120512426
OTC121337072
PRUF121362457
GFR102040147(GBGT1)
FAB101806513(GBGT1)
PHI102103511(ABO)
PMAJ107212008(GBGT1)
CCAE111937029(GBGT1)
CCW104688481(GBGT1)
ETL114059121
ZAB102073256(GBGT1)
FPG101921547(GBGT1)
FCH102050463(GBGT1)
CLV102095912(GBGT1)
EGZ104129328
NNI104023282(GBGT1)
PLET104627305(GLT6D1)
ACUN113486511(GBGT1)
TALA104363600(GBGT1)
PADL103915270(GBGT1)
ACHC115335226
AAM106483758(GBGT1)
AROW112964277
NPD112955910(GBGT1)
DNE112979913(GBGT1)
ASN102388459(GBGT1)
AMJ102565956(GBGT1)
CPOO109313975(GBGT1)
GGN109292997(GBGT1)
PSS102455930(GBGT1)
CMY102938627
CPIC101945380(GBGT1)
TST117889501
CABI116824002(GBGT1)
MRV120386791(GBGT1)
PVT110079644(GBGT1)
SUND121936036(GBGT1)
VKO123028392(GBGT1)
PMUA114589368(GBGT1)
ZVI118083772(GBGT1)
GJA107124818(GBGT1)
DRE100005375(si:ch211-135f11.4) 100005565(gbgt1l8) 100005704(si:dkey-110k5.10) 387303(gbgt1l4) 447881(gbgt1l3) 563897(gbgt1l5) 566487(gbgt1l2)
SRX107726394 107732598 107732624 107747816 107747818 107747827
SANH107680407 107680408 107687663 107687696 107687702 107703160
SGH107554410 107592280 107592391 107597221 107597222 107599955 107599982
CCAR109066903 109073532 109084337 109084598 109090452 109096308 109099031 109099041
CAUA113048788 113048790 113091380 113091387 113093767 113093769 113093789 113093790 113093791 113106834 113107731
PPRM120469831 120469855(gbgt1l1) 120469856 120492581 120492582 120492752
MAMB125266605 125266608 125270868 125270877 125270898 125279747
IPU108260034 108260038 108262004 108279304
PHYP113528687 113531111 113531290 113535471
SMEO124379102 124379514 124379517 124379518 124379519 124379520 124379521
TFD113642193 113643872 113645540 113645553 113646411 113662876 113662877 113662878 113662880 113662881 125138391 125138413
AMEX103028363
EEE113567823 113567860 113569052 113569053 113569272 113583525 113591966(abo)
TRU101067861
TNGGSTEN00020153G001
LCO104928926 104931896 104939769
NCC104957060 104960712
CGOB115004920 115008381
ELY117252456 117256701 117268756
PLEP121955086 121956892
SLUC116034799 116035209 116060445
ECRA117941309 117944096 117945063
PFLV114552989 114553901 114570339
GAT120813179 120828061 120835006 120835856
PPUG119220178 119229407
MSAM119886768 119895977
CUD121507191 121529122
ALAT119013560 119013945 119017792 119017794 119017795 119018539 119021038
MZE101467158 101480789
ONL100704949 100710225
OAU116319404 116326512
OLA101155669 101174260
OML112145421 112160595
XMA102220530(gbgt1) 102220535 102232496
XCO114135177 114142919 114160500(gbgt1)
XHE116710598 116718900 116736301(gbgt1)
PRET103462851 103464991 103469020(gbgt1)
PFOR103136522 103139590 103146879
PLAI106949161 106951144
PMEI106922789 106924471 106927187
GAF122821863 122834415 122842601
CVG107082024 107087987
CTUL119778562 119781763 119789605
GMU124856283 124862367 124863849 124866914
NFU107381862 107381863 107385470 107390254
KMR108228886 108239823 108251530
ALIM106511352 106523577 106528111
NWH119412206 119421205
AOCE111576205 111576206 111576208 111581210 111583435
CSEM103386423
POV109629071 109643274
SSEN122768523 122774639 122774640 122785122
HHIP117762003 117766136
HSP118104403 118124064
LCF108873243 108876865 108899640
SDU111220711 111225192 111225276 111239801(gbgt1)
SLAL111645940 111649580(gbgt1) 111659413 111659436 111670902
XGL120784939 120789858 120807357
HCQ109522118
BPEC110164356 110166708
MALB109956078 109972655
BSPL114852344 114852345 114860876
SASA100194757(gbgt1) 106563649 106565313 106591072 106592470 106592471 106592658 106593699 106594443 106603993 106607464 106609536
OTW112225900 112233764 112238627 112241057 112258518 112264537
OMY110486140 110491256 110493996 110499918 110507938 110507939 110510239 110538060 110538061 118938868 118938904 118943004
OGO123995966 124000716 124004275 124014534 124015040 124015201
ONE115104034 115110144 115122935 115133691 115143597 115146862
SALP111962053 111980919 111981608 112069843
SNH120021890 120034500 120034688 120043974 120044497 120044499 120049126 120049185 120049430 120050483 120056744
ELS105008995 105009532 105009827 105009969 105016779 105027180 105028509 105031151 105031152 106024698 114828867 114828941
SFM108927512 108931896
PKI111839748 111846635 111846689 111846766
AANG118213113 118220398 118220551
LOC102685500 102693332 102696413(gbgt1) 102698054
PSPA121306702 121306711 121313236 121328687
ARUT117396906 117403512 117403809 117422695 117964649
LCM102355873 102356395
CMK103183073(gbgt1l5)
 » show all
Reference
1  [PMID:4823436]
  Authors
Kijimoto S, Ishibashi T, Makita A.
  Title
Biosynthesis of Forssman hapten from globoside by alpha-N-acetylgalactosaminyltransferase of guinea pig tissues.
  Journal
Biochem Biophys Res Commun 56:177-84 (1974)
DOI:10.1016/S0006-291X(74)80331-1
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.88
IUBMB Enzyme Nomenclature: 2.4.1.88
ExPASy - ENZYME nomenclature database: 2.4.1.88
BRENDA, the Enzyme Database: 2.4.1.88
CAS: 52037-97-5

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