KEGG   ENZYME: 2.4.2.38Help
Entry
EC 2.4.2.38                 Enzyme                                 

Name
glycoprotein 2-beta-D-xylosyltransferase;
beta1,2-xylosyltransferase;
UDP-D-xylose:glycoprotein (D-xylose to the 3,6-disubstituted mannose of 4-N-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl}asparagine) 2-beta-D-xylosyltransferase;
UDP-D-xylose:glycoprotein (D-xylose to the 3,6-disubstituted mannose of N4-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl}asparagine) 2-beta-D-xylosyltransferase
Class
Transferases;
Glycosyltransferases;
Pentosyltransferases
BRITE hierarchy
Sysname
UDP-alpha-D-xylose:N4-{beta-D-GlcNAc-(1->2)-alpha-D-mannosyl-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] 2-beta-D-xylosyltransferase (configuration-inverting)
Reaction(IUBMB)
UDP-alpha-D-xylose + N4-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] = UDP + N4-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-[beta-D-Xyl-(1->2)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] [RN:R06016]
Reaction(KEGG)
R06016(G)
Show
Substrate
UDP-alpha-D-xylose [CPD:C00190];
N4-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein]
Product
UDP [CPD:C00015];
N4-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-[beta-D-Xyl-(1->2)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein]
Comment
Specific for N-linked oligosaccharides (N-glycans).
History
EC 2.4.2.38 created 2001
Pathway
ec00513  Various types of N-glycan biosynthesis
ec01100  Metabolic pathways
Orthology
K03714  glycoprotein 2-beta-D-xylosyltransferase
Genes
RSS: 109441942
APLC: 110987877
SKO: 102800701
HRO: HELRODRAFT_150984
LGI: LOTGIDRAFT_128470 LOTGIDRAFT_153919 LOTGIDRAFT_233310
CRG: 105319840 105333687
MYI: 110443248 110455369 110458688
OBI: 106875510 106877045
LAK: 106163443 106172208 112041729
SHX: MS3_04673
EPA: 110252249
ATH: AT5G55500(XYLT)
CRB: 17876330
BOE: 106328005
THJ: 104811644
CPAP: 110820842
CIT: 102626878
TCC: 18593385
VRA: 106776281
VAR: 108343439
CCAJ: 109789838
CAM: 101507410
ADU: 107465751
AIP: 107624152
LJA: Lj6g3v0813360.1(Lj6g3v0813360.1)
LANG: 109330108
FVE: 101314264
PPER: 18778489
PMUM: 103326601
PAVI: 110758283
CSV: 101217309
CMO: 103501220
MCHA: 111010335
CMAX: 111477326
CMOS: 111442689
CPEP: 111797708
RCU: 8277560
JCU: 105633042
POP: 7485076
JRE: 108984915
VVI: 100232898(XT1)
SLY: 101253606
SPEN: 107024140
SOT: 102594653(xt1)
CANN: 107878772
NTA: 107760241(xylt) 107795800(xylt)
NSY: 104214329
NTO: 104116748
INI: 109178158
SIND: 105176760
HAN: 110926525
LSV: 111882303
DCR: 108223942
BVG: 104891804
SOE: 110774679
NNU: 104606563
OSA: 4345969
DOSA: Os08t0503800-01(Os08g0503800)
OBR: 102707144
BDI: 100843487
ATS: 109773455(LOC109773455)
SBI: 8055192
ZMA: 732746(xt1)
SITA: 101770206
PDA: 103723962
EGU: 105038937
MUS: 103992376
AOF: 109834768
ATR: 18446655
SMO: SELMODRAFT_168165(XylT)
PPP: 112291590
SPAR: SPRG_04092
 » show all
Taxonomy
Reference
1  [PMID:9395463]
  Authors
Zeng Y, Bannon G, Thomas VH, Rice K, Drake R, Elbein A.
  Title
Purification and specificity of beta1,2-xylosyltransferase, an enzyme that contributes to the allergenicity of some plant proteins.
  Journal
J Biol Chem 272:31340-7 (1997)
DOI:10.1074/jbc.272.50.31340
Reference
2  [PMID:10781814]
  Authors
Strasser R, Mucha J, Mach L, Altmann F, Wilson IB, Glossl J, Steinkellner H.
  Title
Molecular cloning and functional expression of beta1, 2-xylosyltransferase cDNA from Arabidopsis thaliana.
  Journal
FEBS Lett 472:105-8 (2000)
DOI:10.1016/S0014-5793(00)01443-5
  Sequence
[ath:AT5G55500]
Other DBs
ExplorEnz - The Enzyme Database: 2.4.2.38
IUBMB Enzyme Nomenclature: 2.4.2.38
ExPASy - ENZYME nomenclature database: 2.4.2.38
BRENDA, the Enzyme Database: 2.4.2.38
CAS: 141256-56-6

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