KEGG   ENZYME: 2.5.1.155
Entry
EC 2.5.1.155                Enzyme                                 
Name
phosphoglycerol geranylfarnesyltransferase;
GFGP synthase
Class
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
Sysname
all-trans pentaprenyl diphosphate:sn-glycerol-1-phosphate pentaprenyltransferase
Reaction(IUBMB)
all-trans-pentaprenyl diphosphate + sn-glycerol 1-phosphate = sn-3-O-(farnesylgeranyl)glycerol 1-phosphate + diphosphate [RN:R13006]
Reaction(KEGG)
R13006
Substrate
all-trans-pentaprenyl diphosphate [CPD:C04217];
sn-glycerol 1-phosphate [CPD:C00623]
Product
sn-3-O-(farnesylgeranyl)glycerol 1-phosphate [CPD:C22513];
diphosphate [CPD:C00013]
Comment
The enzyme, characterized from the archaeon Aeropyrum pernix, catalyses the first pathway-specific step in the biosynthesis of the core membrane C25,C25-diether lipids in some archaea. It does not act on geranylgeranyl diphosphate. cf. EC 2.5.1.41, phosphoglycerol geranylgeranyltransferase.
History
EC 2.5.1.155 created 2022
Orthology
K25920  phosphoglycerol geranylfarnesyltransferase
Genes
APEAPE_0621.1
ACJACAM_0473
Reference
1  [PMID:29427665]
  Authors
Yoshida R, Yoshimura T, Hemmi H.
  Title
Biosynthetic machinery for C25,C25-diether archaeal lipids from the hyperthermophilic archaeon Aeropyrum pernix.
  Journal
Biochem Biophys Res Commun 497:87-92 (2018)
DOI:10.1016/j.bbrc.2018.02.028
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.5.1.155
IUBMB Enzyme Nomenclature: 2.5.1.155
ExPASy - ENZYME nomenclature database: 2.5.1.155
BRENDA, the Enzyme Database: 2.5.1.155

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