KEGG   ENZYME: 2.5.1.131Help
Entry
EC 2.5.1.131                Enzyme                                 

Name
(4-{4-[2-(gamma-L-glutamylamino)ethyl]phenoxymethyl}furan-2-yl)methanamine synthase;
MfnF
Class
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
BRITE hierarchy
Sysname
[5-(aminomethyl)furan-3-yl]methyl-diphosphate:gamma-L-glutamyltyramine [5-(aminomethyl)furan-3-yl]methyltransferase
Reaction(IUBMB)
[5-(aminomethyl)furan-3-yl]methyl diphosphate + gamma-L-glutamyltyramine = (4-{4-[2-(gamma-L-glutamylamino)ethyl]phenoxymethyl}furan-2-yl)methanamine + diphosphate [RN:R11040]
Reaction(KEGG)
Substrate
[5-(aminomethyl)furan-3-yl]methyl diphosphate [CPD:C21069];
gamma-L-glutamyltyramine [CPD:C20926]
Product
(4-{4-[2-(gamma-L-glutamylamino)ethyl]phenoxymethyl}furan-2-yl)methanamine [CPD:C21070];
diphosphate [CPD:C00013]
Comment
The enzyme, isolated from the archaeon Methanocaldococcus jannaschii, participates in the biosynthesis of the methanofuran cofactor.
History
EC 2.5.1.131 created 2015
Pathway
ec00680  Methane metabolism
ec01100  Metabolic pathways
Orthology
K07072  (4-(4-[2-(gamma-L-glutamylamino)ethyl]phenoxymethyl)furan-2-yl)methanamine synthase
Genes
HAS: Halsa_0952
RBA: RB6209
PSL: Psta_3592
PIR: VN12_07525
RUL: UC8_21020
MFF: MFFC18_12350
PLM: Plim_0257
PEH: Spb1_10160
PBS: Plabr_4664
PLS: VT03_12545
IPA: Isop_3533
MOX: DAMO_2658
MJA: MJ_0840
MMP: MMP0072
MMD: GYY_00365
MAE: Maeo_0623
MVO: Mvol_1437
MTH: MTH_834
METC: MTCT_0748
MWO: MWSIV6_1211(mfnF)
METE: tca_00801
MST: Msp_0386
MRU: mru_1695
MSI: Msm_0851
MEB: Abm4_0505
MMIL: sm9_1778
MEYE: TL18_07945
MOL: YLM1_1163
METH: MBMB1_0691
MFC: BRM9_1504
MCUB: MCBB_0702(mfnF)
MFV: Mfer_0209
MKA: MK0113
AFU: AF_0479
FPL: Ferp_0819
GAC: GACE_1625
GAH: GAH_00950
MAC: MA_1474
MBAR: MSBR2_1212
MBAK: MSBR3_1317
MMA: MM_2511
MMAC: MSMAC_2262
METM: MSMTP_0946
MTHR: MSTHT_0226
MTHE: MSTHC_0506
MHOR: MSHOH_2801
MBU: Mbur_1316
MMET: MCMEM_1763
MMH: Mmah_1620
MPY: Mpsy_2545
MTP: Mthe_0173
MCJ: MCON_2321
MHI: Mhar_2357
MHU: Mhun_0572
MLA: Mlab_0269
MEMA: MMAB1_1686
MPI: Mpet_1052
MBN: Mboo_0921
MPL: Mpal_0580
MPD: MCP_1325
MEZ: Mtc_1030
RCI: RCIX2219
BARB: AOA66_0933
 » show all
Taxonomy
Reference
1  [PMID:26100040]
  Authors
Wang Y, Xu H, Jones MK, White RH
  Title
Identification of the Final Two Genes Functioning in Methanofuran Biosynthesis in Methanocaldococcus jannaschii.
  Journal
J Bacteriol 197:2850-8 (2015)
DOI:10.1128/JB.00401-15
  Sequence
[mja:MJ_0840]
Other DBs
ExplorEnz - The Enzyme Database: 2.5.1.131
IUBMB Enzyme Nomenclature: 2.5.1.131
ExPASy - ENZYME nomenclature database: 2.5.1.131
BRENDA, the Enzyme Database: 2.5.1.131

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