Entry
Name
validamine 7-phosphate valienyltransferase;
vldE (gene name);
valL (gene name)
Class
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
BRITE hierarchy
Sysname
GDP-valienol:validamine 7-phosphate valienyltransferase
Reaction(IUBMB)
GDP-valienol + validamine 7-phosphate = validoxylamine A 7'-phosphate + GDP [RN:
R11497 ]
Reaction(KEGG)
Substrate
GDP-valienol [CPD:
C21368 ];
validamine 7-phosphate [CPD:
C21216 ]
Product
validoxylamine A 7'-phosphate [CPD:
C21219 ];
GDP [CPD:
C00035 ]
Comment
The enzyme, characterized from several Streptomyces strains, is involved in the biosynthesis of the antifungal agent validamycin A.
History
EC 2.5.1.135 created 2016
Pathway
ec00525 Acarbose and validamycin biosynthesis
ec01110 Biosynthesis of secondary metabolites
Orthology
K20436 validamine 7-phosphate valienyltransferase
Genes
» show all
Taxonomy
Reference
Authors
Asamizu S, Yang J, Almabruk KH, Mahmud T
Title
Pseudoglycosyltransferase catalyzes nonglycosidic C-N coupling in validamycin a biosynthesis.
Journal
Reference
Authors
Zheng L, Zhou X, Zhang H, Ji X, Li L, Huang L, Bai L, Zhang H
Title
Structural and functional analysis of validoxylamine A 7'-phosphate synthase ValL involved in validamycin A biosynthesis.
Journal
Sequence
Reference
Authors
Cavalier MC, Yim YS, Asamizu S, Neau D, Almabruk KH, Mahmud T, Lee YH
Title
Mechanistic insights into validoxylamine A 7'-phosphate synthesis by VldE using the structure of the entire product complex.
Journal
Sequence
Other DBs
ExPASy - ENZYME nomenclature database: 2.5.1.135