KEGG   ENZYME: 2.5.1.107
Entry
EC 2.5.1.107                Enzyme                                 

Name
verruculogen prenyltransferase;
FtmPT3
Class
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
Sysname
dimethylallyl-diphosphate:verruculogen dimethylallyl-O-transferase
Reaction(IUBMB)
dimethylallyl diphosphate + verruculogen = diphosphate + fumitremorgin A [RN:R10341]
Reaction(KEGG)
R10341
Substrate
dimethylallyl diphosphate [CPD:C00235];
verruculogen [CPD:C20045]
Product
diphosphate [CPD:C00013];
fumitremorgin A [CPD:C20564]
Comment
Found in a number of fungi. Catalyses the last step in the biosynthetic pathway of the indole alkaloid fumitremorgin A. The enzyme from the fungus Neosartorya fischeri is also active with fumitremorgin B and 12alpha,13alpha-dihydroxyfumitremorgin C.
History
EC 2.5.1.107 created 2013
Pathway
ec00404  Staurosporine biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K18279  verruculogen prenyltransferase
Genes
NFI: NFIA_093400
Reference
1  [PMID:23109474]
  Authors
Mundt K, Wollinsky B, Ruan HL, Zhu T, Li SM
  Title
Identification of the verruculogen prenyltransferase FtmPT3 by a combination of chemical, bioinformatic and biochemical approaches.
  Journal
Chembiochem 13:2583-92 (2012)
DOI:10.1002/cbic.201200523
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.5.1.107
IUBMB Enzyme Nomenclature: 2.5.1.107
ExPASy - ENZYME nomenclature database: 2.5.1.107
BRENDA, the Enzyme Database: 2.5.1.107

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