KEGG ENZYME: 2.5.1.117

ENZYME: 2.5.1.117

Entry

EC 2.5.1.117 Enzyme

Name

homogentisate solanesyltransferase;
HST;
PDS2 (gene name)

Class

Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)

Sysname

all-trans-nonaprenyl diphosphate:homogentisate nonaprenyltransferase

Reaction(IUBMB)

all-trans-nonaprenyl diphosphate + homogentisate = diphosphate + 2-methyl-6-all-trans-nonaprenylbenzene-1,4-diol + CO2 [RN:R08782]

Reaction(KEGG)

R08782

Substrate

all-trans-nonaprenyl diphosphate [CPD:C04145];
homogentisate [CPD:C00544]

Product

diphosphate [CPD:C00013];
2-methyl-6-all-trans-nonaprenylbenzene-1,4-diol [CPD:C17570];
CO2 [CPD:C00011]

Comment

Requires Mg2+ for activity. Part of the biosynthesis pathway of plastoquinol-9. The enzymes purified from the plant Arabidopsis thaliana and the alga Chlamydomonas reinhardtii are also active in vitro with unsaturated C10-C20 prenyl diphosphates, producing main products that are not decarboxylated [2].

History

EC 2.5.1.117 created 2014

Pathway

ec00130

Ubiquinone and other terpenoid-quinone biosynthesis

ec01100

Metabolic pathways

ec01110

Biosynthesis of secondary metabolites

Orthology

K12501

homogentisate solanesyltransferase

Genes

ATH:	AT3G11945(HST)

ALY:

9320940

CRB:

17893368

CSAT:

104745405 104764953 104776009

EUS:	EUTSA_v10020917mg

BRP:	103859421 103870296

BNA:	106353069 106401877 106415089 106452511

BOE:	106295456 106328784

RSZ:	108857256 108861640

THJ:

104799273

CPAP:

110811676

CIT:	102623177 102623846

CIC:	CICLE_v10011942mg

TCC:

18599202

GRA:

105799584

GHI:	107889470 107891223

GAB:

108454348

DZI:

111311614

EGR:

104446383

GMX:	106794098 732619(VTE2-2)

GSJ:	114368608 114391749

PVU:	PHAVU_007G263400g PHAVU_007G263600g

VRA:

VAR:

VUN:

CCAJ:

MTR:	MTR_1g054305

CAM:

101499831

LJA:	Lj5g3v0380030.1(Lj5g3v0380030.1)

ADU:

107488364

AIP:	107638265 107640277 107643163

LANG:

FVE:

RCN:

PPER:

PMUM:

PAVI:

MDM:	103413543 103453758

ZJU:	107432279 107432297

CSV:	101215738 101215980

CMO:	103486726 103486727

MCHA:

111019344 111019365

CMAX:

111467177 111481663 111481664 111498286 111498673

CMOS:

111435517 111442127 111442432 111450149 111450175

CPEP:

111790845 111790846 111799849 111799850 111803401

RCU:

8258414

JCU:	105648960 105648962

HBR:	110649073 110650511

MESC:

POP:

PEU:

JRE:

QSU:

VVI:

SLY:	101248379 101261100

SPEN:

107014921 107016124

SOT:	102579801 102594989

CANN:

107863628 107870331

NTA:	107763448 107769019 107817989 107825180

NSY:	104237036 104244646

NTO:	104097789 104111561

NAU:	109213402 109223328

INI:

SIND:

OEU:

HAN:

LSV:

CCAV:

DCR:

BVG:

SOE:

CQI:	110689168 110704797

NNU:

104597646

PSOM:

113309639

OSA:	4329918 4343702

DOSA:

Os02t0605500-01(Os02g0605500) Os07t0576000-01(Os07g0576000)

OBR:	102701141 102706213

BDI:	100825292 100843188

ATS:	109758564 109781870(LOC109781870)

SBI:	8055688 8056504

ZMA:	100192987 100280305(cl627_1)

SITA:

PDA:

EGU:

MUS:

DCT:

PEQ:

AOF:	109833364 109845764

ATR:

18448880

SMO:	SELMODRAFT_110629 SELMODRAFT_229530 SELMODRAFT_404704 SELMODRAFT_438363 SELMODRAFT_444463

PPP:

112292815

CRE:	CHLREDRAFT_118917(HST1)

VCN:	VOLCADRAFT_78084

CSL:	COCSUDRAFT_15913

CVR:	CHLNCDRAFT_22974

APRO:

F751_1997

OLU:	OSTLU_32069

OTA:	OT_ostta06g01340

BPG:	Bathy05g01370

MIS:	MICPUN_108125

MPP:	MICPUCDRAFT_58789

CME:	CYME_CMS413C

GSL:	Gasu_34090

CCP:	CHC_T00000930001

SMIN:

v1.2.009000.t1(symbB.v1.2.009000.t1) v1.2.009000.t2(symbB.v1.2.009000.t2) v1.2.009000.t3(symbB.v1.2.009000.t3)

PTI:	PHATRDRAFT_2738

FCY:	FRACYDRAFT_189402

TPS:	THAPSDRAFT_263902

EHX:	EMIHUDRAFT_115547 EMIHUDRAFT_95285

GTT:	GUITHDRAFT_157479

FLM:

MY04_4982

» show all

Reference

1 [PMID:16989822]

Authors

Sadre R, Gruber J, Frentzen M

Title

Characterization of homogentisate prenyltransferases involved in plastoquinone-9 and tocochromanol biosynthesis.

Journal

FEBS Lett 580:5357-62 (2006)
DOI:10.1016/j.febslet.2006.09.002

Sequence

[cre:CHLREDRAFT_118917]

Reference

2 [PMID:20400515]

Authors

Sadre R, Frentzen M, Saeed M, Hawkes T

Title

Catalytic reactions of the homogentisate prenyl transferase involved in plastoquinone-9 biosynthesis.

Journal

J Biol Chem 285:18191-8 (2010)
DOI:10.1074/jbc.M110.117929

Sequence

[cre:CHLREDRAFT_118917] [ath:AT3G11945]

Other DBs

ExplorEnz - The Enzyme Database:

2.5.1.117

IUBMB Enzyme Nomenclature:

2.5.1.117

ExPASy - ENZYME nomenclature database:

2.5.1.117

BRENDA, the Enzyme Database:

2.5.1.117

DBGET integrated database retrieval system