KEGG   ENZYME: 2.5.1.120
Entry
EC 2.5.1.120                Enzyme                                 

Name
aminodeoxyfutalosine synthase;
MqnE;
AFL synthase;
aminofutalosine synthase;
S-adenosyl-L-methionine:3-[(1-carboxyvinyl)-oxy]benzoate adenosyltransferase (bicarbonate-hydrolysing, 6-amino-6-deoxyfutalosine-forming)
Class
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
Sysname
S-adenosyl-L-methionine:3-[(1-carboxyvinyl)-oxy]benzoate adenosyltransferase (HCO3--hydrolysing, 6-amino-6-deoxyfutalosine-forming)
Reaction(IUBMB)
S-adenosyl-L-methionine + 3-[(1-carboxyvinyl)oxy]benzoate + H2O = 6-amino-6-deoxyfutalosine + L-methionine + HCO3- [RN:R10667]
Reaction(KEGG)
R10667
Substrate
S-adenosyl-L-methionine [CPD:C00019];
3-[(1-carboxyvinyl)oxy]benzoate [CPD:C20772];
H2O [CPD:C00001]
Product
6-amino-6-deoxyfutalosine [CPD:C20773];
L-methionine [CPD:C00073];
HCO3- [CPD:C00288]
Comment
This enzyme is a member of the 'AdoMet radical' (radical SAM) family. S-Adenosyl-L-methionine acts as both a radical generator and as the source of the transferred adenosyl group. The enzyme, found in several bacterial species, is part of the futalosine pathway for menaquinone biosynthesis.
History
EC 2.5.1.120 created 2014
Pathway
ec00130  Ubiquinone and other terpenoid-quinone biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K18285  aminodeoxyfutalosine synthase
Genes
HPY: HP0654
HEO: C694_03380
HPJ: jhp_0599
HPA: HPAG1_0639
HPS: HPSH_03585
HHP: HPSH112_03740
HHQ: HPSH169_03355
HHR: HPSH417_03165
HPG: HPG27_616
HPP: HPP12_0667
HPL: HPB8_857
HPZ: HPKB_0690
HPD: KHP_0667
HEY: MWE_0854
HPYR: K747_07365
HPYI: K750_05585
HPYU: K751_04110
HPYM: K749_02000
HEB: U063_0958
HEZ: U064_0962
HHE: HH_1021
HAC: Hac_0839
HMS: HMU06060
HCE: HCW_05760
HCM: HCD_05315
HCP: HCN_0074
WSU: WS2177
SUA: Saut_1516
SULN: FJR47_06880(mqnE)
SULG: FJR48_03675(mqnE)
SULC: CVO_02635(mqnE)
SPAL: FM071_07125(mqnE)
SULR: B649_03315
CJE: Cj1368
CJU: C8J_1287
CJI: CJSA_1302
CJM: CJM1_1328
CJS: CJS3_1466
CJEJ: N564_01364
CJEU: N565_01404
CJEN: N755_01401
CJEI: N135_01456
CJER: H730_07805
CJY: QZ67_01505(mqnE_2)
CJQ: UC78_1315(mqnE_2)
CJR: CJE1560
CFZ: CSG_2310
CLA: CLA_0427
CCQ: N149_1332(mqnE)
CCF: YSQ_02015
CCY: YSS_07410
CCOI: YSU_02050
CCOF: VC76_06860(mqnE_2)
CCOO: ATE51_00826(mqnE_1)
CIS: CINS_0406
CVO: CVOL_0417
CPEL: CPEL_0436
CGRA: CGRAC_1021
CURE: CUREO_1051
CHYO: CHH_0511
CSPF: CSF_0597
CCUN: CCUN_1423
CLX: CLAN_0672
CAVI: CAV_1189
CHW: A2J15_004620(mqnE)
CAMY: CSUIS_0728
COJ: CORN_0434
CGEO: CGEO_1102
CCOR: CCORG_0672
ABU: Abu_0251
ABT: ABED_0234
ASK: EI285_08550(mqnE)
ATP: ATR_0180
AELL: AELL_0398
AAQI: AAQM_0315
ACIB: ACBT_1955
ASUI: ASUIS_0323
ACRE: ACRYA_1762
ACLO: ACLO_0374
ALK: ALEK_3080
AMYT: AMYT_2431
AMAR: AMRN_2478
ACAA: ACAN_2465
AMOL: AMOL_2449
APAI: APAC_2268
APOC: APORC_1850
HBV: ABIV_2310
HEBR: AEBR_2684
PACO: AACT_0429
ARC: ABLL_0385
SDL: Sdel_1686
SMUL: SMUL_2362
SHAL: SHALO_2108
SULJ: SJPD1_2127
SULT: FA592_03180(mqnE)
HYO: NNO_1448
SUN: SUN_0538
NIS: NIS_0648
NAM: NAMH_1275
CMED: FE773_03450(mqnE)
CPAF: C6V80_07275(mqnE)
GSU: GSU0441(mqnC-2)
GSK: KN400_0416(mqnC-2)
GME: Gmet_3391(mqnC-2)
GUR: Gura_4284
GLO: Glov_0625
GBM: Gbem_0234(mqnC-2)
GEO: Geob_0418(mqnC-2)
GEM: GM21_0218
GEB: GM18_0263
PCA: Pcar_0319(mqnC-2)
PPD: Ppro_3578
DES: DSOUD_0278(mqnC-2)
DEU: DBW_0510
DVU: DVU2756
DVL: Dvul_0551
DVM: DvMF_1188
DDE: Dde_0798
DDS: Ddes_1279
DMA: DMR_08720
DGG: DGI_2623
DTR: RSDT_0540(mqnE)
DFL: DFE_3185
DMS: E8L03_14105(mqnE)
DAS: Daes_2223
DPI: BN4_20498
PPRF: DPRO_3994(mqnE)
PSEL: GM415_11850(mqnE)
DBA: Dbac_2962
DRT: Dret_0149
DSF: UWK_02735
DOL: Dole_1271
DML: Dmul_31780(cofH)
DTO: TOL2_C34500(cofH)
DOV: DSCO28_01310(mqnE)
DWD: DSCW_12280(mqnE)
DALK: DSCA_05040(mqnE)
ADE: Adeh_0372
SFU: Sfum_3089
DAX: FDQ92_08525(mqnE)
DBR: Deba_2194
BBEV: BBEV_0644
BHA: BH3411
BCL: ABC2933
BKW: BkAM31D_19845(mqnE_2)
SALE: EPH95_08990(mqnE)
BSE: Bsel_1178
BRW: GOP56_13065(mqnE)
PPY: PPE_03905
PPO: PPM_4103(M1_4511)
PPOL: X809_36635
PPOY: RE92_16725
PMW: B2K_05750
PLV: ERIC2_c29720(cofH2)
PSAB: PSAB_19705
PRI: PRIO_5647
PSWU: SY83_00115
PLW: D5F53_02780(mqnE)
PLEN: EIM92_08800(mqnE)
PPSC: EHS13_08755(mqnE)
PLUT: EI981_23755(mqnE)
PALB: EJC50_10910(mqnE)
PBK: Back11_30130(mqnE)
PPRT: ET464_19395(mqnE)
ASOC: CB4_01045(mqnE_1)
COH: EAV92_01450(mqnE)
COHN: KCTCHS21_45070(mqnE)
SACA: FFV09_06490(mqnE)
TVU: AB849_002130(mqnE)
STH: STH817
SWO: Swol_1157
SLP: Slip_1167
SALQ: SYNTR_0718
DRM: Dred_2195
DAE: Dtox_1643
PTH: PTH_0209(ThiH)
DAU: Daud_1089
SGY: Sgly_2856
TFR: BR63_14140(mqnE)
HMO: HM1_1947
HCV: FTV88_1659(mqnE)
CTHM: CFE_1271
CHY: CHY_1806
MTA: Moth_1846
MTHO: MOTHE_c18760(mqnE)
MTHZ: MOTHA_c19560(mqnE)
ADG: Adeg_1450
TACI: TDSAC_0246
MHG: MHY_27660
MFUN: GXM21_06140(mqnE) GXM21_06145(mqnE)
MANA: MAMMFC1_02995(mqnE_1) MAMMFC1_03449(mqnE_3)
STED: SPTER_38990(mqnE)
SCO: SCO4494(SCD35.01)
SALB: XNR_3569
SMA: SAVERM_4813(cofH1)
SGR: SGR_4206
SGB: WQO_14525
SCT: SCAT_3453
SFA: Sfla_3609
SBH: SBI_06076
SHY: SHJG_5673
SVE: SVEN_3124
STRP: F750_3111
SFI: SFUL_2949
SALU: DC74_3919
SALL: SAZ_20730
STRE: GZL_04979
SLD: T261_4549
STRM: M444_20155
SAMB: SAM23877_4308(mqnE)
SPRI: SPRI_3302
SRW: TUE45_05083(mqnE_2)
SLE: sle_31070(sle_31070)
SRN: A4G23_03229(mqnE_2)
STRD: NI25_16410
SLAU: SLA_3191
SALJ: SMD11_3743
SLX: SLAV_21775(mqnE3)
SFK: KY5_4605
SGE: DWG14_03600(mqnE)
SRJ: SRO_3180
SKY: D0C37_19480(mqnE)
SGD: ELQ87_16665(mqnE)
SQZ: FQU76_20070(mqnE)
SCYA: EJ357_26895(mqnE)
SNQ: CP978_19475(mqnE)
SKA: CP970_18415(mqnE)
SVN: CP980_14565(mqnE)
KSK: KSE_33060
FAL: FRAAL1010
ACE: Acel_0259
SAQ: Sare_4505
MIL: ML5_0333
MICH: FJK98_01710(mqnE)
MTEM: GCE86_27245(mqnE)
MCAB: HXZ27_01780(mqnE)
ASE: ACPL_421
AMS: AMIS_2050
ACTN: L083_0397
AFS: AFR_01470
ACTS: ACWT_0306
CAI: Caci_8066
SNA: Snas_0587
HAU: Haur_2163
DRA: DR_0366
DGE: Dgeo_2097
DFC: DFI_12970
DEIN: DAAJ005_15875(mqnE)
DGA: DEGR_29780(mqnE)
TRA: Trad_0908
TTH: TT_C0452
TTJ: TTHA0804
TAQ: TO73_1465
MRB: Mrub_0787
CTA: CTA_0466
CTY: CTR_4271
CRA: CTO_0466
CTRQ: A363_00459
CTO: CTL2C_573
CTJ: JALI_4271
CTZ: CTB_4271
CSW: SW2_4341
CES: ESW3_4341
CTRB: BOUR_00455
CTEC: EC599_4401
CFS: FSW4_4341
CFW: FSW5_4341
CTFW: SWFP_4601
CTCH: O173_02335
CTRI: BN197_4321
CTRA: BN442_4321
CTCT: CTW3_02340
CMU: TC_0710
CMUR: Y015_03735
CMX: DNC_03590
CMZ: TAC_03735
CPA: CP_0240
CPJ: CPj0513(CPj0513)
CPT: CpB0534
CPM: G5S_0559
CPEC: CPE3_0236
CPEO: CPE1_0236
CPER: CPE2_0236
CHB: G5O_0261
CHR: Cpsi_2431
CPSC: B711_0266
CPSN: B712_0259
CPSB: B595_0265
CPSG: B598_0260
CPSM: B602_0259
CPSI: B599_0258
CPSV: B600_0271
CPSW: B603_0259
CPST: B601_0258
CPSD: BN356_2381
CPSA: AO9_01235
CAV: M832_00620(cofH)
CCA: CCA_00230
CAB: CAB227
CABO: AB7_2531
CFE: BAE81548.1(CF0776)
CHLA: C834K_0249
XII: AMD24_00441(mqnE_2)
MIN: Minf_1916(thiH)
MKC: kam1_401
VBS: EGM51_03005(mqnC)
RBA: RB2748
PSL: Psta_0917
PIR: VN12_23070(mqnE_2)
RUL: UC8_19200(mqnE_1)
MFF: MFFC18_03410(mqnE_1)
TTF: THTE_2437
PLM: Plim_0097
PEH: Spb1_08680(mqnE_1)
PLS: VT03_28800(mqnE_1)
PLH: VT85_20755(mqnE_2)
GMR: GmarT_50850(mqnE_2)
BVO: Pan97_13950(mqnE_1)
GES: VT84_02115(mqnE_1)
FTJ: FTUN_3248
IPA: Isop_1895
SACI: Sinac_1135
PBOR: BSF38_04469(mqnE)
AGV: OJF2_56500(mqnE_2)
ACA: ACP_0913
GRW: FTO74_05150(mqnE)
TALB: FTW19_14115(mqnE)
ABAS: ACPOL_0222
EDA: GWR55_07695(mqnE)
SUS: Acid_1309
FSC: FSU_2870
GAU: GAU_1634
GBA: J421_3267
AFD: Alfi_1359
AOK: A3BBH6_14110(mqnC-2)
ACOU: A5CBH24_12130(mqnC-2)
TTZ: FHG85_11080(mqnE)
BACC: BRDCF_p1368(cofH)
CPI: Cpin_4713
CHIT: FW415_14890(mqnE)
CHIH: GWR21_01295(mqnE)
FGG: FSB75_03820(mqnE)
ARK: D6B99_13205(mqnE)
AGI: FSB73_12810(mqnE)
ARAC: E0W69_005745(mqnE)
FLN: FLA_3666
PSEG: D3H65_03410(mqnE)
PGIN: FRZ67_04170(mqnE)
PGO: FSB84_27780(mqnE)
FLS: GLV81_10245(mqnE)
LACS: H4075_09750(mqnE)
SGN: SGRA_3725
PHE: Phep_1880
PEJ: FYC62_07435(mqnE)
PEK: FFJ24_007745(mqnE)
SPSC: E2P86_09140(mqnE)
SPHZ: E3D81_13170(mqnE)
SPHE: GFH32_06720(mqnE)
SPDR: G6053_09275(mqnE)
MUC: MuYL_2738
MGOT: MgSA37_02948(mqnE_2)
MUH: HYN43_009490(mqnE)
MGIN: FRZ54_17480(mqnE)
MGK: FSB76_30905(mqnE)
MRUB: DEO27_010040(mqnE)
MGOS: DIU38_010635(mqnE)
AGD: FRZ59_13255(mqnE)
OLI: FKG96_14680(mqnE)
AAE: aq_648
HTH: HTH_1238
TAL: Thal_0761
TTK: TST_1168
GTL: EP073_12060(mqnE)
CABY: Cabys_3286(mqnE)
THET: F1847_05655(mqnE)
TAV: G4V39_03365(mqnE)
TMAI: FVE67_01015(mqnE)
MOX: DAMO_1584
FPL: Ferp_1892
GAC: GACE_1763
GAH: GAH_00871
TVO: TVG1448112(TVG1448112)
FAI: FAD_1708
CDIV: CPM_0509
ACJ: ACAM_0191
IHO: Igni_1086
IIS: EYM_01165
PIS: Pisl_1325
PCL: Pcal_0738
PAS: Pars_0220
PYR: P186_2546
POG: Pogu_2263
TNE: Tneu_0222
CMA: Cmaq_1417
TTN: TTX_1950(thiH)
TUZ: TUZN_1542
VDI: Vdis_0278
VMO: VMUT_1357
NMR: Nmar_0742
NCT: NMSP_0686(cofH_1)
NGA: Ngar_c27070(cofH3)
NVN: NVIE_015990(cofH2)
NEV: NTE_00789
TAA: NMY3_02629(mqnE_2)
NFN: NFRAN_0237(mqnE)
NCV: NCAV_1093(mqnE)
NBV: T478_0614
NDV: NDEV_1291
CCAI: NAS2_0521
 » show all
Reference
1  [PMID:24083939]
  Authors
Mahanta N, Fedoseyenko D, Dairi T, Begley TP
  Title
Menaquinone biosynthesis: formation of aminofutalosine requires a unique radical SAM enzyme.
  Journal
J Am Chem Soc 135:15318-21 (2013)
DOI:10.1021/ja408594p
  Sequence
[sco:SCO4494] [ttj:TTHA0804]
Other DBs
ExplorEnz - The Enzyme Database: 2.5.1.120
IUBMB Enzyme Nomenclature: 2.5.1.120
ExPASy - ENZYME nomenclature database: 2.5.1.120
BRENDA, the Enzyme Database: 2.5.1.120

DBGET integrated database retrieval system