Entry
Name
aminodeoxyfutalosine synthase;
MqnE;
AFL synthase;
aminofutalosine synthase;
S-adenosyl-L-methionine:3-[(1-carboxyvinyl)-oxy]benzoate adenosyltransferase (bicarbonate-hydrolysing, 6-amino-6-deoxyfutalosine-forming)
Class
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:3-[(1-carboxyvinyl)-oxy]benzoate adenosyltransferase (HCO3--hydrolysing, 6-amino-6-deoxyfutalosine-forming)
Reaction(IUBMB)
S-adenosyl-L-methionine + 3-[(1-carboxyvinyl)oxy]benzoate + H2O = 6-amino-6-deoxyfutalosine + L-methionine + HCO3- [RN:
R10667 ]
Reaction(KEGG)
Substrate
S-adenosyl-L-methionine [CPD:
C00019 ];
3-[(1-carboxyvinyl)oxy]benzoate [CPD:
C20772 ];
H2O [CPD:
C00001 ]
Product
Comment
This enzyme is a member of the 'AdoMet radical' (radical SAM) family. S-Adenosyl-L-methionine acts as both a radical generator and as the source of the transferred adenosyl group. The enzyme, found in several bacterial species, is part of the futalosine pathway for menaquinone biosynthesis.
History
EC 2.5.1.120 created 2014
Pathway
ec00130 Ubiquinone and other terpenoid-quinone biosynthesis
ec01110 Biosynthesis of secondary metabolites
Orthology
K18285 aminodeoxyfutalosine synthase
Genes
HSH : NHP194022_16570(mqnE)
CCOO : ATE51_00826(mqnE_1)
GBN : GEOBRER4_02290(mqnC-2)
DVE : DESUT3_01690(mqnC-2)
PPOR : JCM14722_28660(mqnE)
BKW : BkAM31D_19845(mqnE_2)
HYI : K2M58_10705(mqnE) K2M58_10710(mqnE)
COHN : KCTCHS21_45070(mqnE)
BTS : Btus_0514 Btus_1478 Btus_1757
KYR : CVV65_04040 CVV65_07730 CVV65_08990
PABS : JIR001_06960(mqnE_1) JIR001_06970(mqnE_2)
CMIC : caldi_02180(mqnE_1) caldi_20340(mqnE_2)
DOR : Desor_1299 Desor_3397
DAI : Desaci_1904 Desaci_1922
DMI : Desmer_1198 Desmer_2662
AACX : DEACI_1819 DEACI_2410
SSG : Selsp_0312 Selsp_2220
SRI : SELR_27040 SELR_27050
SELE : ADJ74_05060 ADJ74_05100
SELO : AXE86_04795 AXE86_04855
SELT : BCS37_01090 BCS37_01135
MFUN : GXM21_06140(mqnE) GXM21_06145(mqnE)
MANA : MAMMFC1_02995(mqnE_1) MAMMFC1_03449(mqnE_3)
SMAL : SMALA_0018 SMALA_4340
SALS : SLNWT_0689 SLNWT_2736
SAMB : SAM23877_4308(mqnE)
SLE : sle_31070(sle_31070)
SGM : GCM10017557_47850(mqnE)
SBRO : GQF42_25420(mqnE) GQF42_32270(mqnE)
STUI : GCM10017668_40660(mqnE)
SAUH : SU9_015290(mqnE) SU9_033115(mqnE)
SANU : K7396_19735(mqnE) K7396_33670(mqnE)
SGOB : test1122_15330(mqnE)
STRI : C7M71_017855 C7M71_025805
MSAG : GCM10017556_29290(mqnE)
ACTR : Asp14428_43930(mqnE)
DVC : Dvina_00765(mqnE) Dvina_31160(mqnE)
DFU : Dfulv_00800(mqnE) Dfulv_28960(mqnE)
DAUR : Daura_00795(mqnE) Daura_29775(mqnE)
DMAT : Dmats_00795(mqnE) Dmats_26190(mqnE)
DEIN : DAAJ005_15875(mqnE)
CSUI : Chls_761(aminodeoxyfutalosine_synthase)
RML : FF011L_21890(mqnE_2)
MFF : MFFC18_03410(mqnE_1)
LCRE : Pla8534_17400(mqnE_1)
AAGG : ETAA8_50360(mqnE_1)
AMUC : Pan181_05860(mqnE_1)
PND : Pla175_15020(mqnE_1)
AMOB : HG15A2_43540(mqnE_2)
GPN : Pan110_52720(mqnE_2)
SDYN : Mal52_35610(mqnE_2)
PLON : Pla110_38330(mqnE_2)
MCAD : Pan265_11320(mqnE_1)
ABAC : LuPra_00778 LuPra_04444
AOK : A3BBH6_14110(mqnC-2)
ACOU : A5CBH24_12130(mqnC-2)
SEDT : TEGAF0_05530(mqnC-2)
MGOT : MgSA37_02948(mqnE_2)
TAM : Theam_0969 Theam_0970
DTE : Dester_0260 Dester_0261
TVO : TVG1448112(TVG1448112)
» show all
Taxonomy
Reference
Authors
Mahanta N, Fedoseyenko D, Dairi T, Begley TP
Title
Menaquinone biosynthesis: formation of aminofutalosine requires a unique radical SAM enzyme.
Journal
Sequence
Other DBs
ExPASy - ENZYME nomenclature database: 2.5.1.120