KEGG   ENZYME: 2.4.99.22
Entry
EC 2.4.99.22                Enzyme                                 

Name
N-acetylglucosaminide alpha-(2,6)-sialyltransferase;
alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3-N-acetylglucosaminide 6-alpha-sialyltransferase;
N-acetylglucosaminide (alpha 2->6)-sialyltransferase;
ST6GlcNAc
Class
Transferases;
Glycosyltransferases;
Transferring other glycosyl groups
Sysname
CMP-N-acetylneuraminate:N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminide N-acetyl-beta-D-glucosamine-6-alpha-N-acetylneuraminyltransferase (configuration-inverting)
Reaction(IUBMB)
CMP-N-acetyl-beta-neuraminate + N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-R = CMP + N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-[N-acetyl-alpha-neuraminyl-(2->6)]-N-acetyl-beta-D-glucosaminyl-R [RN:R12636]
Reaction(KEGG)
R12636
Substrate
CMP-N-acetyl-beta-neuraminate [CPD:C00128];
N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-R [CPD:C22294]
Product
CMP [CPD:C00055];
N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-[N-acetyl-alpha-neuraminyl-(2->6)]-N-acetyl-beta-D-glucosaminyl-R [CPD:C22295]
Comment
Attaches N-acetylneuraminic acid in alpha-2,6-linkage to N-acetyl-beta-D-glucosamine. The enzyme from rat liver also acts on beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl residues, but more slowly.
History
EC 2.4.99.22 created 2020
Reference
1  [PMID:6547092]
  Authors
Paulson JC, Weinstein J, de Souza-e-Silva U
  Title
Biosynthesis of a disialylated sequence in N-linked oligosaccharides: identification of an N-acetylglucosaminide (alpha 2----6)-sialyltransferase in Golgi apparatus from rat liver.
  Journal
Eur J Biochem 140:523-30 (1984)
DOI:10.1111/j.1432-1033.1984.tb08133.x
Other DBs
ExplorEnz - The Enzyme Database: 2.4.99.22
IUBMB Enzyme Nomenclature: 2.4.99.22
ExPASy - ENZYME nomenclature database: 2.4.99.22
BRENDA, the Enzyme Database: 2.4.99.22

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