KEGG ENZYME: 2.5.1.108

ENZYME: 2.5.1.108

Entry

EC 2.5.1.108                Enzyme

Name

2-(3-amino-3-carboxypropyl)histidine synthase;
Dph2

Class

Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)

Sysname

S-adenosyl-L-methionine:L-histidine-[translation elongation factor 2] 2-[(3S)-3-amino-3-carboxypropyl]transferase

Reaction(IUBMB)

S-adenosyl-L-methionine + L-histidine-[translation elongation factor 2] = S-methyl-5'-thioadenosine + 2-[(3S)-3-amino-3-carboxypropyl]-L-histidine-[translation elongation factor 2] [RN:R10455]

Reaction(KEGG)

R10455

Substrate

S-adenosyl-L-methionine [CPD:C00019];
L-histidine-[translation elongation factor 2] [CPD:C20663]

Product

S-methyl-5'-thioadenosine [CPD:C00170];
2-[(3S)-3-amino-3-carboxypropyl]-L-histidine-[translation elongation factor 2] [CPD:C04441]

Comment

A [4Fe-4S] enzyme that modifies a histidine residue of the translation elongation factor 2 (EF2) via a 3-amino-3-carboxypropyl radical. The enzyme is present in archae and eukaryotes but not in eubacteria. The enzyme is a member of the 'AdoMet radical' (radical SAM) family and generates the 3-amino-3-carboxypropyl radical by an uncanonical clevage of S-adenosyl-L-methionine. The relevant histidine of EF2 is His715 in mammals, His699 in yeast and His600 in Pyrococcus horikoshii. Part of diphthamide biosynthesis.

History

EC 2.5.1.108 created 2013

Orthology

K07561

2-(3-amino-3-carboxypropyl)histidine synthase

Genes

HSA:	1801(DPH1)

PTR:	454415(DPH1)

PPS:	100982647(DPH1)

GGO:	101129660(DPH1)

PON:	100458975(DPH1)

NLE:	100586565(DPH1)

HMH:	116458470(DPH1)

MCC:	721275(DPH1)

MCF:	102121428(DPH1)

MTHB:

126938866

MNI:	105471686(DPH1)

CSAB:

103242124(DPH1)

CATY:

105584140(DPH1)

PANU:

101020410(DPH1)

TGE:	112609454(DPH1)

MLEU:

105544693(DPH1)

RRO:	104682026(DPH1)

RBB:

108526254

TFN:	117067937(DPH1)

PTEH:

111521306(DPH1)

CANG:

105521755(DPH1)

CJC:	100401736(DPH1)

SBQ:	101044961(DPH1)

CIMI:

108313303(DPH1)

MMUR:

105857922(DPH1)

LCAT:

123620679(DPH1)

PCOQ:

105817365(DPH1)

OGA:	100943175(DPH1)

MMU:	116905(Dph1)

MCAL:

110305553(Dph1)

MPAH:

110331660(Dph1)

RNO:	287523(Dph1)

MCOC:

116076932(Dph1)

ANU:	117710201(Dph1)

MUN:	110551476(Dph1)

CGE:	100765648(Dph1)

MAUA:

110339816(Dph1)

PROB:

127218926(Dph1)

PLEU:

114691423(Dph1)

MORG:

121457043(Dph1)

MFOT:

126492428

AAMP:

119811996(Dph1)

NGI:	103730524(Dph1)

HGL:	101700222(Dph1)

CPOC:

100715978(Dph1)

CCAN:

109690016(Dph1)

DORD:

105985868(Dph1)

DSP:	122103448(Dph1)

PLOP:

125365901(Dph1)

NCAR:

124981077

OCU:

100340691

TUP:	102497125(DPH1)

GVR:	103584797(DPH1)

CFA:	480653(DPH1)

CLUD:

112677560(DPH1)

VVP:	112933095(DPH1)

VLG:	121473953(DPH1)

NPO:	129516391(DPH1)

AML:	100466082(DPH1)

UMR:	103667386(DPH1)

UAH:	113269133(DPH1)

UAR:	123777023(DPH1)

ELK:

111151686

LLV:

125087824

MPUF:

101674774(DPH1)

NVS:	122906337(DPH1)

ORO:	101371699(DPH1)

EJU:	114213914(DPH1)

ZCA:	113939492(DPH1)

MLX:	118025208(DPH1)

NSU:	110592818(DPH1)

LWW:	102742905(DPH1)

FCA:	101083810(DPH1)

PYU:	121017324(DPH1)

PCOO:

112854964(DPH1)

PBG:	122485107(DPH1)

LRUF:

124513073

PTG:	102950536(DPH1)

PPAD:

109255182(DPH1)

PUC:

125926875

AJU:

106983186

HHV:	120246378(DPH1)

BTA:	534099(DPH1)

BOM:	102283537(DPH1)

BIU:	109574109(DPH1)

BBUB:

102407230(DPH1)

BBIS:

105003889(DPH1)

CHX:	106501727(DPH1)

OAS:	101104511(DPH1)

BTAX:

128064651(DPH1)

ODA:	120866215(DPH1)

CCAD:

122447557(DPH1)

SSC:	100525608(DPH1)

CFR:	102512929(DPH1)

CBAI:

105071505(DPH1)

CDK:	105088105(DPH1)

VPC:	102543918(DPH1)

BACU:

103020317(DPH1)

LVE:	103081677(DPH1)

OOR:	101279783(DPH1)

DLE:	111185867(DPH1)

PCAD:

102975515(DPH1)

PSIU:

116745188(DPH1)

NASI:

112393578(DPH1)

ECB:	100060117(DPH1)

EPZ:	103554995(DPH1)

EAI:	106822029(DPH1)

MYB:	102259154(DPH1)

MYD:	102774413(DPH1)

MMYO:

118672005(DPH1)

MLF:	102434848(DPH1)

MNA:	107535621(DPH1)

PKL:	118702523(DPH1)

HAI:	109386901(DPH1)

DRO:	112308716(DPH1)

SHON:

119003789(DPH1)

AJM:	119040691(DPH1)

PDIC:

114503272(DPH1)

PHAS:

123817656(DPH1)

MMF:	118634199(DPH1)

RFQ:	117013886(DPH1)

PALE:

102890379(DPH1)

PGIG:

120621053(DPH1)

PVP:	105291845(DPH1)

RAY:	107507708(DPH1)

MJV:	108391807(DPH1)

TOD:	119231051(DPH1)

SARA:

101538519(DPH1)

LAV:	100665713(DPH1)

TMU:

101361771

ETF:	101641117(DPH1)

DNM:	101415198(DPH1)

MDO:	100018617(DPH1)

GAS:	123247445(DPH1)

SHR:	100932196(DPH1)

AFZ:

127558825

PCW:	110222142(DPH1)

OAA:	100092375(DPH1)

GGA:	417564(DPH1)

PCOC:

116228081(DPH1)

MGP:	100541629(DPH1)

CJO:	107322679(DPH1)

TPAI:

128083465(DPH1)

NMEL:

110407890(DPH1)

APLA:

101799692(DPH1)

ACYG:

106041387(DPH1)

AFUL:

116497412(DPH1)

TGU:	100230974(DPH1)

LSR:	110482086(DPH1)

SCAN:

103820278(DPH1)

PMOA:

120507652(DPH1)

OTC:	121345826(DPH1)

PRUF:

121361722(DPH1)

GFR:	102035981(DPH1)

FAB:	101821750(DPH1)

PHI:	102113503(DPH1)

PMAJ:

107212770(DPH1)

CCAE:

111937942(DPH1)

CCW:	104691204(DPH1)

CBRC:

103621577(DPH1)

ETL:	114060480(DPH1)

ZAB:	102068714(DPH1)

ACHL:

103801060(DPH1)

SVG:	106853262(DPH1)

FPG:	101918525(DPH1)

FCH:	102046767(DPH1)

CLV:	102093067(DPH1)

EGZ:	104131833(DPH1)

NNI:	104012796(DPH1)

ACUN:

113487328(DPH1)

TALA:

116964457(DPH1)

AFOR:

103898079

ACHC:

115347425(DPH1)

HLE:	104835576(DPH1)

AGEN:

126039744

GCL:

127024589

CCRI:

104162193(DPH1)

CSTI:

104561970(DPH1)

OHA:	104332811(DPH1)

NNT:	104402550(DPH1)

SHAB:

115601869(DPH1)

DPUB:

104302834(DPH1)

CPEA:

104386516(DPH1)

CVF:	104286614(DPH1)

CUCA:

104058702(DPH1)

TEO:	104380079(DPH1)

AROW:

112960696(DPH1)

NPD:	112954686(DPH1)

TGT:	104571347(DPH1)

DNE:	112986399(DPH1)

ASN:	102373929(DPH1)

AMJ:	102572925(DPH1)

CPOO:

109316973(DPH1)

GGN:	109293390(DPH1)

PSS:	102446537(DPH1)

CMY:	102944597(DPH1)

CPIC:

101934242(DPH1)

TST:	117867502(DPH1)

CABI:

116829457(DPH1)

MRV:	120387446(DPH1)

ACS:	100567562(dph1)

PVT:	110084253(DPH1)

SUND:

121917083(DPH1)

PBI:	103060999(DPH1)

PMUR:

107296196(DPH1)

CTIG:

120319416(DPH1)

TSR:	106554992(DPH1)

PGUT:

117669786(DPH1)

PTEX:

113450002(DPH1)

NSS:	113427754(DPH1)

VKO:	123023676(DPH1)

PMUA:

114585363(DPH1)

ZVI:	118097161(DPH1)

HCG:	128336248(DPH1)

GJA:	107119413(DPH1)

STOW:

125446005(DPH1)

XLA:	443615(dph1.L)

XTR:	100216186(dph1)

NPR:	108787960(DPH1)

RTEM:

120927589(DPH1)

BBUF:

120994768(DPH1)

BGAR:

122923229

DRE:	550559(dph1)

SRX:	107743654(dph1) 107744807

SANH:

107664954 107685060

SGH:	107585615 107592641

CCAR:

109056563 109095810

CAUA:

113058909 113069522(dph1) 113114859

CGIB:

127972665

PTET:

122359057

LROH:

127176867(dph1)

PPRM:

120478938(dph1)

MAMB:

125248371(dph1)

CIDE:

127495682

MASI:

127422542 127430280

IPU:

108278197

PHYP:

113533104(dph1)

SMEO:

124394264(dph1)

TFD:	113643433(dph1)

AMEX:

103028439(dph1)

CMAO:

118801689(dph1)

EEE:	113569787(dph1)

TRU:	101074864(dph1)

TNG:	GSTEN00030061G001

LCO:	104923539(dph1)

NCC:	104962091(dph1)

CGOB:

115017647(dph1)

ELY:	117260331(dph1)

EFO:	125889257(dph1)

PLEP:

121943694(dph1)

SLUC:

116041119(dph1)

ECRA:

117941657(dph1)

ESP:	116671873(dph1)

PFLV:

114553317(dph1)

GAT:	120822372(dph1)

PPUG:

119215307(dph1)

MSAM:

119883056(dph1)

SCHU:

122878775(dph1)

CUD:	121516477(dph1)

ALAT:

119010927(dph1)

MZE:	101468218(dph1)

ONL:	100694665(dph1)

OAU:	116336003(dph1)

OLA:	101164330(dph1)

OML:	112149900(dph1)

XMA:	102236846(dph1)

XCO:	114133320(dph1)

XHE:	116708088(dph1)

PRET:

103474164(dph1)

PFOR:

103139622(dph1)

PLAI:

106937301(dph1)

PMEI:

106924905(dph1)

GAF:	122833087(dph1)

CVG:	107089877(dph1)

CTUL:

119795424(dph1)

GMU:	124883962(dph1)

NFU:	107380120(dph1)

KMR:	108246325(dph1)

ALIM:

106535228(dph1)

NWH:	119411308(dph1)

AOCE:

111569743(dph1)

MCEP:

125013964(dph1)

CSEM:

103378239(dph1)

POV:	109630404(dph1)

SSEN:

122772941(dph1)

HHIP:

117772978(dph1)

HSP:	118106334(dph1)

LCF:

108877969

SDU:	111232318(dph1)

SLAL:

111656715(dph1)

XGL:	120792191(dph1)

HCQ:	109518487(dph1)

SSCV:

125972034

BPEC:

110163645(dph1)

MALB:

109968534(dph1)

BSPL:

114868165(dph1)

SASA:

106581169(dph1) 106612930

STRU:

115206357(dph1)

OTW:	112265534 112267114

OMY:	110503945(dph1) 110507778

OGO:	123992726 124005133

ONE:	115118172 115123823(dph1) 115125626

SALP:

111982831

SNH:	120018184(dph1)

CCLU:

121567974

ELS:	105023187(dph1)

SFM:	108932081(dph1)

PKI:	111847109(dph1)

AANG:

118209965(dph1)

LOC:	102694122(dph1)

PSPA:

121308654(dph1)

ARUT:

117429582 117430380

PSEX:

120531623(dph1)

LCM:	102356549 102362800(DPH1)

CMK:	103186918(dph1)

RTP:

109911802

CPLA:

122563919(dph1)

BFO:

118425627

BBEL:

109467939

CIN:

100175202

SCLV:

120334730

SPU:

590421

APLC:

110976648

AJC:

117122152

SKO:

100378925

DME:	Dmel_CG11652(Dph1)

DER:

6544364

DSE:

6605319

DSI:	Dsimw501_GD12784(Dsim_GD12784)

DYA:	Dyak_GE20188

DAN:

6507156

DSR:

110178916

DPO:

4812993

DPE:

6602801

DMN:

108152505

DWI:

6645473

DGR:

6557946

DMO:	Dmoj_GI13721

DAZ:

108613629

DNV:

108651878

DHE:

111592804

DVI:

6623641

CCAT:

101454442

BOD:

106619704

RZE:	108371638 108375372

MDE:

101891032

SCAC:

106082945

LCQ:

111687020

LSQ:

119600244

HIS:

119647785

ACOZ:

120958012

AARA:

120903171

AMER:

121600001 121601355

ASTE:

118503487

AALI:

118466860

AAG:

5575478

AALB:

109431303 109432003 115264575

CQU:	CpipJ_CPIJ007880

CPII:

120417993

CNS:

116337899

BCOO:

119072078

AME:

552087

ACER:

107999244

ALAB:

122716605

BIM:

100742824

BBIF:

117204339

BVK:

117233437

BVAN:

117153251

BTER:

100648784

BPYO:

122569216

CCAL:

108632411

OBB:

114871148

MGEN:

117224552

NMEA:

116428905

CGIG:

122402708

SOC:

105204836

MPHA:

105827800

AEC:

105150583

ACEP:

105620195

PBAR:

105423357

VEM:

105561228

HST:

105191986

DQU:

106747427

CFO:

105257743

FEX:

115235918

LHU:

105679855

PGC:

109856788

OBO:

105275571

PCF:

106786512

PFUC:

122525886

VPS:

122635404

NVI:

100124031

CSOL:

105361299

TPRE:

106656759

LHT:

122507453

LBD:

127288058

MDL:

103578195

CGLO:

123266336

FAS:

105272247

DAM:

107035500

AGIF:

122849581

CINS:

118065937

CCIN:

107267076

DSM:

124410999

NPT:

124219762

NFB:

124184036

NLO:

107224960

TCA:

660204

DPA:

109544261

SOY:

115879847

AGRG:

126742924

ATD:

109594059

CSET:

123308660

AGB:

108909995

LDC:

111504614

NVL:

108558695

APLN:

108742182 112904624

PPYR:

116180995

OTU:

111421311

BMOR:

692933

BMAN:

114247696

MSEX:

115450930

DPL:	KGM_201785

BANY:

112055264

NIQ:

126775321

PMAC:

106711106

PPOT:

106108517

PXU:

106117585

PRAP:

110991470

PBX:

123710407

PNAP:

125053578

ZCE:

119836319

CCRC:

123700572

HAW:

110370774

HZE:

124639373

TNL:	113496384 113506536

SLIU:

111359935

OFU:

114361887

PXY:

105386869

CFEL:

113368328

API:

100160913

DNX:

107171092

AGS:

114129255

RMD:

113556639

BTAB:

109044711

DCI:

103521750

CLEC:

106666049

HHAL:

106685912

NLU:

111045601

PHU:	Phum_PHUM041770

FOC:

113217954

TPAL:

117644367

ZNE:

110834467

CSEC:

111867598

SGRE:

126326039 126354043

FCD:

110853011

DPX:	DAPPUDRAFT_307434

DMK:

116931112

DPZ:

124313725

PVM:

113814263

PJA:

122252087

PCHN:

125031100

PMOO:

119583456

HAME:

121858842

PCLA:

123764297

PTRU:

123503634

ESN:

126986339

HAZT:

108677646

EAF:

111712181

LSM:

121127879

PPOI:

119103350 119103382

ISC:	IscW_ISCW004253

DSV:

119452867

RSAN:

119400505 119400516

VDE:

111245365

VJA:

111268206

TUT:

107372150

DPTE:

113793774 113794438 113796754

DFR:

124490164

CSCU:

111617475 111639168

PTEP:

107455657

SDM:

118187469

LPOL:

106463137

PMEO:

129594174

CEL:	CELE_C14B1.5(dph-1)

CBR:	CBG_09207(Cbr-dph-1)

BMY:	BM_BM8194(Bma-dph-1)

LOA:	LOAG_06255

NAI:	NECAME_16867

TSP:

Tsp_02291

HRO:	HELRODRAFT_113590 HELRODRAFT_83835

LGI:	LOTGIDRAFT_153055

PCAN:

112563107

BGT:	106070236 106076550

GAE:

121368872

HRF:

124133306

HRJ:

124289277

CRG:

105343490

MYI:

110461373

PMAX:

117332998

MCAF:

127712710

MMER:

123544199

DPOL:

127862556

OBI:

106869814

OSN:	115212882 115227608 115229556 115229850

LAK:

106178089

SMM:	Smp_030930.1

SHX:	MS3_00008643(DPH1_1)

EGL:

EGR_08329

NVE:

5506664

EPA:

110234679

ATEN:

116297752

ADF:	107327170 107329582

AMIL:

114948626

SPIS:

111321849

DGT:

114538233

XEN:

124434303

HMG:

100197050

TAD:	TRIADDRAFT_3141

AQU:

100640276

ATH:

AT5G62030

ALY:

9300842

CRB:

17875347

CSAT:

104726793 104739420 104762325

EUS:	EUTSA_v10004160mg

BRP:

103874640

BNA:

106427201

BOE:

106336400

RSZ:

108805289

THJ:

104798941

CIT:

102622644

CIC:	CICLE_v10001185mg

TCC:

18607388

GRA:

105795453

GHI:	107908609 121203425

GAB:

108475932

DZI:

111308673

EGR:

104452750

GMX:

100797181

GSJ:

114424997

PVU:	PHAVU_002G038000g

VRA:

106776523

VAR:

108318976

VUN:

114166536

CCAJ:

109810882

APRC:

113869154

MTR:

11442353

TPRA:

123905992

CAM:

101514419

PSAT:

127120877

LJA:	Lj2g3v2124830.1(Lj2g3v2124830.1)

ADU:	107475020 107475029 107475034 107475126 107488450

AIP:	107625618 107643175

AHF:	112727821 112748643

LANG:

109348570

FVE:

101291951

RCN:

112179850

PPER:

18789979

PMUM:

103319117

PAVI:

110764828

PDUL:

117625971 117627153

MDM:

103435443

MSYL:

126619254

PXB:	103929922 103953629

ZJU:

107416271

MNT:	21384015 21404258

CSV:

101214699

CMO:

103495461

BHJ:

120078323

MCHA:

111021686

CMAX:

111486020

CMOS:

111434567

CPEP:

111792145

RCU:

8277537

JCU:

105635596

HBR:	110645538 110646025 110646064 110646074 110646083

MESC:

110600059

POP:

7491070

PEU:

105115044

PALZ:

118027746

JRE:

109007067

CILL:

122311262

QSU:

112007080

QLO:

115976522

TWL:

119984194

VVI:

100252989

VRI:

117913391

SLY:

101256980

SPEN:

107023734

SOT:

102581184

SSTN:

125851659

CANN:

107872862

NTA:

107791245

NSY:

104212199

NTO:

104104957

NAU:

109227210

INI:

109152915

ITR:

116026551

SIND:

105165124

OEU:

111377255

EGT:

105973704

SSPL:

121780297 121782839 121783065

APAN:

127255643

HAN:

110930111

ECAD:

122599901

LSV:

111887509

CCAV:

112529220

DCR:

108224438

CSIN:

114272626

BVG:

104891236

SOE:

110793601

CQI:	110708239 110711126

NNU:

104604110

PSOM:

113301694 113356111

OSA:

4331131

DOSA:

Os02t0815600-01(Os02g0815600)

OBR:

102718717

OGL:

127764705

BDI:

100829197

ATS:

109779032

TDC:	119318497 119325255

TAES:

123128959 123139707 123146122

TUA:	125515383 125515413

LPER:

127305372

SBI:

8056439

ZMA:

100284663

SITA:

101767368

SVS:

117841546

PVIR:

120646230 120657592

PHAI:

112902883

PDA:

103706948

EGU:

105059175

MUS:

103985278

ZOF:	121967404 122052626

DCT:

110093728

PEQ:

110032881

AOF:

109851117

ATR:

18422363

SMO:	SELMODRAFT_156702 SELMODRAFT_271325

PPP:

112292317

CRE:	CHLRE_09g408500v5

VCN:	VOLCADRAFT_95203

MNG:	MNEG_10366

CSL:	COCSUDRAFT_19880

CVR:	CHLNCDRAFT_23248

APRO:

F751_2153

OLU:	OSTLU_43090

OTA:	OT_ostta15g00765

BPG:	Bathy02g02350

MIS:	MICPUN_89023

MPP:	MICPUCDRAFT_48766

CME:	CYME_CMT628C

GSL:	Gasu_14140

CCP:	CHC_T00008649001

SCE:	YIL103W(DPH1)

SEUB:

DI49_2682

SPAO:

SPAR_I00670

AGO:	AGOS_ADL229W

ERC:

Ecym_3310

KLA:	KLLA0_F03971g

KMX:	KLMA_80145(DPH1)

LTH:	KLTH0G10054g

VPO:	Kpol_1003p27

ZRO:	ZYRO0D02662g

CGR:	CAGL0G02761g

NCS:	NCAS_0B06320(NCAS0B06320)

NDI:	NDAI_0B03620(NDAI0B03620)

TPF:	TPHA_0C03300(TPHA0C03300)

TBL:	TBLA_0G02400(TBLA0G02400)

TGB:	HG536_0B03300

TDL:	TDEL_0C03900(TDEL0C03900)

KAF:	KAFR_0H03400(KAFR0H03400)

KNG:	KNAG_0H02110(KNAG0H02110)

ZMK:	HG535_0D02190

PPA:	PAS_chr4_0072

DHA:	DEHA2E10758g

PIC:	PICST_35812

PGU:	PGUG_05659

SPAA:

SPAPADRAFT_60716

LEL:	LELG_00973

CAL:	CAALFM_C205840WA(CaO19.5207)

CTP:	CTRG_01524

COT:	CORT_0A09210

CDU:	CD36_20280

CTEN:

CANTEDRAFT_114183

YLI:	YALI0F22055g

CLU:	CLUG_02084

CLUS:

A9F13_02g02101

CAUR:

CJI96_0001711

SLB:	AWJ20_2165(DPH1)

PKZ:	C5L36_0D03100

BNN:	FOA43_002305(DPH1)

BBRX:

BRETT_005086(DPH1)

OPA:	HPODL_04172

SLUD:

SCDLUD_002769

NCR:

NCU08503

NTE:	NEUTE1DRAFT83361(NEUTE1DRAFT_83361)

SMP:	SMAC_06261

PAN:	PODANSg6601

TTT:	THITE_2123893

MTM:	MYCTH_2312174

CTHR:

CTHT_0005330

MGR:

MGG_03237

TMN:	UCRPA7_5131

SSCK:

SPSK_09046

FGR:	FGSG_00636

FPU:	FPSE_06400

FVR:	FVEG_00560

FOX:	FOXG_00953

NHE:	NECHADRAFT_65768

TRE:	TRIREDRAFT_76050

TRR:	M419DRAFT_136015

MAW:

MAC_05653

MAJ:

MAA_10721

CMT:

CCM_05185

PLJ:	VFPFJ_07105

PTKZ:

JDV02_006338(DPH1)

VAL:	VDBG_05263

VDA:	VDAG_06912

CFJ:	CFIO01_07286

CLUP:

CLUP02_01507

CHIG:

CH63R_10398

SAPO:

SAPIO_CDS0148

ELA:	UCREL1_1570

PFY:	PFICI_08847

SSL:	SS1G_10656

BFU:	BCIN_04g04550

MBE:

MBM_05350

PSCO:

LY89DRAFT_158125

GLZ:	GLAREA_09659

ANI:

AN6283.2

AFM:	AFUA_2G12440

ACT:	ACLA_071340

NFI:	NFIA_087580

AOR:	AO090026000391

ANG:	ANI_1_2500024(An02g04630)

AFV:	AFLA_005891

ALUC:

AKAW2_21229S(DPH1)

ACHE:

ACHE_40854S(DPH1)

APUU:

APUU_51197A(DPH1)

PCS:	Pc20g14680

PDP:	PDIP_89200

TMF:	EYB26_007297

TRG:	TRUGW13939_07054

CIM:	CIMG_05212

CPW:	CPC735_064790

URE:	UREG_06411

PBL:	PAAG_06214

PBN:	PADG_07032

ABE:

ARB_04875

TVE:

TRV_06574

AJE:	HCAG_03806

BGH:	BDBG_05574

PNO:	SNOG_07675(SNOG_07674)

PTE:

PTT_12706

BZE:	COCCADRAFT_109068

BSC:	COCSADRAFT_160372

BOR:	COCMIDRAFT_2894

AALT:

CC77DRAFT_1090814

ZTR:	MYCGRDRAFT_66970

PFJ:	MYCFIDRAFT_26269

FFU:	CLAFUR5_01409

BCOM:

BAUCODRAFT_123562

NPA:	UCRNP2_7348

TML:	GSTUM_00001067001

SPO:	SPBC3B8.05

CNE:

CNA07400

CNB:

CNBA7230

CNG:	CNAG_00762

CGI:	CGB_A8510W

TMS:	TREMEDRAFT_29921

TASA:

A1Q1_04953

TVS:	TRAVEDRAFT_144365

DSQ:	DICSQDRAFT_60750

SHS:	STEHIDRAFT_155864

HIR:	HETIRDRAFT_48027

PSQ:	PUNSTDRAFT_65664

ADL:	AURDEDRAFT_80258

FME:	FOMMEDRAFT_169554

GTR:	GLOTRDRAFT_55327

LBC:	LACBIDRAFT_243952

CCI:	CC1G_00080

ABP:	AGABI1DRAFT58324(AGABI1DRAFT_58324)

ABV:	AGABI2DRAFT202335(AGABI2DRAFT_202335)

PCUB:

JR316_0004706

MRR:	Moror_17646

E1B28_004630

SCM:	SCHCO_02576699(SCHCODRAFT_02576699)

CPUT:

CONPUDRAFT_168751

SLA:	SERLADRAFT_446577

WSE:	WALSEDRAFT_38823

WIC:	J056_000195

UMA:	UMAG_03038

PFP:	PFL1_06481

MGL:

MGL_0765

MRT:

MRET_0053

MSYM:

MSY001_2121

PGR:	PGTG_12915

MLR:	MELLADRAFT_42750

ECU:	ECU07_0980

EIN:	Eint_070930

EHE:	EHEL_070960

ERO:	EROM_070930

NCE:	NCER_101904

MBR:	MONBRDRAFT_16819

SRE:	PTSG_05983

DDI:	DDB_G0284257(dph1)

DPP:	DICPUDRAFT_150525

DFA:	DFA_09388(dph1)

EHI:	EHI_199050(87.t00020)

EDI:	EDI_263630

EIV:	EIN_169340

ACAN:

ACA1_188750

PFA:	PF3D7_1413800

PFH:	PFHG_04023

PREI:

PRSY57_1413100

PGAB:

PGSY75_1413800

PYO:	PY17X_1031300

PCB:	PCHAS_1029700

PBE:	PBANKA_1028900

PVV:	PVVCY_1003430

PKN:	PKNH_1344500

PVX:	PVX_085760

PCY:	PCYB_134290

TAN:

TA12765

TPV:

TP02_0364

TOT:	TOT_020000356

BEQ:	BEWA_021030

BBO:	BBOV_III005980

BMIC:

BmR1_04g09315

BBIG:

BBBOND_0308040

CPV:

cgd6_2230

CHO:	Chro.60261

TGO:	TGME49_261060

TET:	TTHERM_00658959

PTM:	GSPATT00001229001 GSPATT00002800001

SMIN:

v1.2.033984.t1(symbB.v1.2.033984.t1)

PTI:	PHATRDRAFT_20589

FCY:	FRACYDRAFT_179110

TPS:	THAPSDRAFT_33476

NGD:	NGA_0470300

AAF:	AURANDRAFT_2324

PIF:	PITG_12187

PSOJ:

PHYSODRAFT_297671

SPAR:

SPRG_05058

EHX:	EMIHUDRAFT_426724

GTT:	GUITHDRAFT_160128

TBR:	Tb927.3.4340

TBG:	TbgDal_III4740

TCR:

467795.9

LMA:	LMJF_29_1780

LIF:	LINJ_29_1900

LDO:	LDBPK_291900

LMI:	LMXM_08_29_1780

LBZ:	LBRM_31_0170

LPAN:

LPMP_291780

NGR:	NAEGRDRAFT_30094

MJA:

MJ_0483

MFE:	Mefer_0668

MVU:	Metvu_0203

MFS:	MFS40622_1754

MIF:	Metin_0596

MJH:	JH146_1399

MESG:

MLAUSG7_0217(dph)

MESA:

MLASG1_1454(dph)

MIG:	Metig_0765

MMP:

MMP0188

MMQ:	MmarC5_1488

MMX:	MmarC6_0764

MMZ:	MmarC7_1187

MMD:

GYY_00960

MMAK:

MMKA1_01920(dph2)

MMAO:

MMOS7_02180(dph2)

MMAD:

MMJJ_08970

MAE:

Maeo_0905

MVN:	Mevan_1190

MVO:

Mvol_1475

MOK:	Metok_1263

METF:

CFE53_06405(dph2)

MTH:

MTH_1319

MMG:	MTBMA_c17050

MWO:	MWSIV6_1708

MTEE:

MTTB_01240

METC:

MTCT_1196

METE:

tca_01273

METZ:

METMT2_1310

METK:

FVF72_04980(dph2)

MTHM:

FZP57_08365(dph2)

METJ:

FZP68_02405(dph2)

MST:

Msp_1537

METB:

AW729_07630

MRU:

mru_0166

MSI:

Msm_1358

MEB:

Abm4_1653

MMIL:

sm9_2228

MEYE:

TL18_00635

MOL:

YLM1_1511

MARO:

MarbSA_13300

METV:

K4897_04525(dph2)

MEL:	Metbo_0198

MEW:	MSWAN_2284

METH:

MBMB1_1930

MFC:

BRM9_2270

MFI:	DSM1535_1204

MCUB:

MCBB_2208(dph2)

MSUB:

BK009_08835

METN:

BK008_04475

METT:

CIT01_04810(dph2)

METO:

CIT02_07880(dph2)

MEME:

HYG87_05805(dph2)

MFV:

Mfer_1013

MKA:	MK1517(dph2)

AFU:

AF_1803

AFG:	AFULGI_00020550

APO:	Arcpr_1300

AVE:	Arcve_1511

AST:	Asulf_00518

FPL:

Ferp_2108

GAC:

GACE_0213

GAH:

GAH_00083

PFU:

PF1063

PFI:

PFC_04550

PHO:	PH1105(PH1105)

PAB:

PAB0746

PYN:

PNA2_1802

PYA:	PYCH_04340

PYS:

Py04_1021

PYC:	TQ32_04345

TKO:

TK1928

TON:

TON_1934

TGA:

TGAM_0526

TSI:

TSIB_0075

TBA:	TERMP_01729

THE:

GQS_05470

THA:

TAM4_694

THM:

CL1_0735

TLT:

OCC_06736

THS:

TES1_1725

TNU:

BD01_2020

TEU:

TEU_04410

TGY:	X802_07755

THV:	ADU37_CDS22900

TCH:	CHITON_0893

TPEP:

A0127_04575

TPIE:

A7C91_05710

TGG:	A3K92_03315

TCE:	A3L02_06565

TBS:	A3L01_00400

THH:	CDI07_00430(dph2)

TSL:	A3L11_04140

TTD:	A3L14_01705

TPRF:

A3L09_04885

TRL:	A3L10_10100

TPAF:

A3L08_03505

THY:	A3L12_03375

TIC:	FH039_03650(dph2)

TCQ:	TIRI35C_0293(dph)

THEM:

FPV09_05705(dph2)

THEI:

K1720_03460(dph2)

PPAC:

PAP_09280

MBA:	Mbar_A1634

MBY:	MSBRM_2909

MBW:	MSBRW_3097

MBAR:

MSBR2_2867

MBAK:

MSBR3_1919

MAC:

MA_0718

MMA:	MM_1877(dph2)

MMAZ:

MmTuc01_1952

MMJ:	MSMAS_2810

MMAC:

MSMAC_1628

MVC:	MSVAZ_2565

MEK:	MSKOL_2572

MLS:	MSLAZ_0394

METM:

MSMTP_2709

MEF:	MSWH1_0470

MEQ:	MSWHS_0478

MSJ:	MSSAC_0663

MSZ:	MSSIH_0606

MSW:	MSSIT_0637

MTHR:

MSTHT_1400

MTHE:

MSTHC_1888

MHOR:

MSHOH_3509

MFZ:	AOB57_005990(dph2)

MBU:

Mbur_1436

MMET:

MCMEM_1920

MELO:

J7W08_08570(dph2)

MMH:

Mmah_1741

MHAZ:

BHR79_04995

MEV:	Metev_1360

MZH:	Mzhil_1842

MPY:

Mpsy_2110

MZI:	HWN40_11645(dph2)

MHZ:	Metho_2235

MTP:

Mthe_1635

MCJ:

MCON_3424

MHI:

Mhar_0746

MHU:

Mhun_2613

MRTJ:

KHC33_03545(dph2)

MLA:

Mlab_0218

MEM:	Memar_1846

MBG:	BN140_0543(dph2)

MEMA:

MMAB1_0680(dph)

MCHK:

MchiMG62_21480(dph2)

MSUM:

OH143_03480(dph2)

MPI:

Mpet_0339

MEND:

L6E24_06480(dph2)

MAQE:

RJ40_09405(dph2)

MOU:	OU421_03830(dph2)

MANQ:

L1994_09200(dph2)

MBN:

Mboo_2168

MFO:	Metfor_0585

MPL:

Mpal_2082

MPD:

MCP_1404

MEZ:	Mtc_1792(dph2)

RCI:	RRC214(dph2)

HAL:

VNG_0854C

HSL:	OE_2257F(dph2)

HDL:	HALDL1_08825

HHB:	Hhub_2059(dph2)

HAGS:

JT689_04780(dph2)

HABO:

JRZ79_03275(dph2)

HNO:	LT974_05170(dph2)

HLU:	LT972_07870(dph2)

HANR:

LJ422_03495(dph2)

HJE:	HacjB3_09855

HALH:

HTSR_1307

HHSR:

HSR6_1380

HSU:	HLASF_1327

HSF:	HLASA_1314

SALR:

FQU85_10060(dph2)

HALR:

EFA46_009840(dph2)

HAAD:

MW046_08545(dph2)

HALX:

M0R89_14715(dph2)

HAXZ:

M0R88_15000(dph2)

SALI:

L593_11010

SAIM:

K0C01_10215(dph2)

HARA:

AArcS_0695(dph2)

HMA:

rrnAC0405

HHI:	HAH_1224(dph2)

HHN:	HISP_06270

HAB:	SG26_13915

HTA:	BVU17_05965

HALJ:

G9465_10610(dph2)

HSIN:

KDQ40_07390(dph2)

NPH:	NP_3154A(dph2)

NMO:	Nmlp_2693(dph2)

NHO:	HWV23_00660(dph2)

NSAL:

HWV07_02775(dph2)

HUT:

Huta_2799

HTI:

HTIA_2708

HALA:

Hrd1104_04445(dph2)

HMU:

Hmuk_2492

HALZ:

E5139_15600(dph2)

HALL:

LC1Hm_1854(dph2)

HAZP:

GBQ70_15620(dph2)

HALI:

BV210_00980

HSN:	DV733_13340(dph2)

HDS:	HSR122_1242(dph2)

HRR:	HZS55_17235(dph2)

HPEL:

HZS54_20585(dph2)

HLT:	I7X12_18430(dph2)

HARC:

HARCEL1_07870(dph2)

HDO:	MUK72_13235(dph2)

SSAI:

N0B31_06665(dph2)

HWA:	HQ_2590A(dph2)

HWC:	Hqrw_2904(dph2)

HVO:	HVO_1631(dph2)

HME:	HFX_1717(dph2)

HGI:	ABY42_07945

HALE:

G3A49_11255(dph2)

HLS:	KU306_13240(dph2)

HLN:	SVXHx_1578(dph2)

HBO:	Hbor_15900

HAQ:	DU484_14040(dph2)

HAJ:	DU500_14070(dph2)

HAER:

DU502_12115(dph2)

HRA:	EI982_18135(dph2)

HLM:	DV707_12005(dph2)

HALM:

FCF25_15125(dph2)

HLA:

Hlac_0813

HALP:

DOS48_04245(dph2)

HALB:

EKH57_06730(dph2)

HEZZ:

EO776_05730(dph2)

HALQ:

Hrr1229_000620(dph2)

HSS:	J7656_10125(dph2)

HSAI:

HPS36_01275(dph2)

HAZZ:

KI388_03185(dph2)

SRUB:

C2R22_10160(dph2)

HAE:	halTADL_0960

HALN:

B4589_014060(dph2)

HALG:

HUG10_05115(dph2)

HALU:

HUG12_11920(dph2)

HMP:	K6T50_04405(dph2)

HRE:	K6T36_04215(dph2)

HRM:	K6T25_11580(dph2)

HACB:

Hbl1158_09990(dph2)

HDF:	AArcSl_2069(dph2)

HAH:	Halar_0736

HTU:

Htur_1803

HSAL:

JMJ58_20450(dph2)

HAKZ:

J0X25_15745(dph2)

NMG:	Nmag_3588(dph2)

HXA:	Halxa_3319

NAT:

NJ7G_3013

NPE:	Natpe_2330

NVR:	FEJ81_10640(dph2)

NPL:	FGF80_10285(dph2)

NAY:	HYG81_18360(dph2)

HALY:

HYG82_01930(dph2)

HJT:	DVR14_19995(dph2) DVR14_24135(dph2)

HLO:	J0X27_00585(dph2)

NGE:	Natgr_0035

HRU:	Halru_1352

HALV:

NGM15_06225(dph2)

NOU:	Natoc_1695

HLR:	HALLA_11610

HLC:	CHINAEXTREME15100

NAJ:	B1756_18750

NAG:	AArcMg_1894

NAN:	AArc1_1786

NBG:	DV706_14895(dph2)

NAS:	GCU68_15115(dph2)

HDA:	BB347_04860

SAWL:

NGM29_15005(dph2)

NAC:	AQV86_00465

MELU:

MTLP_10430(dph2)

MEAM:

MU439_00775(dph2)

TAC:

Ta0255

TVO:	TVG1411317(TVG1411317)

PTO:

PTO0430

FAC:	FACI_IFERC01G0731

FAI:

FAD_1627

CDIV:

CPM_1838

TAR:	TALC_00446

MAX:	MMALV_03710

MER:	MMINT_13250

MEAR:

Mpt1_c01750(dph2)

MEUZ:

KRP56_01970(dph2)

MARC:

AR505_1420

ABI:

Aboo_0484

ACF:	AciM339_0558

APE:	APE_0447.1

ACJ:

ACAM_0327

SMR:

Smar_0630

SHC:	Shell_0161

IHO:

Igni_0998

IIS:

EYM_06540

DKA:

DKAM_1412

DFD:	Desfe_0036

DMU:	Desmu_0037

TAG:

Tagg_0035

IAG:

Igag_1048

THG:	TCELL_0451

HBU:

Hbut_1652

PFM:	Pyrfu_0174

PDL:	Pyrde_0521

STO:	STK_22630(dph2)

SOH:	D1869_12445(dph2)

SSO:

SSO0293

SOL:

Ssol_1270

SSOA:

SULA_1313(dph2)

SSOL:

SULB_1314(dph2)

SSOF:

SULC_1312(dph2)

SSHI:

J5U23_03142

SCAS:

SACC_02060

SAI:

Saci_0175

SACN:

SacN8_00830

SACR:

SacRon12I_00830

SACS:

SUSAZ_00880

SIS:	LS215_1947

SIA:	M1425_1807

SIM:	M1627_1925

SID:

M164_1855

SIY:	YG5714_1924

SIN:	YN1551_1001

SII:

LD85_2066

SIH:

SiH_1783

SIR:

SiRe_1703

SIC:

SiL_1697

SULA:

BFU36_04350

SULE:

GFS03_10115(dph2)

SULO:

GFS33_01930(dph2)

SULL:

EWF20_13510(dph2)

MSE:

Msed_1864

MEMJ:

MJ1HA_2126

MCN:

Mcup_0419

MHK:	DFR87_09260(dph2)

MPRU:

DFR88_08880(dph2)

MTEN:

GWK48_02770(dph2)

MJN:	MjAS7_0023

AHO:

Ahos_1225

AMAN:

B6F84_10225

ABRI:

DFR85_09860(dph2)

ASUL:

DFR86_08905(dph2)

AAMB:

D1866_01025(dph2)

ACIH:

HS5_26250

SACD:

HS1genome_2340

SAZO:

D1868_08180(dph2)

CSTY:

KN1_07720

STEP:

IC006_1548

SAHS:

HS7_06230

PAI:

PAE2994

PIS:

Pisl_0393

PCL:

Pcal_1114

PAS:

Pars_1360

PYR:

P186_1539

POG:

Pogu_0854

TNE:

Tneu_1734

PYW:	PYWP30_01853

CMA:

Cmaq_1133

TTN:	TTX_1298(dph2)

TUZ:

TUZN_0093

VDI:

Vdis_1857

VMO:

VMUT_0294

TPE:

Tpen_0882

THB:	N186_05830

TCB:	TCARB_0227

THF:	MA03_05250

THEL:

IG193_03225(dph2)

ASC:

ASAC_1193

ACIA:

SE86_07135

CLG:	Calag_1163

FFO:	FFONT_1102

NMR:

Nmar_1563

NIR:	NSED_00690

NKR:	NKOR_08505

NID:	NPIRD3C_0492

NIN:	NADRNF5_0328

NIW:	Nisw_06085(dph2)

NCL:	C5F47_08195(dph2)

NOX:	C5F49_08080(dph2)

NUE:	C5F50_11440(dph2)

NIP:	NsoK4_08345(dph2)

NZT:	NZOSNM25_000224

NCT:	NMSP_0196(dph2)

NIC:	DSQ20_09105(dph2)

NGA:	Ngar_c07660

NVN:	NVIE_013020

NEV:

NTE_02703

TAA:	NMY3_00914

NFN:	NFRAN_1881

NCV:

NCAV_0164

CSY:	CENSYa_2018

CSU:	CSUB_C0414

NBV:	T478_1283(dph2)

TAH:	SU86_004630

NIU:	DSQ19_01390(dph2)

NDV:

NDEV_1927

CCAI:

NAS2_0164

BARC:

AOA65_2291(dph2)

BARB:

AOA66_0106(dph2)

NEQ:

NEQ226

MARH:

Mia14_0794

FLT:	Sv326_0100

MIY:	Micr_00898(dph2_2)

NCON:

LC1Nh_1144(dph2)

AGW:	QT03_C0001G1299

ARG:	QT11_C0001G0164

» show all

Reference

1 [PMID:15485916]

Authors

Liu S, Milne GT, Kuremsky JG, Fink GR, Leppla SH

Title

Identification of the proteins required for biosynthesis of diphthamide, the target of bacterial ADP-ribosylating toxins on translation elongation factor 2.

Journal

Mol Cell Biol 24:9487-97 (2004)
DOI:10.1128/MCB.24.21.9487-9497.2004

Sequence

[mmu:116905] [sce:YIL103W]

Reference

2 [PMID:20559380]

Authors

Zhang Y, Zhu X, Torelli AT, Lee M, Dzikovski B, Koralewski RM, Wang E, Freed J, Krebs C, Ealick SE, Lin H

Title

Diphthamide biosynthesis requires an organic radical generated by an iron-sulphur enzyme.

Journal

Nature 465:891-6 (2010)
DOI:10.1038/nature09138