KEGG   ENZYME: 2.4.2.62
Entry
EC 2.4.2.62                 Enzyme                                 

Name
xylosyl alpha-1,3-xylosyltransferase;
XXYLT1 (gene name)
Class
Transferases;
Glycosyltransferases;
Pentosyltransferases
Sysname
UDP-alpha-D-xylose:[EGF-like domain protein]-3-O-[alpha-D-xylosyl-(1->3)-beta-D-glucosyl]-L-serine 3-alpha-D-xylosyltransferase (configuration-retaining)
Reaction(IUBMB)
UDP-alpha-D-xylose + [protein with EGF-like domain]-3-O-[alpha-D-xylosyl-(1->3)-beta-D-glucosyl]-L-serine = UDP + [protein with EGF-like domain]-3-O-[alpha-D-xylosyl-(1->3)-alpha-D-xylosyl-(1->3)-beta-D-glucosyl]-L-serine [RN:R12637]
Reaction(KEGG)
R12637(G)
Substrate
UDP-alpha-D-xylose [CPD:C00190];
[protein with EGF-like domain]-3-O-[alpha-D-xylosyl-(1->3)-beta-D-glucosyl]-L-serine
Product
UDP [CPD:C00015];
[protein with EGF-like domain]-3-O-[alpha-D-xylosyl-(1->3)-alpha-D-xylosyl-(1->3)-beta-D-glucosyl]-L-serine
Comment
The enzyme, found in animals and insects, is involved in the biosynthesis of the alpha-D-xylosyl-(1->3)-alpha-D-xylosyl-(1->3)-beta-D-glucosyl trisaccharide on epidermal growth factor-like (EGF-like) domains. When present on Notch proteins, the trisaccharide functions as a modulator of the signalling activity of this protein.
History
EC 2.4.2.62 created 2020
Pathway
ec00514  Other types of O-glycan biosynthesis
Orthology
K23800  xylosyl alpha-1,3-xylosyltransferase
Genes
HSA: 152002(XXYLT1)
PTR: 460947(XXYLT1)
PPS: 100970153(XXYLT1)
GGO: 101142478(XXYLT1)
PON: 100460349(XXYLT1)
NLE: 100579225(XXYLT1)
MCC: 708627(XXYLT1)
MCF: 102136008(XXYLT1)
CSAB: 103241959(XXYLT1)
CATY: 105575156(XXYLT1)
RRO: 104657013(XXYLT1)
RBB: 108530512(XXYLT1)
TFN: 117084423(XXYLT1)
CJC: 100399864(XXYLT1)
SBQ: 101049767(XXYLT1)
MMUR: 105879789(XXYLT1)
MMU: 268880(Xxylt1)
MCAL: 110311553(Xxylt1)
MPAH: 110329798(Xxylt1)
RNO: 363799(Xxylt1)
MCOC: 116085792(Xxylt1)
MUN: 110557090(Xxylt1)
CGE: 100760146(Xxylt1)
PLEU: 114710019(Xxylt1)
NGI: 103726562
HGL: 101724924(Xxylt1)
CCAN: 109692776 109692777(Xxylt1)
OCU: 100338252(XXYLT1)
TUP: 102500896(XXYLT1)
CFA: 609818(XXYLT1)
VVP: 112913548(XXYLT1)
AML: 100470521(XXYLT1)
UMR: 103678915(XXYLT1)
UAH: 113253333(XXYLT1)
ORO: 101362175(XXYLT1)
ELK: 111155075
MPUF: 101693162(XXYLT1)
EJU: 114206925(XXYLT1)
FCA: 101089207(XXYLT1)
PTG: 102954768(XXYLT1)
PPAD: 109266573(XXYLT1)
AJU: 106976341(XXYLT1)
BTA: 533703(XXYLT1)
BOM: 102265999(XXYLT1) 102282131
BIU: 109556401(XXYLT1)
BBUB: 102397599(XXYLT1)
CHX: 102181630(XXYLT1)
OAS: 105609977(XXYLT1)
SSC: 110256394(XXYLT1)
CFR: 102511937(XXYLT1)
CDK: 105101269(XXYLT1)
BACU: 102999507(XXYLT1)
LVE: 103078312(XXYLT1)
OOR: 101269331(XXYLT1)
DLE: 111172441(XXYLT1)
PCAD: 102990205(XXYLT1)
ECB: 100069238(XXYLT1)
EPZ: 103552433(XXYLT1)
EAI: 106843195(XXYLT1)
MYB: 102244349(XXYLT1)
MYD: 102759616(XXYLT1)
MMYO: 118676028(XXYLT1)
MNA: 107527359(XXYLT1)
HAI: 109386885(XXYLT1)
DRO: 112301008(XXYLT1)
SHON: 118982990(XXYLT1)
AJM: 119055245(XXYLT1)
MMF: 118617640(XXYLT1)
PALE: 102896075(XXYLT1)
RAY: 107505287(XXYLT1)
MJV: 108399253(XXYLT1)
LAV: 104846154(XXYLT1)
TMU: 101340699
MDO: 103101409(XXYLT1)
SHR: 100925178(XXYLT1)
PCW: 110193092(XXYLT1)
OAA: 100080620(XXYLT1)
GGA: 424896(XXYLT1)
MGP: 100546151(XXYLT1)
CJO: 107318249(XXYLT1)
NMEL: 110398006(XXYLT1)
APLA: 101796087(XXYLT1)
ACYG: 106039246(XXYLT1)
TGU: 100221149(XXYLT1)
LSR: 110473868(XXYLT1)
SCAN: 103815639(XXYLT1)
GFR: 102032493(XXYLT1)
FAB: 101813758(XXYLT1)
PHI: 102103383(XXYLT1)
PMAJ: 107208582(XXYLT1)
CCAE: 111933472(XXYLT1)
CCW: 104693481(XXYLT1)
ETL: 114057622(XXYLT1)
FPG: 101911641(XXYLT1)
FCH: 102047871(XXYLT1)
CLV: 102093152(XXYLT1)
EGZ: 104127086(XXYLT1)
NNI: 104015739(XXYLT1)
ACUN: 113483453(XXYLT1)
PADL: 103913852(XXYLT1)
AAM: 106485860(XXYLT1)
ASN: 102370903(XXYLT1)
AMJ: 102576451(XXYLT1) 109286051
PSS: 102452329(XXYLT1)
CMY: 102941143(XXYLT1)
CPIC: 101933120(XXYLT1)
ACS: 100556346(xxylt1)
PVT: 110087099(XXYLT1)
PBI: 103068189(XXYLT1)
PMUR: 107291698(XXYLT1)
TSR: 106551580(XXYLT1)
PMUA: 114598177(XXYLT1)
GJA: 107125633(XXYLT1)
XLA: 446386(xxylt1.S)
XTR: 100495920(xxylt1)
NPR: 108795948(XXYLT1)
DRE: 449721(xxylt1)
SGH: 107551790(xxylt1) 107581703
IPU: 108271417(xxylt1)
PHYP: 113536584(xxylt1)
AMEX: 103024552(xxylt1)
EEE: 113568717(xxylt1)
TRU: 101068186(xxylt1)
LCO: 104917761(xxylt1)
NCC: 104941403
MZE: 101466919(xxylt1)
ONL: 100690495(xxylt1)
OLA: 101163562(xxylt1)
XMA: 102231578(xxylt1)
XCO: 114151515(xxylt1)
PRET: 103463487(xxylt1)
CVG: 107101869(xxylt1)
NFU: 107392723(xxylt1)
KMR: 108234396(xxylt1)
ALIM: 106511148(xxylt1)
AOCE: 111569259(xxylt1) 111585648
CSEM: 103392422(xxylt1)
POV: 109625868(xxylt1)
LCF: 108881258(xxylt1)
SDU: 111217564(xxylt1)
SLAL: 111649488(xxylt1)
HCQ: 109522088(xxylt1)
BPEC: 110160195(xxylt1)
MALB: 109958238(xxylt1)
SASA: 106573863 106613663(xxylt1)
OTW: 112252170
SALP: 111952861
ELS: 105011423(xxylt1)
SFM: 108937178(xxylt1)
PKI: 111848178(xxylt1)
LCM: 102357578(XXYLT1)
CMK: 103184429(xxylt1)
RTP: 109922623 109931054(xxylt1)
BFO: 118408601
CIN: 100176443
APLC: 110976527
SKO: 100375634
DME: Dmel_CG11388(Xxylt)
DER: 6548393
DSE: 6615836
DSI: Dsimw501_GD29218(Dsim_GD29218)
DAN: 6495736
DSR: 110191656
DPE: 6590999
DMN: 108160957
DWI: 6640167
DAZ: 108616316
DNV: 115564424
DHE: 111600132
MDE: 101896527
LCQ: 111678025
AAG: 5571606
AALB: 109408514
AME: 724932
BIM: 100749882
BTER: 100643598
CCAL: 108626498
OBB: 114877841
SOC: 105204935
MPHA: 105839668
AEC: 105152620
ACEP: 105620818
PBAR: 105429965
VEM: 105569072
HST: 105186701
DQU: 106749119
CFO: 105254221
LHU: 105669086
PGC: 109859868
OBO: 105275640
PCF: 106789677
NVI: 100123940
CSOL: 105363607
MDL: 103580061
TCA: 660293
DPA: 109539050
ATD: 109599045
NVL: 108558286
API: 100166315
DNX: 107161488
RMD: 113548568
BTAB: 109038038
CLEC: 106663143
ZNE: 110827477
PVM: 113805334
DPTE: 113798364
PCAN: 112558122
CRG: 105318731
MYI: 110458899
OBI: 106876761
LAK: 106176825
NVE: 5509033
EPA: 110254287
ADF: 107337704
AMIL: 114973463
PDAM: 113674169
SPIS: 111332430
DGT: 114518404
HMG: 100205303
 » show all
Reference
1  [PMID:8982869]
  Authors
Minamida S, Aoki K, Natsuka S, Omichi K, Fukase K, Kusumoto S, Hase S
  Title
Detection of UDP-D-xylose: alpha-D-xyloside alpha 1-->3xylosyltransferase activity in human hepatoma cell line HepG2.
  Journal
J Biochem 120:1002-6 (1996)
DOI:10.1093/oxfordjournals.jbchem.a021492
Reference
2  [PMID:22117070]
  Authors
Sethi MK, Buettner FF, Ashikov A, Krylov VB, Takeuchi H, Nifantiev NE, Haltiwanger RS, Gerardy-Schahn R, Bakker H
  Title
Molecular cloning of a xylosyltransferase that transfers the second xylose to O-glucosylated epidermal growth factor repeats of notch.
  Journal
J Biol Chem 287:2739-48 (2012)
DOI:10.1074/jbc.M111.302406
  Sequence
[hsa:152002]
Reference
3  [PMID:26414444]
  Authors
Yu H, Takeuchi M, LeBarron J, Kantharia J, London E, Bakker H, Haltiwanger RS, Li H, Takeuchi H
  Title
Notch-modifying xylosyltransferase structures support an SNi-like retaining mechanism.
  Journal
Nat Chem Biol 11:847-54 (2015)
DOI:10.1038/nchembio.1927
  Sequence
[mmu:268880]
Other DBs
ExplorEnz - The Enzyme Database: 2.4.2.62
IUBMB Enzyme Nomenclature: 2.4.2.62
ExPASy - ENZYME nomenclature database: 2.4.2.62
BRENDA, the Enzyme Database: 2.4.2.62

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