KEGG   ENZYME: 2.4.2.42
Entry
EC 2.4.2.42                 Enzyme                                 

Name
UDP-D-xylose:beta-D-glucoside alpha-1,3-D-xylosyltransferase;
beta-glucoside alpha-1,3-xylosyltransferase;
UDP-alpha-D-xylose:beta-D-glucoside 3-alpha-D-xylosyltransferase;
GXYLT1 (gene name);
GXYLT2 (gene name)
Class
Transferases;
Glycosyltransferases;
Pentosyltransferases
Sysname
UDP-alpha-D-xylose:[protein with EGF-like domain]-3-O-(beta-D-glucosyl)-L-serine 3-alpha-D-xylosyltransferase (configuration-retaining)
Reaction(IUBMB)
UDP-alpha-D-xylose + [protein with EGF-like domain]-3-O-(beta-D-glucosyl)-L-serine = UDP + [protein with EGF-like domain]-3-O-[alpha-D-xylosyl-(1->3)-beta-D-glucosyl]-L-serine [RN:R09290]
Reaction(KEGG)
R09290(G)
Substrate
UDP-alpha-D-xylose [CPD:C00190];
[protein with EGF-like domain]-3-O-(beta-D-glucosyl)-L-serine
Product
UDP [CPD:C00015];
[protein with EGF-like domain]-3-O-[alpha-D-xylosyl-(1->3)-beta-D-glucosyl]-L-serine
Comment
The enzyme, found in animals and insects, is involved in the biosynthesis of the alpha-D-xylosyl-(1->3)-alpha-D-xylosyl-(1->3)-beta-D-glucosyl trisaccharide on epidermal growth factor-like (EGF-like) domains [2,3]. When present on Notch proteins, the trisaccharide functions as a modulator of the signalling activity of this protein.
History
EC 2.4.2.42 created 2010, modified 2020
Pathway
ec00514  Other types of O-glycan biosynthesis
Orthology
K13676  UDP-D-xylose:beta-D-glucoside alpha-1,3-D-xylosyltransferase
Genes
HSA: 283464(GXYLT1) 727936(GXYLT2)
PTR: 460509(GXYLT2) 466957(GXYLT1)
PPS: 100985954(GXYLT1) 100988228(GXYLT2)
GGO: 101131995(GXYLT1) 101151401(GXYLT2)
PON: 100435193(GXYLT1) 100459853(GXYLT2)
NLE: 100597787(GXYLT1) 100607817(GXYLT2)
MCC: 693538(GXYLT2) 698940(GXYLT1)
MCF: 102135022(GXYLT2) 102144908(GXYLT1)
CSAB: 103227904(GXYLT2) 103238166(GXYLT1)
CATY: 105571610(GXYLT1) 105585698(GXYLT2)
RRO: 104672381(GXYLT1) 104680147(GXYLT2)
RBB: 108517557(GXYLT1) 108542237(GXYLT2)
TFN: 117083143(GXYLT2) 117090274(GXYLT1)
CJC: 100386599(GXYLT2) 100411087(GXYLT1)
SBQ: 101040626(GXYLT2) 101049571(GXYLT1)
MMUR: 105859685(GXYLT1) 105883883(GXYLT2)
MMU: 223827(Gxylt1) 232313(Gxylt2)
MCAL: 110296667(Gxylt2) 110310682(Gxylt1)
MPAH: 110316485(Gxylt2) 110335039(Gxylt1)
RNO: 300173(Gxylt1) 688618(Gxylt2)
MCOC: 116078255(Gxylt1) 116099339(Gxylt2)
MUN: 110549975(Gxylt2)
CGE: 100758512(Gxylt2) 100760543(Gxylt1)
PLEU: 114693059(Gxylt1) 114695406(Gxylt2)
NGI: 103732868(Gxylt2) 103743526(Gxylt1)
HGL: 101720209(Gxylt1) 101726179(Gxylt2)
CCAN: 109689454(Gxylt2) 109690443(Gxylt1)
OCU: 100341344(GXYLT1) 100352331(GXYLT2)
TUP: 102474441(GXYLT2) 102485746(GXYLT1)
CFA: 486604(GXYLT1) 610815(GXYLT2)
VVP: 112913313(GXYLT2) 112921204(GXYLT1)
AML: 100470272(GXYLT1) 100483731(GXYLT2)
UMR: 103674257(GXYLT2) 103675585(GXYLT1)
UAH: 113257086(GXYLT2) 113257488(GXYLT1)
ORO: 101377029(GXYLT2) 101385061(GXYLT1)
MPUF: 101689056(GXYLT2) 101692100(GXYLT1)
EJU: 114207785(GXYLT2) 114224114(GXYLT1)
FCA: 101094332(GXYLT2) 101099221(GXYLT1)
PTG: 102951546(GXYLT2) 102956795(GXYLT1)
PPAD: 109254519(GXYLT2) 109268838(GXYLT1)
AJU: 106969540(GXYLT2) 106978300(GXYLT1)
BTA: 507299(GXYLT2) 617596(GXYLT1)
BOM: 102277093(GXYLT2) 102285532(GXYLT1)
BIU: 109559212(GXYLT1) 109576395(GXYLT2)
BBUB: 102408141(GXYLT2) 102411466(GXYLT1)
CHX: 102169917(GXYLT2) 102183938(GXYLT1)
OAS: 101104350(GXYLT2) 101110670(GXYLT1)
SSC: 100511227(GXYLT2) 110260763(GXYLT1)
CFR: 102508071(GXYLT2) 102520859(GXYLT1)
CDK: 105084730(GXYLT1) 105095272(GXYLT2)
BACU: 103000611(GXYLT2) 103008875(GXYLT1)
LVE: 103078226(GXYLT2) 103088996(GXYLT1)
OOR: 101280985(GXYLT2) 101286808(GXYLT1)
DLE: 111174105(GXYLT1) 111174184(GXYLT2)
PCAD: 102980719(GXYLT2) 102985794(GXYLT1)
ECB: 100054009(GXYLT1) 100061938(GXYLT2)
EPZ: 103552325(GXYLT2) 103563522(GXYLT1)
EAI: 106827919(GXYLT2) 106845838(GXYLT1)
MYB: 102242934(GXYLT1) 102251404(GXYLT2)
MYD: 102768844(GXYLT2) 102772351(GXYLT1)
MMYO: 118650059(GXYLT1) 118668566(GXYLT2)
MNA: 107528194(GXYLT1) 107542735(GXYLT2)
HAI: 109372996(GXYLT2) 109392190(GXYLT1)
DRO: 112301302(GXYLT2) 112318576(GXYLT1)
SHON: 118983448(GXYLT2) 118995200(GXYLT1)
AJM: 119041637(GXYLT1) 119052870(GXYLT2)
MMF: 118623175(GXYLT1) 118633374(GXYLT2)
PALE: 102891305(GXYLT1) 102897366(GXYLT2)
RAY: 107499416(GXYLT1) 107512462(GXYLT2)
MJV: 108392160(GXYLT2) 108403828(GXYLT1)
LAV: 100664083(GXYLT2) 100676954(GXYLT1)
MDO: 100021054(GXYLT2) 103093804(GXYLT1)
SHR: 100913319(GXYLT2) 100914661(GXYLT1)
PCW: 110203303(GXYLT1) 110222550(GXYLT2)
OAA: 100075610(GXYLT1) 100092108(GXYLT2)
GGA: 416097(GXYLT2) 417789(GXYLT1)
MGP: 100541215(GXYLT2) 100549495(GXYLT1)
CJO: 107309638(GXYLT1) 107319858(GXYLT2)
NMEL: 110392677(GXYLT1) 110404829(GXYLT2)
APLA: 101792975(GXYLT2) 101802170(GXYLT1)
ACYG: 106035465(GXYLT2) 106047708(GXYLT1)
TGU: 100223705(GXYLT2) 100228034(GXYLT1)
LSR: 110475083(GXYLT2) 110478572(GXYLT1)
SCAN: 103817096(GXYLT2) 103820373(GXYLT1)
GFR: 102034563(GXYLT2) 102041440(GXYLT1)
FAB: 101812256(GXYLT2) 101821381(GXYLT1)
PHI: 102105605(GXYLT1) 102106110(GXYLT2)
PMAJ: 107204860(GXYLT1) 107210489(GXYLT2)
CCAE: 111931989(GXYLT1) 111934951(GXYLT2)
CCW: 104683376(GXYLT2) 104698322(GXYLT1)
ETL: 114062218(GXYLT1) 114062769(GXYLT2)
FPG: 101915838(GXYLT2) 101924236(GXYLT1)
FCH: 102048910(GXYLT1) 102051059(GXYLT2)
CLV: 102091906(GXYLT1) 102092274(GXYLT2)
EGZ: 104127589(GXYLT1) 104132654(GXYLT2)
NNI: 104013608(GXYLT1) 104016934(GXYLT2)
ACUN: 113475852(GXYLT1) 113484952(GXYLT2)
PADL: 103919998(GXYLT1) 103921101(GXYLT2)
AAM: 106488912(GXYLT1) 106497625(GXYLT2)
ASN: 102379806(GXYLT1) 102385178(GXYLT2)
AMJ: 102566316(GXYLT1) 102575340(GXYLT2)
PSS: 102444264(GXYLT2) 102451499(GXYLT1)
CMY: 102936565(GXYLT1) 102942330(GXYLT2)
CPIC: 101938422(GXYLT2) 101951340(GXYLT1)
ACS: 100553234(gxylt2) 100557426(gxylt1)
PVT: 110077714(GXYLT2) 110082142(GXYLT1)
PBI: 103062931(GXYLT1) 103066003(GXYLT2) 112542742
PMUR: 107295297(GXYLT2) 107302568(GXYLT1)
TSR: 106540802(GXYLT2) 106541996(GXYLT1)
PMUA: 114591826(GXYLT2) 114605175(GXYLT1)
GJA: 107107122(GXYLT1) 107125990(GXYLT2)
XLA: 108714713(gxylt2.L) 446519(gxylt2.S) 734649(gxylt1.L)
XTR: 100127708(gxylt1) 100486141(gxylt2)
NPR: 108783850(GXYLT1) 108788230(GXYLT2)
DRE: 100333154(gxylt1a) 556315(gxylt1b) 567541(gxylt2)
IPU: 108271924(gxylt2) 108274953(gxylt1)
PHYP: 113529530(gxylt1) 113536056(gxylt2)
EEE: 113570964(gxylt2) 113571847(gxylt1)
TRU: 101065240(gxylt2) 101066878 101071833(gxylt1)
LCO: 104922188(gxylt2) 104925411
NCC: 104961697(gxylt1) 104962548 104965653(gxylt2)
OLA: 101157411(gxylt1) 101159738 101162041(gxylt2)
KMR: 108229894 108235031(gxylt1b) 108242220(gxylt2)
AOCE: 111575164 111579794(gxylt1) 111589026(gxylt2)
CSEM: 103380119 103382837(gxylt1) 103386266(gxylt2)
POV: 109623966(gxylt1) 109632644 109642166(gxylt2)
BPEC: 110161803(gxylt1) 110169615 110170253(gxylt2)
MALB: 109956012(gxylt2) 109973070(gxylt1)
SFM: 108923350(gxylt2) 108931401(gxylt1)
PKI: 111834525(gxylt2) 111851272(gxylt1)
LCM: 102361255(GXYLT1) 102363854(GXYLT2)
CMK: 103179380(gxylt1) 103179794(gxylt2)
BFO: 118424347
APLC: 110976956
DME: Dmel_CG9996(shams)
DER: 6555493
DSE: 6619649
DSI: Dsimw501_GD29629(Dsim_GD29629)
DAN: 6499892
DSR: 110191078
DPE: 6592080
DMN: 108156282
DAZ: 108620928
DNV: 108658138
DHE: 111598557
DVI: 26530678
MDE: 101892990
LCQ: 111686240
AAG: 5567113
AME: 552516
BIM: 105680243
BTER: 100642542
CCAL: 108624939
OBB: 114876708
SOC: 105197417
MPHA: 105834450
AEC: 105148280
ACEP: 105624457
PBAR: 105429220
VEM: 105561196
HST: 105189094
DQU: 106747982
CFO: 105247945
LHU: 105675354
PGC: 109861264
OBO: 105284350
PCF: 106788258
NVI: 103315280
CSOL: 105363126
MDL: 103572051
TCA: 658303
DPA: 109540289
ATD: 109600080
NVL: 108559792
BMOR: 101736966
BMAN: 114245785
PMAC: 106721580
PRAP: 110997499
HAW: 110373439
TNL: 113504759
PXY: 105382370
API: 100160782
DNX: 107162550
AGS: 114131129
RMD: 113548485
BTAB: 109040731
CLEC: 106673605
ZNE: 110828365
CSCU: 111640028
PTEP: 107440914
PCAN: 112559034
CRG: 105331239
MYI: 110463433
OBI: 106869585
NVE: 5511342
EPA: 110252337
ADF: 107334530
AMIL: 114976297
PDAM: 113681050
SPIS: 111324593
HMG: 100200448
 » show all
Reference
1  [PMID:9128735]
  Authors
Omichi K, Aoki K, Minamida S, Hase S
  Title
Presence of UDP-D-xylose: beta-D-glucoside alpha-1,3-D-xylosyltransferase involved in the biosynthesis of the Xyl alpha 1-3Glc beta-Ser structure of glycoproteins in the human hepatoma cell line HepG2.
  Journal
Eur J Biochem 245:143-6 (1997)
DOI:10.1111/j.1432-1033.1997.00143.x
Reference
2  [PMID:17317689]
  Authors
Ishimizu T, Sano K, Uchida T, Teshima H, Omichi K, Hojo H, Nakahara Y, Hase S
  Title
Purification and substrate specificity of UDP-D-xylose:beta-D-glucoside alpha-1,3-D-xylosyltransferase involved in the biosynthesis of the Xyl alpha1-3Xyl alpha1-3Glc beta1-O-Ser on epidermal growth factor-like domains.
  Journal
J Biochem 141:593-600 (2007)
DOI:10.1093/jb/mvm064
Reference
3  [PMID:19940119]
  Authors
Sethi MK, Buettner FF, Krylov VB, Takeuchi H, Nifantiev NE, Haltiwanger RS, Gerardy-Schahn R, Bakker H
  Title
Identification of glycosyltransferase 8 family members as xylosyltransferases acting on O-glucosylated notch epidermal growth factor repeats.
  Journal
J Biol Chem 285:1582-6 (2010)
DOI:10.1074/jbc.C109.065409
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.4.2.42
IUBMB Enzyme Nomenclature: 2.4.2.42
ExPASy - ENZYME nomenclature database: 2.4.2.42
BRENDA, the Enzyme Database: 2.4.2.42

DBGET integrated database retrieval system