KEGG   ENZYME: 2.4.2.58Help
Entry
EC 2.4.2.58                 Enzyme                                 

Name
hydroxyproline O-arabinosyltransferase;
HPAT
Class
Transferases;
Glycosyltransferases;
Pentosyltransferases
BRITE hierarchy
Sysname
UDP-beta-L-arabinofuranose:[protein]-trans-4-hydroxy-L-proline L-arabinofuranosyl transferase (configuration-retaining)
Reaction(IUBMB)
UDP-beta-L-arabinofuranose + [protein]-trans-4-hydroxy-L-proline = UDP + [protein]-trans-4-(beta-L-arabinofuranosyl)oxy-L-proline
Substrate
UDP-beta-L-arabinofuranose [CPD:C18094];
[protein]-trans-4-hydroxy-L-proline
Product
UDP [CPD:C00015];
[protein]-trans-4-(beta-L-arabinofuranosyl)oxy-L-proline
Comment
The enzyme, found in plants and mosses, catalyses the O-arabinosylation of hydroxyprolines in hydroxyproline-rich glycoproteins. The enzyme acts on the first hydroxyproline in the motif Val-hydroxyPro-hydroxyPro-Ser.
History
EC 2.4.2.58 created 2016
Pathway
ec00514  Other types of O-glycan biosynthesis
Orthology
K20782  hydroxyproline O-arabinosyltransferase
Genes
RSS: 109441171 109441790
ATH: AT2G25260 AT5G13500 AT5G25265
ALY: ARALYDRAFT_481381 ARALYDRAFT_488171 ARALYDRAFT_910571
CRB: 17881438 17882682 17890411
CSAT: 104703055 104705602 104706849 104713988 104735354 104736546 104753988 104769568 104771004
EUS: EUTSA_v10000212mg EUTSA_v10004426mg EUTSA_v10013935mg
BRP: 103837084 103846569 103850878 103854763 103856021 103864620
BNA: 106365903 106372293(BNAC09G43590D) 106382636 106382638 106384241 106403926 106406190 106431918 106449936 106449943 111204278 111204370 111213923
BOE: 106315592 106318351 106324665 106331662 106338956 106340467
RSZ: 108806378 108827137 108836463 108847337 108849661
LJA: Lj0g3v0324599.1(Lj0g3v0324599.1) Lj0g3v0324599.2(Lj0g3v0324599.2) Lj2g3v3022970.1(Lj2g3v3022970.1) Lj2g3v3022970.2(Lj2g3v3022970.2) Lj5g3v0528950.1(Lj5g3v0528950.1)
DOSA: Os01t0272600-01(Os01g0272600) Os05t0386000-01(Os05g0386000) Os06t0180000-01(Os06g0180000)
ATS: 109733679(LOC109733679) 109768197(LOC109768197) 109773924(LOC109773924)
MNG: MNEG_5605
 » show all
Taxonomy
Reference
1  [PMID:24036508]
  Authors
Ogawa-Ohnishi M, Matsushita W, Matsubayashi Y
  Title
Identification of three hydroxyproline O-arabinosyltransferases in Arabidopsis thaliana.
  Journal
Nat Chem Biol 9:726-30 (2013)
DOI:10.1038/nchembio.1351
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.4.2.58
IUBMB Enzyme Nomenclature: 2.4.2.58
ExPASy - ENZYME nomenclature database: 2.4.2.58
BRENDA, the Enzyme Database: 2.4.2.58

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