KEGG   ENZYME: 2.4.2.59
Entry
EC 2.4.2.59                 Enzyme                                 
Name
sulfide-dependent adenosine diphosphate thiazole synthase;
Thi4 (ambiguous)
Class
Transferases;
Glycosyltransferases;
Pentosyltransferases
Sysname
NAD+:glycine ADP-D-ribosyltransferase (sulfide-adding)
Reaction(IUBMB)
NAD+ + glycine + sulfide = nicotinamide + ADP-5-ethyl-4-methylthiazole-2-carboxylate + 3 H2O [RN:R12026]
Reaction(KEGG)
R12026
Substrate
NAD+ [CPD:C00003];
glycine [CPD:C00037];
sulfide [CPD:C00283]
Product
nicotinamide [CPD:C00153];
ADP-5-ethyl-4-methylthiazole-2-carboxylate [CPD:C20784];
H2O [CPD:C00001]
Comment
This iron dependent enzyme, found in most archaea, is involved in the biosynthesis of thiamine phosphate. The homologous enzyme from plants and fungi (EC 2.4.2.60, cysteine-dependent adenosine diphosphate thiazole synthase) uses an intrinsic cysteine as sulfur donor and, unlike the archaeal enzyme, is a single turn-over enzyme.
History
EC 2.4.2.59 created 2018
Pathway
ec00730  Thiamine metabolism
ec01100  Metabolic pathways
Orthology
K22699  sulfide-dependent adenosine diphosphate thiazole synthase
Genes
DSDGD606_19515
DMADMR_31420
DCBC3Y92_06440
DGGDGI_1133
DMSE8L03_06730
DAFDesaf_0994
DSXGD604_13095
DOLDole_2426
DALDalk_2394
DOVDSCO28_45120
DLIdnl_00920(thiG)
DMMdnm_073520(thiG)
DAODesac_0998
DAXFDQ92_03460
DBRDeba_1981
HMRHipma_0421
DAVDESACE_08810
DHRLGS26_09060
BBARRHAL1_03078
CAULKCG34_24290
MALUKU6B_16750
CLJCLJU_c30580
CSQCSCA_1812
CDRKB9W14_10240
CFERD4Z93_11890
CLOSDMR38_15480
DKUDesku_1659
DAUDaud_0859
TJRTherJR_1442
ADGAdeg_0421 Adeg_1609
GEKkuro4_04070
TNRThena_0778
TACITDSAC_0747
MBXBCGT_0584
MPHLMPHLCCUG_05062(ksdD_3)
SLKSLUN_34370
HBSIPV69_04150
VAIBU251_06310 BU251_06360
TAITaci_1358
TLITlie_1851
AMOAnamo_0225
BCELBcellWH2_01838
BISDXK01_001245
PSOECE91St14_02970
PDIBDI_1609
PARCCI960_06610
PMERINE87_00229
PGOLK6V26_06880
PJOLK449_05640
PMZHMPREF0659_A5800
PITPIN17_A0608
PNIJ5A59_03980
PHERprwr041_11060
PSCJJ4856_09105
RBCBN938_1539
TTZFHG85_07515
MBASALGA_3764
PAAPaes_1007
PROCPtc2401_01068
PRSB9H02_06355
PROSCHL67_06345
TTKTST_0727(thi1)
TAMTheam_0077
DTEDester_1473
TMATM0787
TMMTmari_0788
TMITHEMA_00715
TMWTHMA_0806
TMQTHMB_0806
TMXTHMC_0806
TPTTpet_0142
TNPTnap_0143
TRQTRQ2_0140
TNACTN_1791
THQT2812B_00715
THZCELL2_00740
THRTRQ7_00715
TLETlet_1750
TTATheth_1374
TMETmel_1590
TAFTHA_1798
THPBG95_08660
THERY592_08765
FNOFnod_1422
FPEFerpe_0640
FIANA23_03490
FRRIB67_05365
NDENIDE1062
NMVNITMOv2_0947
NIONITINOP_1921
NJANSJP_2079
NKFNkreftii_003088
NIFW02_33410
TIDThein_1804
TOPTOPB45_0915
TCMHL41_01820
THETF1847_03705
CTHITHC_0653
TAVG4V39_01630
TMAIFVE67_08730
MJAMJ_0601
MFEMefer_1385
MVUMetvu_1585
MFSMFS40622_1580
MIFMetin_1281
MJHJH146_0825
MESGMLAUSG7_1377(thi)
MESAMLASG1_0803(thi)
MIGMetig_0735 Metig_1112
MMPMMP1352
MMQMmarC5_0226
MMXMmarC6_1321
MMZMmarC7_0597
MMAKMMKA1_15750
MMAOMMOS7_14560
MMADMMJJ_14870
MAEMaeo_0798
MVNMevan_0663
MVOMvol_0738
MOKMetok_0500
METFCFE53_00030
MTHMTH_1620
MMGMTBMA_c02060
MWOMWSIV6_0166(Thi4)
MTEEMTTB_13720
METCMTCT_1479
METEtca_01569
METZMETMT2_1460
METKFVF72_03520
MTHMFZP57_00720
METJFZP68_05735
MEBAbm4_1461
MELMetbo_0536 Metbo_1265
MEWMSWAN_0974 MSWAN_1853
METHMBMB1_1137 MBMB1_1486
MFCBRM9_0713 BRM9_1347
MFIDSM1535_0665 DSM1535_2031
MCUBMCBB_1020 MCBB_1725
MSUBBK009_06380
METNBK008_01970
METTCIT01_06780
METOCIT02_02510 CIT02_10600
MEMEHYG87_01485 HYG87_07505
MFVMfer_0175
MKAMK0430
AFUAF_0702
AFGAFULGI_00007840
APOArcpr_1423
AVEArcve_1405
ASTAsulf_00980
FPLFerp_0628
GACGACE_0145
GAHGAH_01007
PFUPF1530
PFIPFC_06880
PHOPH1357(PH1357)
PABPAB0536(thi1)
PYNPNA2_1583 PNA2_1941
PYAPYCH_06240 PYCH_08650
PYSPy04_1231
PYCTQ32_10505
TKOTK0434
TGATGAM_1270
THEGQS_02015
THMCL1_0036
TLTOCC_06556
THSTES1_1982
TNUBD01_0513
TEUTEU_09505
TGYX802_10050
THVADU37_CDS17350 ADU37_CDS22280
TCHCHITON_1554
TPEPA0127_02260
TPIEA7C91_09070
TCEA3L02_01985
TTDA3L14_05500
TPRFA3L09_06395
TPAFA3L08_06895
THYA3L12_03095
TICFH039_06460
TCQTIRI35C_0994(thi)
THEMFPV09_02920
PPACPAP_08770
MBAMbar_A2100
MBYMSBRM_2409
MBWMSBRW_2643
MBARMSBR2_2375
MBAKMSBR3_2431
MACMA_2851
MMAMM_0222
MMAZMmTuc01_0227
MMJMSMAS_1078
MMACMSMAC_2441
MVCMSVAZ_1117
MEKMSKOL_1072
MLSMSLAZ_1169
METMMSMTP_1119
MEFMSWH1_1762
MEQMSWHS_1554
MSJMSSAC_2840
MSZMSSIH_2497
MSWMSSIT_2540
MTHRMSTHT_0054
MTHEMSTHC_0676
MHORMSHOH_1299
MFZAOB57_002245
MBUMbur_2109
MMETMCMEM_0306 MCMEM_0840
MELOJ7W08_02430 J7W08_11625
MMHMmah_0298
MHAZBHR79_02030
MEVMetev_0188
MZHMzhil_1372
MZIHWN40_08730
MTPMthe_1121
MCJMCON_3229
MHIMhar_2378
MHUMhun_1935
MRTJKHC33_14740
MLAMlab_0277
MEMMemar_2251
MBGBN140_1460(thi1)
MEMAMMAB1_1869
MCHKMchiMG62_25690
MSUMOH143_05540
MPIMpet_0116
MENDL6E24_07545
MFOMetfor_0238
MEZMtc_1604(thi4-1) Mtc_2398(thi4-2)
HALVNG_2604G(thi1)
HSLOE_4651F(thi4)
HHBHhub_1122(thi4)
HAGSJT689_11965
HABOJRZ79_10305
HNOLT974_00705
HLULT972_12875
HANRLJ422_10530
HJEHacjB3_12970
HSUHLASF_0331
HSFHLASA_0330
SALRFQU85_03530
HALREFA46_011875
HAADMW046_08650
HALXM0R89_10525
HAXZM0R88_11005
SALIL593_09560
SAIMK0C01_03160
HARAAArcS_1966(thi4)
HMArrnAC1782(thi1)
HHIHAH_2313(thi1)
HHNHISP_11780
HABSG26_04110
HTABVU17_11255
HALJG9465_07010
HSINKDQ40_01865
NPHNP_5174A(thi4)
NMONmlp_3882(thi4)
NHOHWV23_12010
NSALHWV07_14560
HUTHuta_2718
HTIHTIA_2465
HALAHrd1104_02040
HMUHmuk_0002
HALZE5139_03335
HALLLC1Hm_2563(thi4)
HAZPGBQ70_03335
HALIBV210_05585
HSNDV733_09670
HDSHSR122_2321(thi4)
HRRHZS55_08655
HPELHZS54_09780
HLTI7X12_05325
HARCHARCEL1_09615
HDOMUK72_07875
HWAHQ_1276A(thi4)
HWCHqrw_1306(thi4)
HVOHVO_0665(thi4)
HMEHFX_0634
HGIABY42_03175
HALEG3A49_03390
HLSKU306_07905
HBOHbor_25460
HAQDU484_06390
HAJDU500_06660
HAERDU502_04335
HRAEI982_09275
HLMDV707_12630
HLAHlac_2980
HALBEKH57_08560
HEZZEO776_03960
HALQHrr1229_002890
HSSJ7656_12905
HSAIHPS36_03250
HAZZKI388_01415
SRUBC2R22_02145
HAEhalTADL_1093
HALNB4589_006725
HALGHUG10_03970
HALUHUG12_12960
HMPK6T50_02080
HREK6T36_01900
HRMK6T25_14540
HACBHbl1158_08970
HDFAArcSl_1355(thi4)
HAHHalar_3704
HTUHtur_1462
HDABB347_01930
HSALJMJ58_01385
HLOJ0X27_03870
HAKZJ0X25_14155
NMGNmag_2419(thi4)
HXAHalxa_2863
NATNJ7G_3680
NPENatpe_2830
NVRFEJ81_13195
NPLFGF80_13125
NAYHYG81_16885
HALYHYG82_19015
HJTDVR14_04265
NGENatgr_0926
HRUHalru_1150
NOUNatoc_0532
HLRHALLA_10200
HLCCHINAEXTREME16945
NAJB1756_03455
NAGAArcMg_1121
NANAArc1_2501
NBGDV706_12525
NASGCU68_13250
SAWLNGM29_17530
MELUMTLP_07010
MEAMMU439_01690
ABIAboo_0963
ACFAciM339_1016
APEAPE_2149.1
ACJACAM_1344
SMRSmar_0052 Smar_0180
SHCShell_0764
IHOIgni_0560
IISEYM_05510
IPCIPA_05695
DKADKAM_0713
DFDDesfe_0795
IAGIgag_0295
THGTCELL_1023
HBUHbut_0253
PFMPyrfu_0366
PDLPyrde_0220 Pyrde_0347
STOSTK_03610
SOHD1869_01525
SSOSSO0436
SOLSsol_1411
SSOASULA_1456
SSOLSULB_1457
SSOFSULC_1455
SSHIJ5U23_03002
SCASSACC_05940
SAISaci_0854(thi)
SACNSacN8_04145
SACRSacRon12I_04135
SACSSUSAZ_03885
SISLS215_1798
SIAM1425_1670
SIMM1627_1786
SIDM164_1717
SIYYG5714_1786
SINYN1551_1140
SIILD85_1927
SIHSiH_1645
SIRSiRe_1566
SICSiL_1558
SULABFU36_03640
SULEGFS03_09395
SULOGFS33_01210
SULLEWF20_02995
MSEMsed_2221
MEMJMJ1HA_2541
MCNMcup_0086
MHKDFR87_07430
MPRUDFR88_07115
MTENGWK48_04735
MJNMjAS7_0513
AHOAhos_0692
AMANB6F84_06895
ABRIDFR85_08045
ASULDFR86_05955
AAMBD1866_11245
ACIHHS5_20660
SACDHS1genome_2409
SAZOD1868_02625
CSTYKN1_20130
STEPIC006_1529
SAHSHS7_05390
PAIPAE0175
PISPisl_1998
PCLPcal_1555
PASPars_1498
PYRP186_0936
POGPogu_0708
TNETneu_1052
PYWPYWP30_02101
CMACmaq_1420
TUZTUZN_0079
VDIVdis_2373
VMOVMUT_0723
VSOVsou_21150
FFOFFONT_0392
NMRNmar_0678
NIRNSED_03435
NKRNKOR_03495
NIDNPIRD3C_1584
NINNADRNF5_1474
NIWNisw_01510
NCLC5F47_05695
NOXC5F49_05585
NUEC5F50_04895
NIPNsoK4_05025
NCTNMSP_1025
NICDSQ20_03585
CSYCENSYa_0361
NGANgar_c21660
NVNNVIE_008130
NEVNTE_02257
TAANMY3_02935
NFNNFRAN_0414(thi)
NCVNCAV_0396(thi)
NBVT478_0555
TAHSU86_002805
NIUDSQ19_03795
NDVNDEV_0758
CCAINAS2_0821
KCRKcr_0795
BARBAOA66_0043
FLTSv326_1000
 » show all
Reference
1  [PMID:26919468]
  Authors
Zhang X, Eser BE, Chanani PK, Begley TP, Ealick SE
  Title
Structural Basis for Iron-Mediated Sulfur Transfer in Archael and Yeast Thiazole  Synthases.
  Journal
Biochemistry 55:1826-38 (2016)
DOI:10.1021/acs.biochem.6b00030
  Sequence
[mja:MJ_0601] [mig:Metig_0735]
Reference
2  [PMID:26928142]
  Authors
Eser BE, Zhang X, Chanani PK, Begley TP, Ealick SE
  Title
From Suicide Enzyme to Catalyst: The Iron-Dependent Sulfide Transfer in Methanococcus jannaschii Thiamin Thiazole Biosynthesis.
  Journal
J Am Chem Soc 138:3639-42 (2016)
DOI:10.1021/jacs.6b00445
  Sequence
[mja:MJ_0601]
Other DBs
ExplorEnz - The Enzyme Database: 2.4.2.59
IUBMB Enzyme Nomenclature: 2.4.2.59
ExPASy - ENZYME nomenclature database: 2.4.2.59
BRENDA, the Enzyme Database: 2.4.2.59

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