KEGG   ENZYME: 2.4.2.62
Entry
EC 2.4.2.62                 Enzyme                                 
Name
xylosyl alpha-1,3-xylosyltransferase;
XXYLT1 (gene name)
Class
Transferases;
Glycosyltransferases;
Pentosyltransferases
Sysname
UDP-alpha-D-xylose:[EGF-like domain protein]-3-O-[alpha-D-xylosyl-(1->3)-beta-D-glucosyl]-L-serine 3-alpha-D-xylosyltransferase (configuration-retaining)
Reaction(IUBMB)
UDP-alpha-D-xylose + [protein with EGF-like domain]-3-O-[alpha-D-xylosyl-(1->3)-beta-D-glucosyl]-L-serine = UDP + [protein with EGF-like domain]-3-O-[alpha-D-xylosyl-(1->3)-alpha-D-xylosyl-(1->3)-beta-D-glucosyl]-L-serine [RN:R12637]
Reaction(KEGG)
R12637(G)
Substrate
UDP-alpha-D-xylose [CPD:C00190];
[protein with EGF-like domain]-3-O-[alpha-D-xylosyl-(1->3)-beta-D-glucosyl]-L-serine
Product
UDP [CPD:C00015];
[protein with EGF-like domain]-3-O-[alpha-D-xylosyl-(1->3)-alpha-D-xylosyl-(1->3)-beta-D-glucosyl]-L-serine
Comment
The enzyme, found in animals and insects, is involved in the biosynthesis of the alpha-D-xylosyl-(1->3)-alpha-D-xylosyl-(1->3)-beta-D-glucosyl trisaccharide on epidermal growth factor-like (EGF-like) domains. When present on Notch proteins, the trisaccharide functions as a modulator of the signalling activity of this protein.
History
EC 2.4.2.62 created 2020
Pathway
ec00514  Other types of O-glycan biosynthesis
Orthology
K23800  xylosyl alpha-1,3-xylosyltransferase
Genes
HSA152002(XXYLT1)
PTR460947(XXYLT1)
PPS100970153(XXYLT1)
GGO101142478(XXYLT1)
PON100460349(XXYLT1)
NLE100579225(XXYLT1)
MCC708627(XXYLT1)
MCF102136008(XXYLT1)
CSAB103241959(XXYLT1)
CATY105575156(XXYLT1)
PANU101013294(XXYLT1)
TGE112619532(XXYLT1)
RRO104657013(XXYLT1)
RBB108530512(XXYLT1)
TFN117084423(XXYLT1)
PTEH111544311(XXYLT1)
CJC100399864(XXYLT1)
SBQ101049767(XXYLT1)
CSYR103264284(XXYLT1)
MMUR105879789(XXYLT1)
OGA100945058(XXYLT1)
MMU268880(Xxylt1)
MCAL110311553(Xxylt1)
MPAH110329798(Xxylt1)
RNO363799(Xxylt1)
MCOC116085792(Xxylt1)
MUN110557090(Xxylt1)
CGE100760146(Xxylt1)
MAUA101823811(Xxylt1)
PLEU114710019(Xxylt1)
MORG121461950(Xxylt1)
NGI103726562
HGL101724924(Xxylt1)
CPOC100735128(Xxylt1)
CCAN109692776 109692777(Xxylt1)
DORD105987929(Xxylt1)
DSP122099632(Xxylt1)
NCAR124990173 124992852
OCU100338252(XXYLT1)
OPI101518350(XXYLT1)
TUP102500896(XXYLT1)
CFA609818(XXYLT1)
VVP112913548(XXYLT1)
VLG121499549(XXYLT1)
AML100470521(XXYLT1)
UMR103678915(XXYLT1)
UAH113253333(XXYLT1)
UAR123802083(XXYLT1)
ELK111155075
LLV125102375
MPUF101693162(XXYLT1)
ORO101362175(XXYLT1)
EJU114206925(XXYLT1)
ZCA113918662(XXYLT1)
MLX118006958(XXYLT1)
FCA101089207(XXYLT1)
PYU121036418(XXYLT1)
PBG122491590(XXYLT1)
PTG102954768(XXYLT1)
PPAD109266573(XXYLT1)
AJU106976341(XXYLT1)
HHV120230653(XXYLT1)
BTA533703(XXYLT1)
BOM102265999(XXYLT1) 102282131
BIU109556401(XXYLT1)
BBUB102397599(XXYLT1)
CHX102181630(XXYLT1)
OAS105609977(XXYLT1)
ODA120869890(XXYLT1)
CCAD122444696(XXYLT1)
SSC110256394(XXYLT1)
CFR102511937(XXYLT1)
CBAI105072427(XXYLT1)
CDK105101269(XXYLT1)
VPC102528842(XXYLT1)
BACU102999507(XXYLT1)
LVE103078312(XXYLT1)
OOR101269331(XXYLT1)
DLE111172441(XXYLT1)
PCAD102990205(XXYLT1)
PSIU116753542(XXYLT1)
ECB100069238(XXYLT1)
EPZ103552433(XXYLT1)
EAI106843195(XXYLT1)
MYB102244349(XXYLT1)
MYD102759616(XXYLT1)
MMYO118676028(XXYLT1)
MLF102440865(XXYLT1)
MNA107527359(XXYLT1)
PKL118723561(XXYLT1)
HAI109386885(XXYLT1)
DRO112301008(XXYLT1)
SHON118982990(XXYLT1)
AJM119055245(XXYLT1)
PDIC114490825(XXYLT1)
PHAS123827253(XXYLT1)
MMF118617640(XXYLT1)
RFQ117012754(XXYLT1)
PALE102896075(XXYLT1)
PGIG120592840(XXYLT1)
PVP105307702 111733621
RAY107505287(XXYLT1)
MJV108399253(XXYLT1)
TOD119257409(XXYLT1)
SARA101536909(XXYLT1)
LAV104846154(XXYLT1)
TMU101340699
DNM101416896(XXYLT1)
MDO103101409(XXYLT1)
GAS123242002(XXYLT1)
SHR100925178(XXYLT1)
PCW110193092(XXYLT1)
OAA100080620(XXYLT1)
GGA424896(XXYLT1)
PCOC116230860(XXYLT1)
MGP100546151(XXYLT1)
CJO107318249(XXYLT1)
NMEL110398006(XXYLT1)
APLA101796087(XXYLT1)
ACYG106039246(XXYLT1)
AFUL116492402(XXYLT1)
TGU100221149(XXYLT1)
LSR110473868(XXYLT1)
SCAN103815639(XXYLT1)
PMOA120508601(XXYLT1)
OTC121341089(XXYLT1)
PRUF121357943(XXYLT1)
GFR102032493(XXYLT1)
FAB101813758(XXYLT1)
PHI102103383(XXYLT1)
PMAJ107208582(XXYLT1)
CCAE111933472(XXYLT1)
CCW104693481(XXYLT1)
ETL114057622(XXYLT1)
ZAB102061732(XXYLT1)
FPG101911641(XXYLT1)
FCH102047871(XXYLT1)
CLV102093152(XXYLT1)
EGZ104127086(XXYLT1)
NNI104015739(XXYLT1)
ACUN113483453(XXYLT1)
TALA104366424(XXYLT1)
PADL103913852(XXYLT1)
ACHC115346738(XXYLT1)
AAM106485860(XXYLT1)
AROW112962147(XXYLT1)
NPD112947459(XXYLT1)
DNE112981707(XXYLT1)
ASN102370903(XXYLT1)
AMJ102576451(XXYLT1) 109286051
CPOO109308306(XXYLT1)
GGN109287781(XXYLT1)
PSS102452329(XXYLT1)
CMY102941143(XXYLT1)
CPIC101933120(XXYLT1)
TST117882760(XXYLT1)
CABI116823526(XXYLT1)
MRV120371831(XXYLT1)
ACS100556346(xxylt1)
PVT110087099(XXYLT1)
SUND121926921(XXYLT1)
PBI103068189(XXYLT1)
PMUR107291698(XXYLT1)
TSR106551580(XXYLT1)
PGUT117669841(XXYLT1)
VKO123018782(XXYLT1)
PMUA114598177(XXYLT1)
ZVI118093982(XXYLT1)
GJA107125633(XXYLT1)
STOW125427075(XXYLT1)
XLA446386(xxylt1.S)
XTR100495920(xxylt1)
NPR108795948(XXYLT1)
RTEM120936815(XXYLT1)
BBUF120997951(XXYLT1)
BGAR122933959(XXYLT1)
DRE449721(xxylt1)
SRX107715806 107718247
SANH107677510 107685961
SGH107551790(xxylt1) 107581703
CCAR109076241 109098340
CAUA113055328 113110938
PPRM120480807(xxylt1)
MAMB125256592(xxylt1)
IPU108271417(xxylt1)
PHYP113536584(xxylt1)
SMEO124391479(xxylt1)
TFD113658942(xxylt1)
AMEX103024552(xxylt1)
EEE113568717(xxylt1)
TRU101068186(xxylt1)
TNGGSTEN00019852G001 GSTEN00019874G001 GSTEN00024527G001
LCO104917761(xxylt1)
NCC104941403
CGOB115007476(xxylt1)
ELY117254288(xxylt1)
PLEP121941278(xxylt1)
SLUC116055357(xxylt1)
ECRA117951046(xxylt1)
PFLV114561949(xxylt1)
GAT120824028(xxylt1)
PPUG119216399(xxylt1)
MSAM119881901 119900612(xxylt1) 119903385 119915313
CUD121512472(xxylt1)
ALAT119028942(xxylt1)
MZE101466919(xxylt1)
ONL100690495(xxylt1)
OAU116334671(xxylt1)
OLA101163562(xxylt1)
OML112150897(xxylt1)
XMA102231578(xxylt1)
XCO114151515(xxylt1)
XHE116726421(xxylt1)
PRET103463487(xxylt1)
PFOR103130648(xxylt1)
PLAI106948180(xxylt1)
PMEI106930556(xxylt1)
GAF122838711(xxylt1)
CVG107101869(xxylt1)
CTUL119794237(xxylt1)
GMU124873399(xxylt1)
NFU107392723(xxylt1)
KMR108234396(xxylt1)
ALIM106511148(xxylt1)
NWH119430766(xxylt1)
AOCE111569259(xxylt1) 111585648
CSEM103392422(xxylt1)
POV109625868(xxylt1)
SSEN122780724(xxylt1)
HHIP117759775(xxylt1)
HSP118120762(xxylt1)
LCF108881258(xxylt1)
SDU111217564(xxylt1)
SLAL111649488(xxylt1)
XGL120791269(xxylt1)
HCQ109522088(xxylt1)
BPEC110160195(xxylt1)
MALB109958238(xxylt1)
BSPL114854640(xxylt1)
SASA106573863 106613663(xxylt1)
OTW112252170(xxylt1)
OMY110498260(xxylt1)
OGO123998583
ONE115109182
SALP111952861
SNH120053746
ELS105011423(xxylt1)
SFM108937178(xxylt1)
PKI111848178(xxylt1)
AANG118224719(xxylt1)
LOC102697515(xxylt1)
PSPA121307632 121323443 121327319(xxylt1)
ARUT117416976(xxylt1) 117423164
LCM102357578(XXYLT1)
CMK103184429(xxylt1)
RTP109922623 109931054(xxylt1)
BFO118408601
BBEL109486527
CIN100176443
SCLV120326789
SPU115918677 115918680 575308 575517
APLC110976527
SKO100375634
DMEDmel_CG11388(Xxylt)
DER6548393
DSE6615836
DSIDsimw501_GD29218(Dsim_GD29218)
DYADyak_GE14358
DAN6495736
DSR110191656
DPODpse_GA10968
DPE6590999
DMN108160957
DWI6640167
DGR6560070
DMODmoj_GI20695
DAZ108616316
DNV115564424
DHE111600132
MDE101896527
SCAC106085421
LCQ111678025
LSQ119607460
HIS119648628
AGAAgaP_AGAP007604
ACOZ120952943
AARA120893808
ASTE118512092
AAG5571606
AALB109408514
CQUCpipJ_CPIJ000257
CPII120427115
BCOO119080146
AME724932
ACER108002892
ALAB122711485
BIM100749882
BBIF117214485
BVK117242626
BVAN117161231
BTER100643598
BPYO122576432
CCAL108626498
OBB114877841
MGEN117224053
NMEA116430770
CGIG122402252
SOC105204935
MPHA105839668
AEC105152620
ACEP105620818
PBAR105429965
VEM105569072
HST105186701
DQU106749119
CFO105254221
FEX115236631
LHU105669086
PGC109859868
OBO105275640
PCF106789677
PFUC122518881
VPS122634460
NVI100123940
CSOL105363607
TPRE106655456
MDL103580061
FAS105268964
DAM107035736
AGIF122859188
CCIN107266371
TCA660293
DPA109539050
SOY115886385
ATD109599045
CSET123312434
AGB108917065
LDC111510685
NVL108558286
APLN108735005
PPYR116171245
OTU111425250
API100166315
DNX107161488
AGS114128320 114128325
RMD113548568
BTAB109038038
DCI103505046
CLEC106663143
HHAL106689874
NLU111059486
PHUPhum_PHUM498320
FOC113205198
TPAL117644944
ZNE110827477
CSEC111862437
DPXDAPPUDRAFT_210281
DMK116929617 116933696 123474008
PVM113805334
PJA122250183
PCHN125026344
HAME121862950
PCLA123758731
PTRU123514520
HAZT108666219
EAF111697990 111699261 111699263 111699268 111699566 111700863 111708450 111709088 111709097 111711480 111712451 111714345 111715508 111715934
LSM121116899
PPOI119096272 119096274
ISCIscW_ISCW023304
DSV119444486 119444958 119445983 119450235
RSAN119383281 119383282 119390457
RMP119170447 119171742
DPTE113798364
DFR124495123
CSCU111613684 111620252 111620253
PTEP107452048 107453466
SDM118183721 118203439
HROHELRODRAFT_157060
LGILOTGIDRAFT_113431
PCAN112558122
BGT106078720
GAE121390449 121390592
HRF124117741 124117744
HRJ124257495
CRG105318731
MYI110458899
PMAX117314575
MMER123527279
OBI106876761
OSN115224413
LAK106176825
NVE5509033
EPA110254287
ATEN116304657
ADF107337704
AMIL114973463
PDAM113674169
SPIS111332430
DGT114518404
XEN124444210
HMG100205303
TADTRIADDRAFT_50070
 » show all
Reference
1  [PMID:8982869]
  Authors
Minamida S, Aoki K, Natsuka S, Omichi K, Fukase K, Kusumoto S, Hase S
  Title
Detection of UDP-D-xylose: alpha-D-xyloside alpha 1-->3xylosyltransferase activity in human hepatoma cell line HepG2.
  Journal
J Biochem 120:1002-6 (1996)
DOI:10.1093/oxfordjournals.jbchem.a021492
Reference
2  [PMID:22117070]
  Authors
Sethi MK, Buettner FF, Ashikov A, Krylov VB, Takeuchi H, Nifantiev NE, Haltiwanger RS, Gerardy-Schahn R, Bakker H
  Title
Molecular cloning of a xylosyltransferase that transfers the second xylose to O-glucosylated epidermal growth factor repeats of notch.
  Journal
J Biol Chem 287:2739-48 (2012)
DOI:10.1074/jbc.M111.302406
  Sequence
[hsa:152002]
Reference
3  [PMID:26414444]
  Authors
Yu H, Takeuchi M, LeBarron J, Kantharia J, London E, Bakker H, Haltiwanger RS, Li H, Takeuchi H
  Title
Notch-modifying xylosyltransferase structures support an SNi-like retaining mechanism.
  Journal
Nat Chem Biol 11:847-54 (2015)
DOI:10.1038/nchembio.1927
  Sequence
[mmu:268880]
Other DBs
ExplorEnz - The Enzyme Database: 2.4.2.62
IUBMB Enzyme Nomenclature: 2.4.2.62
ExPASy - ENZYME nomenclature database: 2.4.2.62
BRENDA, the Enzyme Database: 2.4.2.62

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