Entry |
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Name |
N-acetyllactosamine synthase;
UDP-galactose---N-acetylglucosamine beta-D-galactosyltransferase;
uridine diphosphogalactose-acetylglucosamine galactosyltransferase;
beta-1,4-galactosyltransferase;
acetyllactosamine synthetase;
lactosamine synthase;
lactosamine synthetase;
lactose synthetase A protein;
N-acetyllactosamine synthetase;
UDP-galactose N-acetylglucosamine beta-4-galactosyltransferase;
UDP-galactose-acetylglucosamine galactosyltransferase;
UDP-galactose-N-acetylglucosamine beta-1,4-galactosyltransferase;
UDP-galactose-N-acetylglucosamine galactosyltransferase;
beta1-4-galactosyltransferase;
UDP-Gal:N-acetylglucosamine beta1-4-galactosyltransferase;
beta1-4GalT;
NAL synthetase;
UDP-beta-1,4-galactosyltransferase;
Gal-T;
UDP-galactose:N-acetylglucosaminide beta1-4-galactosyltransferase;
UDPgalactose:N-acetylglucosaminyl(beta1-4)galactosyltransferase;
beta-N-acetylglucosaminide beta1-4-galactosyltransferase;
UDP-galactose:N-acetyl-D-glucosamine 4-beta-D-galactosyltransferase
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Class |
Transferases;
Glycosyltransferases;
Hexosyltransferases
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Sysname |
UDP-alpha-D-galactose:N-acetyl-D-glucosamine 4-beta-D-galactosyltransferase
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Reaction(IUBMB) |
UDP-alpha-D-galactose + N-acetyl-D-glucosamine = UDP + N-acetyllactosamine [RN: R01205 R06055]
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Reaction(KEGG) |
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Substrate |
UDP-alpha-D-galactose [CPD: C00052];
N-acetyl-D-glucosamine [CPD: C00140]
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Product |
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Comment |
The reaction is catalysed by a component of EC 2.4.1.22 (lactose synthase), which is identical with EC 2.4.1.38 (beta-N-acetylglucosaminyl-glycopeptide beta-1,4-galactosyltransferase), and by an enzyme from the Golgi apparatus of animal tissues. Formerly listed also as EC 2.4.1.98.
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History |
EC 2.4.1.90 created 1976 (EC 2.4.1.98 created 1980, incorporated 1984)
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Orthology |
K07966 | beta-1,4-galactosyltransferase 1 |
K07967 | beta-1,4-galactosyltransferase 2 |
K07968 | beta-1,4-galactosyltransferase 3 |
K07969 | beta-1,4-galactosyltransferase 4 |
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Genes |
» show all
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Reference |
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Authors |
Deshmukh DS, Bear WD, Soifer D. |
Title |
Isolation and characterization of an enriched Golgi fraction from rat brain. |
Journal |
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Reference |
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Authors |
Helting T, Erbing B. |
Title |
Galactosyltransfer in mouse mastocytoma: purification and properties of N-acetyllactosamine synthetase. |
Journal |
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Reference |
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Authors |
Hill RL, Brew K. |
Title |
Lactose synthetase. |
Journal |
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Reference |
|
Authors |
Humphreys-Beher MG. |
Title |
Isolation and characterization of UDP-galactose:N-acetylglucosamine 4 beta-galactosyltransferase activity induced in rat parotid glands treated with isoproterenol. |
Journal |
J Biol Chem 259:5797-802 (1984) |
Reference |
|
Authors |
Schachter H, Jabbal I, Hudgin RL, Pinteric L, McGuire EJ, Roseman S. |
Title |
Intracellular localization of liver sugar nucleotide glycoprotein glycosyltransferases in a Golgi-rich fraction. |
Journal |
J Biol Chem 245:1090-100 (1970) |
Other DBs |
ExplorEnz - The Enzyme Database: | 2.4.1.90 |
ExPASy - ENZYME nomenclature database: | 2.4.1.90 |
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