KEGG   ENZYME: 2.5.1.115
Entry
EC 2.5.1.115                Enzyme                                 

Name
homogentisate phytyltransferase;
HPT;
VTE2 (gene name)
Class
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
Sysname
phytyl-diphosphate:homogentisate phytyltransferase
Reaction(IUBMB)
phytyl diphosphate + homogentisate = diphosphate + 2-methyl-6-phytylbenzene-1,4-diol + CO2 [RN:R07500]
Reaction(KEGG)
R07500
Substrate
phytyl diphosphate [CPD:C05427];
homogentisate [CPD:C00544]
Product
diphosphate [CPD:C00013];
2-methyl-6-phytylbenzene-1,4-diol [CPD:C15882];
CO2 [CPD:C00011]
Comment
Requires Mg2+ for activity [3]. Involved in the biosynthesis of the vitamin E tocopherols. While the enzyme from the cyanobacterium Synechocystis PCC 6803 has an appreciable activity with geranylgeranyl diphosphate (EC 2.5.1.116, homogentisate geranylgeranyltransferase), the enzyme from the plant Arabidopsis thaliana has only a low activity with that substrate [1,3,4].
History
EC 2.5.1.115 created 2014
Pathway
ec00130  Ubiquinone and other terpenoid-quinone biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K09833  homogentisate phytyltransferase / homogentisate geranylgeranyltransferase
Genes
ATH: AT2G18950(HPT1)
ALY: 9322319
CRB: 17890967
CSAT: 104700961 104747741 104767264 104767267
EUS: EUTSA_v10022720mg
BRP: 103828352
BNA: 106357630 106435342
BOE: 106301964
RSZ: 108807240
THJ: 104819975
TCC: 18589276
GRA: 105783372
GHI: 121225293
GAB: 108450426
EGR: 104437423
GMX: 100301896(G4DT) 100777408(PT10B) 100777517(PT01) 100777935(PT10D) 100786181(PT11A) 100786739 100787246(PT11C) 100787771(PT11B) 100809827(PT03) 100812378(G2DT) 100819685(VTE2-1) 732648(HPT1)
CAM: 101500582
LJA: Lj0g3v0082139.1(Lj0g3v0082139.1) Lj0g3v0207399.1(Lj0g3v0207399.1) Lj0g3v0207399.2(Lj0g3v0207399.2) Lj0g3v0271809.1(Lj0g3v0271809.1) Lj0g3v0361429.2(Lj0g3v0361429.2) Lj2g3v3133590.1(Lj2g3v3133590.1) Lj4g3v2120440.1(Lj4g3v2120440.1) Lj6g3v2116900.1(Lj6g3v2116900.1)
PXB: 103934858
ZJU: 107403648
MNT: 21399785
CSV: 101221791
CMO: 103492819
BHJ: 120079349
MCHA: 111020832
RCU: 8287864
VVI: 100232967(HGGT) 100257787
CANN: 107850218
OEU: 111402203
EGT: 105976586
CCAV: 112516610
NCOL: 116250791
DOSA: Os06t0658900-01(Os06g0658900)
APRO: F751_6870
OLU: OSTLU_119481(hpt1)
SMIN: v1.2.025201.t1(symbB.v1.2.025201.t1)
FCY: FRACYDRAFT_291522(VTE2)
MSAK: MSAS_37510
SYN: slr1736
SYY: SYNGTS_1198(ubiA)
SYT: SYNGTI_1198(ubiA)
SYS: SYNPCCN_1197(ubiA)
SYQ: SYNPCCP_1197(ubiA)
SYP: SYNPCC7002_A0703(hggT)
CYA: CYA_1788
CYB: CYB_2237
SYV: AWQ23_03665(ubiA)
AMR: AM1_4541
MAR: MAE_41250
MPK: VL20_3746
CYT: cce_0241
TER: Tery_3881
GVI: gll0283(ubiA)
GLJ: GKIL_2663(ubiA)
ANA: alr3448
NON: NOS3756_12030(ubiA_1)
NSH: GXM_00460
AVA: Ava_3472
NAZ: Aazo_3462
ANB: ANA_C20682(ubiA)
AWA: AA650_08020(ubiA)
CALH: IJ00_11015(ubiA)
CTHE: Chro_0306
CAU: Caur_3427
CAG: Cagg_0386
 » show all
Reference
1  [PMID:11706191]
  Authors
Collakova E, DellaPenna D
  Title
Isolation and functional analysis of homogentisate phytyltransferase from Synechocystis sp. PCC 6803 and Arabidopsis.
  Journal
Plant Physiol 127:1113-24 (2001)
DOI:10.1104/pp.010421
  Sequence
[ath:AT2G18950] [syn:slr1736]
Reference
2  [PMID:12011362]
  Authors
Savidge B, Weiss JD, Wong YH, Lassner MW, Mitsky TA, Shewmaker CK, Post-Beittenmiller D, Valentin HE
  Title
Isolation and characterization of homogentisate phytyltransferase genes from Synechocystis sp. PCC 6803 and Arabidopsis.
  Journal
Plant Physiol 129:321-32 (2002)
DOI:10.1104/pp.010747
  Sequence
[ath:AT2G18950] [syn:slr1736]
Reference
3  [PMID:16989822]
  Authors
Sadre R, Gruber J, Frentzen M
  Title
Characterization of homogentisate prenyltransferases involved in plastoquinone-9 and tocochromanol biosynthesis.
  Journal
FEBS Lett 580:5357-62 (2006)
DOI:10.1016/j.febslet.2006.09.002
  Sequence
[ath:AT2G18950]
Reference
4  [PMID:21223386]
  Authors
Yang W, Cahoon RE, Hunter SC, Zhang C, Han J, Borgschulte T, Cahoon EB
  Title
Vitamin E biosynthesis: functional characterization of the monocot homogentisate  geranylgeranyl transferase.
  Journal
Plant J 65:206-17 (2011)
DOI:10.1111/j.1365-313X.2010.04417.x
Other DBs
ExplorEnz - The Enzyme Database: 2.5.1.115
IUBMB Enzyme Nomenclature: 2.5.1.115
ExPASy - ENZYME nomenclature database: 2.5.1.115
BRENDA, the Enzyme Database: 2.5.1.115

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