KEGG   ENZYME: 2.5.1.108
Entry
EC 2.5.1.108                Enzyme                                 
Name
2-(3-amino-3-carboxypropyl)histidine synthase;
Dph2
Class
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
Sysname
S-adenosyl-L-methionine:L-histidine-[translation elongation factor 2] 2-[(3S)-3-amino-3-carboxypropyl]transferase
Reaction(IUBMB)
S-adenosyl-L-methionine + L-histidine-[translation elongation factor 2] = S-methyl-5'-thioadenosine + 2-[(3S)-3-amino-3-carboxypropyl]-L-histidine-[translation elongation factor 2] [RN:R10455]
Reaction(KEGG)
R10455
Substrate
S-adenosyl-L-methionine [CPD:C00019];
L-histidine-[translation elongation factor 2] [CPD:C20663]
Product
S-methyl-5'-thioadenosine [CPD:C00170];
2-[(3S)-3-amino-3-carboxypropyl]-L-histidine-[translation elongation factor 2] [CPD:C04441]
Comment
A [4Fe-4S] enzyme that modifies a histidine residue of the translation elongation factor 2 (EF2) via a 3-amino-3-carboxypropyl radical. The enzyme is present in archae and eukaryotes but not in eubacteria. The enzyme is a member of the 'AdoMet radical' (radical SAM) family and generates the 3-amino-3-carboxypropyl radical by an uncanonical clevage of S-adenosyl-L-methionine. The relevant histidine of EF2 is His715 in mammals, His699 in yeast and His600 in Pyrococcus horikoshii. Part of diphthamide biosynthesis.
History
EC 2.5.1.108 created 2013
Orthology
K07561  2-(3-amino-3-carboxypropyl)histidine synthase
Genes
HSA1801(DPH1)
PTR454415(DPH1)
PPS100982647(DPH1)
GGO101129660(DPH1)
PON100458975(DPH1)
NLE100586565(DPH1)
MCC721275(DPH1)
MCF102121428(DPH1)
CSAB103242124(DPH1)
CATY105584140(DPH1)
PANU101020410(DPH1)
TGE112609454(DPH1)
RRO104682026(DPH1)
RBB108526254
TFN117067937(DPH1)
PTEH111521306(DPH1)
CJC100401736(DPH1)
SBQ101044961(DPH1)
MMUR105857922(DPH1)
OGA100943175(DPH1)
MMU116905(Dph1)
MCAL110305553(Dph1)
MPAH110331660(Dph1)
RNO287523(Dph1)
MCOC116076932(Dph1)
MUN110551476(Dph1)
CGE100765648(Dph1)
PLEU114691423(Dph1)
NGI103730524(Dph1)
HGL101700222(Dph1)
CPOC100715978(Dph1)
CCAN109690016(Dph1)
DORD105985868(Dph1)
DSP122103448(Dph1)
NCAR124981077
OCU100340691(DPH1)
TUP102497125(DPH1)
CFA480653(DPH1)
VVP112933095(DPH1)
VLG121473953(DPH1)
AML100466082(DPH1)
UMR103667386(DPH1)
UAH113269133(DPH1)
UAR123777023(DPH1)
ELK111151686
LLV125087824
MPUF101674774(DPH1)
ORO101371699(DPH1)
EJU114213914(DPH1)
ZCA113939492(DPH1)
MLX118025208(DPH1)
FCA101083810(DPH1)
PYU121017324(DPH1)
PBG122485107(DPH1)
PTG102950536(DPH1)
PPAD109255182(DPH1)
AJU106983186(DPH1)
HHV120246378(DPH1)
BTA534099(DPH1)
BOM102283537(DPH1)
BIU109574109(DPH1)
BBUB102407230(DPH1)
CHX106501727(DPH1)
OAS101104511(DPH1)
ODA120866215(DPH1)
CCAD122447557(DPH1)
SSC100525608(DPH1)
CFR102512929(DPH1)
CBAI105071505(DPH1)
CDK105088105(DPH1)
VPC102543918(DPH1)
BACU103020317(DPH1)
LVE103081677(DPH1)
OOR101279783(DPH1)
DLE111185867(DPH1)
PCAD102975515(DPH1)
PSIU116745188(DPH1)
ECB100060117(DPH1)
EPZ103554995(DPH1)
EAI106822029(DPH1)
MYB102259154(DPH1)
MYD102774413(DPH1)
MMYO118672005(DPH1)
MLF102434848(DPH1)
MNA107535621(DPH1)
PKL118702523(DPH1)
HAI109386901(DPH1)
DRO112308716(DPH1)
SHON119003789(DPH1)
AJM119040691(DPH1)
PDIC114503272(DPH1)
PHAS123817656(DPH1)
MMF118634199(DPH1)
RFQ117013886(DPH1)
PALE102890379(DPH1)
PGIG120621053(DPH1)
PVP105291845(DPH1)
RAY107507708(DPH1)
MJV108391807(DPH1)
TOD119231051(DPH1)
SARA101538519(DPH1)
LAV100665713(DPH1)
TMU101361771
DNM101415198(DPH1)
MDO100018617(DPH1)
GAS123247445(DPH1)
SHR100932196(DPH1)
PCW110222142(DPH1)
OAA100092375(DPH1)
GGA417564(DPH1)
PCOC116228081(DPH1)
MGP100541629(DPH1)
CJO107322679(DPH1)
NMEL110407890(DPH1)
APLA101799692(DPH1)
ACYG106041387(DPH1)
AFUL116497412(DPH1)
TGU100230974(DPH1)
LSR110482086(DPH1)
SCAN103820278(DPH1)
PMOA120507652(DPH1)
OTC121345826(DPH1)
PRUF121361722(DPH1)
GFR102035981(DPH1)
FAB101821750(DPH1)
PHI102113503(DPH1)
PMAJ107212770(DPH1)
CCAE111937942(DPH1)
CCW104691204(DPH1)
ETL114060480(DPH1)
ZAB102068714(DPH1)
FPG101918525(DPH1)
FCH102046767(DPH1)
CLV102093067(DPH1)
EGZ104131833(DPH1)
NNI104012796(DPH1)
ACUN113487328(DPH1)
TALA116964457(DPH1)
ACHC115347425(DPH1)
AROW112960696(DPH1)
NPD112954686(DPH1)
DNE112986399(DPH1)
ASN102373929(DPH1)
AMJ102572925(DPH1)
CPOO109316973(DPH1)
GGN109293390(DPH1)
PSS102446537(DPH1)
CMY102944597(DPH1)
CPIC101934242(DPH1)
TST117867502(DPH1)
CABI116829457(DPH1)
MRV120387446(DPH1)
ACS100567562(dph1)
PVT110084253(DPH1)
SUND121917083(DPH1)
PBI103060999(DPH1)
PMUR107296196(DPH1)
TSR106554992(DPH1)
PGUT117669786(DPH1)
VKO123023676(DPH1)
PMUA114585363(DPH1)
ZVI118097161(DPH1)
GJA107119413(DPH1)
XLA443615(dph1.L)
XTR100216186(dph1)
NPR108787960(DPH1)
RTEM120927589(DPH1)
BBUF120994768(DPH1)
BGAR122923229
DRE550559(dph1)
SRX107743654(dph1) 107744807
SANH107664954 107685060
SGH107585615 107592641
CCAR109056563 109095810
CAUA113058909 113069522(dph1) 113114859
IPU108278197(dph1)
PHYP113533104(dph1)
SMEO124394264(dph1)
TFD113643433(dph1)
AMEX103028439(dph1)
EEE113569787(dph1)
TRU101074864(dph1)
TNGGSTEN00030061G001
LCO104923539(dph1)
NCC104962091(dph1)
CGOB115017647(dph1)
ELY117260331(dph1)
PLEP121943694(dph1)
SLUC116041119(dph1)
ECRA117941657(dph1)
PFLV114553317(dph1)
GAT120822372(dph1)
PPUG119215307(dph1)
MSAM119883056(dph1)
CUD121516477(dph1)
MZE101468218(dph1)
ONL100694665(dph1)
OAU116336003(dph1)
OLA101164330(dph1)
OML112149900(dph1)
XMA102236846(dph1)
XCO114133320(dph1)
XHE116708088(dph1)
PRET103474164(dph1)
PFOR103139622(dph1)
PLAI106937301(dph1)
PMEI106924905(dph1)
GAF122833087(dph1)
CVG107089877(dph1)
CTUL119795424(dph1)
GMU124883962(dph1)
NFU107380120(dph1)
KMR108246325(dph1)
ALIM106535228(dph1)
NWH119411308(dph1)
AOCE111569743(dph1)
CSEM103378239(dph1)
POV109630404(dph1)
SSEN122772941(dph1)
HHIP117772978(dph1)
LCF108877969(dph1)
SDU111232318(dph1)
SLAL111656715(dph1)
XGL120792191(dph1)
HCQ109518487(dph1)
BPEC110163645(dph1)
MALB109968534(dph1)
SASA106581169(dph1) 106612930
OTW112265534 112267114
OMY110503945(dph1) 110507778
OGO123992726 124005133
ONE115118172 115123823(dph1) 115125626
SALP111982831
SNH120018184(dph1)
ELS105023187(dph1)
SFM108932081(dph1)
PKI111847109(dph1)
AANG118209965(dph1)
LOC102694122(dph1)
PSPA121308654(dph1)
ARUT117429582 117430380
LCM102356549 102362800(DPH1)
CMK103186918(dph1)
RTP109911802
BFO118425627
BBEL109467939
CIN100175202
SCLV120334730
SPU590421
APLC110976648
SKO100378925
DMEDmel_CG11652(Dph1)
DER6544364
DSE6605319
DSIDsimw501_GD12784(Dsim_GD12784)
DYADyak_GE20188
DAN6507156
DSR110178916
DPODpse_GA11120
DPE6602801
DMN108152505
DWI6645473
DGR6557946
DMODmoj_GI13721
DAZ108613629
DNV108651878
DHE111592804
DVI6623641
CCAT101454442
BOD106619704
MDE101891032
SCAC106082945
LCQ111687020
ACOZ120958012
AARA120903171
AAG5575478
AALB109431303 109432003 115264575
CQUCpipJ_CPIJ007880
CPII120417993
CNS116337899
AME552087
ACER107999244
ALAB122716605
BIM100742824
BBIF117204339
BVK117233437
BVAN117153251
BTER100648784
BPYO122569216
CCAL108632411
OBB114871148
MGEN117224552
NMEA116428905
CGIG122402708
SOC105204836
MPHA105827800
AEC105150583
ACEP105620195
PBAR105423357
VEM105561228
HST105191986
DQU106747427
CFO105257743
FEX115235918
LHU105679855
PGC109856788
OBO105275571
PCF106786512
PFUC122525886
VPS122635404
NVI100124031
CSOL105361299
TPRE106656759
MDL103578195
CGLO123266336
FAS105272247
DAM107035500
AGIF122849581
CCIN107267076
TCA660204
DPA109544261
SOY115879847
ATD109594059
CSET123308660
AGB108909995
LDC111504614
NVL108558695
APLN108742182 112904624
PPYR116180995
OTU111421311
BMOR692933
BMAN114247696
MSEX115450930
DPLKGM_201785
BANY112055264
PMAC106711106
PPOT106108517
PXU106117585 106118762 106120426 106122941
PRAP110991470
ZCE119836319
HAW110370774
TNL113496384 113506536
OFU114361887
PXY105386869
API100160913
DNX107171092
AGS114129255
RMD113556639
BTAB109044711
DCI103521750
CLEC106666049
HHAL106685912
NLU111045601 120355788
PHUPhum_PHUM041770
FOC113217954
ZNE110834467
CSEC111867598
FCD110853011
DPXDAPPUDRAFT_307434
DMK116931112
PVM113814263
PJA122252087
PCHN125031100
HAME121858842
PCLA123764297
PTRU123503634
HAZT108677646
EAF111712181
ISCIscW_ISCW004253
DSV119452867
RSAN119400505 119400516
VDE111245365
VJA111268206
TUT107372150
DPTE113793774 113794438 113796754
DFR124490164
CSCU111617475 111639168
PTEP107455657
SDM118187469
CELCELE_C14B1.5(dph-1)
CBRCBG_09207(Cbr-dph-1)
BMYBM_BM8194(Bma-dph-1)
LOALOAG_06255
NAINECAME_16867
TSPTsp_02291
HROHELRODRAFT_113590 HELRODRAFT_83835
LGILOTGIDRAFT_153055
PCAN112563107
BGT106070236 106076550
GAE121368872
HRF124133306
HRJ124289277
CRG105343490
MYI110461373
PMAX117332998
MMER123534411 123544199
OBI106869814
OSN115212882 115227608 115229556 115229850
LAK106178089
SMMSmp_030930.1
SHXMS3_0016241
EGLEGR_08329
NVE5506664
EPA110234679
ATEN116297752
ADF107327170 107329582
AMIL114948626
SPIS111321849
DGT114538233
XEN124434303
HMG100197050
TADTRIADDRAFT_3141
AQU100640276
ATHAT5G62030
ALY9300842
CRB17875347
CSAT104726793 104739420 104762325
EUSEUTSA_v10004160mg
BRP103874640
BNA106427201
BOE106336400
RSZ108805289
THJ104798941
CIT102622644
CICCICLE_v10001185mg
TCC18607388
GRA105795453
GHI107908609 121203425
GAB108475932
DZI111308673
EGR104452750
GMX100797181
GSJ114424997
PVUPHAVU_002G038000g
VRA106776523
VAR108318976
VUN114166536
CCAJ109810882
APRC113869154
MTRMTR_5g007970
CAM101514419
LJALj2g3v2124830.1(Lj2g3v2124830.1)
ADU107475020 107475029 107475126 107475129
AIP107625618 107643175
AHF112727821 112748643
LANG109348570
FVE101291951
RCN112179850
PPER18789979
PMUM103319117
PAVI110764828
PDUL117625971 117627153
MDM103435443
PXB103929922 103953629
ZJU107416271
MNT21384015 21404258
CSV101214699
CMO103495461
BHJ120078323
MCHA111021686
CMAX111486020
CMOS111434567
CPEP111792145
RCU8277537
JCU105635596
HBR110645538 110646025 110646064 110646074 110646083
MESC110600059
POP7491070
PEU105115044
PALZ118027746
JRE109007067
QSU112007080 112035180
QLO115976522
TWL119984194
VVI100252989
VRI117913391
SLY101256980
SPEN107023734
SOT102581184
CANN107872862
NTA107791245
NSY104212199
NTO104104957
NAU109227210
INI109152915
ITR116026551
SIND105165124
OEU111377255
EGT105973704
SSPL121780297 121782839 121783065
HAN110930111
ECAD122599901
LSV111887509
CCAV112529220
DCR108224438
CSIN114272626
BVG104891236
SOE110793601
CQI110708239 110711126
NNU104604110
PSOM113301694 113356111
OSA4331131
DOSAOs02t0815600-01(Os02g0815600)
OBR102718717
BDI100829197
ATS109779032
TDC119318497 119325255
TAES123128959 123139707 123146122
SBI8056439
ZMA100284663
SITA101767368
SVS117841546
PVIR120646230 120657592
PHAI112902883
PDA103706948
EGU105059175
MUS103985278
DCT110093728
PEQ110032881
AOF109851117
ATR18422363
SMOSELMODRAFT_156702 SELMODRAFT_271325
PPP112292317
CRECHLRE_09g408500v5
VCNVOLCADRAFT_95203
MNGMNEG_10366
CSLCOCSUDRAFT_19880
CVRCHLNCDRAFT_23248
APROF751_2153
OLUOSTLU_43090
OTAOT_ostta15g00765
BPGBathy02g02350
MISMICPUN_89023
MPPMICPUCDRAFT_48766
CMECYME_CMT628C
GSLGasu_14140
CCPCHC_T00008649001
SCEYIL103W(DPH1)
AGOAGOS_ADL229W
ERCEcym_3310
KLAKLLA0_F03971g
KMXKLMA_80145(DPH1)
LTHKLTH0G10054g
VPOKpol_1003p27
ZROZYRO0D02662g
CGRCAGL0G02761g
NCSNCAS_0B06320(NCAS0B06320)
NDINDAI_0B03620(NDAI0B03620)
TPFTPHA_0C03300(TPHA0C03300)
TBLTBLA_0G02400(TBLA0G02400)
TDLTDEL_0C03900(TDEL0C03900)
TGBHG536_0B03300
KAFKAFR_0H03400(KAFR0H03400)
ZMKHG535_0D02190
PPAPAS_chr4_0072
DHADEHA2E10758g
PICPICST_35812
PGUPGUG_05659
SPAASPAPADRAFT_60716
LELLELG_00973
CALCAALFM_C205840WA(CaO19.5207)
CTPCTRG_01524
COTCORT_0A09210
CDUCD36_20280
CTENCANTEDRAFT_114183
YLIYALI0F22055g
CLUCLUG_02084
CLUSA9F13_02g02101
CAURCJI97_003249
SLBAWJ20_2165(DPH1)
PKZC5L36_0D03100
BNNFOA43_002305(DPH1)
BBRXBRETT_005086(DPH1)
NCRNCU08503
NTENEUTE1DRAFT83361(NEUTE1DRAFT_83361)
SMPSMAC_06261
PANPODANSg6601
TTTTHITE_2123893
MTMMYCTH_2312174
CTHRCTHT_0005330
MGRMGG_03237
TMNUCRPA7_5131
SSCKSPSK_09046
FGRFGSG_00636
FPUFPSE_06400
FVRFVEG_00560
FOXFOXG_00953
NHENECHADRAFT_65768
TRETRIREDRAFT_76050
TRRM419DRAFT_136015
MAWMAC_05653
MAJMAA_10721
CMTCCM_05185
PLJVFPFJ_07105
VALVDBG_05263
VDAVDAG_06912
CFJCFIO01_07286
SAPOSAPIO_CDS0148
ELAUCREL1_1570
PFYPFICI_08847
SSLSS1G_10656
BFUBCIN_04g04550
MBEMBM_05350
PSCOLY89DRAFT_158125
GLZGLAREA_09659
ANIAN6283.2
AFMAFUA_2G12440
ACTACLA_071340
NFINFIA_087580
AORAO090026000391
ANGANI_1_2500024(An02g04630)
AFVAFLA_005891
ALUCAKAW2_21229S(DPH1)
ACHEACHE_40854S(DPH1)
APUUAPUU_51197A(DPH1)
PCSPc20g14680
PDPPDIP_89200
TMFPMAA_092530
TRGTRUGW13939_07054
CIMCIMG_05212
CPWCPC735_064790
UREUREG_06411
PBLPAAG_06214
PBNPADG_07032
ABEARB_04875
TVETRV_06574
AJEHCAG_03806
BGHBDBG_05574
PNOSNOG_07675(SNOG_07674)
PTEPTT_12706
BZECOCCADRAFT_109068
BSCCOCSADRAFT_160372
BORCOCMIDRAFT_2894
AALTCC77DRAFT_1090814
ZTRMYCGRDRAFT_66970
PFJMYCFIDRAFT_26269
BCOMBAUCODRAFT_123562
NPAUCRNP2_7348
TMLGSTUM_00001067001
SPOSPBC3B8.05
CNECNA07400
CNBCNBA7230
CGICGB_A8510W
TMSTREMEDRAFT_29921
TASAA1Q1_04953
TVSTRAVEDRAFT_144365
DSQDICSQDRAFT_60750
SHSSTEHIDRAFT_155864
HIRHETIRDRAFT_48027
PSQPUNSTDRAFT_65664
ADLAURDEDRAFT_80258
FMEFOMMEDRAFT_169554
GTRGLOTRDRAFT_55327
LBCLACBIDRAFT_243952
MRRMoror_17646
CCICC1G_00080
SCMSCHCODRAFT_46508
ABPAGABI1DRAFT58324(AGABI1DRAFT_58324)
ABVAGABI2DRAFT202335(AGABI2DRAFT_202335)
CPUTCONPUDRAFT_168751
SLASERLADRAFT_446577
WSEWALSEDRAFT_38823
WICJ056_000195
UMAUMAG_03038
PFPPFL1_06481
MGLMGL_0765
MRTMRET_0053
MSYMMSY001_2121
PGRPGTG_12915
MLRMELLADRAFT_42750
ECUECU07_0980
EINEint_070930
EHEEHEL_070960
EROEROM_070930
NCENCER_101904
MBRMONBRDRAFT_16819
SREPTSG_05983
DDIDDB_G0284257(dph1)
DPPDICPUDRAFT_150525
DFADFA_09388(dph1)
EHIEHI_199050(87.t00020)
EDIEDI_263630
EIVEIN_169340
ACANACA1_188750
PFAPF3D7_1413800
PFHPFHG_04023
PREIPRSY57_1413100
PYOPY17X_1031300
PCBPCHAS_102970(PC000703.00.0)
PBEPBANKA_1028900
PVVPVVCY_1003430
PKNPKNH_1344500
PVXPVX_085760
PCYPCYB_134290
TANTA12765
TPVTP02_0364
TOTTOT_020000356
BEQBEWA_021030
BBOBBOV_III005980(17.m07527)
BMICBmR1_04g09315
BBIGBBBOND_0308040
CPVcgd6_2230
CHOChro.60261
TGOTGME49_261060
TETTTHERM_00658959
PTMGSPATT00001229001 GSPATT00002800001
SMINv1.2.033984.t1(symbB.v1.2.033984.t1)
PTIPHATRDRAFT_20589
FCYFRACYDRAFT_179110
TPSTHAPSDRAFT_33476
NGDNGA_0470300
AAFAURANDRAFT_2324
PIFPITG_12187
PSOJPHYSODRAFT_297671
SPARSPRG_05058
EHXEMIHUDRAFT_426724
GTTGUITHDRAFT_160128
TBRTb927.3.4340
TBGTbgDal_III4740
TCR467795.9
LMALMJF_29_1780
LIFLINJ_29_1900
LDOLDBPK_291900
LMILMXM_08_29_1780
LBZLBRM_31_0170
LPANLPMP_291780
NGRNAEGRDRAFT_30094
MJAMJ_0483
MFEMefer_0668
MVUMetvu_0203
MFSMFS40622_1754
MIFMetin_0596
MJHJH146_1399
MESGMLAUSG7_0217(dph)
MESAMLASG1_1454(dph)
MIGMetig_0765
MMPMMP0188
MMQMmarC5_1488
MMXMmarC6_0764
MMZMmarC7_1187
MMDGYY_00960
MMAKMMKA1_01920(dph2)
MMAOMMOS7_02180(dph2)
MMADMMJJ_08970
MAEMaeo_0905
MVNMevan_1190
MVOMvol_1475
MOKMetok_1263
METFCFE53_06405(dph2)
MTHMTH_1319
MMGMTBMA_c17050
METCMTCT_1196
MWOMWSIV6_1708
METEtca_01273
METZMETMT2_1310
METKFVF72_04980(dph2)
MTHMFZP57_08365(dph2)
METJFZP68_02405(dph2)
MTEEMTTB_01240
MSTMsp_1537
METBAW729_07630
MRUmru_0166
MSIMsm_1358
MEBAbm4_1653
MMILsm9_2228
MEYETL18_00635
MOLYLM1_1511
MAROMarbSA_13300
MELMetbo_0198
MEWMSWAN_2284
METHMBMB1_1930
MFCBRM9_2270
MFIDSM1535_1204
MCUBMCBB_2208(dph2)
MSUBBK009_08835
METNBK008_04475
METTCIT01_04810(dph2)
METOCIT02_07880(dph2)
MEMEHYG87_05805(dph2)
MFVMfer_1013
MKAMK1517(dph2)
AFUAF_1803
AFGAFULGI_00020550
APOArcpr_1300
AVEArcve_1511
ASTAsulf_00518
FPLFerp_2108
GACGACE_0213
GAHGAH_00083
PFUPF1063
PFIPFC_04550
PHOPH1105(PH1105)
PABPAB0746
PYNPNA2_1802
PYAPYCH_04340
PYSPy04_1021
PYCTQ32_04345
TKOTK1928
TONTON_1934
TGATGAM_0526
TSITSIB_0075
TBATERMP_01729
THEGQS_05470
THATAM4_694
THMCL1_0735
TLTOCC_06736
THSTES1_1725
TNUBD01_2020
TEUTEU_04410
TGYX802_07755
THVADU37_CDS22900
TCHCHITON_0893
TPEPA0127_04575
TPIEA7C91_05710
TGGA3K92_03315
TCEA3L02_06565
TBSA3L01_00400
THHCDI07_00430(dph2)
TSLA3L11_04140
TTDA3L14_01705
TPRFA3L09_04885
TRLA3L10_10100
TPAFA3L08_03505
THYA3L12_03375
TICFH039_03650(dph2)
TCQTIRI35C_0293(dph)
THEMFPV09_05705(dph2)
PPACPAP_09280
MBAMbar_A1634
MBYMSBRM_2909
MBWMSBRW_3097
MBARMSBR2_2867
MBAKMSBR3_1919
MACMA_0718
MMAMM_1877(dph2)
MMAZMmTuc01_1952
MMJMSMAS_2810
MMACMSMAC_1628
MVCMSVAZ_2565
MEKMSKOL_2572
MLSMSLAZ_0394
METMMSMTP_2709
MEFMSWH1_0470
MEQMSWHS_0478
MSJMSSAC_0663
MSZMSSIH_0606
MSWMSSIT_0637
MTHRMSTHT_1400
MTHEMSTHC_1888
MHORMSHOH_3509
MFZAOB57_005990(dph2)
MBUMbur_1436
MMETMCMEM_1920
MELOJ7W08_08570(dph2)
MMHMmah_1741
MHAZBHR79_04995
MEVMetev_1360
MZHMzhil_1842
MPYMpsy_2110
MZIHWN40_11645(dph2)
MHZMetho_2235
MTPMthe_1635
MCJMCON_3424
MHIMhar_0746
MHUMhun_2613
MRTJKHC33_03545(dph2)
MLAMlab_0218
MEMMemar_1846
MBGBN140_0543(dph2)
MEMAMMAB1_0680(dph)
MCHKMchiMG62_21480(dph2)
MPIMpet_0339
MBNMboo_2168
MFOMetfor_0585
MPLMpal_2082
MPDMCP_1404
MEZMtc_1792(dph2)
RCIRRC214(dph2)
HALVNG_0854C
HSLOE_2257F(dph2)
HDLHALDL1_08825
HHBHhub_2059(dph2)
HAGSJT689_04780(dph2)
HABOJRZ79_03275(dph2)
HNOLT974_05170(dph2)
HLULT972_07870(dph2)
HANRLJ422_03495(dph2)
HJEHacjB3_09855
HALHHTSR_1307
HHSRHSR6_1380
HSUHLASF_1327
HSFHLASA_1314
SALRFQU85_10060(dph2)
HALREFA46_009840(dph2)
HARAAArcS_0695(dph2)
HAADMW046_08545(dph2)
HALXM0R89_14715(dph2)
HMArrnAC0405
HHIHAH_1224(dph2)
HHNHISP_06270
HABSG26_13915
HTABVU17_05965
HALJG9465_10610(dph2)
HSINKDQ40_07390(dph2)
NPHNP_3154A(dph2)
NMONmlp_2693(dph2)
NHOHWV23_00660(dph2)
NSALHWV07_02775(dph2)
HUTHuta_2799
HTIHTIA_2708
HALAHrd1104_04445(dph2)
HMUHmuk_2492
HALZE5139_15600(dph2)
HALLLC1Hm_1854(dph2)
HAZPGBQ70_15620(dph2)
HALIBV210_00980
HSNDV733_13340(dph2)
HDSHSR122_1242(dph2)
HRRHZS55_17235(dph2)
HPELHZS54_20585(dph2)
HLTI7X12_18430(dph2)
HARCHARCEL1_07870(dph2)
HDOMUK72_13235(dph2)
HWAHQ_2590A(dph2)
HWCHqrw_2904(dph2)
HVOHVO_1631(dph2)
HMEHFX_1717(dph2)
HGIABY42_07945
HALEG3A49_11255(dph2)
HBOHbor_15900
HAQDU484_14040(dph2)
HAJDU500_14070(dph2)
HAERDU502_12115(dph2)
HRAEI982_18135(dph2)
HLMDV707_12005(dph2)
HALMFCF25_15125(dph2)
HLAHlac_0813
HALPDOS48_04245(dph2)
HALBEKH57_06730(dph2)
HEZZEO776_05730(dph2)
HALQHrr1229_000620(dph2)
HSSJ7656_10125(dph2)
HSAIHPS36_01275(dph2)
HAZZKI388_03185(dph2)
SRUBC2R22_10160(dph2)
HAEhalTADL_0960
HALNB4589_014060(dph2)
HALGHUG10_05115(dph2)
HALUHUG12_11920(dph2)
HMPK6T50_04405(dph2)
HREK6T36_04215(dph2)
HRMK6T25_11580(dph2)
HACBHbl1158_09990(dph2)
HDFAArcSl_2069(dph2)
HAHHalar_0736
HTUHtur_1803
HDABB347_04860
HJTDVR14_19995(dph2) DVR14_24135(dph2)
HALYHYG82_01930(dph2)
HSALJMJ58_20450(dph2)
HLOJ0X27_00585(dph2)
HAKZJ0X25_15745(dph2)
NMGNmag_3588(dph2)
HXAHalxa_3319
NATNJ7G_3013
NPENatpe_2330
NVRFEJ81_10640(dph2)
NPLFGF80_10285(dph2)
NAYHYG81_18360(dph2)
NGENatgr_0035
HRUHalru_1352
NOUNatoc_1695
SALIL593_11010
SAIMK0C01_10215(dph2)
HLRHALLA_11610
HLCCHINAEXTREME15100
NAJB1756_18750
NAGAArcMg_1894
NANAArc1_1786
NBGDV706_14895(dph2)
NASGCU68_15115(dph2)
NACAQV86_00465
MELUMTLP_10430(dph2)
MEAMMU439_00775(dph2)
TACTa0255
TVOTVG1411317(TVG1411317)
PTOPTO0430
FACFACI_IFERC01G0731
FAIFAD_1627
CDIVCPM_1838
TARTALC_00446
MAXMMALV_03710
MERMMINT_13250
MEARMpt1_c01750(dph2)
MARCAR505_1420
ABIAboo_0484
ACFAciM339_0558
APEAPE_0447.1
ACJACAM_0327
SMRSmar_0630
SHCShell_0161
IHOIgni_0998
IISEYM_06540
DKADKAM_1412
DFDDesfe_0036
DMUDesmu_0037
TAGTagg_0035
IAGIgag_1048
THGTCELL_0451
HBUHbut_1652
PFMPyrfu_0174
PDLPyrde_0521
STOSTK_22630(dph2)
SOHD1869_12445(dph2)
SSOSSO0293
SOLSsol_1270
SSOASULA_1313(dph2)
SSOLSULB_1314(dph2)
SSOFSULC_1312(dph2)
SSHIJ5U23_03142
SCASSACC_02060
SAISaci_0175
SACNSacN8_00830
SACRSacRon12I_00830
SACSSUSAZ_00880
SISLS215_1947
SIAM1425_1807
SIMM1627_1925
SIDM164_1855
SIYYG5714_1924
SINYN1551_1001
SIILD85_2066
SIHSiH_1783
SIRSiRe_1703
SICSiL_1697
SULABFU36_04350
SULEGFS03_10115(dph2)
SULOGFS33_01930(dph2)
SULLEWF20_13510(dph2)
MSEMsed_1864
MCNMcup_0419
MHKDFR87_09260(dph2)
MPRUDFR88_08880(dph2)
MTENGWK48_02770(dph2)
MJNMjAS7_0023
AHOAhos_1225
AMANB6F84_10225
ABRIDFR85_09860(dph2)
ASULDFR86_08905(dph2)
AAMBD1866_01025(dph2)
ACIHHS5_26250
SACDHS1genome_2340
SAZOD1868_08180(dph2)
CSTYKN1_07720
STEPIC006_1548
SAHSHS7_06230
PAIPAE2994
PISPisl_0393
PCLPcal_1114
PASPars_1360
PYRP186_1539
POGPogu_0854
TNETneu_1734
PYWPYWP30_01853
CMACmaq_1133
TTNTTX_1298(dph2)
TUZTUZN_0093
VDIVdis_1857
VMOVMUT_0294
TPETpen_0882
THBN186_05830
TCBTCARB_0227
THFMA03_05250
THELIG193_03225(dph2)
ASCASAC_1193
ACIASE86_07135
CLGCalag_1163
FFOFFONT_1102
NMRNmar_1563
NIRNSED_00690
NKRNKOR_08505
NIDNPIRD3C_0492
NINNADRNF5_0328
NIWNisw_06085(dph2)
NCLC5F47_08195(dph2)
NOXC5F49_08080(dph2)
NUEC5F50_11440(dph2)
NIPNsoK4_08345(dph2)
NCTNMSP_0196(dph2)
NICDSQ20_09105(dph2)
CSYCENSYa_2018
NGANgar_c07660
NVNNVIE_013020
NEVNTE_02703
TAANMY3_00914
NFNNFRAN_1881
NCVNCAV_0164
CSUCSUB_C0414
NBVT478_1283(dph2)
TAHSU86_004630
NIUDSQ19_01390(dph2)
NDVNDEV_1927
CCAINAS2_0164
BARCAOA65_2291(dph2)
BARBAOA66_0106(dph2)
NEQNEQ226
MARHMia14_0794
FLTSv326_0100
MIYMicr_00898(dph2_2)
NCONLC1Nh_1144(dph2)
AGWQT03_C0001G1299
ARGQT11_C0001G0164
 » show all
Reference
1  [PMID:15485916]
  Authors
Liu S, Milne GT, Kuremsky JG, Fink GR, Leppla SH
  Title
Identification of the proteins required for biosynthesis of diphthamide, the target of bacterial ADP-ribosylating toxins on translation elongation factor 2.
  Journal
Mol Cell Biol 24:9487-97 (2004)
DOI:10.1128/MCB.24.21.9487-9497.2004
  Sequence
[mmu:116905] [sce:YIL103W]
Reference
2  [PMID:20559380]
  Authors
Zhang Y, Zhu X, Torelli AT, Lee M, Dzikovski B, Koralewski RM, Wang E, Freed J, Krebs C, Ealick SE, Lin H
  Title
Diphthamide biosynthesis requires an organic radical generated by an iron-sulphur enzyme.
  Journal
Nature 465:891-6 (2010)
DOI:10.1038/nature09138
  Sequence
[pho:PH1105]
Reference
3  [PMID:20931132]
  Authors
Zhu X, Dzikovski B, Su X, Torelli AT, Zhang Y, Ealick SE, Freed JH, Lin H
  Title
Mechanistic understanding of Pyrococcus horikoshii Dph2, a [4Fe-4S] enzyme required for diphthamide biosynthesis.
  Journal
Mol Biosyst 7:74-81 (2011)
DOI:10.1039/c0mb00076k
  Sequence
[pho:PH1105]
Reference
4  [PMID:27465315]
  Authors
Dong M, Horitani M, Dzikovski B, Pandelia ME, Krebs C, Freed JH, Hoffman BM, Lin H
  Title
Organometallic Complex Formed by an Unconventional Radical S-Adenosylmethionine Enzyme.
  Journal
J Am Chem Soc 138:9755-8 (2016)
DOI:10.1021/jacs.6b04155
Other DBs
ExplorEnz - The Enzyme Database: 2.5.1.108
IUBMB Enzyme Nomenclature: 2.5.1.108
ExPASy - ENZYME nomenclature database: 2.5.1.108
BRENDA, the Enzyme Database: 2.5.1.108

DBGET integrated database retrieval system