KEGG   ENZYME: 2.4.1.90Help
Entry
EC 2.4.1.90                 Enzyme                                 

Name
N-acetyllactosamine synthase;
UDP-galactose---N-acetylglucosamine beta-D-galactosyltransferase;
uridine diphosphogalactose-acetylglucosamine galactosyltransferase;
beta-1,4-galactosyltransferase;
acetyllactosamine synthetase;
lactosamine synthase;
lactosamine synthetase;
lactose synthetase A protein;
N-acetyllactosamine synthetase;
UDP-galactose N-acetylglucosamine beta-4-galactosyltransferase;
UDP-galactose-acetylglucosamine galactosyltransferase;
UDP-galactose-N-acetylglucosamine beta-1,4-galactosyltransferase;
UDP-galactose-N-acetylglucosamine galactosyltransferase;
beta1-4-galactosyltransferase;
UDP-Gal:N-acetylglucosamine beta1-4-galactosyltransferase;
beta1-4GalT;
NAL synthetase;
UDP-beta-1,4-galactosyltransferase;
Gal-T;
UDP-galactose:N-acetylglucosaminide beta1-4-galactosyltransferase;
UDPgalactose:N-acetylglucosaminyl(beta1-4)galactosyltransferase;
beta-N-acetylglucosaminide beta1-4-galactosyltransferase;
UDP-galactose:N-acetyl-D-glucosamine 4-beta-D-galactosyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
UDP-alpha-D-galactose:N-acetyl-D-glucosamine 4-beta-D-galactosyltransferase
Reaction(IUBMB)
UDP-alpha-D-galactose + N-acetyl-D-glucosamine = UDP + N-acetyllactosamine [RN:R01205 R06055]
Reaction(KEGG)
Substrate
UDP-alpha-D-galactose [CPD:C00052];
N-acetyl-D-glucosamine [CPD:C00140]
Product
UDP [CPD:C00015];
N-acetyllactosamine [CPD:C00611]
Comment
The reaction is catalysed by a component of EC 2.4.1.22 (lactose synthase), which is identical with EC 2.4.1.38 (beta-N-acetylglucosaminyl-glycopeptide beta-1,4-galactosyltransferase), and by an enzyme from the Golgi apparatus of animal tissues. Formerly listed also as EC 2.4.1.98.
History
EC 2.4.1.90 created 1976 (EC 2.4.1.98 created 1980, incorporated 1984)
Orthology
K07966  beta-1,4-galactosyltransferase 1
K07967  beta-1,4-galactosyltransferase 2
K07968  beta-1,4-galactosyltransferase 3
K07969  beta-1,4-galactosyltransferase 4
Genes
HSA: 2683(B4GALT1) 8702(B4GALT4) 8703(B4GALT3) 8704(B4GALT2)
PTR: 100608173(B4GALT4) 100613700(B4GALT1) 456522(B4GALT2) 457451(B4GALT3)
PPS: 100974756(B4GALT1) 100980267(B4GALT2) 100980499(B4GALT3) 100994562(B4GALT4)
GGO: 101133326(B4GALT2) 101138982(B4GALT1) 101146705(B4GALT4) 101152694(B4GALT3) 109026348
PON: 100174763(B4GALT3) 100437696(B4GALT2) 100438031(B4GALT1) 100443591(B4GALT4)
NLE: 100597531(B4GALT1) 100598306(B4GALT2) 100600025(B4GALT4) 100600657(B4GALT3)
MCC: 703541(B4GALT1) 704038(B4GALT2) 711983(B4GALT4) 719920(B4GALT3)
MCF: 102115300(B4GALT2) 102123574(B4GALT3) 102131044(B4GALT1) 102142820(B4GALT4)
CSAB: 103219294(B4GALT1) 103223692(B4GALT3) 103224947(B4GALT2) 103228234(B4GALT4)
RRO: 104657610(B4GALT4) 104665338(B4GALT3) 104669045(B4GALT2) 104674271(B4GALT1)
RBB: 108518246(B4GALT1) 108521170(B4GALT3) 108531771(B4GALT4) 108535685(B4GALT2)
CJC: 100385157(B4GALT1) 100402903(B4GALT4) 100413633(B4GALT3) 100414763 100896540(B4GALT2)
SBQ: 101029385(B4GALT4) 101039415(B4GALT2) 101048901(B4GALT3) 101054125(B4GALT1)
MMU: 14595(B4galt1) 53418(B4galt2) 56375(B4galt4) 57370(B4galt3)
RNO: 24390(B4galt1) 303923(B4galt4) 313536(B4galt2) 494342(B4galt3)
CGE: 100689346(B4galt3) 100689430(B4galt1) 100689434(B4galt2) 100689435(B4galt4)
NGI: 103741594(B4galt1) 103741937(B4galt4) 103743868(B4galt2) 103745954(B4galt3)
HGL: 101698779 101702700(B4galt3) 101718811(B4galt2) 101721414(B4galt1) 101723638(B4galt4)
CCAN: 109681413 109689965 109693205(B4galt3) 109694543(B4galt4) 109695495(B4galt2)
OCU: 100345726(B4GALT1) 100351419(B4GALT2) 100357504(B4GALT4) 100358436(B4GALT3)
TUP: 102470291(B4GALT4) 102470655(B4GALT1) 102489782(B4GALT2) 102501629(B4GALT3)
CFA: 476397 481579(B4GALT1) 482527(B4GALT2) 488650(B4GALT3) 608143(B4GALT4)
AML: 100471634(B4GALT2) 100477164(B4GALT1) 100479119 100481658(B4GALT4) 100482718(B4GALT3)
UMR: 103657308 103667105(B4GALT1) 103670800(B4GALT2) 103672017(B4GALT3) 103678795(B4GALT4)
ORO: 101362571(B4GALT1) 101364688(B4GALT2) 101366805(B4GALT3) 101385802(B4GALT4)
FCA: 101084809(B4GALT2) 101089738(B4GALT3) 101100325(B4GALT4) 101100927(B4GALT1)
PTG: 102955088(B4GALT2) 102959538(B4GALT1) 102965736(B4GALT3) 102966539(B4GALT4)
AJU: 106970225(B4GALT2) 106976144(B4GALT1) 106978533(B4GALT3) 106980243(B4GALT4)
BTA: 100125390(B4GALT2) 281781(B4GALT1) 511328(B4GALT4) 515771(B4GALT3)
BOM: 102269762(B4GALT1) 102273575(B4GALT3) 102279871(B4GALT4) 102283249(B4GALT2)
BIU: 109556391(B4GALT2) 109563168(B4GALT1) 109576562(B4GALT4) 109578355(B4GALT3)
PHD: 102317609(B4GALT2) 102321948(B4GALT1) 102340702(B4GALT4) 102343232(B4GALT3)
CHX: 100860927(B4GALT1) 102190262(B4GALT4) 102191101(B4GALT2) 102191287(B4GALT3)
OAS: 100620048(B4GALT1) 101103686(B4GALT3) 101104949(B4GALT4) 101114825(B4GALT2)
SSC: 100154856(B4GALT3) 100511655(B4GALT1) 100514465 100736821(B4GALT2)
CFR: 102510375(SIGLEC6) 102516080(B4GALT2) 102517623(B4GALT1) 102522848(B4GALT4) 102523348(B4GALT3)
CDK: 105085573(B4GALT1) 105090333(B4GALT4) 105090897(B4GALT2) 105100111(B4GALT3)
BACU: 102999260(B4GALT1) 103001417(B4GALT2) 103005928(B4GALT4) 103014433(B4GALT3)
LVE: 103083911(B4GALT3) 103084555(B4GALT4) 103086401(B4GALT1) 103086978(B4GALT2)
OOR: 101278293(B4GALT3) 101278923(B4GALT4) 101285364(B4GALT1) 101285582(B4GALT2)
ECB: 100065936 100066144(B4GALT3) 100066149(B4GALT2) 100068209(B4GALT1) 100071082(B4GALT4)
EPZ: 103540622 103547412(B4GALT4) 103548278(B4GALT2) 103555031(B4GALT1) 103559988(B4GALT3)
EAI: 106822347 106823399(B4GALT4) 106827571(B4GALT3) 106840352 106841463(B4GALT1) 106847911(B4GALT2)
MYB: 102240062(B4GALT1) 102243483(B4GALT4) 102245477(B4GALT3) 102248727(B4GALT2)
MYD: 102751484(B4GALT1) 102755410 102770964(B4GALT3) 102772464 102774860(B4GALT2) 102775104(B4GALT4)
HAI: 109371790(B4GALT1) 109376935(B4GALT3) 109383427(B4GALT2) 109386911(B4GALT4)
RSS: 109435224(B4GALT3) 109446346(B4GALT4) 109448661(B4GALT1) 109457878(B4GALT2)
PALE: 102878748(B4GALT1) 102879802(B4GALT4) 102884318(B4GALT2) 102897413(B4GALT3)
LAV: 100657659(B4GALT2) 100659897(B4GALT1) 100662008(B4GALT4) 100666904 100671768(B4GALT3)
TMU: 101341812 101348830 101352100 101358819
MDO: 100010600(B4GALT1) 100015888(B4GALT4) 100028240 100032749(B4GALT3) 100617718(B4GALT2)
SHR: 100917085(B4GALT3) 100918732(B4GALT2) 100929465(B4GALT1) 100933479(B4GALT4) 100934965
OAA: 100075607 100075703(B4GALT1) 100092000(B4GALT2)
GGA: 396121(B4GALT1) 396122(B4GALT2) 418341(B4GALT4) 418342(B4GALT3)
MGP: 100543545(B4GALT1) 100543680(B4GALT2) 100547867(B4GALT4) 100548019
CJO: 107306674(B4GALT1) 107307393 107317480(B4GALT2) 107320407(B4GALT4) 107320437
APLA: 101792176(B4GALT4) 101792630(B4GALT3) 101792817(B4GALT1)
ACYG: 106037583(B4GALT4) 106037599(B4GALT3) 106040136(B4GALT1) 106049039(B4GALT2)
TGU: 100219809 100223650(B4GALT1) 100230291(B4GALT4) 100230857(B4GALT2)
GFR: 102034619 102034782(B4GALT4) 102035894(B4GALT3) 102036032(B4GALT2) 102041517(B4GALT1)
FAB: 101805871(B4GALT2) 101807052(B4GALT1) 101809643 101809954(B4GALT4)
PHI: 102104795(B4GALT3) 102106294(B4GALT2) 102108146(B4GALT4) 102108330 102109081(B4GALT1)
PMAJ: 107198186(B4GALT1) 107205999(B4GALT4) 107206030(B4GALT3) 107208264(B4GALT2)
CCAE: 111933140(B4GALT2) 111939072(B4GALT4) 111939118 111941228(B4GALT1)
CCW: 104687053(B4GALT4) 104687054 104689823(B4GALT1) 104695261(B4GALT2)
FPG: 101910439(B4GALT3) 101915659(B4GALT4) 101915824 101916596(B4GALT2) 101918852(B4GALT1)
FCH: 102046112(B4GALT1) 102051115(B4GALT4) 102051290 102056545(B4GALT2) 102057757(B4GALT3)
CLV: 102088289(B4GALT1) 102088677(B4GALT2) 102093764(B4GALT4) 102093948 102094059(B4GALT3)
EGZ: 104123065(B4GALT1) 104125508(B4GALT2) 104126496(B4GALT3) 104126497(B4GALT4)
AAM: 106484931(B4GALT2) 106486901(B4GALT1) 106490693 106490705(B4GALT4) 106500494(B4GALT3)
ASN: 102370415 102370808(B4GALT4) 102371026 102372956(B4GALT1) 102376584(B4GALT2) 102388067(B4GALT3)
AMJ: 102558168(B4GALT2) 102559129(B4GALT1) 102569919(B4GALT4) 102572436 102575172 106737239(B4GALT3)
PSS: 102448865(B4GALT3) 102450039 102453780(B4GALT4) 102459690(B4GALT1) 102461193
CMY: 102937222(B4GALT3) 102941460 102941864(B4GALT2) 102942662(B4GALT1) 102946330(B4GALT4)
CPIC: 101932379(B4GALT1) 101933315 101945883(B4GALT2) 101952944 101953425(B4GALT4) 101953612(B4GALT3)
ACS: 100553459 100553568(b4galt4) 100557158 100557558(b4galt2) 100558708(b4galt3) 100561064(b4galt1)
PVT: 110073738(B4GALT2) 110074017 110074021(B4GALT4) 110081027(B4GALT3) 110087350(B4GALT1) 110089672
PBI: 103050267 103063173(B4GALT3) 103065477(B4GALT1) 103068003 103068176(B4GALT4) 103068203(B4GALT2)
GJA: 107106045(B4GALT4) 107106046 107110573(B4GALT1) 107120293(B4GALT2) 107121751(B4GALT3) 107122018
XLA: 100190782(b4galt2.S) 108696936 108704693 108706812(b4galt1.1.S) 108706813(b4galt1.2.S) 108707823(b4galt4.L) 108709275 108712215(b4galt1.1.L) 108712216(b4galt1.2.L) 108712940 108712957 108714282(b4galt2.L) 379106(MGC52827) 414540 444709(b4galt4.S) 446718(b4galt3.S) 496041
XTR: 100145518(b4galt1.1) 100485024 100486704 100488464(b4galt4) 100492356(b4galt2) 448369(b4galt3) 549418(b4galt1.2) 733985(b4galt3)
NPR: 108788802 108791634 108792261 108797172 108797173(B4GALT4) 108800777(B4GALT3) 108802209
DRE: 100148828(b4galt2) 492760(b4galt4) 550425(b4galt1) 556544(si:dkey-199f5.8) 561756(b4galt3) 768123(b4galt1l)
SRX: 107712663 107713046 107713844 107717362 107719754 107723150 107723151 107730805(b4galt2) 107737602 107739830 107750327 107751321 107752248(b4galt4) 107758898
SANH: 107657457 107662077 107665944 107666799 107668306 107672040 107677371 107692709 107697619 107699583 107700994 107702948
SGH: 107557142 107557767(b4galt4) 107557953 107560945 107562374 107565367 107576632 107587100 107592109 107593408 107599894 107600525
CCAR: 109046140 109046469 109047435 109059855 109060458 109064225 109090593 109105806 109106057 109108968 109113239(b4galt2)
IPU: 108256292 108260163(b4galt4) 108260689 108267387(b4galt2) 108276285 108277608(B4galt1)
AMEX: 103022975(b4galt3) 103028729 103031892 103033307(b4galt2) 103039461 103042661(b4galt4)
TRU: 101061200(b4galt4) 101061762 101065400 101066088(b4galt1) 101072068(b4galt2) 101075953 101076002 101076959 101077184
TNG: GSTEN00006674G001 GSTEN00007296G001 GSTEN00007669G001 GSTEN00008153G001 GSTEN00010496G001 GSTEN00012074G001 GSTEN00019044G001 GSTEN00026511G001 GSTEN00036575G001
LCO: 104917723(b4galt2) 104930288 104933217 104935626(b4galt4) 104938299(b4galt1) 109137286
NCC: 104941447 104948903(b4galt2) 104962020 104965999(b4galt4) 104966142
MZE: 101464552 101466383(b4galt4) 101466647 101472320(b4galt1) 101482004 101486761 112429855 112432595
OLA: 100301598(b4galt2) 101159351(b4galt3) 101162708 101164915(b4galt4) 101171148(b4galt1)
XMA: 102216445(b4galt1) 102221477(b4galt4) 102223611 102231933(b4galt2) 102233588 102233843 102235410 111606205 111606296
PRET: 103456521 103457015 103457016 103457033 103457329 103467443 103471786(b4galt1) 103475412(b4galt4) 103477521 103479896
NFU: 107373064 107373848 107379065 107381099(b4galt1) 107382441 107382995 107383812(b4galt2) 107386424(b4galt4) 107395677 107396800
KMR: 108235243 108237029(b4galt4) 108241697(b4galt2) 108248973(b4galt1) 108250944 108251055
CSEM: 103376904 103377879 103384643 103388849 103390794(b4galt1) 103395579 103396367(b4galt2)
LCF: 108877881 108879172 108883305(b4galt2) 108885296(b4galt1) 108893526(b4galt4) 108899405 108900792
SDU: 111219126 111219224(b4galt3) 111230961(b4galt2) 111233512(b4galt1) 111234517(b4galt4) 111235761 111237265
HCQ: 109508336 109510050 109510054 109511382 109512237 109517999(b4galt4) 109524074(b4galt2) 109528716
BPEC: 110158487(b4galt4) 110161009 110164179(b4galt2) 110164938 110168019(b4galt1) 110170479
MALB: 109952194 109954372 109955445(b4galt2) 109959384(b4galt4) 109963721 109972105
SASA: 106563608(b4galt4) 106566510(b4galt3) 106569086 106582539 106597479 106599387 106602598 106602599 106603047 106604638 106605235 106609883 106611645
OTW: 112220987 112226941 112228922 112229713(b4galt3) 112230385 112231086 112231206(b4galt4) 112231848 112245005 112246171 112247375 112256274 112260467
ELS: 105006928 105007535(b4galt1) 105008880 105008881 105009278 105010876(b4galt4) 105021088 105022694(b4galt2) 105022911 105022912 105022921 106024204
SFM: 108919177 108924680(b4galt4) 108925913 108925916 108927818 108935233(b4galt2) 108938816 108939369
LCM: 102350195(B4GALT2) 102355225(B4GALT3) 102355454 102355730 102357329 102358769 102367388
CMK: 103173410 103177647 103181973 103182791(b4galt2) 103184325 103185094(b4galt4)
BFO: BRAFLDRAFT_232340 BRAFLDRAFT_232365 BRAFLDRAFT_68357 BRAFLDRAFT_68811
CIN: 100175041
DPA: 109536817
BMOR: 101738885
DPL: KGM_206689
PMAC: 106710215
PRAP: 110995450
HAW: 110377712 110377716
PXY: 105398071
PHU: Phum_PHUM597160
FCD: 110842915
DPX: DAPPUDRAFT_111185 DAPPUDRAFT_335532
ISC: IscW_ISCW007584 IscW_ISCW017744
TUT: 107361940
CEL: CELE_Y73E7A.7(bre-4)
CBR: CBG22165(Cbr-bre-4)
NAI: NECAME_01984 NECAME_07203 NECAME_17866
BMY: Bm1_02765
LOA: LOAG_08675
HRO: HELRODRAFT_122556 HELRODRAFT_186192 HELRODRAFT_71994 HELRODRAFT_90454
LGI: LOTGIDRAFT_113306
CRG: 105319220 105321834 105323048 105325111 105333755 105346666
MYI: 110446269 110449332 110449812 110455597 110456388 110458234
OBI: 106871325
LAK: 106153459 106153460 106153491 106159634 106159675 106160325 106162097 106164458 106164999 106166688 106166703 106174637 106174904 106177178 106181686 106181689
SMM: Smp_007950 Smp_056260 Smp_146430
SHX: MS3_01473 MS3_07047
OVI: T265_03047 T265_03525 T265_05578 T265_09073 T265_13123
EPA: 110233851 110244157
ADF: 107350754
 » show all
Taxonomy
Reference
1  [PMID:99178]
  Authors
Deshmukh DS, Bear WD, Soifer D.
  Title
Isolation and characterization of an enriched Golgi fraction from rat brain.
  Journal
Biochim Biophys Acta 542:284-95 (1978)
DOI:10.1016/0304-4165(78)90024-7
Reference
2  [PMID:4631039]
  Authors
Helting T, Erbing B.
  Title
Galactosyltransfer in mouse mastocytoma: purification and properties of N-acetyllactosamine synthetase.
  Journal
Biochim Biophys Acta 293:94-104 (1973)
DOI:10.1016/0005-2744(73)90379-3
Reference
3  [PMID:812340]
  Authors
Hill RL, Brew K.
  Title
Lactose synthetase.
  Journal
Adv Enzymol Relat Areas Mol Biol 43:411-90 (1975)
Reference
4  [PMID:6201486]
  Authors
Humphreys-Beher MG.
  Title
Isolation and characterization of UDP-galactose:N-acetylglucosamine 4 beta-galactosyltransferase activity induced in rat parotid glands treated with isoproterenol.
  Journal
J Biol Chem 259:5797-802 (1984)
Reference
5  [PMID:4392041]
  Authors
Schachter H, Jabbal I, Hudgin RL, Pinteric L, McGuire EJ, Roseman S.
  Title
Intracellular localization of liver sugar nucleotide glycoprotein glycosyltransferases in a Golgi-rich fraction.
  Journal
J Biol Chem 245:1090-100 (1970)
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.90
IUBMB Enzyme Nomenclature: 2.4.1.90
ExPASy - ENZYME nomenclature database: 2.4.1.90
BRENDA, the Enzyme Database: 2.4.1.90
CAS: 9054-94-8

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