KEGG   ENZYME: 2.4.2.26
Entry
EC 2.4.2.26                 Enzyme                                 

Name
protein xylosyltransferase;
UDP-D-xylose:core protein beta-D-xylosyltransferase;
UDP-D-xylose:core protein xylosyltransferase;
UDP-D-xylose:proteoglycan core protein beta-D-xylosyltransferase;
UDP-xylose-core protein beta-D-xylosyltransferase;
uridine diphosphoxylose-core protein beta-xylosyltransferase;
uridine diphosphoxylose-protein xylosyltransferase;
UDP-D-xylose:protein beta-D-xylosyltransferase
Class
Transferases;
Glycosyltransferases;
Pentosyltransferases
Sysname
UDP-alpha-D-xylose:protein beta-D-xylosyltransferase (configuration-inverting)
Reaction(IUBMB)
UDP-alpha-D-xylose + [protein]-L-serine = UDP + [protein]-3-O-(beta-D-xylosyl)-L-serine [RN:R05925]
Reaction(KEGG)
R05925(G)
Substrate
UDP-alpha-D-xylose [CPD:C00190];
[protein]-L-serine [CPD:C02189]
Product
UDP [CPD:C00015];
[protein]-3-O-(beta-D-xylosyl)-L-serine
Comment
Involved in the biosynthesis of the linkage region of glycosaminoglycan chains as part of proteoglycan biosynthesis (chondroitin, dermatan and heparan sulfates).
History
EC 2.4.2.26 created 1976, modified 2002, modified 2016
Pathway
ec00532  Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate
ec00534  Glycosaminoglycan biosynthesis - heparan sulfate / heparin
ec01100  Metabolic pathways
Orthology
K00771  protein xylosyltransferase
Genes
HSA: 64131(XYLT1) 64132(XYLT2)
PTR: 453955(XYLT1) 455118(XYLT2)
PPS: 100970715(XYLT1) 100973069(XYLT2)
GGO: 101133399(XYLT2) 101134207(XYLT1)
PON: 100434979(XYLT1) 100459725(XYLT2)
NLE: 100596549(XYLT1) 100600245(XYLT2)
MCC: 705139(XYLT2) 718187(XYLT1)
MCF: 102133732(XYLT2) 102145035(XYLT1)
CSAB: 103228945(XYLT1) 103242938(XYLT2)
CATY: 105579440(XYLT2) 105586860(XYLT1)
RRO: 104667853(XYLT1) 104680299(XYLT2)
RBB: 108516436(XYLT2) 108540514(XYLT1)
TFN: 117067215(XYLT2) 117097607(XYLT1)
CJC: 100385693(XYLT2) 100404925(XYLT1)
SBQ: 101048643(XYLT2) 101052785(XYLT1)
MMUR: 105866054(XYLT1) 105885112(XYLT2)
MMU: 217119(Xylt2) 233781(Xylt1)
MCAL: 110298937(Xylt1) 110305618(Xylt2)
MPAH: 110324603(Xylt1) 110331511(Xylt2)
RNO: 64133(Xylt1) 64134(Xylt2)
MCOC: 116078066(Xylt2) 116102843(Xylt1)
MUN: 110551206(Xylt2) 110561537(Xylt1)
CGE: 100756878(Xylt1) 100759604(Xylt2)
PLEU: 114692136(Xylt1) 114692896(Xylt2)
NGI: 103728937(Xylt1) 103738383(Xylt2)
HGL: 101703898(Xylt2) 101726675(Xylt1)
CCAN: 109681494(Xylt2) 109701227(Xylt1)
OCU: 100342073(XYLT2) 103348571(XYLT1)
TUP: 102477995(XYLT2) 102483871(XYLT1)
CFA: 493990(XYLT2) 494008(XYLT1)
VVP: 112917856(XYLT2) 112923234(XYLT1)
AML: 100478159(XYLT1) 100479254(XYLT2)
UMR: 103660938(XYLT2) 103668841(XYLT1)
UAH: 113265616(XYLT2) 113270750(XYLT1)
ORO: 101368985(XYLT2) 101371971(XYLT1)
MPUF: 101681326(XYLT1) 101689070(XYLT2)
EJU: 114199671(XYLT1) 114201165(XYLT2)
FCA: 101096940(XYLT1) 101099511(XYLT2)
PTG: 102968094(XYLT2) 102968197(XYLT1)
PPAD: 109247296(XYLT2) 109278382(XYLT1)
AJU: 106970469(XYLT1) 106985169(XYLT2)
BTA: 493989(XYLT2) 541295(XYLT1)
BOM: 102280747(XYLT2) 102281178(XYLT1)
BIU: 109573274(XYLT2) 109578118(XYLT1)
BBUB: 102396805(XYLT2) 102400893(XYLT1)
CHX: 102178593(XYLT1) 102188252(XYLT2)
OAS: 101107112(XYLT2) 101111512(XYLT1)
SSC: 100514160(XYLT1) 100514793(XYLT2)
CFR: 102509305(XYLT2) 102515495(XYLT1)
CDK: 105091164(XYLT1) 105097743(XYLT2)
BACU: 103016087(XYLT1) 103016682(XYLT2)
LVE: 103071417(XYLT2) 103077954(XYLT1)
OOR: 101271334(XYLT1) 101278276(XYLT2)
DLE: 111163478(XYLT1) 111166270(XYLT2)
PCAD: 102981709(XYLT2) 102995802
ECB: 100053250(XYLT1) 100069884(XYLT2)
EPZ: 103549570(XYLT2) 103554524(XYLT1)
EAI: 106826421(XYLT2) 106828822(XYLT1)
MYB: 102241358(XYLT1) 102260510(XYLT2)
MYD: 102761761(XYLT1) 102772248(XYLT2)
MMYO: 118655757(XYLT1) 118671294(XYLT2)
MNA: 107524360(XYLT1) 107529845(XYLT2)
HAI: 109374526(XYLT1) 109380831(XYLT2)
DRO: 112314780(XYLT1) 112316427(XYLT2)
SHON: 118978057(XYLT2) 119002016(XYLT1)
AJM: 119052613(XYLT2) 119055036(XYLT1)
MMF: 118634734(XYLT2) 118642476(XYLT1)
PALE: 102887640(XYLT2) 102892920(XYLT1)
RAY: 107516794(XYLT1) 107517605(XYLT2)
MJV: 108384407(XYLT2) 108405106
MDO: 100012411(XYLT2) 100018495(XYLT1)
SHR: 100929128(XYLT1) 100934708(XYLT2)
PCW: 110198235(XYLT1) 110198409(XYLT2)
OAA: 100087573(XYLT1) 103169376(XYLT2)
GGA: 414780(XYLT2) 414781(XYLT1)
MGP: 100539167(XYLT2) 100544774(XYLT1)
CJO: 107320702(XYLT1) 107322312(XYLT2)
NMEL: 110406087(XYLT1) 110407355(XYLT2)
APLA: 101801382(XYLT2) 101802041(XYLT1)
ACYG: 106033456(XYLT1) 106034663(XYLT2)
TGU: 100223613(XYLT2) 100228294(XYLT1)
LSR: 110475558(XYLT1) 110484259(XYLT2)
SCAN: 103817898(XYLT1) 103819826(XYLT2)
GFR: 102035184(XYLT2) 102038830(XYLT1)
FAB: 101808039(XYLT1) 101813773(XYLT2)
PHI: 102101523(XYLT1) 102112563(XYLT2)
PMAJ: 107210973(XYLT1) 107212594(XYLT2)
CCAE: 111936262(XYLT1) 111937345(XYLT2)
CCW: 104684890(XYLT1) 104694365(XYLT2)
ETL: 114055960(XYLT2) 114058272(XYLT1)
FPG: 101911600(XYLT2) 101922681(XYLT1)
FCH: 102051439(XYLT1) 102060281(XYLT2)
CLV: 102085335(XYLT1) 102089671(XYLT2)
EGZ: 104125342(XYLT2) 104126969(XYLT1)
NNI: 104015168(XYLT1) 104020731(XYLT2)
ACUN: 113485745(XYLT1) 113486801(XYLT2)
PADL: 103916756(XYLT2) 103917635(XYLT1)
AAM: 106486639(XYLT1) 106500030(XYLT2)
ASN: 102369712(XYLT2) 102382672(XYLT1)
AMJ: 102573706(XYLT1) 106737159(XYLT2)
PSS: 102453154(XYLT2) 102461402(XYLT1)
CMY: 102937617(XYLT2) 102940763(XYLT1)
CPIC: 101942777(XYLT1) 101948787(XYLT2)
ACS: 100567768(xylt2) 103281029(xylt1)
PVT: 110083993(XYLT1) 110091236(XYLT2)
PBI: 103059572(XYLT1) 103066222(XYLT2)
PMUR: 107283824(XYLT2) 107296997(XYLT1)
TSR: 106546646(XYLT2) 106554032
PMUA: 114584897(XYLT1) 114590565(XYLT2)
GJA: 107110059(XYLT2) 107111229(XYLT1)
XLA: 108701100(xylt2.L) 108703114(xylt1.S) 444363(xylt1.L)
XTR: 100145490(xylt1) 448400(xylt2)
NPR: 108796396(XYLT2) 108799804(XYLT1)
DRE: 560951(xylt1) 563446(xylt2)
IPU: 108258104(xylt2) 108260954(xylt1)
PHYP: 113523799(xylt1) 113528589(xylt2)
AMEX: 103031104(xylt2) 103042681
EEE: 113575216(xylt2) 113591639
LCO: 104923371 104927359(xylt1) 104929516(xylt2)
ONL: 100698514(xylt1) 100698784(xylt2) 100703873
PRET: 103464839(xylt1) 103469073 103469119(xylt2)
CVG: 107087449(xylt2) 107089096(xylt1) 107091768
KMR: 108236328(xylt1) 108242925(xylt2) 108249138
CSEM: 103384069(xylt1) 103393209(xylt2) 103393434
POV: 109627325(xylt1) 109645849(xylt2)
LCF: 108875693(xylt1) 108881037(xylt2) 108888628
SDU: 111223695 111229267(xylt1) 111230276(xylt2)
SLAL: 111651086(xylt2) 111662412 111666726(xylt1)
HCQ: 109514914(xylt2) 109527511(xylt1) 109527787
BPEC: 110154460 110158203(xylt2) 110175714(xylt1)
MALB: 109952717 109957983(xylt1) 109958891(xylt2)
ELS: 105012217(xylt1) 105012907(xylt2) 105030590
PKI: 111847989(xylt2) 111849346 111850869(xylt1)
LCM: 102362525(XYLT1) 102363581(XYLT2)
CMK: 103175642(xylt2) 103178860(xylt1)
RTP: 109922602(xylt1) 109934118(xylt2)
CIN: 619275(xt)
DME: Dmel_CG32300(oxt)
DER: 6546418
DSE: 6610464
DSI: Dsimw501_GD13401(Dsim_oxt)
DYA: Dyak_GE21716(Dyak_oxt)
DAN: 6508045
DSR: 110188878
DPO: Dpse_GA16815(Dpse_oxt)
DPE: 6601254
DMN: 108151559
DWI: 6645002
DAZ: 108613781
DNV: 108651712
DHE: 111599764
DVI: 6623988
MDE: 101891944
LCQ: 111676881
AAG: 5569146
AALB: 109621710
AME: 413854
BIM: 100749329
BTER: 100642262
CCAL: 108630428
OBB: 114875538
SOC: 105207992
MPHA: 105830437
AEC: 105154547
ACEP: 105619481
PBAR: 105423976
VEM: 105559146
HST: 105191014
DQU: 106741831
CFO: 105249153
LHU: 105677546
PGC: 109857930
OBO: 105286509
PCF: 106783999
NVI: 100120497
CSOL: 105367904
MDL: 103568249
TCA: 657929
DPA: 109541768
ATD: 109605152
NVL: 108569283
BMOR: 101739145
BMAN: 114242724
PMAC: 106719105
PRAP: 110992106
HAW: 110370094
TNL: 113495808
PXY: 105394592
API: 100163472
DNX: 107173852
AGS: 114121366
RMD: 113549199
BTAB: 109033474
CLEC: 106671121
ZNE: 110833247
FCD: 110848438
PVM: 113803270
TUT: 107368395
DPTE: 113790806
CEL: CELE_Y50D4C.4(sqv-6)
CBR: CBG17882(Cbr-sqv-6)
TSP: Tsp_08280
PCAN: 112564047
CRG: 105346131
MYI: 110449879
OBI: 106882818
EGL: EGR_04417
NVE: 5508293
EPA: 110245347
ADF: 107330153
AMIL: 114953194
PDAM: 113670361
SPIS: 111330280
DGT: 114539486
HMG: 100202092
AQU: 100635901
SMIN: v1.2.020832.t1(symbB.v1.2.020832.t1)
 » show all
Reference
1  [PMID:5030630]
  Authors
Stoolmiller AC, Horwitz AL, Dorfman A.
  Title
Biosynthesis of the chondroitin sulfate proteoglycan. Purification and properties of xylosyltransferase.
  Journal
J Biol Chem 247:3525-32 (1972)
Reference
2  [PMID:11099377]
  Authors
Gotting C, Kuhn J, Zahn R, Brinkmann T, Kleesiek K
  Title
Molecular cloning and expression of human UDP-d-Xylose:proteoglycan core protein beta-d-xylosyltransferase and its first isoform XT-II.
  Journal
J Mol Biol 304:517-28 (2000)
DOI:10.1006/jmbi.2000.4261
  Sequence
[hsa:64131 64132] [rno:64133 64134]
Other DBs
ExplorEnz - The Enzyme Database: 2.4.2.26
IUBMB Enzyme Nomenclature: 2.4.2.26
ExPASy - ENZYME nomenclature database: 2.4.2.26
BRENDA, the Enzyme Database: 2.4.2.26
CAS: 55576-38-0

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