KEGG   ENZYME: 2.5.1.132
Entry
EC 2.5.1.132                Enzyme                                 
Name
3-deoxy-D-glycero-D-galacto-nonulopyranosonate 9-phosphate synthase;
3-deoxy-D-glycero-D-galacto-nononate 9-phosphate synthase;
2-keto-3-deoxy-D-glycero-D-galacto-9-phosphonononic acid synthase;
Kdn 9-P synthase
Class
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
Sysname
phosphoenolpyruvate:D-mannose-6-phosphate 1-(2-carboxy-2-oxoethyl)transferase
Reaction(IUBMB)
phosphoenolpyruvate + D-mannose 6-phosphate + H2O = 3-deoxy-D-glycero-D-galacto-non-2-ulopyranosonate 9-phosphate + phosphate [RN:R11439]
Reaction(KEGG)
R11439
Substrate
phosphoenolpyruvate [CPD:C00074];
D-mannose 6-phosphate [CPD:C00275];
H2O [CPD:C00001]
Product
3-deoxy-D-glycero-D-galacto-non-2-ulopyranosonate 9-phosphate [CPD:C21383];
phosphate [CPD:C00009]
Comment
The enzyme participates in the biosynthesis of the sialic acid 3-deoxy-D-glycero-D-galacto-non-2-ulopyranosonate (Kdn). The human sialic acid synthase (EC 2.5.1.57) is also able to catalyse the reaction. Kdn is abundant in extracellular glycoconjugates of lower vertebrates such as fish and amphibians, but is also found in the capsular polysaccharides of bacteria that belong to the Bacteroides genus.
History
EC 2.5.1.132 created 2016
Pathway
ec00520  Amino sugar and nucleotide sugar metabolism
ec01100  Metabolic pathways
Orthology
K05304  sialic acid synthase
K21279  3-deoxy-D-glycero-D-galacto-nononate 9-phosphate synthase
Genes
HSA54187(NANS)
PTR743934(NANS)
PPS100982112(NANS)
GGO101124502(NANS)
PON100446862(NANS)
NLE100603154(NANS)
MCC715459(NANS)
MCF102120030(NANS)
CSAB103219150(NANS)
CATY105593048(NANS)
PANU101020165(NANS)
TGE112607835(NANS)
RRO104657773(NANS)
RBB108539113(NANS)
TFN117098940(NANS)
PTEH111536614(NANS)
CJC100411585(NANS)
SBQ101027621(NANS)
CSYR103273474(NANS)
MMUR105873791(NANS)
LCAT123645941(NANS)
OGA100951418(NANS)
MMU94181(Nans)
MCAL110292645(Nans)
MPAH110323062(Nans)
RNO298071(Nans)
MCOC116095967(Nans)
MUN110551128(Nans)
CGE100767837(Nans)
MAUA101830178(Nans)
PLEU114702354(Nans)
MORG121458558(Nans)
AAMP119826497(Nans)
NGI103749137(Nans)
HGL101721582(Nans)
CPOC100716456(Nans)
CCAN109697287(Nans)
DORD105990839(Nans)
DSP122121805(Nans)
NCAR124964919
OCU100356934(NANS)
OPI101522937(NANS)
TUP102496776(NANS)
CFA481624(NANS)
CLUD112649641(NANS)
VVP112930767(NANS)
VLG121494904(NANS)
AML100471912(NANS)
UMR103678504(NANS)
UAH113260417(NANS)
UAR123781029(NANS)
ELK111146174
LLV125083268
MPUF101687668(NANS)
ORO101377441(NANS)
EJU114213569(NANS)
ZCA113934273(NANS)
MLX118017911(NANS)
FCA101092303(NANS)
PYU121034713(NANS)
PBG122474611(NANS)
PTG102952743(NANS)
PPAD109270098(NANS)
AJU106981299(NANS)
HHV120233531(NANS)
BTA540602(NANS)
BOM102266035(NANS)
BIU109563072(NANS)
BBUB102402717(NANS)
CHX102171423(NANS)
OAS101104048(NANS)
ODA120862645(NANS)
CCAD122452923(NANS)
SSC100155883(NANS)
CFR102511644(NANS)
CBAI105067382(NANS)
CDK105086903(NANS)
VPC102528094(NANS)
BACU103016138(NANS)
LVE103074242(NANS)
OOR101286113(NANS)
DLE111187968(NANS)
PCAD102975186(NANS)
PSIU116755813(NANS)
ECB100064126(NANS)
EPZ103550229(NANS)
EAI106842931(NANS)
MYB102254698(NANS)
MYD102770256(NANS)
MMYO118667273(NANS)
MLF102435662(NANS)
MNA107544993(NANS)
PKL118716275(NANS)
HAI109386412(NANS)
DRO112304493(NANS)
SHON118979589(NANS)
AJM119045927(NANS)
PDIC114509777(NANS)
PHAS123819942(NANS)
MMF118629683(NANS)
RFQ117032312(NANS)
PALE102882391(NANS)
PGIG120597479(NANS)
PVP105296243(NANS)
RAY107511690(NANS)
MJV108386331(NANS)
TOD119231857(NANS)
SARA101558462(NANS)
LAV100659127(NANS)
TMU101361417
DNM101415935(NANS)
MDO100014569(NANS)
GAS123231260(NANS)
SHR100915225(NANS)
PCW110220562(NANS)
OAA100074951(NANS)
GGA427283(NANS)
PCOC116234839(NANS)
MGP100540972(NANS)
CJO107306381(NANS)
NMEL110389693(NANS)
APLA101793548(NANS)
ACYG106046483(NANS)
AFUL116500909(NANS)
TGU100227675(NANS)
LSR110472303(NANS)
SCAN103821217(NANS)
PMOA120509468(NANS)
OTC121334701(NANS)
PRUF121355663(NANS)
GFR102036907(NANS)
FAB101817049(NANS)
PHI102108606(NANS)
PMAJ107198262(NANS)
CCAE111940921(NANS)
CCW104689769(NANS)
CBRC103616433(NANS)
ETL114056942(NANS)
ZAB102065706(NANS)
FPG101910977(NANS)
FCH102058691(NANS)
CLV102088004(NANS)
EGZ104135026(NANS)
NNI104014067(NANS)
PLET104620779(NANS)
PCRI104025538(NANS)
ACUN113489989(NANS)
TALA104366421(NANS)
PADL103923247(NANS)
ACHC115336739(NANS)
HALD104312067(NANS)
CCRI104155775(NANS)
CSTI104550675(NANS)
EHS104517044(NANS)
CMAC104481639(NANS)
FGA104074239(NANS)
GSTE104263825(NANS)
LDI104355132(NANS)
MNB103774718(NANS)
OHA104331297(NANS)
AAM106487451(NANS)
AROW112968978(NANS)
NPD112946284(NANS)
DNE112982754(NANS)
ASN102371122(NANS)
AMJ102562418(NANS)
CPOO109323518(NANS)
CMY102930222(NANS)
CPIC101940249(NANS)
TST117878892(NANS)
CABI116832497(NANS)
MRV120408042(NANS)
ACS100558551(nans)
PVT110077827(NANS)
SUND121924222(NANS)
PBI103051012(NANS)
PMUR107293127(NANS)
TSR106556782(NANS)
PGUT117661676(NANS)
VKO123030229(NANS)
PMUA114587657(NANS)
ZVI118097903(NANS)
GJA107122992(NANS)
STOW125437185(NANS)
XLA432051(nans.S) 447417(nans.L)
XTR100492893(nans)
NPR108783786(NANS)
RTEM120946942(NANS)
BBUF120989333(NANS)
BGAR122920937(NANS)
DRE322780(nansa) 492779(nansb)
SRX107723182 107754352 107754390 107758866
SANH107665955 107686966 107686967 107692601
SGH107557947 107566238 107566239
CCAR109076464 109090623 109090659
CAUA113044320 113066551 113066555 113066556 113066635 113085422 113105679
PPRM120475377(nansb) 120475384 120475385 120475386 120478311(nansa)
MAMB125247499 125247713 125247908 125247921 125248041 125251616 125251645 125272478(nansa)
IPU100528493(nansa) 108260162
PHYP113531522(nans)
SMEO124378730 124381237(nansa)
TFD113635339(nansa)
AMEX111195185(nans)
EEE113568448(nans) 113589926
TRU778024(nans)
TNGGSTEN00033532G001
LCO104922341(nans)
CGOB115010173 115010214
ELY117254746(nansa)
EFO125885917(nansa)
PLEP121942582(nansa)
SLUC116042899(nansa)
ECRA117956637(nansa)
PFLV114570372(nans)
GAT120825501 120825503
PPUG119218410(nansa)
MSAM119884880 119899378 119899379
CUD121507902 121508708 121508709
ALAT119028006
MZE101481190 106674567
ONL100695579 100695847 100696106
OAU116310552 116310553 116310587
OLA101166198(nans)
OML112137589(nansa)
XMA102234709(nans)
XCO114145362(nans)
XHE116720640(nans)
PRET103467988(nans) 103472627
PFOR103148741(nans)
PLAI106938624(nans)
PMEI106905478(nans)
GAF122829775(nansa)
CVG107083396(nans) 107083415 107083416
CTUL119787144 119787154 119787177
GMU124868545 124868562
NFU107390917 107390934
KMR108241432 108241509
ALIM106528334(nans)
NWH119422378 119422379
AOCE111575007(nans)
MCEP125003896 125004087 125004788
CSEM103384124 103384125
POV109627210 109627438
SSEN122770577 122771631
HHIP117769790 117769798
HSP118122966 118126039
LCF108885367 108885368
SDU111229256 111229269
SLAL111656109 111659703
XGL120800959(nansa)
HCQ109519806 109519931
BPEC110166192 110166235
MALB109953770(nans)
BSPL114858266 114858277 114858282
SASA100195066(sias) 106594767 106609889
OTW112231840 112261351
OMY110497423 110497424 110534455
OGO124001941 124001943 124012735
ONE115137363 115137722 115145762 115146546
SALP111971593 112068285 112080022
SNH120034903 120051990 120052901
CCLU121534521 121535761 121535762
ELS105022900(nans)
SFM108920829
PKI111855408(nans)
AANG118227907(nansa)
LOC102687418(nans)
PSPA121319344(nansa)
ARUT117420829(nansa)
CMK103177631(nansa) 103177633
RTP109938218(nans)
BFO118412951 118412952
BBEL109471483 109471485
SCLV120347367
SPU577884
APLC110979925
SKO100367009 100376912
DMEDmel_CG5232(NANS)
DER6553702
DSE6606666
DSIDsimw501_GD18832(Dsim_GD18832)
DYADyak_GE26192
DSR110190443
DPO4800832
DPE6598731
DMN108156913
DWI6650267
DGR6568185
DMODmoj_GI24828
DAZ108621816
DNV108653385
DHE111601415
CCAT101459749
BOD106619099
MDE101899077
SCAC106086863
LCQ111687367
LSQ119609198
HIS119658663
AGAAgaP_AGAP004460
ACOZ120950612
AARA120897604
ASTE118508544
AAG5563645
AALB109400878
CQUCpipJ_CPIJ013964
CPII120415920
CNS116345828
BCOO119073869
TCA103312199
DPA109539228
SOY115879752
ATD109597067
CSET123315673
AGB108917229
LDC111503205
NVL108567369
APLN108741788 112904754
PPYR116164831
BMOR101744099
BMAN114246626
MSEX115444962
DPLKGM_201756
BANY112054184
PMAC106708951 106709065
PPOT106100777 106100789
PXU106124172 106124788
PRAP110994857
ZCE119829783
HAW110380482
HZE124629863
TNL113496613 113506267
SLIU111353605
OFU114364386
PXY105391284
API100166349 100570600
DNX107161705
AGS114120104
RMD113549718
BTAB109035180
DCI103520284
CLEC106666066
HHAL106681070
NLU111058090
PHUPhum_PHUM018360
FOC113212662
TPAL117647422
ZNE110829049
CSEC111874253
FCD110842189
DPXDAPPUDRAFT_300651
DMK116933060
PVM113802701
PJA122265930
PCHN125046868
HAME121873235
PCLA123769285
PTRU123507890
HAZT108677748
EAF111695997
PPOI119112814 119113236
VDE111250001
VJA111258697
TUT107368038
CSCU111619307
PTEP107452120
SDM118205491
MMER123559815 123565563
AAFAURANDRAFT_30675
EHXEMIHUDRAFT_437804(NEUB)
NCOAAW31_00110
NMUNmul_A0408
NLCEBAPG3_000870
SLACSKTS_36140
ARCABLL_2687
AHSAHALO_2546
AMYTAMYT_2597
HEBRAEBR_0577 AEBR_2874
PCAPcar_1277(neuB)
DVMDvMF_1832
DFLDFE_1272
DSDGD606_11120
DMADMR_13530
DCBC3Y92_14295
DGGDGI_4066
DMSE8L03_20250
DAFDesaf_0142
DASDaes_2970
DPIBN4_12645
DEJAWY79_17810
PPRFDPRO_1430
PSELGM415_02085 GM415_02270
DDNDND132_2824
PSEFPSDVSF_27550
DSXGD604_00905
EAHFA04_24335
EAKEKH55_4784
RLGRleg_0440
RHVBA939_07200
RRGJ3P73_04755
RPERPE_4236
MMYRMXMO3_03623
BVRBVIR_1970
BLAGBLTE_00400(neuB)
HDIHDIA_0896(pseI)
LABRCHH27_23610
LAGGB0E33_04290
MALGMALG_05073
PSEBEOK75_20575
CBOTATE48_13380
SPANAWL63_07225
SPZRG5C33_06875
PALGHFP57_17520
CMANA9D14_11725
RCERC1_3771(nans)
DEXHWD60_03420
HLIHLI_08585
GRCGI584_08485
BOUI5818_06175
PYGAWM70_17110
ACELacsn021_05140
CLCCalla_1077
TTOThethe_00855
SLAUSLA_6887
RTXTI83_02490
RTCAPU90_03985
RRYC1O28_12555
MPROBJP34_26850
TBETrebr_1643
BPAAK7I13_00555
SSMSpirs_4263
BHPBHAMNSH16_00325
BTHBT_1714
BTHOBtheta7330_01302(neuB_1) Btheta7330_02995(neuB_2)
BHLBache_2153
BCELBcellWH2_03092(neuB)
BISDXK01_006200
BEGINE88_01921(neuB)
BSTEK6V31_10255
BFEK6V30_22135
BSABacsa_3466
BVSBARVI_00420
PGINFRZ67_17740
SHTKO02_22675
MUCMuYL_3260
MGKFSB76_19830
CAMUCA2015_3635
RHOZGXP67_24460
RSIRunsl_2328
RUNDR864_20420
RUPDTQ70_21560
FJGBB050_02206(legI)
FCOFCOL_12635
FGLEM308_00620
FCMBIW12_03115
FFAFFWV33_07925
FCRHYN56_01615
FENJ0383_14490
FCVAWN65_10295
CATCA2559_07305
KDIKrodi_2064
DOKMED134_13631(neuB)
DDOI597_1525(legI)
DODDCS32_01450
ASLAeqsu_2923
AICJK629_04875
NDODDD_2293
NOMAAT17_10860
NSDBST91_07935
NOBCW736_00515
PRNBW723_03025 BW723_09690
LUTLupro_02285
SMISLDL76_16005
OLLCW732_09090
TAJC1A40_00900
AUEC5O00_09755
AQAD1815_16910
EMARD1013_15690
MESQC7H62_1954
SINHLS482_08950
SABUMBM09_06180
PTANCRYO30217_01041(neuB)
BBAUAEM51_01345
TAVG4V39_08720
BGWVE98_C0001G0439
MACMA_3767
MVCMSVAZ_0733
MEKMSKOL_0716
MHAZBHR79_03025
MAXMMALV_05370
 » show all
Reference
1  [PMID:10438460]
  Authors
Angata T, Nakata D, Matsuda T, Kitajima K, Troy FA 2nd
  Title
Biosynthesis of KDN (2-keto-3-deoxy-D-glycero-D-galacto-nononic acid). Identification and characterization of a KDN-9-phosphate synthetase activity from trout testis.
  Journal
J Biol Chem 274:22949-56 (1999)
DOI:10.1074/jbc.274.33.22949
Reference
2  [PMID:10749855]
  Authors
Lawrence SM, Huddleston KA, Pitts LR, Nguyen N, Lee YC, Vann WF, Coleman TA, Betenbaugh MJ
  Title
Cloning and expression of the human N-acetylneuraminic acid phosphate synthase gene with 2-keto-3-deoxy-D-glycero- D-galacto-nononic acid biosynthetic ability.
  Journal
J Biol Chem 275:17869-77 (2000)
DOI:10.1074/jbc.M000217200
  Sequence
[hsa:54187]
Reference
3  [PMID:18804026]
  Authors
Wang L, Lu Z, Allen KN, Mariano PS, Dunaway-Mariano D
  Title
Human symbiont Bacteroides thetaiotaomicron synthesizes 2-keto-3-deoxy-D-glycero-D- galacto-nononic acid (KDN).
  Journal
Chem Biol 15:893-7 (2008)
DOI:10.1016/j.chembiol.2008.08.005
  Sequence
[bth:BT_1714]
Other DBs
ExplorEnz - The Enzyme Database: 2.5.1.132
IUBMB Enzyme Nomenclature: 2.5.1.132
ExPASy - ENZYME nomenclature database: 2.5.1.132
BRENDA, the Enzyme Database: 2.5.1.132

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