KEGG   ENZYME: 2.5.1.147
Entry
EC 2.5.1.147                Enzyme                                 

Name
5-amino-6-(D-ribitylamino)uracil---L-tyrosine 4-hydroxyphenyl transferase;
cofH (gene name);
cbiF (gene name) (ambiguous)
Class
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
Sysname
5-amino-6-(D-ribitylamino)uracil:L-tyrosine, 4-hydroxyphenyl transferase
Reaction(IUBMB)
5-amino-6-(D-ribitylamino)uracil + L-tyrosine + S-adenosyl-L-methionine = 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil + 2-iminoacetate + L-methionine + 5'-deoxyadenosine [RN:R12161]
Reaction(KEGG)
R12161
Substrate
5-amino-6-(D-ribitylamino)uracil [CPD:C04732];
L-tyrosine [CPD:C00082];
S-adenosyl-L-methionine [CPD:C00019]
Product
5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil [CPD:C21971];
2-iminoacetate [CPD:C15809];
L-methionine [CPD:C00073];
5'-deoxyadenosine [CPD:C05198]
Comment
The enzyme is involved in the production of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO), the precursor of the redox cofactor coenzyme F420, which is found in methanogens and in various actinobacteria. FO is also produced by some cyanobacteria and eukaryotes. The enzyme, which forms a complex with EC 4.3.1.32, 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase, is a radical SAM enzyme that uses the 5'-deoxyadenosyl radical to initiate the reaction.
History
EC 2.5.1.147 created 2010 as EC 2.5.1.77, part transferred 2018 to EC 2.5.1.147
Pathway
ec00680  Methane metabolism
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K11779  FO synthase
K11781  5-amino-6-(D-ribitylamino)uracil---L-tyrosine 4-hydroxyphenyl transferase
Genes
CPS: CPS_4048 CPS_4049
MARS: A8C75_03570
EBA: p2A350
HOH: Hoch_0059
RPB: RPB_4423
OCA: OCAR_5007
PZU: PHZ_c2536
PDE: Pden_1114 Pden_1115
SWI: Swit_0717
BBEV: BBEV_1717(fbiC)
MTU: Rv1173(fbiC)
MTV: RVBD_1173
MTC: MT1210
MRA: MRA_1184(fbiC)
MTG: MRGA327_07395(fbiC)
MTUR: CFBS_1252(fbiC)
MTO: MTCTRI2_1205(fbiC)
MTD: UDA_1173(fbiC)
MTN: ERDMAN_1316(fbiC)
MTJ: J112_06345(fbiC)
MTUE: J114_06345(fbiC)
MTX: M943_06155(fbiC)
MTUL: TBHG_01157
MTUT: HKBT1_1250(fbiC)
MTUU: HKBT2_1256(fbiC)
MTQ: HKBS1_1254(fbiC)
MBO: BQ2027_MB1206(fbiC)
MBB: BCG_1236(fbiC)
MBT: JTY_1209(fbiC)
MBM: BCGMEX_1208(fbiC)
MBX: BCGT_1005
MAF: MAF_11920(fbiC)
MMIC: RN08_1318
MCE: MCAN_11841(fbiC)
MCQ: BN44_11312(fbiC)
MCV: BN43_30241(fbiC)
MCX: BN42_21039(fbiC)
MCZ: BN45_30234(fbiC)
MLE: ML1492(fbiC)
MLB: MLBr01492
MPA: MAP_2611c
MAO: MAP4_1207
MAVI: RC58_05980(fbiC)
MAVU: RE97_05975(fbiC)
MAV: MAV_1312
MIT: OCO_12230
MIA: OCU_12190
MID: MIP_01953
MYO: OEM_12380
MCHI: AN480_07165(fbiC)
MMAL: CKJ54_05940(fbiC)
MLP: MLM_1243
MUL: MUL_1020(fbiC)
MMC: Mmcs_4032
MKM: Mkms_4107
MJL: Mjls_4262
MMI: MMAR_4279(fbiC)
MMAE: MMARE11_40940(fbiC)
MMM: W7S_05970(fbiC)
MLI: MULP_04464(fbiC)
MKN: MKAN_07265(fbiC)
MYV: G155_22255(fbiC)
MYE: AB431_23285(fbiC)
MHAD: B586_07415(fbiC)
MYN: MyAD_20555(fbiC)
MDX: BTO20_08855(fbiC)
MSHG: MSG_03833(fbiC)
MFJ: MFLOJ_48330(fbiC)
MXE: MYXE_14930(fbiC)
MNV: MNVI_05210(fbiC)
MPAG: C0J29_23420(fbiC)
MSM: MSMEG_5126(fbiC)
MSG: MSMEI_4998(fbiC)
MSB: LJ00_25350(fbiC)
MSN: LI99_25355(fbiC)
MSH: LI98_25360(fbiC)
MVA: Mvan_4533
MGI: Mflv_2167
MNE: D174_20945(fbiC)
MGO: AFA91_14910(fbiC)
MPHL: MPHLCCUG_04074(mqnE)
MVQ: MYVA_4308(fbiC)
MLL: B1R94_06840(fbiC)
MHAS: MHAS_02879(fbiC)
MDU: MDUV_01960(fbiC)
MCHT: MCHIJ_26390(fbiC)
MDR: MDOR_28370(fbiC)
MMAG: MMAD_41900(fbiC)
MMOR: MMOR_20550(fbiC)
MFX: MFAL_38670(fbiC)
MAIC: MAIC_42080(fbiC)
MAB: MAB_1319
MMV: MYCMA_0695(fbiC)
MABB: MASS_1319(fbiC)
MIZ: BAB75_07105(fbiC)
MSTE: MSTE_01287
MSAO: MYCSP_05810(fbiC)
MSAL: DSM43276_01185(mqnE)
MJD: JDM601_1161(fbiC)
MTER: 4434518_01112(fbiC)
MMIN: MMIN_27930(fbiC)
MHIB: MHIB_06830(fbiC)
MKR: MKOR_00500(fbiC)
NFA: NFA_47520
NCY: NOCYR_4499(fbiC)
NBR: O3I_035915(fbiC)
NNO: NONO_c64550(fbiC)
NSL: BOX37_25530(fbiC)
NSR: NS506_01897(fbiC)
NTP: CRH09_33525(fbiC)
NOZ: DMB37_14595(fbiC)
RER: RER_41830(fbiC)
REY: O5Y_19555(fbiC)
REB: XU06_19700(fbiC)
ROP: ROP_60060(fbiC)
REQ: REQ_14170
RPY: Y013_22830(fbiC)
RHB: NY08_5017
RAV: AAT18_08315(fbiC)
RFA: A3L23_03076(fbiC)
RHW: BFN03_02640(fbiC)
RHS: A3Q41_00251(fbiC)
RRZ: CS378_23345(fbiC)
RHU: A3Q40_02330(fbiC)
RQI: C1M55_20650(fbiC)
RHQ: IM25_12240(fbiC)
RHOD: AOT96_01090(fbiC)
RBY: CEJ39_09030(fbiC)
GBR: Gbro_3326
GPO: GPOL_c31240(fbiC2)
GOR: KTR9_3365
GIT: C6V83_14745(fbiC)
GRU: GCWB2_17305(mqnE)
GOM: D7316_05361(fbiC_1)
SCO: SCO4429(fbiC)
SALB: XNR_2222
SMA: SAVERM_3794(cofG)
SGR: SGR_4235
SGB: WQO_14275(fbiC)
SCB: SCAB_52181(fbiC)
SCT: SCAT_2338(fbiC)
SFA: Sfla_3633
SBH: SBI_06333(fbiC)
SHY: SHJG_4710
SVE: SVEN_3084
SDV: BN159_5026(fbiC)
SALS: SLNWT_4334
STRP: F750_3084
SFI: SFUL_2886
SCI: B446_16865(fbiC)
SRC: M271_20760(fbiC) M271_38995(fbiC)
SALU: DC74_3703
SALL: SAZ_19675(fbiC)
SLV: SLIV_16290(fbiC)
SGU: SGLAU_14900(fbiC)
SVT: SVTN_16080(fbiC)
STRE: GZL_05186
SCW: TU94_14370(fbiC)
SLD: T261_4807
SLC: SL103_02830(fbiC)
STRM: M444_15375(fbiC)
STRC: AA958_12800(fbiC)
SAMB: SAM23877_3304(fbiC)
SPRI: SPRI_4317
SCZ: ABE83_21500(fbiC)
SCX: AS200_26105(fbiC)
SRW: TUE45_04323(mqnE_1)
STRF: ASR50_19115(fbiC)
SLE: sle_40200(sle_40200)
SRN: A4G23_02305(mqnE_1)
SPAV: Spa2297_14305(fbiC)
STRT: A8713_13345(fbiC)
SCLF: BB341_11230(fbiC)
SGS: AVL59_44175(fbiC)
STSI: A4E84_17315(fbiC)
SNR: SNOUR_23810(fbiC)
SPLU: LK06_018940(fbiC)
STRD: NI25_22395(fbiC)
SNW: BBN63_19680(fbiC)
SAUO: BV401_26765(fbiC) BV401_35045(fbiC)
SSIA: A7J05_20325(fbiC)
SVU: B1H20_13635(fbiC)
SPUN: BFF78_24080(fbiC)
SGV: B1H19_17935(fbiC)
SLAU: SLA_3135
SALF: SMD44_03660(fbiC)
SALJ: SMD11_3959(fbiC)
SLX: SLAV_16495(mqnE2)
STRO: STRMOE7_16995(fbiC)
SFK: KY5_3501c
SNZ: DC008_14780(fbiC)
SGE: DWG14_04813(fbiC)
SRJ: SRO_4209
SLK: SLUN_16960(fbiC)
SDX: C4B68_22925(fbiC)
SAST: CD934_19070(fbiC)
STIR: DDW44_12900(fbiC)
SGZ: C0216_28065(fbiC)
KSK: KSE_45370(fbiC)
KAB: B7C62_13575(fbiC)
KAU: B6264_08870(fbiC)
NDK: I601_0314(mqnE)
NBE: Back2_26860(fbiC)
KFL: Kfla_6490
PSIM: KR76_06880
TFU: Tfu_2519
NDA: Ndas_3771
NAL: B005_0949(cofG)
NGV: CDO52_24260(fbiC)
STRR: EKD16_20105(mqnE)
TCU: Tcur_4075
SRO: Sros_1376
NOA: BKM31_38790(fbiC)
FAL: FRAAL1263
ACE: Acel_0769
GOB: Gobs_1483
BSD: BLASA_1295(fbiC)
MMAR: MODMU_1466(fbiC)
KRA: Krad_3629
SEN: SACE_6594
AMD: AMED_6904(fbiC)
AMN: RAM_35420(fbiC)
AMM: AMES_6798(fbiC)
AMZ: B737_6798(fbiC)
AOI: AORI_1815(fbiC)
AJA: AJAP_30405(fbiC)
AMQ: AMETH_5642(fbiC)
AMYC: CU254_27985(fbiC)
AMYB: BKN51_01275(fbiC)
AORI: SD37_32150(fbiC)
ACTI: UA75_18405
ACAD: UA74_17915
AHG: AHOG_15900(mqnE)
ACTA: C1701_18075(fbiC)
ALO: CRK57346
SAQ: Sare_0888
MIL: ML5_1202
MTUA: CSH63_19720(fbiC)
VMA: VAB18032_09475(fbiC)
PLAB: C6361_20395(fbiC)
PLAT: C6W10_23365(fbiC)
CAI: Caci_8766
TBI: Tbis_0746
AEY: CDG81_19075(fbiC)
RXY: Rxyl_0975
SYN: sll1659
SYZ: MYO_12520
SYY: SYNGTS_0250(cofH)
SYT: SYNGTI_0250(cofH)
SYS: SYNPCCN_0250(cofH)
SYQ: SYNPCCP_0250(cofH)
SYC: syc0843_c
TEL: tlr1597(cofG)
THN: NK55_04740(cofH)
THEC: FFX45_05945(cofH)
CYI: CBM981_0450(cofH)
LET: O77CONTIG1_00551(mqnE)
HHG: XM38_009170(cofH)
THEU: HPC62_14945(cofH)
GEE: GM3708_16
MAR: MAE_44400
MPK: VL20_2553
CYL: AA637_02275(cofH)
ENN: FRE64_08190(cofH)
CYT: cce_4539
TER: Tery_2116
ARP: NIES39_L02990(cofH)
OXY: HCG48_14355(cofH)
LFS: HFV01_04975(cofH)
GVI: glr0776(cofG)
GLJ: GKIL_2220(cofH)
ANA: alr4129
NSH: GXM_01176
AVA: Ava_0775
NAZ: Aazo_0194
ANB: ANA_C11401(cofH)
ANN: EH233_04440(cofH)
CALH: IJ00_17760
NSP: BMF81_01996(cofH)
DOU: BMF77_01492(fbiC_1)
DFS: HGD76_10455(cofH)
CCUR: IAR63_12380(cofH)
TOQ: HCG51_15175(cofH)
CTHE: Chro_1933
TRO: trd_A0899(cofH)
MJA: MJ_1431
MMP: MMP0056(cofH) MMP0057(cofH)
MMAK: MMKA1_00580(cofH) MMKA1_00590(cofH)
MMAO: MMOS7_00820(cofH) MMOS7_00830(cofH)
MMAD: MMJJ_10390(mqnE_1) MMJJ_10400(mqnE_2)
MAE: Maeo_0750
MVO: Mvol_1375
METF: CFE53_02480(cofH)
MTH: MTH_820
MMG: MTBMA_c12170(cofH)
METC: MTCT_0736
MWO: MWSIV6_1196(cofH)
METE: tca_00787(fbiC_1)
METK: FVF72_07445(cofH)
MTHM: FZP57_05680(cofH)
MST: Msp_0392(cofH)
METB: AW729_05100(cofH)
MRU: mru_1266(cofH)
MSI: Msm_0079
MEB: Abm4_0772(cofH)
MMIL: sm9_0991(cofH)
MEYE: TL18_05430(cofH)
MOL: YLM1_0639
METH: MBMB1_0707(cofH1) MBMB1_1031(cofH3)
MFC: BRM9_1217(cofH1) BRM9_1488(cofH2)
MFI: DSM1535_1898(cofH1) DSM1535_2180(cofH3)
MCUB: MCBB_0164(cofH_1) MCBB_0722(cofH_3)
METT: CIT01_01905(cofH) CIT01_08975(cofH)
METO: CIT02_01855(cofH) CIT02_03225(cofH)
MFV: Mfer_0690
MKA: MK0897(thiH_1)
AFU: AF_0798
FPL: Ferp_0003
GAC: GACE_2059
GAH: GAH_00663
MFZ: AOB57_001355(cofH) AOB57_001360(cofH)
MZI: HWN40_09685(cofH)
MTP: Mthe_0284
MCJ: MCON_3335(cofH)
MHI: Mhar_0763
MLA: Mlab_0123
MBG: BN140_0224(cofH1) BN140_1481(cofH3)
MEMA: MMAB1_0286(cofH) MMAB1_1902(cofH)
MPD: MCP_2456(cofH-1) MCP_2457(cofH-2)
MEZ: Mtc_0997(cofH-1) Mtc_0998(cofH-2)
RCI: RCIX459(cofH-2) RCIX460(cofH-1)
HAL: VNG_1938C
HSL: OE_3723R(cofH)
HHB: Hhub_3265(cofH)
HALH: HTSR_1968(cofH)
HHSR: HSR6_2043(cofH)
SALR: FQU85_06460(cofH)
HALR: EFA46_002145(cofH)
HMA: rrnAC3278
HHI: HAH_0519(cofH)
HALJ: G9465_17525(cofH)
NPH: NP_2394A(cofH)
NMO: Nmlp_3320(cofH)
HUT: Huta_1308
HTI: HTIA_1198
HALA: Hrd1104_08980(cofH)
HMU: Hmuk_1418
HALZ: E5139_10245(cofH)
HALL: LC1Hm_0634(cofH)
HRR: HZS55_04965(cofH)
HPEL: HZS54_05045(cofH)
HWA: HQ_3127A(cofH)
HWC: Hqrw_3668(cofH)
HVO: HVO_2198(cofH)
HME: HFX_2254(thiH)
HALE: G3A49_14430(cofH)
HAER: DU502_15190(cofH)
HRA: EI982_15065(cofH)
HALM: FCF25_02470(cofH)
HLA: Hlac_2018
HALB: EKH57_14575(cofH)
HEZZ: EO776_10065(cofH)
HALQ: Hrr1229_009800(cofH)
HALN: B4589_007640(cofH)
HALG: HUG10_09405(cofH)
HALU: HUG12_06420(cofH)
HDF: AArcSl_2517(cofH)
HTU: Htur_0645
HALY: HYG82_19890(cofH)
NMG: Nmag_2637(cofH)
NAT: NJ7G_3947
NVR: FEJ81_14745(cofH) FEJ81_22750(cofH)
NPL: FGF80_13885(cofH)
SALI: L593_13865
NAS: GCU68_09425(cofH)
NMR: Nmar_0592
NID: NPIRD3C_1666(cofH)
NIN: NADRNF5_1569(cofH)
NIW: Nisw_01900(cofH)
NCL: C5F47_06150(cofH)
NOX: C5F49_05910(cofH)
NUE: C5F50_04480(cofH)
NCT: NMSP_1084(cofH_2)
NIC: DSQ20_03190(cofH)
NGA: Ngar_c12350(cofH1)
NVN: NVIE_011280(cofH1)
NEV: NTE_02502
TAA: NMY3_02529(mqnE_1)
NFN: NFRAN_0113(cofH)
NCV: NCAV_0880(cofH)
NDV: NDEV_0671(cofH)
CCAI: NAS2_0578
 » show all
Reference
1  [PMID:23072415]
  Authors
Decamps L, Philmus B, Benjdia A, White R, Begley TP, Berteau O
  Title
Biosynthesis of F0, precursor of the F420 cofactor, requires a unique two radical-SAM domain enzyme and tyrosine as substrate.
  Journal
J Am Chem Soc 134:18173-6 (2012)
DOI:10.1021/ja307762b
Reference
2  [PMID:25781338]
  Authors
Philmus B, Decamps L, Berteau O, Begley TP
  Title
Biosynthetic versatility and coordinated action of 5'-deoxyadenosyl radicals in deazaflavin biosynthesis.
  Journal
J Am Chem Soc 137:5406-13 (2015)
DOI:10.1021/ja513287k
Other DBs
ExplorEnz - The Enzyme Database: 2.5.1.147
IUBMB Enzyme Nomenclature: 2.5.1.147
ExPASy - ENZYME nomenclature database: 2.5.1.147
BRENDA, the Enzyme Database: 2.5.1.147

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