KEGG   ENZYME: 2.5.1.102Help
Entry
EC 2.5.1.102                Enzyme                                 

Name
geranyl-pyrophosphate---olivetolic acid geranyltransferase;
GOT (ambiguous)
Class
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
BRITE hierarchy
Sysname
geranyl-diphosphate:olivetolate geranyltransferase
Reaction(IUBMB)
geranyl diphosphate + 2,4-dihydroxy-6-pentylbenzoate = diphosphate + cannabigerolate [RN:R10176]
Reaction(KEGG)
Substrate
geranyl diphosphate [CPD:C00341];
2,4-dihydroxy-6-pentylbenzoate [CPD:C20417]
Product
diphosphate [CPD:C00013];
cannabigerolate [CPD:C20406]
Comment
Part of the cannabinoids biosynthetic pathway of the plant Cannabis sativa. The enzyme can also use neryl diphosphate as substrate, forming cannabinerolate.
History
EC 2.5.1.102 created 2012
Reference
1  [PMID:9607329]
  Authors
Fellermeier M, Zenk MH
  Title
Prenylation of olivetolate by a hemp transferase yields cannabigerolic acid, the  precursor of tetrahydrocannabinol.
  Journal
FEBS Lett 427:283-5 (1998)
DOI:10.1016/S0014-5793(98)00450-5
Other DBs
ExplorEnz - The Enzyme Database: 2.5.1.102
IUBMB Enzyme Nomenclature: 2.5.1.102
ExPASy - ENZYME nomenclature database: 2.5.1.102
BRENDA, the Enzyme Database: 2.5.1.102

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