KEGG   ENZYME: 2.4.2.59Help
Entry
EC 2.4.2.59                 Enzyme                                 

Name
sulfide-dependent adenosine diphosphate thiazole synthase;
Thi4 (ambiguous)
Class
Transferases;
Glycosyltransferases;
Pentosyltransferases
BRITE hierarchy
Sysname
NAD+:glycine ADP-D-ribosyltransferase (sulfide-adding)
Reaction(IUBMB)
NAD+ + glycine + sulfide = nicotinamide + ADP-5-ethyl-4-methylthiazole-2-carboxylate + 3 H2O [RN:R12026]
Reaction(KEGG)
Substrate
NAD+ [CPD:C00003];
glycine [CPD:C00037];
sulfide [CPD:C00283]
Product
nicotinamide [CPD:C00153];
ADP-5-ethyl-4-methylthiazole-2-carboxylate [CPD:C20784];
H2O [CPD:C00001]
Comment
This iron dependent enzyme, found in most archaea, is involved in the biosynthesis of thiamine phosphate. The homologous enzyme from plants and fungi (EC 2.4.2.60, cysteine-dependent adenosine diphosphate thiazole synthase) uses an intrinsic cysteine as sulfur donor and, unlike the archaeal enzyme, is a single turn-over enzyme.
History
EC 2.4.2.59 created 2018
Pathway
ec00730  Thiamine metabolism
ec01100  Metabolic pathways
Orthology
K22699  sulfide-dependent adenosine diphosphate thiazole synthase
Genes
DMA: DMR_31420
DGG: DGI_1133
DAF: Desaf_0994
DOL: Dole_2426
DAL: Dalk_2394
DAO: Desac_0998
DAX: FDQ92_03460
DBR: Deba_1981
HMR: Hipma_0421
DAV: DESACE_08810
CSQ: CSCA_1812
DAU: Daud_0859
TACI: TDSAC_0747
TAI: Taci_1358
TLI: Tlie_1851
PDI: BDI_1609
MBAS: ALGA_3764
PAA: Paes_1007
TTK: TST_0727(thi1)
TMA: TM0787
TMW: THMA_0806
TMQ: THMB_0806
TMX: THMC_0806
TPT: Tpet_0142
TRQ: TRQ2_0140
TNA: CTN_1791
TNP: Tnap_0143
TLE: Tlet_1750
TME: Tmel_1590
TAF: THA_1798
THER: Y592_08765
FNO: Fnod_1422
NDE: NIDE1062
NJA: NSJP_2079
CTHI: THC_0653
MJA: MJ_0601
MMP: MMP1352
MAE: Maeo_0798
MVO: Mvol_0738
MTH: MTH_1620
METC: MTCT_1479
MWO: MWSIV6_0166(Thi4)
METE: tca_01569
MEB: Abm4_1461
MFV: Mfer_0175
MKA: MK0430
AFU: AF_0702
FPL: Ferp_0628
GAC: GACE_0145
GAH: GAH_01007
ABI: Aboo_0963
PHO: PH1357(PH1357)
PAB: PAB0536(thi1)
PFU: PF1530
PFI: PFC_06880
PYS: Py04_1231
TKO: TK0434
TGA: TGAM_1270
THE: GQS_02015
THM: CL1_0036
TLT: OCC_06556
THS: TES1_1982
TNU: BD01_0513
TEU: TEU_09505
PPAC: PAP_08770
MAC: MA_2851
MBAR: MSBR2_2375
MBAK: MSBR3_2431
MMA: MM_0222
MMAC: MSMAC_2441
METM: MSMTP_1119
MTHE: MSTHC_0676
MTHR: MSTHT_0054
MHOR: MSHOH_1299
MBU: Mbur_2109
MMH: Mmah_0298
MTP: Mthe_1121
MCJ: MCON_3229
MHI: Mhar_2378
MHU: Mhun_1935
MLA: Mlab_0277
MBG: BN140_1460(thi1)
MEMA: MMAB1_1869
MPI: Mpet_0116
MEZ: Mtc_1604(thi4-1) Mtc_2398(thi4-2)
HAL: VNG_2604G(thi1)
HSL: OE_4651F(thi4)
HHB: Hhub_1122(thi4)
HMA: rrnAC1782(thi1)
HHI: HAH_2313(thi1)
NPH: NP_5174A(thi4)
NMO: Nmlp_3882(thi4)
HUT: Huta_2718
HTI: HTIA_2465
HMU: Hmuk_0002
HWA: HQ_1276A(thi4)
HWC: Hqrw_1306(thi4)
HVO: HVO_0665(thi4)
HME: HFX_0634
HLA: Hlac_2980
HTU: Htur_1462
NMG: Nmag_2419(thi4)
NAT: NJ7G_3680
SALI: L593_09560
ACJ: ACAM_1344
SMR: Smar_0052
IHO: Igni_0560
IIS: EYM_05510
DKA: DKAM_0713
IAG: Igag_0295
HBU: Hbut_0253
STO: STK_03610
SSO: SSO0436
SOL: Ssol_1411
SSOA: SULA_1456
SSOL: SULB_1457
SSOF: SULC_1455
SAI: Saci_0854(thi)
SID: M164_1717
SII: LD85_1927
SIH: SiH_1645
SIR: SiRe_1566
SIC: SiL_1558
MSE: Msed_2221
MCN: Mcup_0086
AHO: Ahos_0692
PAI: PAE0175
PIS: Pisl_1998
PCL: Pcal_1555
PAS: Pars_1498
PYR: P186_0936
POG: Pogu_0708
TNE: Tneu_1052
CMA: Cmaq_1420
TUZ: TUZN_0079
VDI: Vdis_2373
VMO: VMUT_0723
NMR: Nmar_0678
NCT: NMSP_1025
NEV: NTE_02257
NFN: NFRAN_0414(thi)
NCV: NCAV_0396(thi)
NBV: T478_0555
NDV: NDEV_0758
KCR: Kcr_0795
BARB: AOA66_0043
 » show all
Taxonomy
Reference
1  [PMID:26919468]
  Authors
Zhang X, Eser BE, Chanani PK, Begley TP, Ealick SE
  Title
Structural Basis for Iron-Mediated Sulfur Transfer in Archael and Yeast Thiazole  Synthases.
  Journal
Biochemistry 55:1826-38 (2016)
DOI:10.1021/acs.biochem.6b00030
  Sequence
[mja:MJ_0601] [mig:Metig_0735]
Reference
2  [PMID:26928142]
  Authors
Eser BE, Zhang X, Chanani PK, Begley TP, Ealick SE
  Title
From Suicide Enzyme to Catalyst: The Iron-Dependent Sulfide Transfer in Methanococcus jannaschii Thiamin Thiazole Biosynthesis.
  Journal
J Am Chem Soc 138:3639-42 (2016)
DOI:10.1021/jacs.6b00445
  Sequence
[mja:MJ_0601]
Other DBs
ExplorEnz - The Enzyme Database: 2.4.2.59
IUBMB Enzyme Nomenclature: 2.4.2.59
ExPASy - ENZYME nomenclature database: 2.4.2.59
BRENDA, the Enzyme Database: 2.4.2.59

DBGET integrated database retrieval system