KEGG   ENZYME: 2.5.1.117
Entry
EC 2.5.1.117                Enzyme                                 

Name
homogentisate solanesyltransferase;
HST;
PDS2 (gene name)
Class
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
Sysname
all-trans-nonaprenyl diphosphate:homogentisate nonaprenyltransferase
Reaction(IUBMB)
all-trans-nonaprenyl diphosphate + homogentisate = diphosphate + 2-methyl-6-all-trans-nonaprenylbenzene-1,4-diol + CO2 [RN:R08782]
Reaction(KEGG)
R08782
Substrate
all-trans-nonaprenyl diphosphate [CPD:C04145];
homogentisate [CPD:C00544]
Product
diphosphate [CPD:C00013];
2-methyl-6-all-trans-nonaprenylbenzene-1,4-diol [CPD:C17570];
CO2 [CPD:C00011]
Comment
Requires Mg2+ for activity. Part of the biosynthesis pathway of plastoquinol-9. The enzymes purified from the plant Arabidopsis thaliana and the alga Chlamydomonas reinhardtii are also active in vitro with unsaturated C10-C20 prenyl diphosphates, producing main products that are not decarboxylated [2].
History
EC 2.5.1.117 created 2014
Pathway
ec00130  Ubiquinone and other terpenoid-quinone biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K12501  homogentisate solanesyltransferase
Genes
ATH: AT3G11945(HST)
ALY: 9320940
CRB: 17893368
CSAT: 104745405 104764953 104776009
EUS: EUTSA_v10020917mg
BRP: 103859421 103870296
BNA: 106353069 106401877 106415089 106452511
BOE: 106295456 106328784
RSZ: 108857256 108861640
THJ: 104799273
CPAP: 110811676
TCC: 18599202
GRA: 105799584
GAB: 108454348
DZI: 111311614
EGR: 104446383
GMX: 106794098 732619(VTE2-2)
VRA: 106772791
VAR: 108324919
VUN: 114189752
CCAJ: 109815147
CAM: 101499831
LJA: Lj5g3v0380030.1(Lj5g3v0380030.1)
ADU: 107488364
LANG: 109348270
FVE: 101315076
RCN: 112191407
PPER: 18771788
PMUM: 103339596
PAVI: 110748815
RCU: 8258414
POP: 7479502
PEU: 105141559
JRE: 109013473
QSU: 111994066
VVI: 100264108
INI: 109181711
SIND: 105159639
OEU: 111391091
HAN: 110898146
LSV: 111905349
CCAV: 112521993
DCR: 108218311
BVG: 104906725
SOE: 110799402
NNU: 104597646
PSOM: 113309639
DOSA: Os02t0605500-01(Os02g0605500) Os07t0576000-01(Os07g0576000)
ATS: 109758564 109781870(LOC109781870)
ZMA: 100192987 100280305(cl627_1)
PDA: 103717661
EGU: 105046456
MUS: 103983014
DCT: 110095454
PEQ: 110023474
ATR: 18448880
PPP: 112292815
CRE: CHLREDRAFT_118917(HST1)
APRO: F751_1997
SMIN: v1.2.009000.t1(symbB.v1.2.009000.t1) v1.2.009000.t2(symbB.v1.2.009000.t2) v1.2.009000.t3(symbB.v1.2.009000.t3)
FLM: MY04_4982
 » show all
Reference
1  [PMID:16989822]
  Authors
Sadre R, Gruber J, Frentzen M
  Title
Characterization of homogentisate prenyltransferases involved in plastoquinone-9 and tocochromanol biosynthesis.
  Journal
FEBS Lett 580:5357-62 (2006)
DOI:10.1016/j.febslet.2006.09.002
  Sequence
Reference
2  [PMID:20400515]
  Authors
Sadre R, Frentzen M, Saeed M, Hawkes T
  Title
Catalytic reactions of the homogentisate prenyl transferase involved in plastoquinone-9 biosynthesis.
  Journal
J Biol Chem 285:18191-8 (2010)
DOI:10.1074/jbc.M110.117929
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.5.1.117
IUBMB Enzyme Nomenclature: 2.5.1.117
ExPASy - ENZYME nomenclature database: 2.5.1.117
BRENDA, the Enzyme Database: 2.5.1.117

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