KEGG   ENZYME: 2.5.1.130
Entry
EC 2.5.1.130                Enzyme                                 
Name
2-carboxy-1,4-naphthoquinone phytyltransferase;
menA (gene name);
ABC4 (gene name);
1,4-dioxo-2-naphthoate phytyltransferase;
1,4-diketo-2-naphthoate phytyltransferase
Class
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
Sysname
phytyl-diphosphate:2-carboxy-1,4-naphthoquinone phytyltransferase
Reaction(IUBMB)
phytyl diphosphate + 2-carboxy-1,4-naphthoquinone = demethylphylloquinone + diphosphate + CO2 [RN:R12255]
Reaction(KEGG)
R12255
Substrate
phytyl diphosphate [CPD:C05427];
2-carboxy-1,4-naphthoquinone [CPD:C22039]
Product
demethylphylloquinone [CPD:C13309];
diphosphate [CPD:C00013];
CO2 [CPD:C00011]
Comment
This enzyme, found in plants and cyanobacteria, catalyses a step in the synthesis of phylloquinone (vitamin K1), an electron carrier associated with photosystem I. The enzyme catalyses the transfer of the phytyl chain synthesized by EC 1.3.1.83, geranylgeranyl diphosphate reductase, to 2-carboxy-1,4-naphthoquinone.
History
EC 2.5.1.130 created 2015
Pathway
ec00130  Ubiquinone and other terpenoid-quinone biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K23094  2-carboxy-1,4-naphthoquinone phytyltransferase
Genes
ATHAT1G60600(ABC4)
ALY9322672
CRB17895973
CSAT104703646 104787111
EUSEUTSA_v10023528mg
BRP103829906
BNA106435024
BOE106323857
RSZ108809221
THJ104799883
CPAP110816205
CIT102624098
CICCICLE_v10028615mg
PVY116113571 116117488
MINC123214646
TCC18608257
GRA105795089
GHI107887436 107908946
GAB108474800
DZI111295322
EGR104452885 104452887 104455139 104455141
GMX100788238 100790629 100791902 100813101
GSJ114369223 114379640 114380739 114402861 114421394
PVUPHAVU_009G192700g
VRA106773008
VAR108322207
VUN114176967
CCAJ109804803
APRC113857810
MTRMTR_4g094100
CAM101504086
LJALj4g3v0363530.1(Lj4g3v0363530.1) Lj4g3v0363530.2(Lj4g3v0363530.2) Lj4g3v0363530.3(Lj4g3v0363530.3)
ADU107481793
AIP107631655
AHF112734405 112792223
LANG109349268
FVE101307197
RCN112188695
PPER18768593
PMUM103336024
PAVI110765956 110774224
PDUL117638183
MDM103444873
PXB103930309 103940989
ZJU107428571
MNT21400742
CSV101221829
CMO103495404
BHJ120078564
MCHA111012238
CMAX111486134
CMOS111434556
CPEP111793077
RCU8282981
JCU105631592
HBR110646504
MESC110618461
POP7496610
PEU105138653
PALZ118048730
JRE109014828
QSU112029288
QLO115967659
TWL120003686
VVI100256517
VRI117909265
SLY101248721
SPEN107004202
SOT102602396
SSTN125853605
CANN107840062
NTA107780450 107819760
NSY104224950
NTO104097428
NAU109223878
INI109167145
ITR116028600
SIND105169246 105169248 105169249
OEU111394670
EGT105949689 105969678
SSPL121756174 121757289
HAN110885784
ECAD122597977
LSV111913253
CCAV112516996
DCR108205031
CSIN114266782 114299780
BVG104904058
SOE110802488
CQI110681714 110718653
NNU104604508
MING122059601
TSS122650365
PSOM113332100 113347325
NCOL116262001
OSA4331897
DOSAOs03t0190100-01(Os03g0190100)
OBR102718997
BDI100820840
ATS109755307 109756016
TDC119278012 119285808 119287690 119291721 119336150
TAES123043710 123088098 123093450 123098729 123168616
TUA125552891 125552893
SBI8081915
ZMA100285808
SITA101782427
SVS117838040
PVIR120647037 120690447
PHAI112875661
PDA103717960
EGU105041933
MUS103971313
DCT110102149
PEQ110025986
AOF109835033
ATR18426868 18443014
SMOSELMODRAFT_57400 SELMODRAFT_67325
PPP112292862
CSLCOCSUDRAFT_57519
CVRCHLNCDRAFT_48633
APROF751_5387
OLUOSTLU_6184
OTAOT_ostta14g02350
BPGBathy12g01570
MISMICPUN_106396
MPPMICPUCDRAFT_5008
CCPCHC_T00003042001
MMOBF6R98_15130
AGEAA314_01378
SYNslr1518(menA)
SYZMYO_114670(menA)
SYYSYNGTS_1454(menA)
SYTSYNGTI_1454(menA)
SYSSYNPCCN_1453(menA)
SYQSYNPCCP_1453(menA)
SYJD082_13930(menA)
SYOC7I86_07530(menA)
SYCsyc0189_d(menA)
SYUM744_09780
SYFSynpcc7942_1366
SYDSyncc9605_2438
SYESyncc9902_2119
SYGsync_2655(menA)
SYRSynRCC307_2253(menA)
SYXSynWH7803_2318(menA)
SYPSYNPCC7002_A1984(menA)
CYACYA_2456(menA)
CYBCYB_2300(menA)
SYNESyn6312_2031
SYNPSyn7502_01720
SYNKKR100_15045
SYNRKR49_07785
SYNDKR52_03885
SYHSyncc8109_2548(menA)
SYNWSynWH8103_02649(menA)
SYVAWQ23_09955
SYLAWQ21_08660
SYNCCB0101_14920
SYNYBM449_06455
DSLDacsa_0079
SYWSYNW2307(menA)
CGCCyagr_2842
CYICBM981_3220(menA)
PMAPro_0201(menA)
PMMPMM0176(menA)
PMTPMT_2059
PMNPMN2A_1544
PMIPMT9312_0178
PMBA9601_01941(menA)
PMCP9515_02051(menA)
PMFP9303_27341(menA)
PMGP9301_01961(menA)
PMHP9215_01941(menA)
PMJP9211_01941(menA)
PMENATL1_02511(menA)
PRCEW14_0219
PRMEW15_0265
CMPCha6605_2936
AMRAM1_1110(menA)
TVNNIES2134_121190(menA)
SLWBRW62_10195
TELtlr2196(menA)
THNNK55_07630(menA)
THECFFX45_04670(menA)
LEPLepto7376_2361
LENLEP3755_34630
LETO77CONTIG1_03563(menA)
LBOLBWT_47030
KOVK9N68_17265(menA)
LSCKIK02_09375(menA)
LSKJ5X98_26325(menA)
HHGXM38_049670(menA_2)
PSEUPse7367_1757
PSERABRG53_3629(menA)
THEUHPC62_05450
GLPGlo7428_3304
GENGM3709_1139
GEEGM3708_3193
CHONNIES4102_21010
MARMAE_35650(menA)
MPKVL20_5668
MIQB5D77_23225
MVZmyaer102_10780(menA)
CANCyan10605_0455
CSNCyast_2263
CYLAA637_12770(menA)
HAOPCC7418_1612
ENNFRE64_02685
CYUUCYN_05230
CYTcce_4479(menA)
CWACwatDRAFT_4882
CYPPCC8801_1521
CYHCyan8802_1548
CYCPCC7424_4753
CYJCyan7822_0437
CYNCyan7425_5119
TERTery_4071
ARPNIES39_C00320(menA)
PAGHNIES204_17120(menA)
PPSUNO713_00788(menA)
OXYHCG48_16755
MVAGD0A34_26160
LFSHFV01_12780
MICMic7113_2146
GEIGEI7407_0557
OACOscil6304_1888
ONIOsc7112_5501
MPROBJP34_18140
PHORJWS08_01890(menA)
PYHNEA10_11570(menA)
CEPCri9333_3866
GVIgll1578(menA)
GLJGKIL_2377(menA)
GMLISF26_01910(menA)
ANAalr0033(menA)
NPUNpun_R6460
NOSNos7107_0580
NOPNos7524_0670
NONNOS3756_11320
NFLCOO91_09025
NOECLI64_20380
NSHGXM_01462
NEDHUN01_21625
AVAAva_2633
NAZAazo_1394
ANBANA_C12891(menA)
ACYAnacy_4417
AWAAA650_07790
ANNEH233_07060
CSGCylst_5780
RSINB6N60_00217
CALOCal7507_0458
CALTCal6303_4483
CALHIJ00_14510
CALNNIES2098_62330
RIVRiv7116_0060
FISFIS3754_15340
NSPBMF81_03398(menA)
NSPHBDGGKGIB_01171(menA_2)
DOUBMF77_04485(menA)
DFSHGD76_01470
CCURIAR63_17360
CRKL3I90_09815(menA)
AFLOHEQ12_11305
TOQHCG51_21615
NCNBZZ01_26795
CTHEChro_4086
PLPPle7327_0137
SCSSta7437_2362
STANSTA3757_22990
KBSEPA93_20655
DRCG0Q07_01480
MZHMzhil_0929
MZIHWN40_04885
 » show all
Reference
1  [PMID:10722690]
  Authors
Johnson TW, Shen G, Zybailov B, Kolling D, Reategui R, Beauparlant S, Vassiliev IR, Bryant DA, Jones AD, Golbeck JH, Chitnis PR
  Title
Recruitment of a foreign quinone into the A(1) site of photosystem I. I. Genetic and physiological characterization of phylloquinone biosynthetic pathway mutants  in Synechocystis sp. pcc 6803.
  Journal
J Biol Chem 275:8523-30 (2000)
DOI:10.1074/jbc.275.12.8523
  Sequence
[syn:slr1518]
Reference
2  [PMID:15686525]
  Authors
Shimada H, Ohno R, Shibata M, Ikegami I, Onai K, Ohto MA, Takamiya K
  Title
Inactivation and deficiency of core proteins of photosystems I and II caused by genetical phylloquinone and plastoquinone deficiency but retained lamellar structure in a T-DNA mutant of Arabidopsis.
  Journal
Plant J 41:627-37 (2005)
DOI:10.1111/j.1365-313X.2004.02326.x
  Sequence
[ath:AT1G60600]
Other DBs
ExplorEnz - The Enzyme Database: 2.5.1.130
IUBMB Enzyme Nomenclature: 2.5.1.130
ExPASy - ENZYME nomenclature database: 2.5.1.130
BRENDA, the Enzyme Database: 2.5.1.130

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