KEGG   ENZYME: 2.4.99.8Help
Entry
EC 2.4.99.8                 Enzyme                                 

Name
alpha-N-acetylneuraminate alpha-2,8-sialyltransferase;
cytidine monophosphoacetylneuraminate-ganglioside GM3;
alpha-2,8-sialyltransferase;
ganglioside GD3 synthase;
ganglioside GD3 synthetase sialyltransferase;
CMP-NeuAc:LM1(alpha2-8) sialyltranferase;
GD3 synthase;
SAT-2
Class
Transferases;
Glycosyltransferases;
Transferring other glycosyl groups
BRITE hierarchy
Sysname
CMP-N-acetylneuraminate:alpha-N-acetylneuraminyl-(2->3)-beta-D-galactoside alpha-(2->8)-N-acetylneuraminyltransferase
Reaction(IUBMB)
CMP-N-acetylneuraminate + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-R = CMP + alpha-N-acetylneuraminyl-(2->8)-alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-R [RN:R04564]
Reaction(KEGG)
Substrate
CMP-N-acetylneuraminate [CPD:C00128];
alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-R
Product
CMP [CPD:C00055];
alpha-N-acetylneuraminyl-(2->8)-alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-R
Comment
Gangliosides act as acceptors.
History
EC 2.4.99.8 created 1984, modified 1986
Pathway
ec00601  Glycosphingolipid biosynthesis - lacto and neolacto series
ec00603  Glycosphingolipid biosynthesis - globo and isoglobo series
ec00604  Glycosphingolipid biosynthesis - ganglio series
ec01100  Metabolic pathways
Orthology
K03371  alpha-N-acetyl-neuraminate alpha-2,8-sialyltransferase (sialyltransferase 8A)
Genes
HSA: 6489(ST8SIA1)
PTR: 465341(ST8SIA1)
PPS: 100970748(ST8SIA1)
GGO: 101134419(ST8SIA1)
PON: 100455082(ST8SIA1)
NLE: 100588840(ST8SIA1)
MCC: 706707(ST8SIA1)
MCF: 102118571(ST8SIA1)
CSAB: 103218743(ST8SIA1)
RRO: 104660754(ST8SIA1)
RBB: 108541110(ST8SIA1)
SBQ: 101042881(ST8SIA1)
MMU: 20449(St8sia1)
MCAL: 110296666(St8sia1)
MPAH: 110316454(St8sia1)
RNO: 25280(St8sia1)
MUN: 110560539(St8sia1)
CGE: 100768920(St8sia1)
NGI: 103736726(St8sia1)
HGL: 101696963(St8sia1)
CCAN: 109700114(St8sia1)
OCU: 100351155(ST8SIA1)
TUP: 102468919(ST8SIA1)
CFA: 477672(ST8SIA1)
VVP: 112917220(ST8SIA1)
AML: 100464397(ST8SIA1)
UMR: 103665233(ST8SIA1)
UAH: 113257801(ST8SIA1)
ORO: 101366887(ST8SIA1)
ELK: 111159987
FCA: 101093029(ST8SIA1)
PTG: 102962819(ST8SIA1)
PPAD: 109268731(ST8SIA1)
AJU: 106967976(ST8SIA1)
BTA: 282352(ST8SIA1)
BOM: 102273511(ST8SIA1)
BIU: 109559591(ST8SIA1)
BBUB: 102401968(ST8SIA1)
CHX: 102187381(ST8SIA1)
OAS: 101117321(ST8SIA1)
SSC: 100625270(ST8SIA1)
CFR: 102512853(ST8SIA1)
CDK: 105096526(ST8SIA1)
BACU: 103009301(ST8SIA1)
LVE: 103076775(ST8SIA1)
OOR: 101285691(ST8SIA1)
DLE: 111176840(ST8SIA1)
PCAD: 102987127(ST8SIA1)
ECB: 100064415(ST8SIA1)
EPZ: 103540886 103554941(ST8SIA1)
EAI: 106825576(ST8SIA1)
MYB: 102249041(ST8SIA1)
MYD: 102758116(ST8SIA1) 102769678
MNA: 107525320(ST8SIA1)
HAI: 109375156(ST8SIA1) 109377322
DRO: 112318440(ST8SIA1)
PALE: 102892181(ST8SIA1)
RAY: 107508581(ST8SIA1)
MJV: 108386987 108398355(ST8SIA1)
LAV: 100659787(ST8SIA1)
TMU: 101359255
MDO: 100011205(ST8SIA1)
SHR: 100920916(ST8SIA1)
PCW: 110213804(ST8SIA1)
OAA: 100080234(ST8SIA1)
GGA: 395860(ST8SIA1)
MGP: 100547921(ST8SIA1)
CJO: 107317147(ST8SIA1)
NMEL: 110396210(ST8SIA1)
APLA: 101797310(ST8SIA1)
ACYG: 106038258(ST8SIA1)
TGU: 100225976(ST8SIA1)
LSR: 110470391(ST8SIA1)
SCAN: 103820535(ST8SIA1)
GFR: 102037290(ST8SIA1)
FAB: 101806998(ST8SIA1)
PHI: 102111773(ST8SIA1)
PMAJ: 107204564(ST8SIA1)
CCAE: 111923319(ST8SIA1)
CCW: 104692305(ST8SIA1)
ETL: 114069418(ST8SIA1)
FPG: 101922614(ST8SIA1)
FCH: 102056471(ST8SIA1)
CLV: 102093502(ST8SIA1)
EGZ: 104135090(ST8SIA1)
NNI: 104012705(ST8SIA1)
ACUN: 113487646(ST8SIA1)
PADL: 103924330(ST8SIA1)
AAM: 106488295(ST8SIA1)
ASN: 102378302(ST8SIA1)
AMJ: 102562267(ST8SIA1)
PSS: 102462829(ST8SIA1)
CMY: 102943965(ST8SIA1)
CPIC: 101937464(ST8SIA1)
ACS: 100337536(st8sia1)
PVT: 110091198(ST8SIA1)
PBI: 103065178(ST8SIA1)
PMUR: 107295788(ST8SIA1)
TSR: 106547779(ST8SIA1)
PMUA: 114605143(ST8SIA1)
GJA: 107105667 107114868(ST8SIA1)
XLA: 108712513 398735(st8sia1.L)
XTR: 444887(st8sia1)
NPR: 108789703 108789879(ST8SIA1) 108800295
DRE: 553210(st8sia1)
SRX: 107748471 107755164
SANH: 107689712(st8sia1)
SGH: 107567669 107597015
CCAR: 109045336 109066147 109081950
IPU: 108279455(ST8SIA1) 108279490
PHYP: 113531749(st8sia1)
AMEX: 103035159(st8sia1)
EEE: 113584008(st8sia1)
TRU: 445978(st8sia1)
TNG: GSTEN00020858G001
LCO: 109141779(st8sia1)
NCC: 104958359(st8sia1)
MZE: 101480363(st8sia1)
ONL: 100695121(st8sia1)
OLA: 100049518(st8sia1)
XMA: 102218717(st8sia1)
XCO: 114141471(st8sia1)
PRET: 103459243(st8sia1)
CVG: 107085992(st8sia1)
NFU: 107379800(st8sia1)
KMR: 108235108(st8sia1)
ALIM: 106533543(st8sia1)
AOCE: 111571510(st8sia1)
CSEM: 103382754(st8sia1)
POV: 109632888(st8sia1)
LCF: 108879661(st8sia1)
SDU: 111224971(st8sia1)
SLAL: 111671912(st8sia1)
HCQ: 109523778(st8sia1)
BPEC: 110170325(st8sia1)
MALB: 109959852(st8sia1)
SASA: 106595526 106609639(st8sia1) 106609665 106609667
OTW: 112242451
SALP: 112077331
ELS: 105020361(st8sia1)
SFM: 108936438 108942102
PKI: 111846118 111846528
LCM: 102350065(ST8SIA1)
CMK: 103181078(st8sia1)
RTP: 109917984(st8sia1)
BFO: BRAFLDRAFT_118664 BRAFLDRAFT_168206 BRAFLDRAFT_199386 BRAFLDRAFT_203706 BRAFLDRAFT_209885 BRAFLDRAFT_225153 BRAFLDRAFT_230705 BRAFLDRAFT_232264 BRAFLDRAFT_241511 BRAFLDRAFT_246955 BRAFLDRAFT_249937 BRAFLDRAFT_280843 BRAFLDRAFT_83348 BRAFLDRAFT_90107 BRAFLDRAFT_96267
SPU: 586329(sia4)
SKO: 100369631 100373622 100373774 100373922 102803225 102803450 102807345
 » show all
Taxonomy
Reference
1  [PMID:7407217]
  Authors
Eppler CM, Morre DJ, Keenan TW.
  Title
Ganglioside biosynthesis in rat liver: alteration of sialyltransferase activities by nucleotides.
  Journal
Biochim Biophys Acta 619:332-43 (1980)
DOI:10.1016/0005-2760(80)90081-8
Reference
2  [PMID:3838172]
  Authors
Higashi H, Basu M, Basu S.
  Title
Biosynthesis in vitro of disialosylneolactotetraosylceramide by a solubilized sialyltransferase from embryonic chicken brain.
  Journal
J Biol Chem 260:824-8 (1985)
Reference
3  [PMID:4044605]
  Authors
McCoy RD, Vimr ER, Troy FA.
  Title
CMP-NeuNAc:poly-alpha-2,8-sialosyl sialyltransferase and the biosynthesis of polysialosyl units in neural cell adhesion molecules.
  Journal
J Biol Chem 260:12695-9 (1985)
Reference
4  [PMID:6766128]
  Authors
Yohe HC, Yu RK.
  Title
In vitro biosynthesis of an isomer of brain trisialoganglioside, GT1a.
  Journal
J Biol Chem 255:608-13 (1980)
Other DBs
ExplorEnz - The Enzyme Database: 2.4.99.8
IUBMB Enzyme Nomenclature: 2.4.99.8
ExPASy - ENZYME nomenclature database: 2.4.99.8
BRENDA, the Enzyme Database: 2.4.99.8
CAS: 67339-00-8

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Pathway (9)   
   KEGG PATHWAY (8)   
   KEGG MODULE (1)   
Chemical substance (29)   
   KEGG COMPOUND (14)   
   KEGG GLYCAN (15)   
Chemical reaction (15)   
   KEGG REACTION (13)   
   KEGG RCLASS (2)   
Gene (342)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (186)   
   KEGG MGENES (90)   
   RefGene (65)   
Protein sequence (51)   
   UniProt (30)   
   SWISS-PROT (6)   
   RefSeq(pep) (14)   
   PMD (1)   
DNA sequence (67)   
   RefSeq(nuc) (14)   
   GenBank (27)   
   EMBL (26)   
All databases (513)   

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