KEGG   ENZYME: 2.5.1.117
Entry
EC 2.5.1.117                Enzyme                                 
Name
homogentisate solanesyltransferase;
HST;
PDS2 (gene name)
Class
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
Sysname
all-trans-nonaprenyl-diphosphate:homogentisate nonaprenyltransferase
Reaction(IUBMB)
all-trans-nonaprenyl diphosphate + homogentisate = diphosphate + 2-methyl-6-all-trans-nonaprenylbenzene-1,4-diol + CO2 [RN:R08782]
Reaction(KEGG)
R08782
Substrate
all-trans-nonaprenyl diphosphate [CPD:C04145];
homogentisate [CPD:C00544]
Product
diphosphate [CPD:C00013];
2-methyl-6-all-trans-nonaprenylbenzene-1,4-diol [CPD:C17570];
CO2 [CPD:C00011]
Comment
Requires Mg2+ for activity. Part of the biosynthesis pathway of plastoquinol-9. The enzymes purified from the plant Arabidopsis thaliana and the alga Chlamydomonas reinhardtii are also active in vitro with unsaturated C10 to C20 prenyl diphosphates, producing main products that are not decarboxylated [2].
History
EC 2.5.1.117 created 2014
Pathway
ec00130  Ubiquinone and other terpenoid-quinone biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K12501  homogentisate solanesyltransferase
Genes
ATHAT3G11945(HST)
ALY9320940
CRB17893368
CSAT104745405 104764953 104776009
EUSEUTSA_v10020917mg
BRP103859421 103870296
BNA106353069 106401877 106415089 106452511
BOE106295456 106328784
RSZ108857256 108861640
THJ104799273
CPAP110811676
CIT102623177 102623846
CICCICLE_v10011942mg
PVY116123782 116141098
MINC123217947
TCC18599202
GRA105799584
GHI107889470 107891223
GAB108454348
DZI111311614
EGR104446383
GMX106794098 732619(VTE2-2)
GSJ114368608 114391749
PVUPHAVU_007G263400g PHAVU_007G263600g
VRA106772791
VAR108324919
VUN114189752
CCAJ109815147
APRC113870943
MTRMTR_1g054305
CAM101499831
LJALj5g3v0380030.1(Lj5g3v0380030.1)
ADU107488364
AIP107638265 107640277 107643163
AHF112740928 112749774 112749775 112801368
LANG109348270
FVE101315076
RCN112191407
PPER18771788
PMUM103339596
PAVI110748815
PDUL117634837
MDM103413543 103453758
ZJU107432279 107432297
MNT112090276 112090288 112090338 112090624 112090625 112090629 112091786 112092455 112092457 112092653 112092669 112093398 112093399 112093962 21386351 21386352 21391268 21392968 21395652 21395653 21397213 21397216 21397218 21397221 21400881 21408641 21408642
CSV101215738 101215980
CMO103486726 103486727
BHJ120090397 120091489
MCHA111019344 111019365
CMAX111467177 111481663 111481664 111498286 111498673
CMOS111435517 111442127 111442432 111450149 111450175
CPEP111790845 111790846 111799849 111799850 111803401
RCU8258414
JCU105648960 105648962
HBR110649073 110650511
MESC110621278 110621370
POP7479502
PEU105141559
PALZ118043922
JRE109013473
QSU111994066
QLO115953720
TWL120013938
VVI100264108
VRI117921155
SLY101248379 101261100
SPEN107014921 107016124
SOT102579801 102594989
CANN107863628 107870331
NTA107763448 107769019 107817989 107825180
NSY104237036 104244646
NTO104097789 104111561
NAU109213402 109223328
INI109181711
ITR116006115 116021727
SIND105159639
OEU111391091
EGT105955266
SSPL121794363 121798679
HAN110898146
ECAD122607555
LSV111905349
CCAV112521993
DCR108218311
CSIN114272823
BVG104906725
SOE110799402
CQI110689168 110704797
NNU104597646
MING122061018
TSS122642920
PSOM113309639
NCOL116249599
OSA4329918 4343702
DOSAOs02t0605500-01(Os02g0605500) Os07t0576000-01(Os07g0576000)
OBR102701141 102706213
BDI100825292 100843188
ATS109758564 109781870
TDC119289099 119317061 119324366 119349253
TAES123065273 123127661 123137417 123142883 123144765 123182829
SBI8055688 8056504
ZMA100192987 100280305
SITA101756828 101765307
SVS117844840 117860950
PVIR120656371 120661772 120692591 120707832
PHAI112879693 112891642
PDA103717661 120105149
EGU105046456
MUS103983014
DCT110095454
PEQ110023474
AOF109833364 109845764
ATR18448880
SMOSELMODRAFT_110629 SELMODRAFT_229530 SELMODRAFT_404704 SELMODRAFT_438363 SELMODRAFT_444463
PPP112292815
CRECHLRE_06g283750v5
VCNVOLCADRAFT_78084
CSLCOCSUDRAFT_15913
CVRCHLNCDRAFT_22974
APROF751_1997
OLUOSTLU_32069
OTAOT_ostta06g01340
BPGBathy05g01370
MISMICPUN_108125
MPPMICPUCDRAFT_58789
CMECYME_CMS413C
GSLGasu_34090
CCPCHC_T00000930001
SMINv1.2.009000.t1(symbB.v1.2.009000.t1) v1.2.009000.t2(symbB.v1.2.009000.t2) v1.2.009000.t3(symbB.v1.2.009000.t3)
PTIPHATRDRAFT_2738
FCYFRACYDRAFT_189402
TPSTHAPSDRAFT_263902
EHXEMIHUDRAFT_115547 EMIHUDRAFT_95285
GTTGUITHDRAFT_157479
FLMMY04_4982
 » show all
Reference
1  [PMID:16989822]
  Authors
Sadre R, Gruber J, Frentzen M
  Title
Characterization of homogentisate prenyltransferases involved in plastoquinone-9 and tocochromanol biosynthesis.
  Journal
FEBS Lett 580:5357-62 (2006)
DOI:10.1016/j.febslet.2006.09.002
  Sequence
Reference
2  [PMID:20400515]
  Authors
Sadre R, Frentzen M, Saeed M, Hawkes T
  Title
Catalytic reactions of the homogentisate prenyl transferase involved in plastoquinone-9 biosynthesis.
  Journal
J Biol Chem 285:18191-8 (2010)
DOI:10.1074/jbc.M110.117929
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.5.1.117
IUBMB Enzyme Nomenclature: 2.5.1.117
ExPASy - ENZYME nomenclature database: 2.5.1.117
BRENDA, the Enzyme Database: 2.5.1.117

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