KEGG   ENZYME: 2.5.1.142
Entry
EC 2.5.1.142                Enzyme                                 

Name
nerylneryl diphosphate synthase;
CPT2;
dimethylallyl-diphosphate:isopentenyl-diphosphate cistransferase (adding 3 isopentenyl units)
Class
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
Sysname
prenyl-diphosphate:3-methylbut-3-en-1-yl-diphosphate cistransferase (adding 3 units of 3-methylbut-3-en-1-yl)
Reaction(IUBMB)
prenyl diphosphate + 3 (3-methylbut-3-en-1-yl diphosphate) = 3 diphosphate + nerylneryl diphosphate [RN:R11940];
(1a) prenyl diphosphate + 3-methylbut-3-en-1-yl diphosphate = diphosphate + neryl diphosphate [RN:R01659];
(1b) neryl diphosphate + 3-methylbut-3-en-1-yl diphosphate = diphosphate + (2Z,6Z)-farnesyl diphosphate [RN:R12638];
(1c) (2Z,6Z)-farnesyl diphosphate + 3-methylbut-3-en-1-yl diphosphate = diphosphate + nerylneryl diphosphate [RN:R12639]
Reaction(KEGG)
Substrate
prenyl diphosphate [CPD:C00235];
3-methylbut-3-en-1-yl diphosphate [CPD:C00129];
neryl diphosphate [CPD:C02569];
(2Z,6Z)-farnesyl diphosphate [CPD:C19760]
Product
diphosphate [CPD:C00013];
nerylneryl diphosphate [CPD:C21784];
neryl diphosphate [CPD:C02569];
(2Z,6Z)-farnesyl diphosphate [CPD:C19760]
Comment
Isolated from the plant Solanum lycopersicum (tomato).
History
EC 2.5.1.142 created 2017
Orthology
K22423  nerylneryl diphosphate synthase
Genes
SLY: 101247737
Reference
1  [PMID:23134568]
  Authors
Akhtar TA, Matsuba Y, Schauvinhold I, Yu G, Lees HA, Klein SE, Pichersky E
  Title
The tomato cis-prenyltransferase gene family.
  Journal
Plant J 73:640-52 (2013)
DOI:10.1111/tpj.12063
  Sequence
Reference
2  [PMID:25786135]
  Authors
Matsuba Y, Zi J, Jones AD, Peters RJ, Pichersky E
  Title
Biosynthesis of the diterpenoid lycosantalonol via nerylneryl diphosphate in Solanum lycopersicum.
  Journal
PLoS One 10:e0119302 (2015)
DOI:10.1371/journal.pone.0119302
Other DBs
ExplorEnz - The Enzyme Database: 2.5.1.142
IUBMB Enzyme Nomenclature: 2.5.1.142
ExPASy - ENZYME nomenclature database: 2.5.1.142
BRENDA, the Enzyme Database: 2.5.1.142

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