Entry
Name
homogentisate solanesyltransferase;
HST;
PDS2 (gene name)
Class
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
BRITE hierarchy
Sysname
all-trans-nonaprenyl-diphosphate:homogentisate nonaprenyltransferase
Reaction(IUBMB)
all-trans-nonaprenyl diphosphate + homogentisate = diphosphate + 2-methyl-6-all-trans-nonaprenylbenzene-1,4-diol + CO2 [RN:
R08782 ]
Reaction(KEGG)
Substrate
all-trans-nonaprenyl diphosphate [CPD:
C04145 ];
homogentisate [CPD:
C00544 ]
Product
diphosphate [CPD:
C00013 ];
2-methyl-6-all-trans-nonaprenylbenzene-1,4-diol [CPD:
C17570 ];
CO2 [CPD:
C00011 ]
Comment
Requires Mg2+ for activity. Part of the biosynthesis pathway of plastoquinol-9. The enzymes purified from the plant Arabidopsis thaliana and the alga Chlamydomonas reinhardtii are also active in vitro with unsaturated C10 to C20 prenyl diphosphates, producing main products that are not decarboxylated [2].
History
EC 2.5.1.117 created 2014
Pathway
ec00130 Ubiquinone and other terpenoid-quinone biosynthesis
ec01110 Biosynthesis of secondary metabolites
Orthology
K12501 homogentisate solanesyltransferase
Genes
CSAT : 104745405 104764953 104776009
BNA : 106353069 106401877 106415089 106452511
GMX : 106794098 732619(VTE2-2)
PVU : PHAVU_007G263400g PHAVU_007G263600g
LJA : Lj5g3v0380030.1(Lj5g3v0380030.1)
AIP : 107638265 107640277 107643163
AHF : 112740928 112749774 112749775 112801368
MSYL : 126594281 126600879
MNT : 112090276 112090288 112090338 112090624 112090625 112090629 112091786 112092455 112092457 112092653 112092669 112093398 112093399 112093962 21386351 21386352 21391268 21392968 21395652 21395653 21397213 21397216 21397218 21397221 21400881 21408641 21408642
CSAV : 115699217 115707809 115713148 115713171 115713185 115713205 115713215
MCHA : 111019344 111019365
CMAX : 111467177 111481663 111481664 111498286 111498673
CMOS : 111435517 111442127 111442432 111450149 111450175
CPEP : 111790845 111790846 111799849 111799850 111803401
MESC : 110621278 110621370
SPEN : 107014921 107016124
SSTN : 125857015 125860216
CANN : 107863628 107870331
NTA : 107763448 107769019 107817989 107825180
SSPL : 121794363 121798679
DOSA : Os02t0605500-01(Os02g0605500) Os07t0576000-01(Os07g0576000)
TDC : 119289099 119317061 119324366 119349253
TAES : 123065273 123127661 123137417 123142883 123144765 123182829
LPER : 127307189 127324533
SITA : 101756828 101765307
PVIR : 120656371 120661772 120692591 120707832
PHAI : 112879693 112891642
SMO : SELMODRAFT_110629 SELMODRAFT_229530 SELMODRAFT_404704 SELMODRAFT_438363 SELMODRAFT_444463
SMIN : v1.2.009000.t1(symbB.v1.2.009000.t1) v1.2.009000.t2(symbB.v1.2.009000.t2) v1.2.009000.t3(symbB.v1.2.009000.t3)
EHX : EMIHUDRAFT_115547 EMIHUDRAFT_95285
» show all
Taxonomy
Reference
Authors
Sadre R, Gruber J, Frentzen M
Title
Characterization of homogentisate prenyltransferases involved in plastoquinone-9 and tocochromanol biosynthesis.
Journal
Sequence
Reference
Authors
Sadre R, Frentzen M, Saeed M, Hawkes T
Title
Catalytic reactions of the homogentisate prenyl transferase involved in plastoquinone-9 biosynthesis.
Journal
Sequence
Other DBs
ExPASy - ENZYME nomenclature database: 2.5.1.117