KEGG ENZYME: 2.4.2.38

ENZYME: 2.4.2.38

Entry

EC 2.4.2.38                 Enzyme

Name

glycoprotein 2-beta-D-xylosyltransferase;
beta1,2-xylosyltransferase;
UDP-D-xylose:glycoprotein (D-xylose to the 3,6-disubstituted mannose of 4-N-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl}asparagine) 2-beta-D-xylosyltransferase;
UDP-D-xylose:glycoprotein (D-xylose to the 3,6-disubstituted mannose of N4-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl}asparagine) 2-beta-D-xylosyltransferase

Class

Transferases;
Glycosyltransferases;
Pentosyltransferases

Sysname

UDP-alpha-D-xylose:N4-{beta-D-GlcNAc-(1->2)-alpha-D-mannosyl-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] 2-beta-D-xylosyltransferase (configuration-inverting)

Reaction(IUBMB)

UDP-alpha-D-xylose + N4-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] = UDP + N4-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-[beta-D-Xyl-(1->2)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] [RN:R06016]

Reaction(KEGG)

R06016(G)

Substrate

UDP-alpha-D-xylose [CPD:C00190];
N4-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein]

Product

UDP [CPD:C00015];
N4-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-[beta-D-Xyl-(1->2)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein]

Comment

Specific for N-linked oligosaccharides (N-glycans).

History

EC 2.4.2.38 created 2001

Pathway

ec00513

Various types of N-glycan biosynthesis

ec01100

Metabolic pathways

Orthology

K03714

glycoprotein 2-beta-D-xylosyltransferase

Genes

SPU:

105445658

APLC:

110987877

SKO:

102800701

BCOO:

119075585 119079690

BTAB:

109042524

LGI:	LOTGIDRAFT_128470 LOTGIDRAFT_153919 LOTGIDRAFT_233310

PCAN:

112571639

BGT:

106080300

GAE:	121367301 121367478 121367479

HRF:	124121880 124130879 124153091

HRJ:

124270140

CRG:	105319840 105333687 105339030

CVN:	111124162 111135242

CANU:

128163491 128179706

OED:	125658138 125679873

MYI:	110443248 110455369 110458688

PMAX:

117331275 117338533 117338575

MMER:

123522824 123523389 123523772 123524440 123528726 123530332 123534390 123544387 123545584 123550581 123550584 123552856 123561823 123563735

OBI:	106875510 106877045

OSN:	115209328 115210847

LAK:	106163443 106172208 112041729

EPA:

110252249

PDAM:

113666318 113666319

SPIS:

111332657 111332658

ATH:	AT5G55500(XYLT)

ALY:

9302172

CRB:

17876330

CSAT:

104726096 104731892 104761588

EUS:	EUTSA_v10013238mg

BRP:

103856986

BNA:	106345988 111211577

BOE:

106328005

RSZ:	108826879 108847859

THJ:

104811644

CPAP:

110820842

CIT:

102626878

CIC:	CICLE_v100081212m

PVY:

116137382

MINC:

123202120 123220484

TCC:

18593385

GRA:	105768513 105781371

GHI:	107903431 107917941 107922453 107932716

GAB:	108450816 108480423

DZI:	111275629 111301565

EGR:	104448163 104450279

GMX:	100810186 100812319 100816008 100816533

GSJ:	114396417 114396542 114423486 114423487

PVU:	PHAVU_006G051000g

VRA:

106776281

VAR:

108343439

VUN:

114188267

CCAJ:

109789838

APRC:

113855059

MTR:

11424626

TPRA:

123916778 123918923

CAM:

101507410

PSAT:

127084814

ADU:

107465751

AIP:

107624152

AHF:	112720198 112790609

LANG:

109330108

PCIN:

129298862 129303317

FVE:

101314264

RCN:	112165880 112168443

PPER:

18778489

PMUM:

103326601

PAVI:

110758283

PDUL:

117625897

MDM:	103407929 103448450

MSYL:

126614451

PXB:	103928133 103940105 103951441 103954513 103954547

ZJU:

107404289

MNT:

21392859

CSV:

101217309

CMO:

103501220

BHJ:

120086722

MCHA:

111010335

CMAX:

111477326

CMOS:

111442689

CPEP:

111797708

RCU:

8277560

JCU:

105633042

HBR:	110633648 110665200

MESC:

110601951

POP:

7485076

PEU:

105116937

PALZ:

118056802

JRE:

108984915

CILL:

122281948

CAVE:

132174827

QSU:	112022592 112022622

QLO:	115957363 115986275

TWL:	119988741 119990155

VVI:

100232898

VRI:

117909098

SLY:

101253606

SPEN:

107024140

SOT:	102594653(xt1)

SSTN:

125875649

CANN:

107878772

LBB:

132619084

NTA:	107760241(xylt) 107795800(xylt)

NSY:

104214329

NTO:

104116748

NAU:

109241583

INI:

109178158

ITR:

116020120

SIND:

105176760

OEU:	111367061 111367063 111395759 111395762

EGT:

105962061

SSPL:

121784918 121807308

SMIL:

131011509

APAN:

127253279

HAN:

110926525

ECAD:

122592692

LSV:

111882303

CCAV:

112505019 112514878

DCR:

108223942

CSIN:

114277880 114323605 114323606

RVL:

131329625

AEW:	130751908 130772486

BVG:

104891804

SOE:

110774679

CQI:

110705963

ATRI:

130807963 130818363

MOF:

131165612

NNU:

104606563

MING:

122089671 122094180

TSS:	122640508 122642953

PSOM:

113336852 113348483

OSA:

4345969

DOSA:

Os08t0503800-01(Os08g0503800)

OBR:

102707144

OGL:

127781753

BDI:

100843487

ATS:

109773455

TDC:	119329564 119337345

TAES:

123151121 123156485 123164878

TUA:

125528379

LPER:

127316875

LRD:	124692938 124693033

SBI:

8055192

ZMA:

732746

SITA:

101770206

SVS:

117860921

PVIR:

120678493 120712775

PHAI:

112898424

PDA:

103723962

EGU:

105038937

MUS:

103992376

ZOF:	121992290 121996235

DCT:	110091925 110106140

PEQ:	110029936 110038399

AOF:

109834768

NCOL:

116258686

ATR:

18446655

SMO:	SELMODRAFT_168165(XylT)

PPP:

112291590

CRE:	CHLRE_09g391282v5

OTA:	OT_ostta02g00040

PSOJ:

PHYSODRAFT_481680 PHYSODRAFT_486427

» show all

Reference

1 [PMID:9395463]

Authors

Zeng Y, Bannon G, Thomas VH, Rice K, Drake R, Elbein A.

Title

Purification and specificity of beta1,2-xylosyltransferase, an enzyme that contributes to the allergenicity of some plant proteins.

Journal

J Biol Chem 272:31340-7 (1997)
DOI:10.1074/jbc.272.50.31340

Reference

2 [PMID:10781814]

Authors

Strasser R, Mucha J, Mach L, Altmann F, Wilson IB, Glossl J, Steinkellner H

Title

Molecular cloning and functional expression of beta1, 2-xylosyltransferase cDNA from Arabidopsis thaliana.

Journal

FEBS Lett 472:105-8 (2000)
DOI:10.1016/S0014-5793(00)01443-5

Sequence

[ath:AT5G55500]

Other DBs

ExplorEnz - The Enzyme Database:

2.4.2.38

IUBMB Enzyme Nomenclature:

2.4.2.38

ExPASy - ENZYME nomenclature database:

2.4.2.38

BRENDA, the Enzyme Database:

2.4.2.38

CAS:	141256-56-6

DBGET integrated database retrieval system