PT2 (gene name);
aromatic prenyltransferase (ambiguous);
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
(1) prenyl diphosphate + a 2-acyl-4-prenylphloroglucinol = diphosphate + a 2-acyl-4,6-bis(prenyl)phloroglucinol [RN:
(2) prenyl diphosphate + a 2-acyl-4,6-bis(prenyl)phloroglucinol = diphosphate + a 2-acyl-4,6,6-tris(prenyl)cyclohexa-2,4-dien-1-one [RN:
prenyl diphosphate [CPD:
The enzyme, characterized from hop (Humulus lupulus), catalyses two successive prenylations of a 2-acyl-4-prenylphloroglucinol during the synthesis of bitter acids. Forms a complex with EC
, 2-acylphloroglucinol 4-prenyltransferase, which catalyses the initial prenylation of the substrates. Requires Mg2+.
EC 188.8.131.52 created 2017
K21605 2-acyl-4-prenylphloroglucinol 6-prenyltransferase
Li H, Ban Z, Qin H, Ma L, King AJ, Wang G
A heteromeric membrane-bound prenyltransferase complex from hop catalyzes three sequential aromatic prenylations in the bitter acid pathway.
ExPASy - ENZYME nomenclature database: 184.108.40.206