KEGG   ENZYME: 2.5.1.152Help
Entry
EC 2.5.1.152                Enzyme                                 

Name
D-histidine 2-aminobutanoyltransferase;
cntL (gene name)
Class
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:D-histidine N-[(3S)-3-amino-3-carboxypropyl]-transferase
Reaction(IUBMB)
S-adenosyl-L-methionine + D-histidine = N-[(3S)-3-amino-3-carboxypropyl]-D-histidine + S-methyl-5'-thioadenosine [RN:R12341]
Reaction(KEGG)
Substrate
S-adenosyl-L-methionine [CPD:C00019];
D-histidine [CPD:C06419]
Product
N-[(3S)-3-amino-3-carboxypropyl]-D-histidine [CPD:C22025];
S-methyl-5'-thioadenosine [CPD:C00170]
Comment
The enzyme, characterized from the bacterium Staphylococcus aureus, participates in the biosynthesis of the metallophore staphylopine, which is involved in the acquisition of nickel, copper, and cobalt.
History
EC 2.5.1.152 created 2019
Orthology
K23120  histidine 2-aminobutanoyltransferase
Genes
YPE: YPO1346
YPK: y2836
YPH: YPC_2841
YPA: YPA_0632
YPN: YPN_2638
YPM: YP_1250(smtA3)
YPP: YPDSF_2353
YPG: YpAngola_A1576
YPZ: YPZ3_1228
YPT: A1122_18845
YPD: YPD4_1191
YPX: YPD8_0954
YPW: CH59_496
YPJ: CH55_1202
YPV: BZ15_2208
YPL: CH46_3783
YPS: YPTB1372
YPO: BZ17_1147
YPY: YPK_2717
YPB: YPTS_1471
YPQ: DJ40_856
YPU: BZ21_648
YPR: BZ20_607
YPC: BZ23_982
YPF: BZ19_780
SERF: L085_18085
PAE: PA4836
PAEV: N297_5005
PAEI: N296_5005
PAEP: PA1S_26285
PAEM: U769_26540
PAEL: T223_26735
PAEG: AI22_07715
PAEC: M802_5003
PAEO: M801_4870
BCEO: I35_7428
BCED: DM42_6942
MAN: A11S_1706
ACU: Atc_0766
BHA: BH2072
LSP: Bsph_1830
SAU: SA2257
SAV: SAV2469
SAW: SAHV_2453
SAM: MW2393
SAS: SAS2360
SAR: SAR2556
SAC: SACOL2478
SAE: NWMN_2366
SAD: SAAV_2535
SUU: M013TW_2429(cntL)
SUJ: SAA6159_02366(fmrO)
SUK: SAA6008_02510(fmrO)
SUZ: MS7_2482
SUG: SAPIG2519
SAUA: SAAG_00295
SAUS: SA40_2217
SAUU: SA957_2301
SAUG: SA268_2374
SAUF: X998_2453
SAB: SAB2352c
SAUB: C248_2519
SAUC: CA347_2548
SAUR: SABB_01208
SAUI: AZ30_12965
SAUD: CH52_06640
SAMS: NI36_12275
SEP: SE0202
SER: SERP2374
SEPP: SEB_00130
SEPS: DP17_1262
SDT: SPSE_2400
SPAS: STP1_1305
SSCH: LH95_11155
SSCZ: RN70_11905
SCAR: DWB96_00445(cntL)
SFF: FOB90_08235(cntL)
AMT: Amet_2051
HSC: HVS_10550
SALQ: SYNTR_0809
AMI: Amir_3919
 » show all
Taxonomy
Reference
1  [PMID:27230378]
  Authors
Ghssein G, Brutesco C, Ouerdane L, Fojcik C, Izaute A, Wang S, Hajjar C, Lobinski R, Lemaire D, Richaud P, Voulhoux R, Espaillat A, Cava F, Pignol D, Borezee-Durant E, Arnoux P
  Title
Biosynthesis of a broad-spectrum nicotianamine-like metallophore in Staphylococcus aureus.
  Journal
Science 352:1105-9 (2016)
DOI:10.1126/science.aaf1018
  Sequence
[sav:SAV2469]
Other DBs
ExplorEnz - The Enzyme Database: 2.5.1.152
IUBMB Enzyme Nomenclature: 2.5.1.152
ExPASy - ENZYME nomenclature database: 2.5.1.152
BRENDA, the Enzyme Database: 2.5.1.152

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