KEGG   ENZYME: 2.5.1.122
Entry
EC 2.5.1.122                Enzyme                                 

Name
4-O-dimethylallyl-L-tyrosine synthase;
SirD;
dimethylallyl diphosphate:L-tyrosine 4-O-dimethylallyltransferase
Class
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
Sysname
prenyl-diphosphate:L-tyrosine 4-O-prenyltransferase
Reaction(IUBMB)
prenyl diphosphate + L-tyrosine = diphosphate + 4-O-prenyl-L-tyrosine [RN:R10968]
Reaction(KEGG)
R10968
Substrate
prenyl diphosphate [CPD:C00235];
L-tyrosine [CPD:C00082]
Product
diphosphate [CPD:C00013];
4-O-prenyl-L-tyrosine [CPD:C20983]
Comment
The enzyme is involved in biosynthesis of the phytotoxin sirodesmin PL by the phytopathogenic ascomycete Leptosphaeria maculans.
History
EC 2.5.1.122 created 2014
Orthology
K21339  4-O-dimethylallyl-L-tyrosine synthase
Genes
TMF: PMAA_031310
BZE: COCCADRAFT_96963
BSC: COCSADRAFT_41511
BOR: COCMIDRAFT_31681
Reference
1  [PMID:19762440]
  Authors
Kremer A, Li SM
  Title
A tyrosine O-prenyltransferase catalyses the first pathway-specific step in the biosynthesis of sirodesmin PL.
  Journal
Microbiology 156:278-86 (2010)
DOI:10.1099/mic.0.033886-0
  Sequence
Reference
2  [PMID:21038099]
  Authors
Zou HX, Xie X, Zheng XD, Li SM
  Title
The tyrosine O-prenyltransferase SirD catalyzes O-, N-, and C-prenylations.
  Journal
Appl Microbiol Biotechnol 89:1443-51 (2011)
DOI:10.1007/s00253-010-2956-x
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.5.1.122
IUBMB Enzyme Nomenclature: 2.5.1.122
ExPASy - ENZYME nomenclature database: 2.5.1.122
BRENDA, the Enzyme Database: 2.5.1.122

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