KEGG   ENZYME: 2.4.2.37Help
Entry
EC 2.4.2.37                 Enzyme                                 

Name
NAD+---dinitrogen-reductase ADP-D-ribosyltransferase;
NAD-azoferredoxin (ADPribose)transferase;
NAD-dinitrogen-reductase ADP-D-ribosyltransferase;
draT (gene name)
Class
Transferases;
Glycosyltransferases;
Pentosyltransferases
BRITE hierarchy
Sysname
NAD+:[dinitrogen reductase] (ADP-D-ribosyl)transferase
Reaction(IUBMB)
NAD+ + [dinitrogen reductase]-L-arginine = nicotinamide + [dinitrogen reductase]-Nomega-alpha-(ADP-D-ribosyl)-L-arginine [RN:R03447]
Reaction(KEGG)
Substrate
NAD+ [CPD:C00003];
[dinitrogen reductase]-L-arginine [CPD:C03315]
Product
nicotinamide [CPD:C00153];
[dinitrogen reductase]-Nomega-alpha-(ADP-D-ribosyl)-L-arginine [CPD:C01253]
Comment
The combined action of this enzyme and EC 3.2.2.24, ADP-ribosyl-[dinitrogen reductase] hydrolase, controls the activity level of nitrogenase (EC 1.18.6.1). In the presence of ammonium, the product of nitrogenase, this enzyme covalently links an ADP-ribose moiety to a specific arginine residue of the dinitrogenase reductase component of nitrogenase, blocking its activity.
History
EC 2.4.2.37 created 1992, modified 2015
Orthology
K05951  NAD+---dinitrogen-reductase ADP-D-ribosyltransferase
Genes
TTU: TERTU_0343
MCA: MCA1828
MMT: Metme_3770
MDN: JT25_015365
MDH: AYM39_06045
MKO: MKLM6_1231
ALV: Alvin_1882
TVI: Thivi_3646
TMB: Thimo_3246
MPUR: MARPU_03075
TAU: Tola_0578
RGE: RGE_42860(draT)
SLT: Slit_0880
DSU: Dsui_0954
DAR: Daro_1416
AZO: azo0537(draT)
AZA: AZKH_0793(draT)
AOA: dqs_0547
GSU: GSU2802(draT)
GSK: KN400_2739(draT)
GME: Gmet_0674(draT)
GUR: Gura_1205
GLO: Glov_0630
GBM: Gbem_2081(draT)
GEO: Geob_2585(draT)
GEM: GM21_2137
GEB: GM18_1869
PCA: Pcar_2092(draT)
PPD: Ppro_3487
DES: DSOUD_2576(draT)
DEU: DBW_0108
DAT: HRM2_09830(draT)
BRO: BRAD285_0319(draT)
RPA: RPA1431(draT1) RPA2405(draT2)
RPB: RPB_3044
RPC: RPC_0878
RPD: RPD_2407
BVR: BVIR_1911
RCP: RCAP_rcc03016(draT)
RHC: RGUI_1803
MAG: amb1575
MGY: MGMSRv2__0346(draT)
MAGX: XM1_3937(draT)
MAGN: WV31_08655
ALI: AZOLI_0684(draT)
ABS: AZOBR_70132(draT)
MGM: Mmc1_1203
AFR: AFE_1524(draT)
CAA: Caka_2843
 » show all
Taxonomy
Reference
1  [PMID:3141411]
  Authors
Lowery RG, Ludden PW.
  Title
Purification and properties of dinitrogenase reductase ADP-ribosyltransferase from the photosynthetic bacterium Rhodospirillum rubrum.
  Journal
J Biol Chem 263:16714-9 (1988)
Reference
2  [PMID:2506427]
  Authors
Fitzmaurice WP, Saari LL, Lowery RG, Ludden PW, Roberts GP.
  Title
Genes coding for the reversible ADP-ribosylation system of dinitrogenase reductase from Rhodospirillum rubrum.
  Journal
Mol Gen Genet 218:340-7 (1989)
  Sequence
[rru:Rru_A1009]
Reference
3  [PMID:24934999]
  Authors
Moure VR, Costa FF, Cruz LM, Pedrosa FO, Souza EM, Li XD, Winkler F, Huergo LF
  Title
Regulation of nitrogenase by reversible mono-ADP-ribosylation.
  Journal
Curr Top Microbiol Immunol 384:89-106 (2015)
DOI:10.1007/82_2014_380
Other DBs
ExplorEnz - The Enzyme Database: 2.4.2.37
IUBMB Enzyme Nomenclature: 2.4.2.37
ExPASy - ENZYME nomenclature database: 2.4.2.37
BRENDA, the Enzyme Database: 2.4.2.37
CAS: 117590-45-1

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