KEGG   ENZYME: 2.4.99.8
Entry
EC 2.4.99.8                 Enzyme                                 

Name
alpha-N-acetylneuraminate alpha-2,8-sialyltransferase;
cytidine monophosphoacetylneuraminate-ganglioside GM3;
alpha-2,8-sialyltransferase;
ganglioside GD3 synthase;
ganglioside GD3 synthetase sialyltransferase;
CMP-NeuAc:LM1(alpha2-8) sialyltranferase;
GD3 synthase;
SAT-2
Class
Transferases;
Glycosyltransferases;
Transferring other glycosyl groups
Sysname
CMP-N-acetylneuraminate:alpha-N-acetylneuraminyl-(2->3)-beta-D-galactoside alpha-(2->8)-N-acetylneuraminyltransferase
Reaction(IUBMB)
CMP-N-acetylneuraminate + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-R = CMP + alpha-N-acetylneuraminyl-(2->8)-alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-R [RN:R04564]
Reaction(KEGG)
R04564 > R04583 R05940(G) R05947(G) R06032(G);
(other) R04632 R04649 R04661 R05113 R05995(G) R06000(G) R06005(G) R06009(G)
Substrate
CMP-N-acetylneuraminate [CPD:C00128];
alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-R
Product
CMP [CPD:C00055];
alpha-N-acetylneuraminyl-(2->8)-alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-R
Comment
Gangliosides act as acceptors.
History
EC 2.4.99.8 created 1984, modified 1986
Pathway
ec00601  Glycosphingolipid biosynthesis - lacto and neolacto series
ec00603  Glycosphingolipid biosynthesis - globo and isoglobo series
ec00604  Glycosphingolipid biosynthesis - ganglio series
ec01100  Metabolic pathways
Orthology
K03371  alpha-N-acetyl-neuraminate alpha-2,8-sialyltransferase (sialyltransferase 8A)
Genes
HSA: 6489(ST8SIA1)
PTR: 465341(ST8SIA1)
PPS: 100970748(ST8SIA1)
GGO: 101134419(ST8SIA1)
PON: 100455082(ST8SIA1)
NLE: 100588840(ST8SIA1)
MCC: 706707(ST8SIA1)
MCF: 102118571(ST8SIA1)
CSAB: 103218743(ST8SIA1)
CATY: 105585055(ST8SIA1)
PANU: 101010038(ST8SIA1)
RRO: 104660754(ST8SIA1)
RBB: 108541110(ST8SIA1)
TFN: 117090396(ST8SIA1)
PTEH: 111540637(ST8SIA1)
SBQ: 101042881(ST8SIA1)
MMUR: 105882799(ST8SIA1)
MMU: 20449(St8sia1)
MCAL: 110296666(St8sia1)
MPAH: 110316454(St8sia1)
RNO: 25280(St8sia1)
MCOC: 116099770(St8sia1)
MUN: 110560539(St8sia1)
CGE: 100768920(St8sia1)
PLEU: 114700282(St8sia1)
NGI: 103736726(St8sia1)
HGL: 101696963(St8sia1)
CCAN: 109700114(St8sia1)
OCU: 100351155(ST8SIA1)
OPI: 101532071(ST8SIA1)
TUP: 102468919(ST8SIA1)
CFA: 477672(ST8SIA1)
VVP: 112917220(ST8SIA1)
VLG: 121480215(ST8SIA1)
AML: 100464397(ST8SIA1)
UMR: 103665233(ST8SIA1)
UAH: 113257801(ST8SIA1)
ORO: 101366887(ST8SIA1)
ELK: 111159987
MPUF: 101693103(ST8SIA1)
EJU: 114216633(ST8SIA1)
MLX: 118025582(ST8SIA1)
FCA: 101093029(ST8SIA1)
PYU: 121038820(ST8SIA1)
PBG: 122473547(ST8SIA1)
PTG: 102962819(ST8SIA1)
PPAD: 109268731(ST8SIA1)
AJU: 106967976(ST8SIA1)
HHV: 120236008(ST8SIA1)
BTA: 282352(ST8SIA1)
BOM: 102273511(ST8SIA1)
BIU: 109559591(ST8SIA1)
BBUB: 102401968(ST8SIA1)
CHX: 102187381(ST8SIA1)
OAS: 101117321(ST8SIA1)
ODA: 120858934(ST8SIA1)
CCAD: 122423333(ST8SIA1)
SSC: 100625270(ST8SIA1)
CFR: 102512853(ST8SIA1)
CBAI: 105062287(ST8SIA1)
CDK: 105096526(ST8SIA1)
BACU: 103009301(ST8SIA1)
LVE: 103076775(ST8SIA1)
OOR: 101285691(ST8SIA1)
DLE: 111176840(ST8SIA1)
PCAD: 102987127(ST8SIA1)
ECB: 100064415(ST8SIA1) 111772030 111772221 111772374
EPZ: 103554941(ST8SIA1)
EAI: 106825576(ST8SIA1)
MYB: 102249041(ST8SIA1)
MYD: 102769678
MMYO: 118650342(ST8SIA1)
MNA: 107525320(ST8SIA1)
HAI: 109375156(ST8SIA1)
DRO: 112318440(ST8SIA1)
SHON: 118978440(ST8SIA1)
AJM: 119048980(ST8SIA1)
MMF: 118624046(ST8SIA1)
PALE: 102892181(ST8SIA1)
PGIG: 120618362(ST8SIA1)
RAY: 107508581(ST8SIA1)
MJV: 108398355(ST8SIA1)
TOD: 119247638(ST8SIA1)
LAV: 100659787(ST8SIA1)
TMU: 101359255
MDO: 100011205(ST8SIA1)
SHR: 100920916(ST8SIA1)
PCW: 110213804(ST8SIA1)
OAA: 100080234(ST8SIA1)
GGA: 395860(ST8SIA1)
PCOC: 116231405(ST8SIA1)
MGP: 100547921(ST8SIA1)
CJO: 107317147(ST8SIA1)
NMEL: 110396210(ST8SIA1)
APLA: 101797310(ST8SIA1)
ACYG: 106038258(ST8SIA1)
TGU: 100225976(ST8SIA1)
LSR: 110470391(ST8SIA1)
SCAN: 103820535(ST8SIA1)
PMOA: 120497130(ST8SIA1)
OTC: 121332784(ST8SIA1)
PRUF: 121362718(ST8SIA1)
GFR: 102037290(ST8SIA1)
FAB: 101806998(ST8SIA1)
PHI: 102111773(ST8SIA1)
PMAJ: 107204564(ST8SIA1)
CCAE: 111923319(ST8SIA1)
CCW: 104692305(ST8SIA1)
ETL: 114069418(ST8SIA1)
FPG: 101922614(ST8SIA1)
FCH: 102056471(ST8SIA1)
CLV: 102093502(ST8SIA1)
EGZ: 104135090(ST8SIA1)
NNI: 104012705(ST8SIA1)
ACUN: 113487646(ST8SIA1)
PADL: 103924330(ST8SIA1)
AAM: 106488295(ST8SIA1)
AROW: 112966614(ST8SIA1)
NPD: 112944369(ST8SIA1)
DNE: 112978905(ST8SIA1)
ASN: 102378302(ST8SIA1)
AMJ: 102562267(ST8SIA1)
CPOO: 109316395(ST8SIA1)
GGN: 109296296(ST8SIA1)
PSS: 102462829(ST8SIA1)
CMY: 102943965(ST8SIA1)
CPIC: 101937464(ST8SIA1)
TST: 117883367(ST8SIA1)
CABI: 116835477(ST8SIA1)
ACS: 100337536(st8sia1)
PVT: 110091198(ST8SIA1)
PBI: 103065178(ST8SIA1)
PMUR: 107295788(ST8SIA1)
TSR: 106547779(ST8SIA1)
PGUT: 117679860(ST8SIA1)
PMUA: 114605143(ST8SIA1)
ZVI: 118091196(ST8SIA1)
GJA: 107105667
XLA: 108712513(st8sia1.S) 398735(st8sia1.L)
XTR: 444887(st8sia1)
NPR: 108789879(ST8SIA1)
DRE: 553210(st8sia1)
SRX: 107748471 107755164
SANH: 107689712(st8sia1)
SGH: 107567669
CCAR: 109045336 109066147
CAUA: 113048254 113061141
IPU: 108279455(ST8SIA1) 108279490
PHYP: 113531749(st8sia1)
AMEX: 103035159(st8sia1)
EEE: 113584008(st8sia1)
TRU: 445978(st8sia1)
TNG: GSTEN00020858G001
LCO: 109141779(st8sia1)
NCC: 104958359(st8sia1)
CGOB: 115028360(st8sia1)
ELY: 117249341(st8sia1)
PLEP: 121961498(st8sia1)
SLUC: 116060120(st8sia1)
ECRA: 117938764(st8sia1)
PFLV: 114550187(st8sia1)
GAT: 100174872
PPUG: 119211090(st8sia1)
MSAM: 119918439(st8sia1)
CUD: 121505444(st8sia1)
MZE: 101480363(st8sia1)
ONL: 100695121(st8sia1)
OAU: 116309833(st8sia1)
OLA: 100049518(st8sia1)
OML: 112155472(st8sia1)
XMA: 102218717(st8sia1)
XCO: 114141471(st8sia1)
XHE: 116736502(st8sia1)
PRET: 103459243(st8sia1)
CVG: 107085992(st8sia1)
CTUL: 119785664(st8sia1)
NFU: 107379800(st8sia1)
KMR: 108235108(st8sia1)
ALIM: 106533543(st8sia1)
AOCE: 111571510(st8sia1)
CSEM: 103382754(st8sia1)
POV: 109632888(st8sia1)
LCF: 108879661(st8sia1)
SDU: 111224971(st8sia1)
SLAL: 111671912(st8sia1)
XGL: 120802191(st8sia1)
HCQ: 109523778(st8sia1)
BPEC: 110170325(st8sia1)
MALB: 109959852(st8sia1)
SASA: 106595526 106609639(st8sia1)
OTW: 112242451(st8sia1)
OMY: 110499835 118936578
SNH: 120036006 120040271
ELS: 105020361(st8sia1)
SFM: 108936438 108942102
PKI: 111846118 111846528
AANG: 118219081(st8sia1) 118231201
LOC: 102694617(st8sia1)
PSPA: 121318379 121319722
ARUT: 117414707 117419486
LCM: 102350065(ST8SIA1)
CMK: 103181078(st8sia1)
RTP: 109917984(st8sia1)
BBEL: 109463850 109463990 109465327 109472725 109473642 109474070 109479623 109485017 109485347
 » show all
Reference
1  [PMID:7407217]
  Authors
Eppler CM, Morre DJ, Keenan TW.
  Title
Ganglioside biosynthesis in rat liver: alteration of sialyltransferase activities by nucleotides.
  Journal
Biochim Biophys Acta 619:332-43 (1980)
DOI:10.1016/0005-2760(80)90081-8
Reference
2  [PMID:3838172]
  Authors
Higashi H, Basu M, Basu S.
  Title
Biosynthesis in vitro of disialosylneolactotetraosylceramide by a solubilized sialyltransferase from embryonic chicken brain.
  Journal
J Biol Chem 260:824-8 (1985)
Reference
3  [PMID:4044605]
  Authors
McCoy RD, Vimr ER, Troy FA.
  Title
CMP-NeuNAc:poly-alpha-2,8-sialosyl sialyltransferase and the biosynthesis of polysialosyl units in neural cell adhesion molecules.
  Journal
J Biol Chem 260:12695-9 (1985)
Reference
4  [PMID:6766128]
  Authors
Yohe HC, Yu RK.
  Title
In vitro biosynthesis of an isomer of brain trisialoganglioside, GT1a.
  Journal
J Biol Chem 255:608-13 (1980)
Other DBs
ExplorEnz - The Enzyme Database: 2.4.99.8
IUBMB Enzyme Nomenclature: 2.4.99.8
ExPASy - ENZYME nomenclature database: 2.4.99.8
BRENDA, the Enzyme Database: 2.4.99.8
CAS: 67339-00-8

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Pathway (9)   
   KEGG PATHWAY (8)   
   KEGG MODULE (1)   
Chemical substance (29)   
   KEGG COMPOUND (14)   
   KEGG GLYCAN (15)   
Chemical reaction (15)   
   KEGG REACTION (13)   
   KEGG RCLASS (2)   
Gene (380)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (228)   
   KEGG MGENES (86)   
   RefGene (65)   
Protein sequence (53)   
   UniProt (30)   
   SWISS-PROT (6)   
   RefSeq(pep) (16)   
   PMD (1)   
DNA sequence (69)   
   RefSeq(nuc) (16)   
   GenBank (27)   
   EMBL (26)   
Protein domain (3)   
   InterPro (3)   
All databases (558)   

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