Entry
Name
tRNA-guanosine34 queuine transglycosylase;
QTRT1 (gene name);
QTRT2 (gene name);
TGT (ambiguous);
guanine insertion enzyme (ambiguous);
tRNA transglycosylase (ambiguous);
Q-insertase (ambiguous);
queuine34 transfer ribonucleate ribosyltransferase;
transfer ribonucleate glycosyltransferase (ambiguous);
tRNA guanine34 transglycosidase (ambiguous);
queuine tRNA-ribosyltransferase;
[tRNA]-guanine34:queuine tRNA-D-ribosyltransferase;
transfer ribonucleic acid guanine34 transglycosylase (ambiguous)
Class
Transferases;
Glycosyltransferases;
Pentosyltransferases
BRITE hierarchy
Sysname
tRNA-guanosine34:queuine tRNA-D-ribosyltransferase
Reaction(IUBMB)
guanine34 in tRNA + queuine = queuine34 in tRNA + guanine [RN:
R03789 ]
Reaction(KEGG)
Substrate
guanine34 in tRNA;
queuine [CPD:
C01449 ]
Product
queuine34 in tRNA;
guanine [CPD:
C00242 ]
Comment
Certain prokaryotic and eukaryotic tRNAs contain the modified base queuine at position 34. In eukaryotes and a small number of prokaryotes queuine is salvaged and incorporated into tRNA directly via a base-exchange reaction, replacing guanine. cf. EC
2.4.2.29 , tRNA-guanosine34 preQ1 transglycosylase.
History
EC 2.4.2.64 created 2020 (EC 2.4.2.29 created 1984, modified 2007, modified 2012, part transferred 2020 to EC 2.4.2.64)
Orthology
K00777 queuine tRNA-ribosyltransferase catalytic subunit
Genes
SHR : 100917837(QTRT1) 116422291
ACHC : 115338391 115348220
SANH : 107661875 107670462
CCAR : 109052182 109052203
MASI : 127450646 127451639
ARUT : 117409793 117965604
LRJ : 133345424 133345687(QTRT1)
LPIC : 129277936 129277937
DSI : Dsimw501_GD23082(Dsim_GD23082)
AALB : 109411099 115267336
ASUA : 134203567 134225589
CFEL : 113376544 113376708
SGRE : 126272962 126315410
PPOI : 119103769 119106840
CBR : CBG_06200(Cbr-tgt-1)
BMY : BM_BM7559(Bma-tgt-1)
RPHI : 132744710 132749524
HSYR : 120156001 120198082
AHF : 112711296 112755781 112770842
QSA : O6P43_015336 O6P43_019611
SSPL : 121784035 121787951
PSOM : 113330574 113332046 113357897
TDC : 119287197 119301900 119310307
TAES : 123104043 123112271 123121793
MFLO : 136541963 136551811
PVIR : 120660706 120695694
SMO : SELMODRAFT_110632 SELMODRAFT_430565
YLI : 2908095(YALI2_F00803g)
NTE : NEUTE1DRAFT121512(NEUTE1DRAFT_121512)
SMP : 10805450(SMAC4_07372)
TATV : 25783326(TrAtP1_012979)
TASP : 36613521(TrAFT101_009771)
MAW : 19244330(J3458_019157)
MBRN : 26242122(G6M90_00g046550)
PLJ : 28883565(PLICBS_000480)
CDET : 87941905(CDEST_05402)
CPW : 9696016(D8B26_004709)
PTRR : 6341249(PtrM4_066180)
ADAC : 96080703(ACET3X_000381)
ABP : AGABI1DRAFT37677(AGABI1DRAFT_37677)
ABV : AGABI2DRAFT69071(AGABI2DRAFT_69071)
SCM : SCHCO_02634555(SCHCODRAFT_02634555)
EHI : EHI_035660(17.t00053)
PLAG : 39741081(PADL01_0715400)
PBRS : 92369041(MKS88_000951)
PTM : GSPATT00020710001 GSPATT00021975001
TCR : 507023.200 511751.30
LMAT : 92513842(LSCM1_03797)
LOI : 92358069(LSCM4_02099)
LEIS : 94178240(GH5_02736)
LENR : 94170330(CUR178_03083)
LEIN : 94187142(JIQ42_03464)
PHET : 94289066(JKF63_02966)
TVA : TVAG_2v0054450 TVAG_2v0240130 TVAG_2v0536770
SSAO : 94299675(SS50377_25652)
» show all
Taxonomy
Reference
Authors
Howes NK, Farkas WR.
Title
Studies with a homogeneous enzyme from rabbit erythrocytes catalyzing the insertion of guanine into tRNA.
Journal
J Biol Chem 253:9082-7 (1978)
Reference
Authors
Shindo-Okada N, Okada N, Ohgi T, Goto T, Nishimura S
Title
Transfer ribonucleic acid guanine transglycosylase isolated from rat liver.
Journal
Reference
Authors
Boland C, Hayes P, Santa-Maria I, Nishimura S, Kelly VP
Title
Queuosine formation in eukaryotic tRNA occurs via a mitochondria-localized heteromeric transglycosylase.
Journal
Sequence
Reference
Authors
Yuan Y, Zallot R, Grove TL, Payan DJ, Martin-Verstraete I, Sepic S, Balamkundu S, Neelakandan R, Gadi VK, Liu CF, Swairjo MA, Dedon PC, Almo SC, Gerlt JA, de Crecy-Lagard V.
Title
Discovery of novel bacterial queuine salvage enzymes and pathways in human pathogens.
Journal
Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.4.2.64
ExPASy - ENZYME nomenclature database: 2.4.2.64