KEGG   ENZYME: 2.5.1.134
Entry
EC 2.5.1.134                Enzyme                                 
Name
cystathionine beta-synthase (O-acetyl-L-serine);
MccB;
O-acetylserine dependent cystathionine beta-synthase
Class
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
Sysname
O-acetyl-L-serine:L-homocysteine 2-amino-2-carboxyethyltransferase
Reaction(IUBMB)
O-acetyl-L-serine + L-homocysteine = L-cystathionine + acetate [RN:R10305]
Reaction(KEGG)
R10305
Substrate
O-acetyl-L-serine [CPD:C00979];
L-homocysteine [CPD:C00155]
Product
L-cystathionine [CPD:C02291];
acetate [CPD:C00033]
Comment
A pyridoxal 5'-phosphate protein. The enzyme, purified from the bacterium Bacillus subtilis, also has a low activity with L-serine (cf. EC 4.2.1.22, cystathionine beta-synthase).
History
EC 2.5.1.134 created 2016
Pathway
ec00270  Cysteine and methionine metabolism
ec01100  Metabolic pathways
Orthology
K17216  cystathionine beta-synthase (O-acetyl-L-serine)
Genes
SDOSD1155_04925
BSUBSU27260(mccA)
BSRI33_2768
BSLA7A1_0368
BSHBSU6051_27260(mccA)
BSYI653_12945
BSUTBSUB_02908(mccA)
BSULBSUA_02908(mccA)
BSUSQ433_14685
BSOBSNT_09120(yrhA)
BSNBSn5_04415
BSQB657_27260(mccA)
BSXC663_2563(mccA)
BSPU712_13400
BSSBSUW23_13185(mccA)
BSTGYO_2966
BLIBL02019(yrhA)
BLDBLi02854(mccA)
BLHBaLi_c29550(mccA)
BAYRBAM_024360
BAQBACAU_2450(yrhA)
BYABANAU_2594(yrhA)
BAMPB938_12590
BQYMUS_2912(yrhA)
BAMLBAM5036_2376(mccA)
BAMARBAU_2573(mccA)
BAMNBASU_2379(mccA)
BAMBBAPNAU_1126(yrhA)
BAMTAJ82_13765
BAMYV529_27200(yrhA)
BMPNG74_02558(mccA)
BAOBAMF_2534(mccA)
BAZBAMTA208_13375(mccA)
BQLLL3_02812(mccA)
BXHBAXH7_02736(yrhA)
BAMIKSO_007195
BAMCU471_25280
BAMFU722_13220
BSIACWD84_08700
BAEBATR1942_11345
BVMB9C48_12460
BSONS101395_01637
BHTDIC78_18025
BMOJHC660_25290(mccA)
BTEQG4P54_13890
BIQAN935_13315
BANBA_4601(cysM)
BARGBAA_4601(cysM)
BATBAS4269
BAHBAMEG_4638(cysM)
BAIBAA_4621(cysM)
BAXH9401_4390
BANTA16_45990
BANRA16R_60350
BANSBAPAT_4416
BANHHYU01_22440
BANVDJ46_3278(mccA)
BCEBC4367
BCABCE_4455(cysM)
BCZBCE33L4117(cysM)
BCRBCAH187_A4506(cysM)
BCBBCB4264_A4492(cysM)
BCUBCAH820_4453(cysM)
BCGBCG9842_B0744(cysM)
BCQBCQ_4157(cysM)
BCXBCA_4485(cysM)
BALBACI_c43590(cysM)
BNCBCN_4283
BCFbcf_21750
BCERBCK_13330
BCYBcer98_3085
BTKBT9727_4106(cysM)
BTLBALH_3958(cysM)
BTBBMB171_C4034(cysM)
BTTHD73_4681
BTHRYBT1520_23215
BTHIBTK_23055
BTCCT43_CH4390(cysM)
BTFYBT020_21540
BTMMC28_3664
BTGBTB_c45130(mccA)
BTIBTG_27210
BTNBTF1_20470
BTHTH175_ch4459
BTHUYBT1518_24320
BTWBF38_127(mccA)
BTHYAQ980_07955
BWEBcerKBAB4_4220
BWWbwei_0566(mccA)
BMYOBG05_1653
BTYBtoyo_1610
BMYCDJ92_1470(mccA)
BBYCY96_21040
BWDCT694_23490
BTROFJR70_15655
BMOBMLA2C4_22815
BNTGSN03_20805
BPACLMD38_05140
BPUBPUM_2361
BPUMBW16_12820
BPUSUP12_11890
BIFN288_18660
BMETBMMGA3_12175(mccA)
BSMBSM4216_1793
BGYBGLY_3173(yrhA)
BXIBK049_15165
BALTCFN77_12620
BSAFBSL056_12970
BITBIS30_03015
BSHILGQ02_13710
BCABEFK13_13840
BRYM0696_13615
BJSMY9_2707
BACIB1NLA3E_16325
GSTHW35_04710
BACWQR42_11965
BACPSB24_16515
BACBOY17_15460
BACYQF06_11820
BACLBS34A_29740(mccA)
BALMBsLM_2695
BACSAUL54_17635
BACAFAY30_17475
BAQUK6959_18315
BHKB4U37_15540
BCOHBC6307_15900
BCIRC2I06_10460(cysK)
BMQBMQ_4595(mccA)
BMDBMD_4581(mccA)
BMEGBG04_1587
BEOBEH_16505
BFXBC359_04740
PKSIE339_19405
BCKBCO26_2431
BAGBcoa_1960
BCOABF29_1573
BCLABC1944
BLEBleG1_1699
BGIBGM20_07525
BKOCKF48_17420
CGOTJ1899_15730
CSUAIM538_17680(cysK)
CFIRNAF01_02890
CSOALIS82_19850
OIHOB1108(cysK)
OCNCUC15_07020
GKAGK2541
GTEGTCCBUS3UF5_28640
GTKGT3570_12445
GTMGT3921_06740
GLIGLN3_05580
BCALCWI35_15565
GTNGTNG_2474
GWCGWCH70_2475
GYCGYMC61_0978
GYAGYMC52_2574
GCTGC56T3_0951
GMCGY4MC1_1026
GGHGHH_c26150(mccA)
GJFM493_13175
GEAGARCT_02595(mccA)
GELIB49_04575
GSEGT50_04125
GSRGS3922_03470
GEJA0V43_10575
GZAIC807_08845
GTHGeoth_1096
PTLAOT13_17160
PTBDER53_00270
PCALBV455_02800(mccA)
AFLAflv_0760
AGNAFK25_10610
ANMGFC28_3611
AAMYGFC30_2790
ANLGFC29_1822
ANDGRQ40_13475
ACAIISX45_10950
ASEDIRT44_02025(cysK)
HHDHBHAL_2022(mccA)
HMNHM131_16230
HLIHLI_06380
TAPGZ22_04625
TAIDKS242_05460
VHLBME96_04130
VILCFK37_01105
VNECFK40_17140
VIMGWK91_05710
FPNABE65_014680
FARABE41_013450
BSJUP17_16920
BMURABE28_015670
PBUTDTO10_03735
PASABAOM_3879(mccA)
PPSRI6J18_20130
PFRIL8956_17560
AQTFN924_05325(cysK)
BTHVCQJ30_10405
PSYHD0S48_17715
PSYOPB01_15155
GRCGI584_17705
POFGS400_02550
NTMBTDUT50_12140
NDTL1999_22115
MSEMGMB29_13385
MDGK8L98_18135
BLENNCTC4824_00045(mccA)
SEDDERJ70_04080
BVQFHE72_15535
RMFD5E69_15365
BVJI5776_17575
BOUI5818_21620
CTHUHUR95_16175(cysK)
MCUIG8O30_08390
GAJMY490_08845
PSUAFLK61_25190
SLMSMM221_11370
STEAC0679_09630
SAUSA0418(cysM)
SAVSAV0459(cysM)
SAWSAHV_0457(cysM)
SAHSaurJH1_0494
SAJSaurJH9_0481
SAMMW0414(cysM)
SASSAS0417
SARSAR0459
SACSACOL0502
SAASAUSA300_0433(cysM)
SAOSAOUHSC_00421
SAENWMN_0424(cysM)
SADSAAV_0402
SUUM013TW_0424
SUVSAVC_01885
SUESAOV_0477
SUJSAA6159_00409
SUKSAA6008_00463(cysM)
SUCECTR2_393
SUTSAT0131_00499
SUQHMPREF0772_10063
SUZMS7_0433(mccA)
SUDST398NM01_0525
SUXSAEMRSA15_03850
SUWSATW20_05280
SUGSAPIG0525
SUFSARLGA251_03930
SAUASAAG_00914
SAUERSAU_000392(cysM)
SAUNSAKOR_00443
SAUSSA40_0398
SAUUSA957_0413
SAUGSA268_0411
SAUZSAZ172_0461
SAUTSAI1T1_2003350
SAUJSAI2T2_1003350
SAUKSAI3T3_1003350
SAUQSAI4T8_1003350
SAUVSAI7S6_1003350
SAUWSAI5S5_1003340
SAUXSAI6T6_1003350
SAUYSAI8T7_1003350
SAUFX998_0486
SABSAB0409
SUYSA2981_0435(cysM)
SAUBC248_0509
SAUMBN843_4420
SAUCCA347_453(mccA)
SAURSABB_06041
SAUIAZ30_02225
SAUDCH52_03555
SAMSNI36_02150
SUHSAMSHR1132_04040
SERSERP0094
SEPSE_2324
SEPPSEB_02319
SEPSDP17_1514
SHASH2549(cysM)
SHHShL2_02334(cysM)
SSPSSP0252
SCASCA_0086(cysM)
SLGSLGD_02457
SLNSLUG_23520
SSDSPSINT_0115
SDTSPSE_2356
SDPNCTC12225_02562(mccA)
SWAA284_11090
SPASSTP1_1534
SXYBE24_10695
SXLSXYLSMQ121_0280
SXOSXYL_00284(cysM)
SHUSHYC_11455(mccA)
SCAPAYP1020_2182(mccA)
SSCHLH95_11035
SSCZRN70_11800
SAGQEP23_10725
SEQOSE1039_22910
SSIFAL483_09475
SCVA4G25_07305
SLZB5P37_06595
SFQC7J90_02465
SHOMEGX58_04085
SMUSC7J88_06870
SCARDWB96_12390
SCHRDWB92_11610
SPICSAMEA4384060_2444(cysM)
SSHNCTC13712_00385(mccA)
SSIMSAMEA4384339_0377(mccA)
SDBCNQ82_00635
SAULI6G39_10120
SRAILN051_10785
SPSDJMB28_01920
STASHYI43_11700
SSCUCEP64_10515
SFFFOB90_08360
SSTESAMEA4384403_2190(mccA)
MVTI6J10_00360
MCLMCCL_1789
MCAKMCCS_23050(cysM)
MACRBHM04_11960
MBOEHT586_11095
MARYLAU42_10665
MBRUMGG13_10085
SBACBVH56_07770
ESIExig_2344
EATEAT1b_0609
EANEab7_2189
EXMU719_12905
EXUESP131_15015
EAPKB235_07390
EACEKKI46_12850
EAURNMQ00_06110
BBEBBR47_47860(mccA)
BLRBRLA_c040920
BFMBP422_19715
BAGRBA6348_07555(cysK)
BRWGOP56_13105(cysK)
BCHSJNE38_25760(cysK)
BCOPJD108_05015(cysK)
PJDPjdr2_5105
PPYPPE_02106
PPMPPSC2_11030(cysM)
PPOPPM_2115(cysM)
PPOLX809_11375
PPQPPSQR21_021950
PPOYRE92_01320
PTAHPL003_19385
PIHUB51_24980
PPEOABE82_11205
PBVAR543_13265
PXLBS614_24795
PKBB4V02_14235
PAIHASL14_00330
ANXACH33_03435
ASOCCB4_01040(mccA)
ATHEK3F53_15480(cysK)
PLNPlano_2472
PKUAUO94_03265
PRTAUC31_13725
PLLI858_010420
PANABBH88_06550
PDGBCM40_02835
PHCBBI08_09605
PMARB0X71_15405
PPLABBI15_08585
PFAEAJGP001_14285
PLXCW734_14635
PMATBBI11_14205
PDECH1Q58_13510
PGQFK545_03595
JEOJMA_30780
SPSYAZE41_06755
SPOOJ3U78_10520
RSTATY39_01125
PAEKD3873_09805
PANCE2636_04655
PLAYDNR44_007330
VIJJNUCC6_21810
NTRB0W44_08995
LFBC1X05_03175(cysK)
TVUAB849_002180(cysK)
KPULGXN76_04265(cysK)
KEBGXN75_04825
PABSJIR001_06870(cysM)
CRNCAR_c05780(mccA)
CVDLHA31_04145
CAESMB_G0948(mccA)
CSRCspa_c14330(mccA)
ACITHPK19_02685
HSLOE_1916F(cysK1)
HDLHALDL1_07230
HHBHhub_1695(cysK1)
HAGSJT689_03820
HJEHacjB3_11215
SALRFQU85_11785
HALXM0R89_11725
HAXZM0R88_11985
SALIL593_14755
NPHNP_4748A(cysK1)
NHOHWV23_10835
NSALHWV07_06325
HUTHuta_0932
HTIHTIA_0785
HALAHrd1104_04120
HMEHFX_1504(cysK1)
HGIABY42_07000
HALEG3A49_10355
HBOHbor_18020
HALMFCF25_14070
HLAHlac_1763
HALPDOS48_04315
HALBEKH57_04805
HEZZEO776_07060
HALQHrr1229_015785
HSSJ7656_09400
HSAIHPS36_14840
HAZZKI388_04730
HALNB4589_002670
HALGHUG10_06270
HALUHUG12_10185
HMPK6T50_05640
HREK6T36_05370
HRMK6T25_10395
HACBHbl1158_11970
HDFAArcSl_1390(cysK2)
HAHHalar_2309
HTUHtur_1013
HSALJMJ58_03860
NMGNmag_3195(cysK1)
HXAHalxa_2901
NVRFEJ81_12600
NGENatgr_0629
HRUHalru_0862
NOUNatoc_1061
HLCCHINAEXTREME17445
NAGAArcMg_1441
NANAArc1_2155
 » show all
Reference
1  [PMID:17056751]
  Authors
Hullo MF, Auger S, Soutourina O, Barzu O, Yvon M, Danchin A, Martin-Verstraete I
  Title
Conversion of methionine to cysteine in Bacillus subtilis and its regulation.
  Journal
J Bacteriol 189:187-97 (2007)
DOI:10.1128/JB.01273-06
  Sequence
[bsu:BSU27260]
Other DBs
ExplorEnz - The Enzyme Database: 2.5.1.134
IUBMB Enzyme Nomenclature: 2.5.1.134
ExPASy - ENZYME nomenclature database: 2.5.1.134
BRENDA, the Enzyme Database: 2.5.1.134

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