KEGG   ENZYME: 2.4.2.57Help
Entry
EC 2.4.2.57                 Enzyme                                 

Name
AMP phosphorylase;
AMPpase;
nucleoside monophosphate phosphorylase;
deoA (gene name)
Class
Transferases;
Glycosyltransferases;
Pentosyltransferases
BRITE hierarchy
Sysname
AMP:phosphate alpha-D-ribosyl 5'-phosphate-transferase
Reaction(IUBMB)
(1) AMP + phosphate = adenine + alpha-D-ribose 1,5-bisphosphate [RN:R10836];
(2) CMP + phosphate = cytosine + alpha-D-ribose 1,5-bisphosphate [RN:R10837];
(3) UMP + phosphate = uracil + alpha-D-ribose 1,5-bisphosphate [RN:R10838]
Reaction(KEGG)
Substrate
AMP [CPD:C00020];
phosphate [CPD:C00009];
CMP [CPD:C00055];
UMP [CPD:C00105]
Product
adenine [CPD:C00147];
alpha-D-ribose 1,5-bisphosphate [CPD:C01151];
cytosine [CPD:C00380];
uracil [CPD:C00106]
Comment
The enzyme from archaea is involved in AMP metabolism and CO2 fixation through type III RubisCO enzymes. The activity with CMP and UMP requires activation by cAMP [2].
History
EC 2.4.2.57 created 2014
Orthology
K18931  AMP phosphorylase
Genes
SRB: P148_SR1C001G0223
MJA: MJ_0667
MFE: Mefer_1403
MVU: Metvu_0291
MFS: MFS40622_1516
MIF: Metin_0751
MJH: JH146_1232
MIG: Metig_0832
MMP: MMP0327(deoA)
MMQ: MmarC5_1346
MMD: GYY_01685
MAE: Maeo_0618
MVO: Mvol_1718
FPL: Ferp_0811
GAC: GACE_0123
GAH: GAH_00259
ABI: Aboo_0332
PHO: PH1598(PH1598)
PAB: PAB1982
PFU: PF1607
PFI: PFC_10580
PYN: PNA2_0183
PYS: Py04_1485
TKO: TK0352
TON: TON_1062
TGA: TGAM_1786
TSI: TSIB_0680
THE: GQS_10255
THA: TAM4_270
THM: CL1_1626
TLT: OCC_02747
THS: TES1_1098
TNU: BD01_1010
TEU: TEU_10940
PPAC: PAP_04670
MAC: MA_3242(deoA)
MBAR: MSBR2_0125
MBAK: MSBR3_0180
MMA: MM_0087
MMAC: MSMAC_2591
METM: MSMTP_1230
MTHE: MSTHC_0574
MTHR: MSTHT_0154
MHOR: MSHOH_2091
MBU: Mbur_0255
MMET: MCMEM_0874
MMH: Mmah_1278
MPY: Mpsy_0111
MTP: Mthe_0462
MCJ: MCON_0583
MHU: Mhun_2262
MLA: Mlab_0067
MBG: BN140_1665(deoA)
MEMA: MMAB1_2139
MPI: Mpet_0506
MBN: Mboo_0523
MPL: Mpal_2125
MPD: MCP_0060
MEZ: Mtc_0258(deoA)
RCI: RCIX1126(deoA)
NPH: NP_3958A(deoA)
HVO: HVO_0965(deoA)
HME: HFX_0962(deoA)
NMG: Nmag_4015(deoA)
DKA: DKAM_0158
TAG: Tagg_0379
HBU: Hbut_0381
TPE: Tpen_0093
BARC: AOA65_1927
 » show all
Taxonomy
Reference
1  [PMID:17303759]
  Authors
Sato T, Atomi H, Imanaka T
  Title
Archaeal type III RuBisCOs function in a pathway for AMP metabolism.
  Journal
Science 315:1003-6 (2007)
DOI:10.1126/science.1135999
  Sequence
[tko:TK0352]
Reference
2  [PMID:23065974]
  Authors
Aono R, Sato T, Yano A, Yoshida S, Nishitani Y, Miki K, Imanaka T, Atomi H
  Title
Enzymatic characterization of AMP phosphorylase and ribose-1,5-bisphosphate isomerase functioning in an archaeal AMP metabolic pathway.
  Journal
J Bacteriol 194:6847-55 (2012)
DOI:10.1128/JB.01335-12
  Sequence
[tko:TK0352]
Reference
3  [PMID:23659790]
  Authors
Nishitani Y, Aono R, Nakamura A, Sato T, Atomi H, Imanaka T, Miki K
  Title
Structure analysis of archaeal AMP phosphorylase reveals two unique modes of dimerization.
  Journal
J Mol Biol 425:2709-21 (2013)
DOI:10.1016/j.jmb.2013.04.026
  Sequence
[tko:TK0352]
Other DBs
ExplorEnz - The Enzyme Database: 2.4.2.57
IUBMB Enzyme Nomenclature: 2.4.2.57
ExPASy - ENZYME nomenclature database: 2.4.2.57
BRENDA, the Enzyme Database: 2.4.2.57

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