KEGG   ENZYME: 2.5.1.2
Entry
EC 2.5.1.2                  Enzyme                                 
Name
thiamine pyridinylase;
pyrimidine transferase;
thiaminase I;
thiamin hydrolase;
thiamin pyridinolase;
thiaminase (ambiguous);
thiamine pyridinolase;
thiamin pyridinylase;
thiamin:base 2-methyl-4-aminopyrimidine-5-methenyltransferase
Class
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
Sysname
thiamine:base 2-methyl-4-aminopyrimidine-5-methenyltransferase
Reaction(IUBMB)
thiamine + pyridine = 1-[(4-amino-2-methylpyrimidin-5-yl)methyl]pyridinium + 4-methyl-5-(2-hydroxyethyl)thiazole [RN:R02863]
Reaction(KEGG)
R02863
Substrate
thiamine [CPD:C00378];
pyridine [CPD:C00747]
Product
1-[(4-amino-2-methylpyrimidin-5-yl)methyl]pyridinium [CPD:C02691];
4-methyl-5-(2-hydroxyethyl)thiazole [CPD:C04294]
Comment
Various bases and thiol compounds can act instead of pyridine.
History
EC 2.5.1.2 created 1961, modified 1976, modified 2001
Pathway
ec00730  Thiamine metabolism
ec01100  Metabolic pathways
Orthology
K10811  thiamine pyridinylase
Genes
SRRSerAS9_2400
SRSSerAS12_2400
SRASerAS13_2401
PPAVLOZ86_19345
BPSBPSS1103
BPMBURPS1710b_A0059
BPLBURPS1106A_A1472
BPDBURPS668_A1560
BPSEBDL_4389
BPSMBBQ_5068
BPSUBBN_4528
BPSDBBX_6232
BPZBP1026B_II1163
BPQBPC006_II1476
BPKBBK_6008
BPSHDR55_4224
BPSABBU_4959
BPSOX996_4304
BUTX994_6054
BTEBTH_II1306
BTQBTQ_4590
BTJBTJ_5573
BTZBTL_4040
BTDBTI_3614
BTVBTHA_3841
BTHEBTN_3627
BTHMBTRA_4326
BTHADR62_3661
BTHLBG87_4047
BOKDM82_5265
BOCBG90_5344
BUUWS70_23065
BSAVWS86_24130
BHGI6G56_22415(bcmE)
BGLbglu_2g17490
BGUKS03_4180
BULBW21_5615
BGPBGL_2c23410
BPLAbpln_2g23690
BUDAQ610_25130
DDEDde_0637
MXAMXAN_4523
MSDMYSTI_05824
MYMA176_002382
MFBMFUL124B02_18185
CCXCOCOR_04713
MFULILAB_30640
MMASMYMAC_004429
SURSTAUR_1070 STAUR_5800
AGEAA314_04006
AVMJQX13_02355 JQX13_08095
MBDMEBOL_006407
CFUSCYFUS_003904
SCLsce5380
SCUSCE1572_16110
CCROCMC5_025790
HOHHoch_1390
RPODE0E05_16885(bcmE)
BJUBJ6T_82380
LABPFJ695_26280(bcmE)
SLMSMM221_15680(bcmE)
CBOCBO0770
CBACLB_0812
CBHCLC_0826
CBYCLM_0920
CBLCLK_0178
CBBCLD_3794
CBICLJ_B0819
CBFCLI_0856
CBMCBF_0826
CBJH04402_00829
CLDCLSPO_c07890
MEDMELS_1668
RFAA3L23_04897
SRNA4G23_01805
SFBCP974_10120(bcmE)
AERAERYTH_06055 AERYTH_16485
CYCPCC7424_0400
MPROBJP34_31205
RSINB6N60_00030
CCURIAR63_14895
FEIK9M53_05980
 » show all
Reference
1  [PMID:13158184]
  Authors
FUJITA A.
  Title
Thiaminase.
  Journal
Adv Enzymol Relat Subj Biochem 15:389-421 (1954)
DOI:10.1002/9780470122600.ch9
Reference
2  [PMID:13471505]
  Authors
KENTEN RH.
  Title
[Pteridium aquilinum (L.) Kuhn.]
  Journal
Biochem J 67:25-33 (1957)
DOI:10.1042/bj0670025
Reference
3  [PMID:4966932]
  Authors
Wittliff JL, Airth RL.
  Title
The extracellular thiaminase I of Bacillus thiaminolyticus. I. Purification and physicochemical properties.
  Journal
Biochemistry 7:736-44 (1968)
DOI:10.1021/bi00842a032
Other DBs
ExplorEnz - The Enzyme Database: 2.5.1.2
IUBMB Enzyme Nomenclature: 2.5.1.2
ExPASy - ENZYME nomenclature database: 2.5.1.2
BRENDA, the Enzyme Database: 2.5.1.2
CAS: 9030-35-7

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