KEGG   ENZYME: 2.5.1.132
Entry
EC 2.5.1.132                Enzyme                                 

Name
3-deoxy-D-glycero-D-galacto-nonulopyranosonate 9-phosphate synthase;
3-deoxy-D-glycero-D-galacto-nononate 9-phosphate synthase;
2-keto-3-deoxy-D-glycero-D-galacto-9-phosphonononic acid synthase;
Kdn 9-P synthase
Class
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
Sysname
phosphoenolpyruvate:D-mannose-6-phosphate 1-(2-carboxy-2-oxoethyl)transferase
Reaction(IUBMB)
phosphoenolpyruvate + D-mannose 6-phosphate + H2O = 3-deoxy-D-glycero-D-galacto-non-2-ulopyranosonate 9-phosphate + phosphate [RN:R11439]
Reaction(KEGG)
R11439
Substrate
phosphoenolpyruvate [CPD:C00074];
D-mannose 6-phosphate [CPD:C00275];
H2O [CPD:C00001]
Product
3-deoxy-D-glycero-D-galacto-non-2-ulopyranosonate 9-phosphate [CPD:C21383];
phosphate [CPD:C00009]
Comment
The enzyme participates in the biosynthesis of the sialic acid 3-deoxy-D-glycero-D-galacto-non-2-ulopyranosonate (Kdn). The human sialic acid synthase (EC 2.5.1.57) is also able to catalyse the reaction. Kdn is abundant in extracellular glycoconjugates of lower vertebrates such as fish and amphibians, but is also found in the capsular polysaccharides of bacteria that belong to the Bacteroides genus.
History
EC 2.5.1.132 created 2016
Pathway
ec00520  Amino sugar and nucleotide sugar metabolism
ec01100  Metabolic pathways
Orthology
K05304  sialic acid synthase
K21279  3-deoxy-D-glycero-D-galacto-nononate 9-phosphate synthase
Genes
HSA: 54187(NANS)
PTR: 743934(NANS)
PPS: 100982112(NANS)
GGO: 101124502(NANS)
PON: 100446862(NANS)
NLE: 100603154(NANS)
MCC: 715459(NANS)
MCF: 102120030(NANS)
CSAB: 103219150(NANS)
CATY: 105593048(NANS)
PANU: 101020165(NANS)
RRO: 104657773(NANS)
RBB: 108539113(NANS)
TFN: 117098940(NANS)
PTEH: 111536614(NANS)
CJC: 100411585(NANS)
SBQ: 101027621(NANS)
MMUR: 105873791(NANS)
MMU: 94181(Nans)
MCAL: 110292645(Nans)
MPAH: 110323062(Nans)
RNO: 298071(Nans)
MCOC: 116095967(Nans)
MUN: 110551128(Nans)
CGE: 100767837(Nans)
PLEU: 114702354(Nans)
NGI: 103749137(Nans)
HGL: 101721582(Nans)
CCAN: 109697287(Nans)
OCU: 100356934(NANS)
TUP: 102496776(NANS)
CFA: 481624(NANS)
VVP: 112930767(NANS)
VLG: 121494904(NANS)
AML: 100471912(NANS)
UMR: 103678504(NANS)
UAH: 113260417(NANS)
ORO: 101377441(NANS)
ELK: 111146174
MPUF: 101687668(NANS)
EJU: 114213569(NANS)
MLX: 118017911(NANS)
FCA: 101092303(NANS)
PYU: 121034713(NANS)
PTG: 102952743(NANS)
PPAD: 109270098(NANS)
AJU: 106981299(NANS)
HHV: 120233531(NANS)
BTA: 540602(NANS)
BOM: 102266035(NANS)
BIU: 109563072(NANS)
BBUB: 102402717(NANS)
CHX: 102171423(NANS)
OAS: 101104048(NANS)
ODA: 120862645(NANS)
CCAD: 122452923(NANS)
SSC: 100155883(NANS)
CFR: 102511644(NANS)
CBAI: 105067382(NANS)
CDK: 105086903(NANS)
BACU: 103016138(NANS)
LVE: 103074242(NANS)
OOR: 101286113(NANS)
DLE: 111187968(NANS)
PCAD: 102975186(NANS)
ECB: 100064126(NANS)
EPZ: 103550229(NANS)
EAI: 106842931(NANS)
MYB: 102254698(NANS)
MYD: 102770256(NANS)
MMYO: 118667273(NANS)
MNA: 107544993(NANS)
HAI: 109386412(NANS)
DRO: 112304493(NANS)
SHON: 118979589(NANS)
AJM: 119045927(NANS)
MMF: 118629683(NANS)
PALE: 102882391(NANS)
PGIG: 120597479(NANS)
RAY: 107511690(NANS)
MJV: 108386331(NANS)
TOD: 119231857(NANS)
LAV: 100659127(NANS)
TMU: 101361417
MDO: 100014569(NANS)
SHR: 100915225(NANS)
PCW: 110220562(NANS)
OAA: 100074951(NANS)
GGA: 427283(NANS)
PCOC: 116234839(NANS)
MGP: 100540972(NANS)
CJO: 107306381(NANS)
NMEL: 110389693(NANS)
APLA: 101793548(NANS)
ACYG: 106046483(NANS)
TGU: 100227675(NANS)
LSR: 110472303(NANS)
SCAN: 103821217(NANS)
PMOA: 120509468(NANS)
GFR: 102036907(NANS)
FAB: 101817049(NANS)
PHI: 102108606(NANS)
PMAJ: 107198262(NANS)
CCAE: 111940921(NANS)
CCW: 104689769(NANS)
ETL: 114056942(NANS)
FPG: 101910977(NANS)
FCH: 102058691(NANS)
CLV: 102088004(NANS)
EGZ: 104135026(NANS)
NNI: 104014067(NANS)
ACUN: 113489989(NANS)
PADL: 103923247(NANS)
AAM: 106487451(NANS)
NPD: 112946284(NANS)
ASN: 102371122(NANS)
AMJ: 102562418(NANS)
CPOO: 109323518(NANS)
CMY: 102930222(NANS)
CPIC: 101940249(NANS)
TST: 117878892(NANS)
CABI: 116832497(NANS)
ACS: 100558551(nans)
PVT: 110077827(NANS)
PBI: 103051012(NANS)
PMUR: 107293127(NANS)
TSR: 106556782(NANS)
PGUT: 117661676(NANS)
PMUA: 114587657(NANS)
ZVI: 118097903(NANS)
GJA: 107122992(NANS)
XLA: 432051(nans.S) 447417(nans.L)
XTR: 100492893(nans)
NPR: 108783786(NANS)
DRE: 322780(nansa) 492779(nansb)
IPU: 100528493(nans) 108260162
PHYP: 113531522(nans)
AMEX: 111195185(nans)
EEE: 113568448(nans) 113589926
TRU: 778024(nans)
LCO: 104922341(nans)
ELY: 117254746(nansa)
PLEP: 121942582(nansa)
SLUC: 116042899(nansa)
ECRA: 117956637(nansa)
PFLV: 114570372(nans)
OLA: 101166198(nans)
OML: 112137589(nansa)
XMA: 102234709(nans)
XCO: 114145362(nans)
XHE: 116720640(nans)
PRET: 103467988(nans) 103472627
ALIM: 106528334(nans)
AOCE: 111575007(nans)
XGL: 120800959(nansa)
MALB: 109953770(nans)
ELS: 105022900(nans)
SFM: 108920829
PKI: 111855408(nans)
AANG: 118227907(nansa)
LOC: 102687418(nans)
PSPA: 121319344(nansa)
ARUT: 117420829(nansa)
CMK: 103177631(nans) 103177633
RTP: 109938218(nans)
SCLV: 120347367
SPU: 577884
APLC: 110979925
DME: Dmel_CG5232(NANS)
DER: 6553702
DSE: 6606666
DSI: Dsimw501_GD18832(Dsim_GD18832)
DSR: 110190443
DPE: 6598731
DMN: 108156913
DWI: 6650267
DGR: 6568185
DAZ: 108621816
DNV: 108653385
DHE: 111601415
CCAT: 101459749
MDE: 101899077
LCQ: 111687367
ACOZ: 120950612
AARA: 120897604
AAG: 5563645
AALB: 109400878
CPII: 120415920
TCA: 103312199
DPA: 109539228
ATD: 109597067
AGB: 108917229
LDC: 111503205
NVL: 108567369
PPYR: 116164831
BMOR: 101744099
BMAN: 114246626
MSEX: 115444962
BANY: 112054184
PRAP: 110994857
ZCE: 119829783
HAW: 110380482
PXY: 105391284
DNX: 107161705
AGS: 114120104
RMD: 113549718
BTAB: 109035180
DCI: 103520284
CLEC: 106666066
HHAL: 106681070
NLU: 111058090
ZNE: 110829049
CSEC: 111874253
FCD: 110842189
DMK: 116933060
PVM: 113802701
HAME: 121873235
EAF: 111695997
VDE: 111250001
VJA: 111258697
TUT: 107368038
CSCU: 111619307
PTEP: 107452120
SDM: 118205491
EHX: EMIHUDRAFT_437804(NEUB)
SLAC: SKTS_36140
AMYT: AMYT_2597
ARC: ABLL_2687
PCA: Pcar_1277(neuB)
DVM: DvMF_1832
DMA: DMR_13530
DGG: DGI_4066
DFL: DFE_1272
DAS: Daes_2970
DPI: BN4_12645
PPRF: DPRO_1430
RLG: Rleg_0440
RPE: RPE_4236
BVR: BVIR_1970
BLAG: BLTE_00400(neuB)
HDI: HDIA_0896(pseI)
MALG: MALG_05073
RCE: RC1_3771(nans)
HLI: HLI_08585
SLAU: SLA_6887
BTH: BT_1714
BTHO: Btheta7330_01302(neuB_1)
BCEL: BcellWH2_03092(neuB)
MUC: MuYL_3260
FJG: BB050_02206(legI)
DOK: MED134_13631(neuB)
DDO: I597_1525(legI)
NDO: DDD_2293
MESQ: C7H62_1954
MAC: MA_3767
 » show all
Reference
1  [PMID:10438460]
  Authors
Angata T, Nakata D, Matsuda T, Kitajima K, Troy FA 2nd
  Title
Biosynthesis of KDN (2-keto-3-deoxy-D-glycero-D-galacto-nononic acid). Identification and characterization of a KDN-9-phosphate synthetase activity from trout testis.
  Journal
J Biol Chem 274:22949-56 (1999)
DOI:10.1074/jbc.274.33.22949
Reference
2  [PMID:10749855]
  Authors
Lawrence SM, Huddleston KA, Pitts LR, Nguyen N, Lee YC, Vann WF, Coleman TA, Betenbaugh MJ
  Title
Cloning and expression of the human N-acetylneuraminic acid phosphate synthase gene with 2-keto-3-deoxy-D-glycero- D-galacto-nononic acid biosynthetic ability.
  Journal
J Biol Chem 275:17869-77 (2000)
DOI:10.1074/jbc.M000217200
  Sequence
[hsa:54187]
Reference
3  [PMID:18804026]
  Authors
Wang L, Lu Z, Allen KN, Mariano PS, Dunaway-Mariano D
  Title
Human symbiont Bacteroides thetaiotaomicron synthesizes 2-keto-3-deoxy-D-glycero-D- galacto-nononic acid (KDN).
  Journal
Chem Biol 15:893-7 (2008)
DOI:10.1016/j.chembiol.2008.08.005
  Sequence
[bth:BT_1714]
Other DBs
ExplorEnz - The Enzyme Database: 2.5.1.132
IUBMB Enzyme Nomenclature: 2.5.1.132
ExPASy - ENZYME nomenclature database: 2.5.1.132
BRENDA, the Enzyme Database: 2.5.1.132

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