KEGG   ENZYME: 2.5.1.150Help
Entry
EC 2.5.1.150                Enzyme                                 

Name
lycopene elongase/hydratase (dihydrobisanhydrobacterioruberin-forming);
lbtA (gene name);
lyeJ (gene name)
Class
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
BRITE hierarchy
Sysname
dimethylallyl-diphosphate:all-trans-lycopene dimethylallyltransferase (hydrating, dihydrobisanhydrobacterioruberin-forming)
Reaction(IUBMB)
(1) dimethylallyl diphosphate + all-trans-lycopene + H2O = dihydroisopentenyldehydrorhodopin + diphosphate [RN:R12285];
(2) dimethylallyl diphosphate + isopentenyldehydrorhodopin + H2O = dihydrobisanhydrobacterioruberin + diphosphate [RN:R12286]
Reaction(KEGG)
Substrate
dimethylallyl diphosphate [CPD:C00235];
all-trans-lycopene [CPD:C05432];
H2O [CPD:C00001];
isopentenyldehydrorhodopin [CPD:C22059]
Product
dihydroisopentenyldehydrorhodopin [CPD:C22058];
diphosphate [CPD:C00013];
dihydrobisanhydrobacterioruberin [CPD:C22060]
Comment
The enzyme, characterized from the bacterium Dietzia sp. CQ4 and the halophilic archaea Halobacterium salinarum and Haloarcula japonica, is bifunctional. It catalyses the elongation of the C40 carotenoid all-trans-lycopene by attaching an isoprene unit at C-2 as well as the hydroxylation of the previous end of the molecule. The enzyme acts at both ends of the substrate, and combined with the action of EC 1.3.99.37, 1-hydroxy-2-isopentenylcarotenoid 3,4-desaturase, it forms the C50 carotenoid dihydrobisanhydrobacterioruberin. cf. EC 2.5.1.149, lycopene elongase/hydratase (flavuxanthin-forming).
History
EC 2.5.1.150 created 2018
Orthology
K20616  lycopene elongase/hydratase (dihydrobisanhydrobacterioruberin-forming)
Genes
HPSE: HPF_03165
LMOI: VV02_03555
KOS: KORDIASMS9_04389
SRG: XF24_00923
MTH: MTH_1809
MMG: MTBMA_c03790
METC: MTCT_1649
MWO: MWSIV6_0342(lye)
METE: tca_01747(menA_2)
METK: FVF72_02655
TEU: TEU_00420
PPAC: PAP_07910
HAL: VNG_1682C
HSL: OE_3380R(lye)
HDL: HALDL1_13225(ubiA)
HHB: Hhub_3181(lye)
HJE: HacjB3_05885(ubiA)
HALH: HTSR_0321(ubiA)
HHSR: HSR6_0307(ubiA)
HSU: HLASF_0239(ubiA)
HSF: HLASA_0239(ubiA)
HMA: rrnAC0320(ubiA)
HHI: HAH_1057(ubiA1)
HHN: HISP_05430(ubiA)
HAB: SG26_13100(ubiA)
NPH: NP_4766A(lyeJ)
NMO: Nmlp_3027(lye)
HUT: Huta_2374
HTI: HTIA_2107
HMU: Hmuk_1361
HALL: LC1Hm_0582(ubiA)
HWA: HQ_2862A(lyeJ)
HWC: Hqrw_3256(lyeJ)
HVO: HVO_2527(lye)
HME: HFX_2549(ubiA)
HGI: ABY42_12665(ubiA)
HLA: Hlac_1898
HDF: AArcSl_1204(lyeJ)
HTU: Htur_2703
NMG: Nmag_1002(lye)
NAT: NJ7G_1611
SALI: L593_04760(ubiA)
HLR: HALLA_16020(ubiA)
POG: Pogu_1956
 » show all
Taxonomy
Reference
1  [PMID:17008032]
  Authors
Tao L, Yao H, Cheng Q
  Title
Genes from a Dietzia sp. for synthesis of C40 and C50 beta-cyclic carotenoids.
  Journal
Gene 386:90-7 (2007)
DOI:10.1016/j.gene.2006.08.006
  Sequence
Reference
2  [PMID:21840984]
  Authors
Dummer AM, Bonsall JC, Cihla JB, Lawry SM, Johnson GC, Peck RF
  Title
Bacterioopsin-mediated regulation of bacterioruberin biosynthesis in Halobacterium salinarum.
  Journal
J Bacteriol 193:5658-67 (2011)
DOI:10.1128/JB.05376-11
  Sequence
[hal:VNG_1682C]
Reference
3  [PMID:25712483]
  Authors
Yang Y, Yatsunami R, Ando A, Miyoko N, Fukui T, Takaichi S, Nakamura S
  Title
Complete biosynthetic pathway of the C50 carotenoid bacterioruberin from lycopene in the extremely halophilic archaeon Haloarcula japonica.
  Journal
J Bacteriol 197:1614-23 (2015)
DOI:10.1128/JB.02523-14
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.5.1.150
IUBMB Enzyme Nomenclature: 2.5.1.150
ExPASy - ENZYME nomenclature database: 2.5.1.150
BRENDA, the Enzyme Database: 2.5.1.150

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