Entry |
|
Name |
homogentisate solanesyltransferase;
HST;
PDS2 (gene name)
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Class |
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
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Sysname |
all-trans-nonaprenyl diphosphate:homogentisate nonaprenyltransferase
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Reaction(IUBMB) |
all-trans-nonaprenyl diphosphate + homogentisate = diphosphate + 2-methyl-6-all-trans-nonaprenylbenzene-1,4-diol + CO2 [RN: R08782]
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Reaction(KEGG) |
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Substrate |
all-trans-nonaprenyl diphosphate [CPD: C04145];
homogentisate [CPD: C00544]
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Product |
diphosphate [CPD: C00013];
2-methyl-6-all-trans-nonaprenylbenzene-1,4-diol [CPD: C17570];
CO2 [CPD: C00011]
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Comment |
Requires Mg2+ for activity. Part of the biosynthesis pathway of plastoquinol-9. The enzymes purified from the plant Arabidopsis thaliana and the alga Chlamydomonas reinhardtii are also active in vitro with unsaturated C10-C20 prenyl diphosphates, producing main products that are not decarboxylated [2].
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History |
EC 2.5.1.117 created 2014
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Pathway |
ec00130 | Ubiquinone and other terpenoid-quinone biosynthesis |
ec01110 | Biosynthesis of secondary metabolites |
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Orthology |
K12501 | homogentisate solanesyltransferase |
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Genes |
» show all
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Reference |
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Authors |
Sadre R, Gruber J, Frentzen M |
Title |
Characterization of homogentisate prenyltransferases involved in plastoquinone-9 and tocochromanol biosynthesis. |
Journal |
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Sequence |
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Reference |
|
Authors |
Sadre R, Frentzen M, Saeed M, Hawkes T |
Title |
Catalytic reactions of the homogentisate prenyl transferase involved in plastoquinone-9 biosynthesis. |
Journal |
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Sequence |
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Other DBs |
ExPASy - ENZYME nomenclature database: | 2.5.1.117 |
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