KEGG   ENZYME: 2.5.1.2Help
Entry
EC 2.5.1.2                  Enzyme                                 

Name
thiamine pyridinylase;
pyrimidine transferase;
thiaminase I;
thiamin hydrolase;
thiamin pyridinolase;
thiaminase (ambiguous);
thiamine pyridinolase;
thiamin pyridinylase;
thiamin:base 2-methyl-4-aminopyrimidine-5-methenyltransferase
Class
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
BRITE hierarchy
Sysname
thiamine:base 2-methyl-4-aminopyrimidine-5-methenyltransferase
Reaction(IUBMB)
thiamine + pyridine = 1-[(4-amino-2-methylpyrimidin-5-yl)methyl]pyridinium + 4-methyl-5-(2-hydroxyethyl)thiazole [RN:R02863]
Reaction(KEGG)
Substrate
thiamine [CPD:C00378];
pyridine [CPD:C00747]
Product
1-[(4-amino-2-methylpyrimidin-5-yl)methyl]pyridinium [CPD:C02691];
4-methyl-5-(2-hydroxyethyl)thiazole [CPD:C04294]
Comment
Various bases and thiol compounds can act instead of pyridine.
History
EC 2.5.1.2 created 1961, modified 1976, modified 2001
Pathway
ec00730  Thiamine metabolism
Orthology
K10811  thiamine pyridinylase
Genes
XNE: XNC1_0590
XNM: XNC2_0577
BPS: BPSS1103
BPM: BURPS1710b_A0059
BPL: BURPS1106A_A1472
BPD: BURPS668_A1560
BPSE: BDL_4389
BPSM: BBQ_5068
BPSU: BBN_4528
BPSD: BBX_6232
BPK: BBK_6008
BPSH: DR55_4224
BPSA: BBU_4959
BPSO: X996_4304
BUT: X994_6054
BTQ: BTQ_4590
BTJ: BTJ_5573
BTZ: BTL_4040
BTD: BTI_3614
BTV: BTHA_3841
BTHE: BTN_3627
BTHM: BTRA_4326
BTHA: DR62_3661
BTHL: BG87_4047
BOK: DM82_5265
BOC: BG90_5344
BGU: KS03_4180
BUL: BW21_5615
MXA: MXAN_4523
SCL: sce5380
RPOD: E0E05_16885(bcmE)
LABP: FJ695_26280(bcmE)
CBO: CBO0770
CBA: CLB_0812
CBH: CLC_0826
CBY: CLM_0920
CBL: CLK_0178
CBB: CLD_3794
CBI: CLJ_B0819
CBF: CLI_0856
CBM: CBF_0826
MED: MELS_1668
 » show all
Taxonomy
Reference
1  [PMID:13158184]
  Authors
FUJITA A.
  Title
Thiaminase.
  Journal
Adv Enzymol Relat Subj Biochem 15:389-421 (1954)
Reference
2  [PMID:13471505]
  Authors
KENTEN RH.
  Title
[Pteridium aquilinum (L.) Kuhn.]
  Journal
Biochem J 67:25-33 (1957)
Reference
3  [PMID:4966932]
  Authors
Wittliff JL, Airth RL.
  Title
The extracellular thiaminase I of Bacillus thiaminolyticus. I. Purification and physicochemical properties.
  Journal
Biochemistry 7:736-44 (1968)
Other DBs
ExplorEnz - The Enzyme Database: 2.5.1.2
IUBMB Enzyme Nomenclature: 2.5.1.2
ExPASy - ENZYME nomenclature database: 2.5.1.2
BRENDA, the Enzyme Database: 2.5.1.2
CAS: 9030-35-7

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