KEGG   ENZYME: 2.4.2.64
Entry
EC 2.4.2.64                 Enzyme                                 

Name
tRNA-guanosine34 queuine transglycosylase;
QTRT1 (gene name);
QTRT2 (gene name);
TGT (ambiguous);
guanine insertion enzyme (ambiguous);
tRNA transglycosylase (ambiguous);
Q-insertase (ambiguous);
queuine34 transfer ribonucleate ribosyltransferase;
transfer ribonucleate glycosyltransferase (ambiguous);
tRNA guanine34 transglycosidase (ambiguous);
queuine tRNA-ribosyltransferase;
[tRNA]-guanine34:queuine tRNA-D-ribosyltransferase;
transfer ribonucleic acid guanine34 transglycosylase (ambiguous)
Class
Transferases;
Glycosyltransferases;
Pentosyltransferases
Sysname
tRNA-guanosine34:queuine tRNA-D-ribosyltransferase
Reaction(IUBMB)
guanine34 in tRNA + queuine = queuine34 in tRNA + guanine [RN:R03789]
Reaction(KEGG)
R03789
Substrate
guanine34 in tRNA;
queuine [CPD:C01449]
Product
queuine34 in tRNA;
guanine [CPD:C00242]
Comment
Certain prokaryotic and eukaryotic tRNAs contain the modified base queuine at position 34. In eukaryotes and a small number of prokaryotes queuine is salvaged and incorporated into tRNA directly via a base-exchange reaction, replacing guanine. cf. EC 2.4.2.29, tRNA-guanosine34 preQ1 transglycosylase.
History
EC 2.4.2.64 created 2020 (EC 2.4.2.29 created 1984, modified 2007, modified 2012, part transferred 2020 to EC 2.4.2.64)
Orthology
K00777  queuine tRNA-ribosyltransferase catalytic subunit
Genes
HSA: 81890(QTRT1)
PTR: 455717(QTRT1)
PPS: 100975608(QTRT1)
GGO: 101154454(QTRT1)
PON: 100444443(QTRT1)
NLE: 100599300(QTRT1)
MCC: 715940(QTRT1)
MCF: 102115330(QTRT1)
CSAB: 103234362(QTRT1)
CATY: 105601458(QTRT1)
RRO: 104670464(QTRT1)
RBB: 108539970(QTRT1)
TFN: 117075432(QTRT1)
CJC: 100411867(QTRT1)
SBQ: 101053078(QTRT1)
MMUR: 105885579(QTRT1)
MMU: 60507(Qtrt1)
MCAL: 110302073(Qtrt1)
MPAH: 110328125(Qtrt1)
RNO: 64016(Qtrt1)
MCOC: 116073357(Qtrt1)
MUN: 110552450(Qtrt1)
CGE: 100771664(Qtrt1)
PLEU: 114695225(Qtrt1)
NGI: 103747548(Qtrt1)
HGL: 101725775(Qtrt1)
CCAN: 109689054(Qtrt1)
OCU: 100348707(QTRT1)
TUP: 102486268(QTRT1)
CFA: 476711(QTRT1)
VVP: 112908096(QTRT1)
AML: 100474205(QTRT1)
UMR: 103678719(QTRT1)
UAH: 113243000(QTRT1)
ORO: 101380771(QTRT1)
ELK: 111162451
MPUF: 101675482(QTRT1)
EJU: 114197726(QTRT1)
FCA: 101096292(QTRT1)
PTG: 102951486(QTRT1)
PPAD: 109254095(QTRT1)
AJU: 106980302(QTRT1)
BTA: 505497(QTRT1)
BOM: 102269615(QTRT1)
BBUB: 102409777(QTRT1)
CHX: 102190121(QTRT1)
OAS: 101119045(QTRT1)
SSC: 100524546(QTRT1)
CFR: 102505536(QTRT1)
CDK: 105087626(QTRT1)
BACU: 103013206(QTRT1)
LVE: 103085623(QTRT1)
OOR: 101281016(QTRT1)
DLE: 111166172(QTRT1)
PCAD: 102991187(QTRT1)
ECB: 100057666(QTRT1)
EPZ: 103562421(QTRT1)
EAI: 106846634(QTRT1)
MYB: 102252641(QTRT1)
MYD: 102769901(QTRT1)
MMYO: 118658971(QTRT1)
MNA: 107533291(QTRT1)
HAI: 109391578(QTRT1)
DRO: 112301579(QTRT1)
AJM: 119055687(QTRT1)
MMF: 118616312(QTRT1)
PALE: 102891985(QTRT1)
RAY: 107515117(QTRT1)
MJV: 108398216(QTRT1)
LAV: 100661071(QTRT1)
TMU: 101353820
MDO: 100011778(QTRT1)
SHR: 100917837(QTRT1) 116422291
PCW: 110214224(QTRT1)
OAA: 100083698(QTRT1)
GGA: 107050606(QTRT1)
CJO: 107307222(QTRT1)
APLA: 113841493
TGU: 115491767(QTRT1)
LSR: 116184701(QTRT1)
PHI: 102103890(QTRT1)
ASN: 102388013(QTRT1)
AMJ: 106737059(QTRT1)
PSS: 102456523(QTRT1)
CMY: 102938523(QTRT1)
CPIC: 101937222(QTRT1)
ACS: 100556886(qtrt1)
PVT: 110078025(QTRT1)
PBI: 103056797(QTRT1)
PMUR: 107298152(QTRT1)
TSR: 106539654(QTRT1)
PMUA: 114587719(QTRT1)
GJA: 107109759(QTRT1)
XLA: 734584(qtrt1.S)
XTR: 394694(qtrt1)
NPR: 108797847(QTRT1)
DRE: 393985(qtrt1)
SGH: 107602698(qtrt1)
IPU: 108257001(qtrt1)
PHYP: 113546205(qtrt1)
AMEX: 103032114(qtrt1)
EEE: 113587306(qtrt1)
TRU: 101077169(qtrt1)
LCO: 104918590(qtrt1)
NCC: 104945819(qtrt1)
MZE: 101473634(qtrt1)
ONL: 100699104(qtrt1)
OLA: 101166387(qtrt1)
XMA: 102224740(qtrt1)
XCO: 114160384(qtrt1)
PRET: 103468778(qtrt1)
CVG: 107093409(qtrt1)
NFU: 107378302(qtrt1)
KMR: 108241278(qtrt1)
ALIM: 106529591(qtrt1)
AOCE: 111573688(qtrt1)
CSEM: 103392727(qtrt1)
POV: 109634183(qtrt1)
LCF: 108902618(qtrt1)
SDU: 111227167(qtrt1)
SLAL: 111653685(qtrt1)
HCQ: 109521451(qtrt1)
BPEC: 110169370(qtrt1)
MALB: 109965920(qtrt1)
SASA: 100380392(qtrt1)
SALP: 111980241(qtrt1)
ELS: 105013084(qtrt1)
SFM: 108935758(qtrt1)
PKI: 111849217(qtrt1)
LCM: 102359857(QTRT1)
RTP: 109917346(qtrt1)
BFO: 118420668
CIN: 100185001
APLC: 110976306
SKO: 100367470
DME: Dmel_CG4947(Tgt)
DER: 6541571
DSE: 6617358
DSI: Dsimw501_GD23082(Dsim_GD23082)
DAN: 6497987
DSR: 110185801
DPE: 6595637
DMN: 108161767
DWI: 6642855
DAZ: 108611522
DNV: 115562151
DHE: 111595851
DVI: 6627534
MDE: 101892666
LCQ: 111685970
AAG: 5574217
AME: 411719
BIM: 100749941
BTER: 100643128
CCAL: 108624278
OBB: 114881519
SOC: 105205254
MPHA: 105829745
AEC: 105143843
ACEP: 105627565
PBAR: 105430955
VEM: 105563264
HST: 105180601
DQU: 106747870
CFO: 105253869
LHU: 105677019
PGC: 109856713
OBO: 105284038
PCF: 106793939
NVI: 100123579
CSOL: 105363287
TCA: 660689
DPA: 109539966
ATD: 109601487
NVL: 108563655
BMOR: 101736624
BMAN: 114252148
PMAC: 106714358
HAW: 110379412
TNL: 113501016
API: 100169167
DNX: 107162526
AGS: 114126904
RMD: 113553103
BTAB: 109044776
CLEC: 106665703
ZNE: 110830643
FCD: 110845705
PVM: 113802034
TUT: 112538462
DPTE: 113791888
CSCU: 111626352
PTEP: 107439662
CEL: CELE_ZK829.6(tgt-1)
CBR: CBG06200(Cbr-tgt-1)
TSP: Tsp_06742
PCAN: 112574329
MYI: 110464409
OBI: 106879987
NVE: 5502103
EPA: 110252722
ADF: 107332948
AMIL: 114947758
PDAM: 113681669
SPIS: 111326609
DGT: 114530376
HMG: 100211412
THJ: 104806793
CPAP: 110816734
CIT: 102616659
TCC: 18592107
GRA: 105785282
GAB: 108483369
EGR: 104447993
VRA: 106759993
VAR: 108330897
VUN: 114164313
CCAJ: 109787925
CAM: 101493451
LJA: Lj1g3v1515820.1(Lj1g3v1515820.1) Lj1g3v4103630.1(Lj1g3v4103630.1) Lj1g3v4103630.2(Lj1g3v4103630.2)
LANG: 109327395
FVE: 101304001
RCN: 112192092
PPER: 18792123
PMUM: 103319572
PAVI: 110751923
MDM: 103436462
PXB: 103962272
ZJU: 107420738
CSV: 101206917
CMO: 103503686
MCHA: 111023258
CMAX: 111476974
CMOS: 111443016
CPEP: 111796751
RCU: 8281696
JCU: 105630652
HBR: 110662862
MESC: 110609228
POP: 7461794
PEU: 105120388
JRE: 109001191
VVI: 100250619
SLY: 101265329
SPEN: 107016207
SOT: 102587790
CANN: 107867442
NSY: 104244094
NTO: 104104993
NAU: 109241757
INI: 109170395
SIND: 105158977
OEU: 111401390
HAN: 110914548
LSV: 111910764
CCAV: 112511508
DCR: 108215784
SOE: 110804024
NNU: 104604272
OSA: 4347331
DOSA: Os09t0469900-01(Os09g0469900)
OBR: 102721303
BDI: 100831593
ATS: 109733234
SBI: 8055996
ZMA: 100273014
SITA: 101765742
EGU: 105058456
DCT: 110116707
PEQ: 110025016
AOF: 109832791
ATR: 18423249
PPP: 112279168
NCR: NCU07015
NTE: NEUTE1DRAFT121512(NEUTE1DRAFT_121512)
MGR: MGG_04110
SSCK: SPSK_05274
MAW: MAC_00019
MAJ: MAA_04847
CMT: CCM_07337
MBE: MBM_02087
ANG: ANI_1_1052124(An14g00580)
PTE: PTT_11067
NPA: UCRNP2_42
ABP: AGABI1DRAFT37677(AGABI1DRAFT_37677)
ABV: AGABI2DRAFT69071(AGABI2DRAFT_69071)
DDI: DDB_G0291802(qtrt1)
DFA: DFA_11372(qtrt1)
EHI: EHI_035660(17.t00053)
PCB: PCHAS_061680(PC300041.00.0)
TAN: TA16175
TPV: TP01_1072
CPV: cgd7_830
SMIN: v1.2.005466.t1(symbB.v1.2.005466.t1)
SPAR: SPRG_04715
 » show all
Reference
1  [PMID:721832]
  Authors
Howes NK, Farkas WR.
  Title
Studies with a homogeneous enzyme from rabbit erythrocytes catalyzing the insertion of guanine into tRNA.
  Journal
J Biol Chem 253:9082-7 (1978)
Reference
2  [PMID:6986171]
  Authors
Shindo-Okada N, Okada N, Ohgi T, Goto T, Nishimura S
  Title
Transfer ribonucleic acid guanine transglycosylase isolated from rat liver.
  Journal
Biochemistry 19:395-400 (1980)
DOI:10.1021/bi00543a023
Reference
3  [PMID:19414587]
  Authors
Boland C, Hayes P, Santa-Maria I, Nishimura S, Kelly VP
  Title
Queuosine formation in eukaryotic tRNA occurs via a mitochondria-localized heteromeric transglycosylase.
  Journal
J Biol Chem 284:18218-27 (2009)
DOI:10.1074/jbc.M109.002477
  Sequence
[mmu:106248]
Reference
4  [PMID:31481610]
  Authors
Yuan Y, Zallot R, Grove TL, Payan DJ, Martin-Verstraete I, Sepic S, Balamkundu S, Neelakandan R, Gadi VK, Liu CF, Swairjo MA, Dedon PC, Almo SC, Gerlt JA, de Crecy-Lagard V.
  Title
Discovery of novel bacterial queuine salvage enzymes and pathways in human pathogens.
  Journal
Proc Natl Acad Sci U S A 116:19126-19135 (2019)
DOI:10.1073/pnas.1909604116
  Sequence
[ctr:CT_193]
Other DBs
ExplorEnz - The Enzyme Database: 2.4.2.64
IUBMB Enzyme Nomenclature: 2.4.2.64
ExPASy - ENZYME nomenclature database: 2.4.2.64
BRENDA, the Enzyme Database: 2.4.2.64
CAS: 72162-89-1

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