| Entry |
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| Name |
verruculogen prenyltransferase;
FtmPT3
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| Class |
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
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| Sysname |
dimethylallyl-diphosphate:verruculogen dimethylallyl-O-transferase
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| Reaction(IUBMB) |
dimethylallyl diphosphate + verruculogen = diphosphate + fumitremorgin A [RN: R10341]
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| Reaction(KEGG) |
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| Substrate |
dimethylallyl diphosphate [CPD: C00235];
verruculogen [CPD: C20045]
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| Product |
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| Comment |
Found in a number of fungi. Catalyses the last step in the biosynthetic pathway of the indole alkaloid fumitremorgin A. The enzyme from the fungus Neosartorya fischeri is also active with fumitremorgin B and 12alpha,13alpha-dihydroxyfumitremorgin C.
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| History |
EC 2.5.1.107 created 2013
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| Pathway |
| ec01110 | Biosynthesis of secondary metabolites |
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| Orthology |
| K18279 | verruculogen prenyltransferase |
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| Genes |
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| Reference |
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| Authors |
Mundt K, Wollinsky B, Ruan HL, Zhu T, Li SM |
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| Title |
Identification of the verruculogen prenyltransferase FtmPT3 by a combination of chemical, bioinformatic and biochemical approaches. |
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| Journal |
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| Sequence |
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| Other DBs |
| ExPASy - ENZYME nomenclature database: | 2.5.1.107 |
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