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Entry
EC 2.4.2.44                 Enzyme                                 

Name
S-methyl-5'-thioinosine phosphorylase;
MTIP;
MTI phosphorylase;
methylthioinosine phosphorylase
Class
Transferases;
Glycosyltransferases;
Pentosyltransferases
BRITE hierarchy
Sysname
S-methyl-5'-thioinosine:phosphate S-methyl-5-thio-alpha-D-ribosyl-transferase
Reaction(IUBMB)
S-methyl-5'-thioinosine + phosphate = hypoxanthine + S-methyl-5-thio-alpha-D-ribose 1-phosphate [RN:R09668]
Reaction(KEGG)
Substrate
S-methyl-5'-thioinosine [CPD:C19787];
phosphate [CPD:C00009]
Product
hypoxanthine [CPD:C00262];
S-methyl-5-thio-alpha-D-ribose 1-phosphate [CPD:C04188]
Comment
No activity with S-methyl-5'-thioadenosine. The catabolism of of 5'-methylthioadenosine in Pseudomonas aeruginosa involves deamination to S-methyl-5'-thioinosine (EC 3.5.4.31, S-methyl-5'-thioadenosine deaminase) and phosphorolysis to hypoxanthine [1].
History
EC 2.4.2.44 created 2011
Pathway
ec00270  Cysteine and methionine metabolism
ec01100  Metabolic pathways
Orthology
K19696  5'-methylthioinosine phosphorylase
Genes
XFA: XF_2353
XFT: PD_1381(deoD)
XFM: Xfasm12_1523
XFN: XfasM23_1466
XFF: XFLM_01035
XFL: P303_06620
XFS: D934_11000
XFH: XFHB_03330
XCC: XCC1285(deoD)
XCB: XC_2956
XCP: XCR_1540
XCV: XCV1388(deoD)
XAX: XACM_1319(deoD)
XAC: XAC1336(deoD)
XCI: XCAW_03012(deoD)
XFU: XFF4834R_chr31650(deoD)
XOO: XOO1869(deoD)
XOM: XOO1764(XOO1764)
XOP: PXO_01730
XOR: XOC_3170
XAL: XALC_2532
XPH: XppCFBP6546_04755(XppCFBP6546P_04755)
SML: Smlt3536
SMT: Smal_2966
SMZ: SMD_3117(mtaP)
SACZ: AOT14_13000(mtaP)
PSUW: WQ53_00595
PSD: DSC_11520
LEZ: GLE_1720(mtnP)
LEM: LEN_3247(mtaP)
DKO: I596_506
PAE: PA3004
PAEV: N297_3110(mtnP)
PAEI: N296_3110(mtnP)
PAP: PSPA7_2155(mtnP)
PAEP: PA1S_10370
PAEM: U769_09910
PAEL: T223_10385
PAEG: AI22_23500
PAEC: M802_3107(mtnP)
PAEO: M801_2975(mtnP)
PMY: Pmen_1591
PPSE: BN5_1390(mtaP)
PSB: Psyr_3280
PSYR: N018_16460
PSP: PSPPH_3200(mtaP)
PMAN: OU5_5481
PSA: PST_1738
PSTT: CH92_13710
PPUU: PputUW4_03513(mtnP)
PKC: PKB_3776
PSET: THL1_2136
PSIL: PMA3_08645
MAQ: Maqu_1935
MHC: MARHY1370
MAD: HP15_2259
MBS: MRBBS_1057(mtnP)
SAGA: M5M_01190
MCA: MCA1986
MAH: MEALZ_3520(mtnP)
MPSY: CEK71_10260(mtnP)
MEJ: Q7A_1240
CYQ: Q91_0834
CYY: CPC19_08455(mtnP)
TIG: THII_0201
NWA: Nwat_2653
TEE: Tel_08760
NTT: TAO_0458
AEH: Mlg_1329
HHA: Hhal_1259
TGR: Tgr7_1751
TKM: TK90_1246
TNI: TVNIR_1603(mtnP_[H])
TVR: TVD_06670
HCH: HCH_02681(mtaP)
ABO: ABO_1021(deoD)
ADI: B5T_01828(deoD)
APAC: S7S_10135
AXE: P40_08710
KAK: Kalk_02995(mtnP)
TOL: TOL_2082
OAI: OLEAN_C17000(mtaP)
SLIM: SCL_1235
SVA: SVA_2035
TBN: TBH_C1140
ENM: EBS_1162(mtaP)
 » show all
Taxonomy
Reference
1  [PMID:21197954]
  Authors
Guan R, Ho MC, Almo SC, Schramm VL
  Title
Methylthioinosine phosphorylase from Pseudomonas aeruginosa. Structure and annotation of a novel enzyme in quorum sensing.
  Journal
Biochemistry 50:1247-54 (2011)
DOI:10.1021/bi101642d
  Sequence
[pae:PA3004]
Other DBs
ExplorEnz - The Enzyme Database: 2.4.2.44
IUBMB Enzyme Nomenclature: 2.4.2.44
ExPASy - ENZYME nomenclature database: 2.4.2.44
BRENDA, the Enzyme Database: 2.4.2.44

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