Entry
Name
triphosphoribosyl-dephospho-CoA synthase;
2'-(5''-triphosphoribosyl)-3-dephospho-CoA synthase;
ATP:dephospho-CoA 5-triphosphoribosyl transferase;
CitG;
ATP:dephospho-CoA 5'-triphosphoribosyl transferase;
MdcB;
ATP:3-dephospho-CoA 5''-triphosphoribosyltransferase;
MadG
Class
Transferases;
Glycosyltransferases;
Pentosyltransferases
BRITE hierarchy
Sysname
ATP:3'-dephospho-CoA 5-triphospho-alpha-D-ribosyltransferase
Reaction(IUBMB)
ATP + 3'-dephospho-CoA = 2'-(5-triphospho-alpha-D-ribosyl)-3'-dephospho-CoA + adenine [RN:
R09675 ]
Reaction(KEGG)
Substrate
Product
2'-(5-triphospho-alpha-D-ribosyl)-3'-dephospho-CoA [CPD:
C19771 ];
adenine [CPD:
C00147 ]
Comment
ATP cannot be replaced by GTP, CTP, UTP, ADP or AMP. The reaction involves the formation of a new alpha (1''->2') glycosidic bond between the two ribosyl moieties, with concomitant displacement of the adenine moiety of ATP [1,4]. The 2'-(5-triphosphoribosyl)-3'-dephospho-CoA produced can be transferred by EC
2.7.7.61 , citrate lyase holo-[acyl-carrier protein] synthase, to the apo-acyl-carrier protein subunit (gamma-subunit) of EC
4.1.3.6 , citrate (pro-3S) lyase, thus converting it from an apo-enzyme into a holo-enzyme [1,3]. Alternatively, it can be transferred to the apo-ACP subunit of malonate decarboxylase by the action of EC
2.7.7.66 , malonate decarboxylase holo-[acyl-carrier protein] synthase [4].
History
EC 2.4.2.52 created 2002 as EC 2.7.8.25, modified 2008, transferred 2013 to EC 2.4.2.52
Orthology
K05966 triphosphoribosyl-dephospho-CoA synthase
K13927 holo-ACP synthase / triphosphoribosyl-dephospho-CoA synthase
K13930 triphosphoribosyl-dephospho-CoA synthase
Genes
ECD : ECDH10B_0573(citG) ECDH10B_0681(citG)
ECOO : ECRM13514_0637(citG)
ECOH : ECRM13516_0582(citG)
ELR : ECO55CA74_03810(citG)
ECW : EcE24377A_0635(citG)
EDJ : ECDH1ME8569_0583(citG)
EFE : EFER_0037(citG) EFER_3126
STY : STY0072(citG2) STY0668(citG)
STT : t0065(citG) t2248(citG)
SEX : STBHUCCB_23790 STBHUCCB_740
SENT : TY21A_00335 TY21A_11400(citG)
STM : STM0063(citG2) STM0619(citG)
SEO : STM14_0074(citG2) STM14_0720(citG)
SEV : STMMW_00641 STMMW_06841
SEY : SL1344_0064(citG2) SL1344_0607(citG)
SEM : STMDT12_C00640 STMDT12_C06810(citG)
SEJ : STMUK_0064(citG2) STMUK_0624(citG)
SEB : STM474_0066(citG) STM474_0640(citG)
SEF : UMN798_0071(citG2) UMN798_0669(citG)
SETU : STU288_00315 STU288_11280(citG)
SETC : CFSAN001921_13940 CFSAN001921_17105
SENR : STMDT2_00641(citG2) STMDT2_06101(citG)
SEND : DT104_00631(citG2) DT104_06481(citG)
SENI : CY43_00310 CY43_03380
SEEN : SE451236_06325 SE451236_09120
SPT : SPA0064(citG) SPA2115(citG)
SPQ : SPAB_00075 SPAB_02941
SEI : SPC_0067(citG) SPC_0632(citG)
SEC : SCH_0057(citG2) SCH_0648(citG)
SEH : SeHA_C0067(citG) SeHA_C0732(citG)
SENH : CFSAN002069_05750(citG) CFSAN002069_08910
SEEH : SEEH1578_09350 SEEH1578_12525(citG)
SEE : SNSL254_A0068(citG) SNSL254_A0673(citG)
SENN : SN31241_10430 SN31241_16240
SEW : SeSA_A0069(citG) SeSA_A0778(citG)
SEA : SeAg_B0070(citG) SeAg_B0659(citG)
SENS : Q786_00315 Q786_03025
SED : SeD_A0068(citG) SeD_A0719(citG)
SEL : SPUL_0067(citG2) SPUL_2345(citG)
SEGA : SPUCDC_0067(citG2) SPUCDC_2331(citG)
SET : SEN0064(citG2) SEN0588(citG)
SENA : AU38_00315 AU38_03010
SENO : AU37_00315 AU37_03005
SENV : AU39_00315 AU39_03010
SENQ : AU40_00340 AU40_03310
SENL : IY59_00330 IY59_03060
SENJ : CFSAN001992_08235(citG) CFSAN001992_10715
SEEC : CFSAN002050_06770 CFSAN002050_09705
SEEB : SEEB0189_016190 SEEB0189_019070
SEEP : I137_00300 I137_10695
SENB : BN855_6120(citG) BN855_640(citG2)
SENE : IA1_00320 IA1_03245
SENC : SEET0819_07210 SEET0819_10060
SES : SARI_02316 SARI_04158
SALZ : EOS98_16025 EOS98_18925(citG)
ENL : A3UG_11840 A3UG_19000 A3UG_21005
ECLG : EC036_36880 EC036_40970
ECLE : ECNIH2_19150 ECNIH2_21535
ECLN : ECNIH4_02075 ECNIH4_04080
ECLI : ECNIH5_18055 ECNIH5_20145
ECLX : LI66_18830 LI66_20790
ECLY : LI62_20290 LI62_22775
ECLO : ENC_25610 ENC_32150
EHM : AB284_04030 AB284_06955
EXF : BFV63_18495 BFV63_20280
ECLA : ECNIH3_18135 ECNIH3_20250
ECLC : ECR091_18070 ECR091_20180
EKB : BFV64_19375 BFV64_21750
ENO : ECENHK_18650 ECENHK_20520
EEC : EcWSU1_03764(citG) EcWSU1_04150(mdcB)
ELG : BH714_13560 BH714_20950
ECAN : CWI88_03685(citG) CWI88_20775
ERN : BFV67_18320 BFV67_20315
ECLS : LI67_014040 LI67_019825 LI67_022350
ECHG : FY206_20585(citG) FY206_22620
ESH : C1N69_11755(citG) C1N69_19055(citG)
ENT : Ent638_3370 Ent638_3778
EAS : Entas_3635 Entas_4060
ENR : H650_11065 H650_13200
ENF : AKI40_0440 AKI40_0796
LNI : CWR52_00515(citG) CWR52_14350 CWR52_16405(citG)
END : A4308_03325 A4308_05240
ENZ : G0034_19065(citG) G0034_21175
ENS : HWQ15_04220(citG) HWQ15_06120
ENK : LOC22_06980(citG) LOC22_08840
EHU : D5067_0001875 D5067_0003850(citG)
EMOR : L6Y89_18200(citG) L6Y89_20375
CDM : AFK67_17215 AFK67_17470
CUI : AFK65_16230 AFK65_16605
CMW : AFK63_01790 AFK63_02045
CTU : CTU_35060(mdcB) CTU_35610(citG)
KPN : KPN_00038(citG2) KPN_01562
KPM : KPHS_07480 KPHS_24710
KPH : KPNIH24_03820 KPNIH24_15895
KPZ : KPNIH27_12020 KPNIH27_22415
KPW : KPNIH30_04005 KPNIH30_12810
KPY : KPNIH31_04030 KPNIH31_11900
KPG : KPNIH32_04010 KPNIH32_12650
KPC : KPNIH10_03805 KPNIH10_12335
KPQ : KPR0928_03815 KPR0928_12340
KPT : VK055_0940(mdcB) VK055_2537(citG)
KPO : KPN2242_02615 KPN2242_10600
KPA : KPNJ1_02916 KPNJ1_04706
KPS : KPNJ2_02917 KPNJ2_04657
KPB : FH42_03715 FH42_14145 FH42_21000
KPNE : KU54_013850 KU54_022740
KPNU : LI86_13785 LI86_22580
KPNK : BN49_2674(mdcB) BN49_4302(citG) BN49_4528(citG2)
KPE : KPK_2895(mdcB) KPK_4711(citG)
KPK : A593_14560 A593_22365
KVQ : SP68_01220 SP68_18625
KOX : KOX_10645 KOX_16595 KOX_21645
KOE : A225_0835 A225_2164 A225_2165 A225_3202
KOY : J415_15940 J415_20965 J415_27075
KOM : HR38_09375 HR38_15110 HR38_19945
KOK : KONIH1_04380 KONIH1_15695
KOC : AB185_20205 AB185_25570 AB185_31800
KQU : AVR78_08385 AVR78_16925
EAE : EAE_00010 EAE_10965 EAE_18285
KQV : B8P98_02655(citG) B8P98_14680 B8P98_23605(citG)
KLL : BJF97_04925 BJF97_15815
KLW : DA718_03360 DA718_13405 DA718_24125(citG) DA718_28145(citG)
KGR : JJJ10_02995 JJJ10_13015 JJJ10_17975(citG) JJJ10_23625(citG)
KPAS : LUW96_03525 LUW96_10920(citG) LUW96_17215(citG) LUW96_22400
ROR : RORB6_05475 RORB6_22490
RON : TE10_13740 TE10_15775
RPLN : B1209_03715 B1209_12140
RAO : DSD31_03945(citG) DSD31_11950
REE : electrica_00727(citG_1) electrica_02353(citG_2)
CRO : ROD_06281(citG) ROD_44581(mdcB)
CFD : CFNIH1_01325 CFNIH1_04480 CFNIH1_13235
CYO : CD187_06140 CD187_17155
CPOT : FOB25_04630(citG) FOB25_13235
CSED : JY391_02070 JY391_15285(citG)
CAMA : F384_01175 F384_02715
CFAR : CI104_07425 CI104_19385(citG)
CIE : AN232_06410 AN232_09040(citG) AN232_23250
CTEL : GBC03_22855(citG) GBC03_24680
CARS : E1B03_08235 E1B03_24285
EBT : EBL_c06560(citG) EBL_c35300(mdcB)
CNT : JT31_09635 JT31_10395
CEM : LH23_07370 LH23_08150
CLAP : NCTC11466_03333 NCTC11466_04146
KSA : C813_19375 C813_26465
KOR : AWR26_01930 AWR26_03870(citG) AWR26_12475(citG)
KRD : A3780_11635 A3780_20195 A3780_22795
KPSE : IP581_19305(citG) IP581_21320
KOO : O9K67_02180 O9K67_03925(citG)
KIE : NCTC12125_04284 NCTC12125_04672
KAS : KATP_03680(mdcB) KATP_07290(citG)
LEF : LJPFL01_3447 LJPFL01_3883
LEW : DAI21_06430 DAI21_08645(citG)
BAGE : BADSM9389_29940 BADSM9389_36730
BFT : MNO13_16210(citG) MNO13_16215(citG) MNO13_18065(citG)
METY : MRY16398_04370(mdcB) MRY16398_08540(citG) MRY16398_42960(citG)
AHN : NCTC12129_03711(citG)
SGOE : A8O29_011075 A8O29_013535(citG)
KIN : AB182_03495 AB182_18885 AB182_27610
PDZ : HHA33_04390 HHA33_06390(citG) HHA33_21445(citG)
IZH : FEM41_08170 FEM41_22720(citG)
PSGC : G163CM_39570(citG_1) G163CM_43550(citG_3)
EBC : C2U52_10420 C2U52_13405(citG) C2U52_30140(citG)
EBU : CUC76_03185 CUC76_11485(citG)
SMW : SMWW4_v1c32140(citG)
SMAF : D781_2918 D781_3743
SFW : WN53_02865 WN53_24540
SFG : AV650_20165 AV650_25595
SRZ : AXX16_1344 AXX16_2149
SERA : Ser39006_011320(citG) Ser39006_012635 Ser39006_015625(citG)
SERQ : CWC46_11315(citG) CWC46_12630 CWC46_15620(citG)
SERM : CLM71_15325(citG) CLM71_19530
SRHZ : FO014_14620 FO014_18700(citG)
RAH : Rahaq_0230 Rahaq_1596
RACE : JHW33_02225(citG) JHW33_17755
RAQ : Rahaq2_0251 Rahaq2_1659
ROX : BV494_03115 BV494_15545
RVC : J9880_08915 J9880_15725(citG)
PAQU : DMB82_0009065(citG)
PCAC : OI450_07675(citG) OI450_18090
DDD : Dda3937_00043(citG) Dda3937_00365
DZE : Dd1591_2317 Dd1591_2611
DDC : Dd586_2257 Dd586_2523
DSO : A4U42_17125 A4U42_18740
CED : LH89_02605 LH89_04020
DFN : CVE23_08795 CVE23_10195(citG)
DAQ : DAQ1742_01535(citG) DAQ1742_02104(citG)
DIC : Dpoa569_002083(citG)
DDA : Dd703_1246 Dd703_2215
SLIG : GTU79_02125 GTU79_11960
PAO : Pat9b_0844 Pat9b_5847
MINT : C7M51_02716(citG_1) C7M51_04150(citG_3)
MTHI : C7M52_00139(citG_1) C7M52_02901(citG_2)
EHO : A9798_06910 A9798_15690
HAV : AT03_02580 AT03_07060
OPO : DSM2777_01455 DSM2777_12335
LRI : NCTC12151_00771 NCTC12151_02912
XFU : XFF4834R_chr05610(mdcB)
XPH : XppCFBP6546_08905(mdcB)
XHD : LMG31886_06570(citG)
VEJ : VEJY3_05325 VEJY3_17176
VAU : VANGNB10_cI1193(citG)
VGA : BSQ33_00665 BSQ33_03225
PAEB : NCGM1900_0198(mdcB)
PPRC : PFLCHA0_c57740(mdcB)
PFW : PF1751_v1c51640(mdcB)
PPUU : PputUW4_05098(mdcB)
PTW : TUM18999_58760(mdcB)
EMO : DM558_04715 DM558_13275(citG)
TMC : LMI_0899 LMI_1331(mdcB)
CDIZ : CEDIAZO_00328(citG_1) CEDIAZO_02596(citG_2) CEDIAZO_03006(citG_3)
COX : E0W60_18130 E0W60_31940
BMV : BMASAVP1_A1261(citG)
BML : BMA10229_A0609(citG)
BPM : BURPS1710b_1589(citG)
BPL : BURPS1106A_1487(mdcB)
BUG : BC1001_3950 BC1001_5560
BGF : BC1003_5453 BC1003_5654
BYI : BYI23_A017220(mdcB) BYI23_B014440
BUE : BRPE67_ACDS17700(mdcB) BRPE67_BCDS01430
BUQ : AC233_22035 AC233_30185
BXE : Bxe_B1845 Bxe_B2435(orf7)
BXB : DR64_4763 DR64_7152(mdcB)
BPH : Bphy_5086 Bphy_5944 Bphy_6486
BGE : BC1002_3221 BC1002_3654
BPX : BUPH_00534 BUPH_06198
BCAI : K788_0001558 K788_00042660 K788_0008559
PSPW : BJG93_17275 BJG93_19405
PARA : BTO02_24115 BTO02_27815
PARB : CJU94_20510 CJU94_21945 CJU94_31185
PHS : C2L64_21220 C2L64_21805 C2L64_27625 C2L64_38285
PTER : C2L65_20875 C2L65_26165 C2L65_34280 C2L65_44090
PGP : CUJ91_21490 CUJ91_26025
PCJ : CUJ87_19280 CUJ87_23430
PTS : CUJ90_08190 CUJ90_19025 CUJ90_28060
PGIS : I6I06_20885 I6I06_22475
PEW : KZJ38_24565(mdcB) KZJ38_25860 KZJ38_30415
PDIO : PDMSB3_0627.1 PDMSB3_1210.1(mdcB) PDMSB3_2112.1(mdcB)
PLG : NCTC10937_05022(mdcB)
CABA : SBC2_35190(citG_1) SBC2_39790(citG_2) SBC2_40940(citG_3)
BUO : BRPE64_ACDS17730 BRPE64_BCDS01570
VAP : Vapar_3080 Vapar_5369
MPT : Mpe_A0789 Mpe_A2611 Mpe_A2891
METP : C1M51_13065(mdcB) C1M51_14285(mdcB) C1M51_15085
RGE : RGE_23180(citG) RGE_40270
LCH : Lcho_0074 Lcho_0652 Lcho_3148
MMS : mma_0109(mdcB1) mma_2558(mdcB2)
SWS : I6J16_04170(citX) I6J16_09205
URU : DSM104443_03009(citG)
AZA : AZKH_1585(citG) AZKH_p0271
MESM : EJ066_19845 EJ066_29730
BJA : bll0265(mdcB) bll1272(mdcB)
BSEP : HAP48_0008330(mdcB)
BBAN : J4G43_019760(mdcB) J4G43_037660(mdcB)
XDI : EZH22_05745(mdcB) EZH22_18265
ANC : GBB76_00740 GBB76_18225
APRA : G3A50_04070(mdcB) G3A50_16485
MEA : Mex_1p0028(mdcB) Mex_1p1765
MDI : METDI0029(mdcB) METDI2517
MZA : B2G69_06895 B2G69_16825
MRD : Mrad2831_0351 Mrad2831_0532
MOR : MOC_0338(mdcB) MOC_0687
META : Y590_00185 Y590_08780
MPHY : MCBMB27_00109 MCBMB27_05333
MEE : DA075_05740 DA075_34110(mdcB)
METD : C0214_00190(mdcB) C0214_10535
METX : A3862_00235 A3862_28290
METS : DK389_12855(mdcB) DK389_20665
METI : DK427_09430(mdcB) DK427_18455
MMES : MMSR116_14780(mdcB) MMSR116_16700
MOG : MMB17_20015 MMB17_21260(mdcB)
MTAD : M6G65_13655 M6G65_15505(mdcB)
MTUN : MTUNDRAET4_2560(mdcB) MTUNDRAET4_2725
CMET : K6K41_18705 K6K41_25465
HDI : HDIA_0496(citG) HDIA_2314
LCK : HN018_16665(mdcB) HN018_25425(mdcB)
AZL : AZL_a08460(citG) AZL_b03190(citG)
ALI : AZOLI_p10686 AZOLI_p10887
ATI : AL072_22830 AL072_27080 AL072_31105
AZZ : DEW08_20160(mdcB) DEW08_26655(citG)
GBM : Gbem_0190(citG-2) Gbem_3856(citG-1)
GBN : GEOBRER4_01760(citG_1) GEOBRER4_37480(citG_2)
GER : KP004_18445 KP004_20730
GSUB : KP001_15595 KP001_17785
GNT : KP003_18465 KP003_20660
GPL : M1B72_01325 M1B72_21195
PTA : HPL003_21055 HPL003_27810
PKB : B4V02_05795 B4V02_06420
PAIH : ASL14_18830 ASL14_24170
STG : MGAS15252_0896(citG)
STZ : SPYALAB49_000889(citG)
SMC : SmuNN2025_1011(citG)
LRU : HMPREF0538_20647(citG)
LFF : LBFF_1031(citXG-1) LBFF_1724(citXG-2)
LALI : LA20249_04895 LA20249_05415
LGM : LG542_05145 LG542_06055(citG)
EFAU : EFAU085_00287(mdcB) EFAU085_p1074
EFU : HMPREF0351_10358(mdcB)
ECAS : ECBG_00932 ECBG_03048
EGA : AL523_04150(citG) AL523_13865
CCOH : SAMEA4530647_2251(citG)
BPRO : PMF13cell1_03167(citG)
EAC : EAL2_808p05990(citXG)
DOR : Desor_4454 Desor_5266
FWA : DCMF_03925 DCMF_16765
MANA : MAMMFC1_01290(citG)
PFAC : PFJ30894_00506(citG)
ERH : ERH_0503 ERH_0746(citG)
ERS : K210_00480 K210_01565
ERL : AOC36_05875 AOC36_09220
ERI : EEI45_06405(citG) EEI45_07290
ERD : G7062_04515(citG) G7062_08970
EIO : H9L01_06230(citG) H9L01_09615
EML : EMELA_v1c00450(citG)
SCQ : SCULI_v1c01730(citG)
SERI : SERIO_v1c06550(citG)
SHJ : SHELI_v1c10430(citG)
SCOU : SCORR_v1c05640(citG)
SCHI : SCHIN_v1c02400(citG)
SGM : GCM10017557_41060(mdcB)
STUI : GCM10017668_34210(mdcB)
PPIO : CE91St28_10980(citXG)
MKA : MK0196(citG_1) MK0876(citG_2)
HJT : DVR14_19245 DVR14_23375
» show all
Taxonomy
Reference
Authors
Schneider K, Dimroth P, Bott M.
Title
Biosynthesis of the prosthetic group of citrate lyase.
Journal
Sequence
Reference
Authors
Schneider K, Dimroth P, Bott M
Title
Identification of triphosphoribosyl-dephospho-CoA as precursor of the citrate lyase prosthetic group.
Journal
Sequence
Reference
Authors
Schneider K, Kastner CN, Meyer M, Wessel M, Dimroth P, Bott M.
Title
Identification of a gene cluster in Klebsiella pneumoniae which includes citX, a gene required for biosynthesis of the citrate lyase prosthetic group.
Journal
Reference
Authors
Hoenke S, Wild MR, Dimroth P
Title
Biosynthesis of triphosphoribosyl-dephospho-coenzyme A, the precursor of the prosthetic group of malonate decarboxylase.
Journal
Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.4.2.52
ExPASy - ENZYME nomenclature database: 2.4.2.52