| Entry |
|
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| Name |
ATP phosphoribosyltransferase;
phosphoribosyl-ATP pyrophosphorylase;
adenosine triphosphate phosphoribosyltransferase;
phosphoribosyladenosine triphosphate:pyrophosphate phosphoribosyltransferase;
phosphoribosyl ATP synthetase;
phosphoribosyl ATP:pyrophosphate phosphoribosyltransferase;
phosphoribosyl-ATP:pyrophosphate-phosphoribosyl phosphotransferase;
phosphoribosyladenosine triphosphate pyrophosphorylase;
phosphoribosyladenosine triphosphate synthetase;
1-(5-phospho-D-ribosyl)-ATP:diphosphate phospho-alpha-D-ribosyl-transferase
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| Class |
Transferases;
Glycosyltransferases;
Pentosyltransferases
 |
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| Sysname |
1-(5-phospho-beta-D-ribosyl)-ATP:diphosphate phospho-alpha-D-ribosyl-transferase
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| Reaction(IUBMB) |
1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate = ATP + 5-phospho-alpha-D-ribose 1-diphosphate [RN: R01071]
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| Reaction(KEGG) |
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| Substrate |
1-(5-phospho-beta-D-ribosyl)-ATP [CPD: C02739];
diphosphate [CPD: C00013]
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| Product |
ATP [CPD: C00002];
5-phospho-alpha-D-ribose 1-diphosphate [CPD: C00119]
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| Comment |
Involved in histidine biosynthesis.
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| History |
EC 2.4.2.17 created 1972
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| Pathway |
| ec01110 | Biosynthesis of secondary metabolites |
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| Orthology |
| K00765 | ATP phosphoribosyltransferase |
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| Genes |
» show all
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| Reference |
|
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| Authors |
AMES BN, MARTIN RG, GARRY BJ. |
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| Title |
The first step of histidine biosynthesis. |
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| Journal |
J Biol Chem 236:2019-26 (1961) |
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| Sequence |
|
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| Reference |
2 |
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| Authors |
Martin, R.G. |
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| Title |
The phosphorolysis of nucleosides by rabbit bone marrow: The nature of feedback inhibition by histidine. |
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| Journal |
J Biol Chem 238:257-268 (1963) |
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| Reference |
|
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| Authors |
Voll MJ, Appella E, Martin RG. |
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| Title |
Purification and composition studies of phosphoribosyladenosine triphosphate:pyrophosphate phosphoribosyltransferase, the first enzyme of histidine biosynthesis. |
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| Journal |
J Biol Chem 242:1760-7 (1967) |
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| Sequence |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 2.4.2.17 |
| ExPASy - ENZYME nomenclature database: | 2.4.2.17 |
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