KEGG   ENZYME: 2.4.2.31
Entry
EC 2.4.2.31                 Enzyme                                 

Name
NAD+---protein-arginine ADP-ribosyltransferase;
ADP-ribosyltransferase;
mono(ADP-ribosyl)transferase;
NAD+:L-arginine ADP-D-ribosyltransferase;
NAD(P)+-arginine ADP-ribosyltransferase;
NAD(P)+:L-arginine ADP-D-ribosyltransferase;
mono-ADP-ribosyltransferase;
ART;
ART1;
ART2;
ART3;
ART4;
ART5;
ART6;
ART7;
NAD(P)+---protein-arginine ADP-ribosyltransferase;
NAD(P)+:protein-L-arginine ADP-D-ribosyltransferase
Class
Transferases;
Glycosyltransferases;
Pentosyltransferases
Sysname
NAD+:protein-L-arginine ADP-D-ribosyltransferase
Reaction(IUBMB)
NAD+ + protein L-arginine = nicotinamide + Nomega-(ADP-D-ribosyl)-protein-L-arginine [RN:R00555]
Reaction(KEGG)
R00555
Substrate
NAD+ [CPD:C00003];
protein L-arginine
Product
nicotinamide [CPD:C00153];
Nomega-(ADP-D-ribosyl)-protein-L-arginine [CPD:C16011]
Comment
Protein mono-ADP-ribosylation is a reversible post-translational modification that plays a role in the regulation of cellular activities [4]. Arginine residues in proteins act as acceptors. Free arginine, agmatine [(4-aminobutyl)guanidine], arginine methyl ester and guanidine can also do so. The enzyme from some, but not all, species can also use NADP+ as acceptor (giving rise to Nomega-[(2'-phospho-ADP)-D-ribosyl]-protein-L-arginine as the product), but more slowly [1,5]. The enzyme catalyses the NAD+-dependent activation of EC 4.6.1.1, adenylate cyclase. Some bacterial enterotoxins possess similar enzymic activities. (cf. EC 2.4.2.36 NAD+---diphthamide ADP-ribosyltransferase).
History
EC 2.4.2.31 created 1984, modified 1990, modified 2006
Orthology
K00775  ADP-ribosyltransferase 3
K06716  ADP-ribosyltransferase 1
K06717  ADP-ribosyltransferase 4
K19977  ADP-ribosyltransferase 5
K19980  ADP-ribosyltransferase 2 / NAD+ glycohydrolase
Genes
HSA: 116969(ART5) 417(ART1) 419(ART3) 420(ART4)
PTR: 450970(ART5) 461241(ART3) 466326(ART1) 473376(ART4)
PPS: 100977452(ART4) 100987803(ART5) 100988371(ART1) 100992183(ART3)
GGO: 101134639(ART4) 101146612(ART3) 101153293(ART5) 101153661(ART1)
PON: 100172886(ART3) 100432433(ART4) 100435792(ART1) 100438048(ART5)
NLE: 100594753(ART5) 100595329(ART1) 100598120(ART3) 100598463(ART4)
MCC: 100424030(ART3) 574238(ART5) 699934(ART4) 718154(ART1)
MCF: 102134161(ART4) 102135068(ART3) 102139792(ART5) 102142531(ART1)
CSAB: 103218681(ART4) 103235821(ART3) 103247979(ART1) 103247980(ART5)
RRO: 104665164(ART5) 104665166(ART1) 104666387(ART4) 104673155(ART3)
RBB: 108530556(ART4) 108532490(ART3) 108543749(ART1) 108543751(ART5)
CJC: 100398626(ART1) 100411310(ART4) 100411495(ART3) 100414071(ART5)
SBQ: 101032538(ART3) 101041761(ART4) 101049965(ART1) 101051460(ART5)
MMU: 109978(Art4) 109979(Art3) 11870(Art1) 11871(Art2a) 11872(Art2b) 11875(Art5)
MCAL: 110293894(Art3) 110296737(Art4) 110298812 110298813 110298950(Art1) 110299293(Art5)
MPAH: 110317267(Art4) 110330755(Art3) 110331381(Art5) 110334641(Art1) 110336159
RNO: 259167(Art5) 293152(Art2b) 305235(Art3) 308873(Art1) 312806(Art4)
MUN: 110550800 110552748(Art4) 110556237(Art3) 110557554(Art1) 110557558(Art5)
HGL: 101718202(Art3) 101718884(Art4) 101722974(Art5) 101723321(Art1) 106007650
CCAN: 109678990 109689052(Art4) 109699391(Art3) 109699871(Art5) 109699873(Art1)
TUP: 102483009(ART1) 102484959(ART3) 102487179 102493683(ART4) 102495500(ART5)
CFA: 476821(ART1) 478434(ART3) 485214(ART5) 486668(ART4)
VVP: 112915624(ART3) 112917555(ART4) 112928698(ART5) 112928702(ART1)
AML: 100469440(ART3) 100476510(ART5) 100476761(ART1) 100482134(ART4)
UMR: 103665328(ART3) 103677779(ART4) 103678010(ART5) 103678104(ART1)
UAH: 113257852(ART4) 113263253(ART3) 113269528(ART1) 113269529(ART5)
ORO: 101374251(ART5) 101379345(ART3) 101383793(ART4) 101386623(ART1)
FCA: 101086418(ART1) 101096491(ART4) 101096839(ART5) 101099636(ART3)
PTG: 102949793(ART5) 102950272(ART1) 102956045(ART3) 102960724(ART4)
PPAD: 109267124(ART5) 109267126(ART1) 109268652(ART4) 109277453(ART3)
AJU: 106965666(ART4) 106966015(ART5) 106966091(ART1) 106981641(ART3)
SSC: 100152653(ART4) 100522086(ART3) 100522939(ART5) 100525416(ART1)
CFR: 102507660(ART4) 102512361(ART1) 102518432(ART5) 102521392(ART3)
CDK: 105091546(ART3) 105096514(ART4) 105096600(ART5) 105098097(ART1)
BACU: 103000152 103001223(ART3) 103018183(ART1) 103018994(ART5) 103020109(ART4)
LVE: 103073305(ART3) 103079853(ART4) 103083699(ART5) 103083970(ART1)
OOR: 101274295(ART4) 101287676(ART1) 101287925(ART5) 101289023(ART3)
DLE: 111170551(ART1) 111170553(ART5) 111176797(ART4) 111187658(ART3)
PCAD: 102980032(ART3) 102983435(ART4) 102992514(ART1) 102992801(ART5)
ECB: 100051066(ART3) 100052937(ART1) 100066272(ART5) 100067242(ART4)
EPZ: 103549340(ART5) 103558520(ART1) 103562218(ART3) 103565487(ART4)
EAI: 106826735(ART4) 106831645(ART1) 106831647(ART5) 106846765(ART3)
MYB: 102240257(ART3) 102246125(ART4) 102249629(ART5) 102252898 102259501(ART1)
MYD: 102757044(ART5) 102757324(ART1) 102761825(ART4) 102771960(ART3) 102773420
MNA: 107525356(ART4) 107532973(ART3) 107533657 107541143(ART1) 107541149(ART5)
HAI: 109371157(ART3) 109372401(ART5) 109372402(ART1) 109383150(ART4)
DRO: 112315853 112316066(ART5) 112316067(ART1) 112318419(ART4) 112319801(ART3)
PALE: 102880138(ART3) 102884668(ART4) 102895427 102896718(ART5) 102896969(ART1)
RAY: 107508614(ART4) 107516365(ART3) 107517327(ART5) 107517334(ART1)
MJV: 108386673(ART4) 108399995(ART1) 108399997(ART5) 108409998
LAV: 100659550(ART3) 100666872(ART5) 100675697(ART1) 100677525(ART4)
GGA: 107052466 107052467 395661(AT2) 427879(ART4) 428123(MADPRT1) 428124(ART7B) 429485(ART1)
ACYG: 106045748(ART4) 106048558(ART1) 106048585(ART5)
PMAJ: 107198791(ART1) 107199071 107204288(ART4)
CCW: 104684214(ART1) 104696403(ART4)
FPG: 101917142 101918738(ART4)
FCH: 102050635(ART4) 114016563(ART1)
CLV: 102095862(ART4) 102097697
NNI: 104011678(ART4) 104011879
ACUN: 113476005(ART1) 113491182(ART4)
PADL: 103915564(ART4)
AAM: 106488204(ART4)
CMY: 102944533(ART4) 102945755 102946663(ART1)
TSR: 106553687 106556745(ART1)
PMUA: 114595490(ART1) 114607675
DRE: 100317105(si:ch211-145b13.6) 100334237(si:ch211-51i16.1) 100537504
CSEM: 103383509(art1)
HCQ: 109511505
PKI: 111838493
ADF: 107338189
 » show all
Reference
1  [PMID:225315]
  Authors
Moss J, Stanley SJ, Oppenheimer NJ.
  Title
Substrate specificity and partial purification of a stereospecific NAD- and guanidine-dependent ADP-ribosyltransferase from avian erythrocytes.
  Journal
J Biol Chem 254:8891-4 (1979)
Reference
2  [PMID:6247348]
  Authors
Moss J, Stanley SJ, Watkins PA.
  Title
Isolation and properties of an NAD- and guanidine-dependent ADP-ribosyltransferase from turkey erythrocytes.
  Journal
J Biol Chem 255:5838-40 (1980)
Reference
3  [PMID:3927821]
  Authors
Ueda K, Hayaishi O.
  Title
ADP-ribosylation.
  Journal
Annu Rev Biochem 54:73-100 (1985)
DOI:10.1146/annurev.bi.54.070185.000445
Reference
4  [PMID:12727863]
  Authors
Corda D, Di Girolamo M.
  Title
Functional aspects of protein mono-ADP-ribosylation.
  Journal
EMBO J 22:1953-8 (2003)
DOI:10.1093/emboj/cdg209
Reference
5  [PMID:16627471]
  Authors
Paone G, Stevens LA, Levine RL, Bourgeois C, Steagall WK, Gochuico BR, Moss J
  Title
ADP-ribosyltransferase-specific modification of human neutrophil peptide-1.
  Journal
J Biol Chem 281:17054-60 (2006)
DOI:10.1074/jbc.M603042200
  Sequence
[hsa:417]
Other DBs
ExplorEnz - The Enzyme Database: 2.4.2.31
IUBMB Enzyme Nomenclature: 2.4.2.31
ExPASy - ENZYME nomenclature database: 2.4.2.31
BRENDA, the Enzyme Database: 2.4.2.31
CAS: 81457-93-4

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