KEGG   ENZYME: 2.5.1.101
Entry
EC 2.5.1.101                Enzyme                                 

Name
N,N'-diacetyllegionaminate synthase;
neuB (gene name);
legI (gene name)
Class
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
Sysname
phosphoenolpyruvate:2,4-diacetamido-2,4,6-trideoxy-alpha-D-mannopyranose 1-(2-carboxy-2-oxoethyl)transferase
Reaction(IUBMB)
2,4-diacetamido-2,4,6-trideoxy-alpha-D-mannopyranose + phosphoenolpyruvate + H2O = N,N'-diacetyllegionaminate + phosphate [RN:R10304]
Reaction(KEGG)
R10304
Substrate
2,4-diacetamido-2,4,6-trideoxy-alpha-D-mannopyranose [CPD:C20424];
phosphoenolpyruvate [CPD:C00074];
H2O [CPD:C00001]
Product
N,N'-diacetyllegionaminate [CPD:C20418];
phosphate [CPD:C00009]
Comment
Requires a divalent metal such as Mn2+. Isolated from the bacteria Legionella pneumophila and Campylobacter jejuni, where it is involved in the biosynthesis of legionaminic acid, a virulence-associated, cell surface sialic acid-like derivative.
History
EC 2.5.1.101 created 2012
Pathway
ec00520  Amino sugar and nucleotide sugar metabolism
ec01100  Metabolic pathways
Orthology
K18430  N,N'-diacetyllegionaminate synthase
Genes
PMAI: CF386_03205(neuB)
SKH: STH12_02025(legI_1)
COZ: A3Q34_06165
PTU: PTUN_a3149(neuB)
MLQ: ASQ50_04385
MARJ: MARI_04460(legI)
ASP: AOR13_2481
ASQ: AVL57_11080
AAW: AVL56_10220
ALE: AV939_10100
LPN: lpg0752(neuB)
LPH: LPV_0878(neuB)
LPO: LPO_0833(neuB)
LPM: LP6_0732(neuB)
LPF: lpl0789(neuB)
LPP: lpp0818(neuB)
LPC: LPC_2540(neuB)
LPA: lpa_01160
LPE: lp12_0762
LCD: clem_09455(neuB_2)
LWA: SAMEA4504053_1066(spsE)
FPH: Fphi_1167
FPI: BF30_1411(neuB)
FPX: KU46_147(neuB)
FHA: CDV26_09130(neuB)
FRC: KX01_1747(neuB)
TCX: Tcr_1458
HTR: EPV75_07835(neuB)
HMAR: HVMH_1511(spsE)
THIG: FE785_07450(neuB)
TEE: Tel_08595
TBN: TBH_C0740
CARI: FNU76_04765(neuB)
POS: DT070_03545(neuB)
JAJ: EKL02_02185(neuB)
TIN: Tint_2652
THI: THI_3181
METR: BSY238_2009(neuB)
ACOM: CEW83_19880(neuB)
HCP: HCN_1148
SULR: B649_08560
CJE: Cj1327(neuB2)
CJB: BN148_1327(neuB2)
CJI: CJSA_1263(neuB2)
CJS: CJS3_1421
CJEJ: N564_02255
CJEU: N565_02345
CJEN: N755_02405
CJEI: N135_01415
CJER: H730_07590
CJY: QZ67_01463(legI_2)
CJQ: UC78_1270(legI)
CJR: CJE1516(ptmC)
CJD: JJD26997_0385(ptmC)
CCO: CCC13826_2303(legI)
CCOC: CCON33237_1630(legI)
CLA: CLA_1235(legI)
CCQ: N149_1290(legI)
CCF: YSQ_02215
CCY: YSS_07200
CCOI: YSU_02250
CCOF: VC76_06660(legI)
CCOO: ATE51_00910(legI)
CAJ: CIG1485E_0029(legI)
CIS: CINS_1194(legI)
CVO: CVOL_1214(legI)
CSM: CSUB8521_1417(legI)
CSF: CSUB8523_1517(legI)
CHV: CHELV3228_1655(legI)
CLX: CLAN_1241(legI)
CAVI: CAV_1241(legI)
CAMZ: CVIC12175_0322(legI)
CAMY: CSUIS_1328(legI)
COJ: CORN_1305(legI)
ABT: ABED_0620
ATP: ATR_1813
AELL: AELL_2683
APAI: APAC_2452
HBV: ABIV_2490
ARC: ABLL_0809
GLO: Glov_3405
DVL: Dvul_2590
DDE: Dde_3681
DFL: DFE_2603
DAS: Daes_1985
DPI: BN4_12680
DAL: Dalk_1661
DTO: TOL2_C35400(neuB)
EMX: FKV68_30710(neuB)
RHT: NT26_3141(neuB)
DEI: C4375_03855(neuB)
DEA: FPZ08_13230(neuB)
RBM: TEF_17315
FAQ: G5B39_16690(neuB)
MAGX: XM1_0956
MAGQ: MGMAQ_1137
MGM: Mmc1_0562
BST: GYO_4022
PPY: PPE_04401
KEB: GXN75_11660(neuB)
EFU: HMPREF0351_10916(neuB)
CARC: NY10_960
CBL: CLK_2101
CBK: CLL_A1556
CBB: CLD_1854
CBN: CbC4_0996
CBT: CLH_1466
CTAE: BGI42_06575(neuB)
CALE: FDN13_00880(neuB)
CRS: FQB35_02420(neuB)
CTH: Cthe_2641
BPB: bpr_I0428(neuB1)
LBW: C3V36_05580(neuB)
DAU: Daud_0019
AWO: Awo_c24840(neuB)
CTHM: CFE_2539
CBAR: PATL70BA_2643(legI)
TIT: Thit_0481
MTA: Moth_0756
MTHO: MOTHE_c07000(legI)
MTHZ: MOTHA_c07940(legI)
CCHA: ELD05_07925(neuB)
TSH: Tsac_2668
HALS: D7D81_05095(neuB) D7D81_17935(neuB)
SPOA: EQM13_03525(neuB)
LPIL: LIP_2376
SYW: SYNW0448(neuB)
SYG: sync_0174
PMF: P9303_01101(spsE)
PMH: P9215_14811(spsE)
PMJ: P9211_12451(spsE)
GMR: GmarT_17240(legI)
GIM: F1728_06160(neuB)
TPED: TPE_0201
LIL: LA_1609(spsE)
LIE: LIF_A1296(spsE)
LIC: LIC_12173(neuB)
LBJ: LBJ_1133
LBL: LBL_1187
BPO: BP951000_1153(spsE)
BPW: WESB_2577
FUL: C4N20_01280(neuB)
BVU: BVU_4040
TFO: BFO_1066(neuB)
DUN: FDZ78_02060(neuB)
CHIH: GWR21_01080(neuB) GWR21_20995(neuB)
PGO: FSB84_04825(neuB)
PEJ: FYC62_11660(neuB)
SDJ: NCTC13534_05285(spsE_1) NCTC13534_05286(spsE_2)
OLI: FKG96_05940(neuB)
DFE: Dfer_3363
ASWU: HUW51_14155(neuB)
FPF: DCC35_14845(neuB)
GFO: GFO_0569
GFL: GRFL_2392
FIN: KQS_03395
ZPR: ZPR_1117
MARB: CJ263_08140(neuB)
MUT: GVT53_17455(neuB)
NDO: DDD_3554
TJE: TJEJU_1144(legI)
KOS: KORDIASMS9_03609(legI)
KAN: IMCC3317_05800(legI)
PPH: Ppha_0527
PMX: PERMA_1627(neuB)
TTK: TST_1473(neuB)
TNP: Tnap_0417
MAE: Maeo_0420
MBU: Mbur_1586
HMU: Hmuk_1456
HALZ: E5139_10440(neuB)
HALP: DOS48_05315(neuB)
NMG: Nmag_0151(neuB)
NCT: NMSP_0147
NDV: NDEV_0150(NeuB) NDEV_0210(neuB2) NDEV_0212
 » show all
Reference
1  [PMID:18275154]
  Authors
Glaze PA, Watson DC, Young NM, Tanner ME
  Title
Biosynthesis of CMP-N,N'-diacetyllegionaminic acid from UDP-N,N'-diacetylbacillosamine in Legionella pneumophila.
  Journal
Biochemistry 47:3272-82 (2008)
DOI:10.1021/bi702364s
  Sequence
[lpn:lpg0752]
Reference
2  [PMID:19282391]
  Authors
Schoenhofen IC, Vinogradov E, Whitfield DM, Brisson JR, Logan SM
  Title
The CMP-legionaminic acid pathway in Campylobacter: biosynthesis involving novel  GDP-linked precursors.
  Journal
Glycobiology 19:715-25 (2009)
DOI:10.1093/glycob/cwp039
  Sequence
[cje:Cj1327]
Other DBs
ExplorEnz - The Enzyme Database: 2.5.1.101
IUBMB Enzyme Nomenclature: 2.5.1.101
ExPASy - ENZYME nomenclature database: 2.5.1.101
BRENDA, the Enzyme Database: 2.5.1.101

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