KEGG   ENZYME: 2.5.1.128
Entry
EC 2.5.1.128                Enzyme                                 

Name
N4-bis(aminopropyl)spermidine synthase
Class
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
Sysname
S-adenosyl 3-(methylsulfanyl)propylamine:spermidine 3-aminopropyltransferase [N4-bis(aminopropyl)spermidine synthesizing]
Reaction(IUBMB)
2 S-adenosyl 3-(methylsulfanyl)propylamine + spermidine = 2 S-methyl-5'-thioadenosine + N4-bis(aminopropyl)spermidine (overall reaction) [RN:R11154];
(1a) S-adenosyl 3-(methylsulfanyl)propylamine + spermidine = S-methyl-5'-thioadenosine + N4-aminopropylspermidine [RN:R11159];
(1b) S-adenosyl 3-(methylsulfanyl)propylamine + N4-aminopropylspermidine = S-methyl-5'-thioadenosine + N4-bis(aminopropyl)spermidine [RN:R11160]
Reaction(KEGG)
Substrate
S-adenosyl 3-(methylsulfanyl)propylamine [CPD:C01137];
spermidine [CPD:C00315];
N4-aminopropylspermidine [CPD:C21009]
Product
S-methyl-5'-thioadenosine [CPD:C00170];
N4-bis(aminopropyl)spermidine [CPD:C21010];
N4-aminopropylspermidine [CPD:C21009]
Comment
The enzyme, characterized from the thermophilic archaeon Thermococcus kodakarensis, synthesizes the branched-chain polyamine N4-bis(aminopropyl)spermidine, which is required for cell growth at high-temperature. When spermine is used as substrate, the enzyme forms N4-aminopropylspermine.
History
EC 2.5.1.128 created 2014
Orthology
K07057  N4-bis(aminopropyl)spermidine synthase
Genes
XNE: XNC1_1697
XNM: XNC2_1647
XDO: XDD1_1808
XHO: A9255_02590
PSEC: CCOS191_4020
PSOS: POS17_3685(Thein_2228)
AAV: Aave_3741
BRO: BRAD285_0841
RPB: RPB_2044
RPD: RPD_3346
XAU: Xaut_2257
SMAZ: LH19_03535
BMYC: DJ92_782
BGY: BGLY_2484
LYB: C3943_17400(speD)
LPAK: GDS87_16170(speD)
TOO: C7K38_01515(speD)
CBY: CLM_3813
CBL: CLK_2780
CBB: CLD_1156
CBI: CLJ_B3650
CBF: CLI_3540
CBM: CBF_3522
CCE: Ccel_1087
TTE: TTE1898
THX: Thet_1792
TIT: Thit_1686
CHY: CHY_0365
ADG: Adeg_0209
CSC: Csac_1231
ATE: Athe_2198
TOC: Toce_1644
MHAD: B586_15270
SRT: Srot_0167
CFL: Cfla_0036
TFU: Tfu_1172
NAL: B005_3858
SRO: Sros_2948
SEN: SACE_6413
AMYY: YIM_05685
AORI: SD37_06795
AMI: Amir_6272
SESP: BN6_75470
KAL: KALB_3773
ACTI: UA75_26960
ACAD: UA74_26375
ALO: CRK59667
SNA: Snas_1462
TTH: TT_C0171
TTJ: TTHA0539
TTR: Tter_0296
TTF: THTE_2394
TLI: Tlie_1345
RMR: Rmar_0533
AAE: aq_1754
HTH: HTH_1277
TAL: Thal_1053
TTK: TST_0020
CEX: CSE_05650
CTHI: THC_1142
BANA: BARAN1_0480(bpsA)
MMP: MMP1657
MMD: GYY_09140
MMAD: MMJJ_11750(bpsA)
MAE: Maeo_0142
MVO: Mvol_1306
AFU: AF_1611
FPL: Ferp_1880
GAC: GACE_1398
GAH: GAH_01086
ABI: Aboo_0499
PFU: PF1111
PFI: PFC_04775
PHO: PH0728(PH0728)
PAB: PAB0872
PYN: PNA2_1371
PYS: Py04_0736
TKO: TK1691
TON: TON_1358
TGA: TGAM_0371
TSI: TSIB_0126
THE: GQS_08760
THA: TAM4_1077
THM: CL1_1351
TLT: OCC_06976
THS: TES1_1386
TNU: BD01_1992
TEU: TEU_04560
PPAC: PAP_09495
 » show all
Reference
1  [PMID:24610711]
  Authors
Okada K, Hidese R, Fukuda W, Niitsu M, Takao K, Horai Y, Umezawa N, Higuchi T, Oshima T, Yoshikawa Y, Imanaka T, Fujiwara S
  Title
Identification of a novel aminopropyltransferase involved in the synthesis of branched-chain polyamines in hyperthermophiles.
  Journal
J Bacteriol 196:1866-76 (2014)
DOI:10.1128/JB.01515-14
  Sequence
[tko:TK1691]
Other DBs
ExplorEnz - The Enzyme Database: 2.5.1.128
IUBMB Enzyme Nomenclature: 2.5.1.128
ExPASy - ENZYME nomenclature database: 2.5.1.128
BRENDA, the Enzyme Database: 2.5.1.128

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